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Earn up to 11.0 AMA PRA Category 1 Credits™ HARVARD MEDICAL SCHOOL TEACHING HOSPITAL Cardiovascular Medicine 2016 Updates for Practitioners October 21–22, 2016 | Boston MA This special program is offered only once every two years. To be assured a spot, early registration is strongly advised. Education for: • Cardiologists • Internists • Family Physicians • Geriatricians • Nurse Practitioners • Physician Assistants • Nurses • Pharmacists In just 1.5 days, you will ensure your knowledge is up to date with the rapid developments that are reshaping cardiovascular medicine: … and other practitioners who care for patients with cardiovascular diseases ϜϜInnovative medical & mechanical therapies for heart failure ϜϜSingle vs. dual antiplatelet therapy: the latest evidence ϜϜTransformative new research on optimal blood pressure ϜϜPCSK9 inhibitors and the new era of lipid management ϜϜChanging views on heart attack causation ϜϜImportant new options in the cardiac catheterization lab ϜϜAdvances in thrombus dissolution and new guidelines for anticoagulation therapy Plus critical updates on idiopathic pulmonary hypertension, renal artery denervation, cardiovascular genetics, stroke prevention in atrial fibrillation, and other timely topics. Register at CardiovascularMedicine2016.com Reasons to Attend In just 1.5 days, you will ensure your knowledge of cardiovascular medicine is up to date, with guidance from the world’s leading authorities in areas currently experiencing rapid change: • Lipid control • Blood pressure management • Heart attack prevention • Acute pulmonary embolism • Idiopathic pulmonary hypertension • Single vs. dual antiplatelet therapy • Renal denervation • Cardiovascular genomics and genetics • Stroke prevention in atrial fibrillation • Left atrial appendage occlusion • Transcatheter valve replacement and repair • Heart failure with preserved injection fraction Special lecture by Patrick O’Gara, MD Dr. O’Gara is Director of Clinical Cardiology at Brigham and Women’s Hospital and recent Past President of the American College of Cardiology. His clinical activities are focused on patients with valvular heart disease, aortic disease, complex coronary artery disease, and other structural heart diseases. He has been named annually among the Top Doctors in Boston and in the U.S. since 2001. Dr. O’Gara’s presentation focuses on new consensus guidelines as well as adjustments that practitioners can make to align their practice with new models of care. Keynote dinner lecture by Bernard J. Gersh, MBChB, DPhil Professor of Medicine and Consultant at the Mayo Clinic, Dr. Gersh received his MBChB from the University of Cape Town and his DPhil from Oxford University as a Rhodes Scholar. He has published 990 manuscripts & book chapters, is the editor of 15 books, and is on the editorial board of 25 journals including Editor-in-Chief of UpToDate in Cardiology. He has received major awards from the ACC, AHA, and in 2013 was designated at the ESC as one of four “legends of modern cardiology.” Dr. Gersh is the 2015 recipient of the Mayo Clinic Distinguished Alumni Award. Dr. Gersh’s presentation focuses on the epidemic of cardiovascular diseases in the developing world, and the implications it has globally and for practitioners in the U.S. Join us from 6:00pm to 8:30pm on October 21 for a special networking reception and dinner. Exchange experiences with colleagues and get extended discussion time with our faculty over hors d’oeuvres and drinks. Then enjoy the keynote lecture by course co-director Dr. Bernard Gersh of the Mayo Clinic — with time built in for discussion and Q&A — followed by a delicious catered dinner. Faculty Disclosure As a provider accredited by ACCME, Mayo Clinic College of Medicine (Mayo School of Continuous Professional Development) must ensure balance, independence, objectivity and scientific rigor in its educational activities. Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty also will disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of this information will be published in course materials so those participants in the activity may formulate their own judgments regarding the presentation. Register at CardiovascularMedicine2016.com HARVARD MEDICAL SCHOOL TEACHING HOSPITAL Dear Colleague: Cardiovascular medicine has evolved rapidly during the past 12 months. Recent advances in prevention, diagnosis, and management will improve our clinical practice and yield improved patient outcomes. That is why it is our pleasure to invite you to the combined Brigham and Women’s Hospital/ Mayo Clinic course: Cardiovascular Medicine 2016: Updates for Practitioners, where internationally recognized leaders in the field will update you on the latest research, medications, and procedures across key areas of cardiovascular medicine. Highlights include: • FDA approval of Vorapaxar and the future of single and dual antiplatelet therapy • The groundbreaking SPRINT trial on optimal blood pressure goals • Deciding when PCSK9 inhibitors are medically justified • Beyond plaque rupture: new insights into acute myocardial infarction • When and how use Entresto® to manage advanced heart failure • The promise of ultrasound-accelerated catheter-directed thrombolysis for pulmonary embolism and deep vein thrombosis • New, novel and combination medical therapies for idiopathic pulmonary hypertension • Updated guidelines for stroke prevention in atrial fibrillation • Important advances in transcatheter valve replacement and repair Cardiologists, internists, family physicians, geriatricians, nurse practitioners, physician assistants, and pharmacists can rely on this program for critical updates and practical education. By participating, you will learn how to put this new information to immediate and practical use, and how to ensure that your patients receive the highest, most up-to-date quality of care and achieve the best possible outcomes. We look forward to seeing you on Friday and Saturday, October 21 and 22, for this fast-paced, intellectually invigorating learning experience. Sincerely, Samuel Z. Goldhaber, MD Peter Libby, MD Bernard J. Gersh, MBChB, DPhil Charanjit S. Rihal, MD Course Co-Directors Register at CardiovascularMedicine2016.com Course Directors Samuel Z. Goldhaber, MD Dr. Goldhaber is Professor of Medicine at Harvard Medical School and Section Head of Vascular Medicine in the Cardiovascular Medicine Division at Brigham and Women’s Hospital (BWH). He is director of the BWH Thrombosis Research Group, medical co-director of the BWH Anticoagulation Management Service, and President and Founding Director of the nonprofit organization, North American Thrombosis Forum (www.NATFonline.org). Peter Libby, MD Dr. Libby is a Senior Physician at Brigham and Women’s Hospital, and holds the Mallinckrodt Professorship of Medicine at Harvard Medical School. He served as Chief of Cardiovascular Medicine at BWH from 1998 — 2014. Dr. Libby has received the Gold Medal of the European Society of Cardiology (2011), the Basic Research Prize of the American Heart Association (2011) and the Lifetime Achievement Award of the Heart Failure Association of the European Society of Cardiology (2014). Bernard J. Gersh, MBChB, DPhil Dr. Gersh is Professor of Medicine at the Mayo Clinic. A Rhodes Scholar, he has published 990 manuscripts and book chapters, is the editor of 15 books, and is on the editorial board of 25 journals including Editor-in-Chief of UpToDate in Cardiology. He has received major awards from the ACC, AHA, and in 2013 was designated at the ESC as one of four “legends of modern cardiology.” Dr. Gersh is the 2015 recipient of the Mayo Clinic Distinguished Alumni Award. Charanjit S. Rihal, MD Dr. Rihal is the William S. and Ann Atherton Professor of Cardiology at the Mayo Clinic and Chair of the Department of Cardiovascular Diseases. Dr. Rihal’s clinical and research interests center around ischemic and valvular heart disease, particularly novel percutaneous interventional procedures. His administrative interests include finding new ways to enhance and deliver value in complex healthcare systems. Learning Objectives Upon conclusion of this program, participants should be able to: • Incorporate state-of-the-art cardiovascular advances into their everyday practice. • Determine appropriate medical management of coronary and peripheral artery disease, high blood pressure, high cholesterol, myocardial infarction, heart failure, stroke prevention in atrial fibrillation, pulmonary embolism, and pulmonary hypertension. • Explain the mechanical treatments available for high blood pressure, advanced heart failure, pulmonary embolism, structural heart disease, and stroke prevention in atrial fibrillation. • Integrate cardiovascular genetics into their daily practice. Course Description This course delivers a concise and comprehensive review of the most important updates in cardiovascular medicine. Cardiologists, internists, vascular specialists, family practitioners, pharmacists, PAs, NPs, and other healthcare providers can rely on this program for critical updates and recommendations for contemporary patient management. The course is based upon collaborative and integrated presentations and discussion from senior clinicians at Brigham and Women’s Hospital and the Mayo Clinic. The faculty is known globally for its expertise in clinical care and teaching. The program is designed for those providers who care for patients with cardiovascular conditions. There will be ample time for Q&A, discussion, and interaction with course faculty. Accreditation Mayo Clinic College of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Mayo Clinic College of Medicine designates this live activity for a maximum of 11.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Other Health Care Professionals A certificate of attendance will be provided to other health care professionals for requesting credits in accordance with state nursing boards, specialty societies, or other professional associations. Attendees should ensure in advance that their credentialing or licensing organization accepts AMA PRA Category 1 Credits™ from the sponsor of this activity. Register at CardiovascularMedicine2016.com Cardiovascular Medic Friday, October 21 Noon – 1:30 pmRegistration 1:30 pm – 1:40 pmSeating 1:40 pm – 1:55 pm Welcome and Introductions Course Directors OPTIMAL ANTIPLATELET THERAPY FOR CORONARY AND PERIPHERAL ARTERY DISEASE 1:55 pm – 2:20 pm Aspirin, Clopidogrel, Ticagrelor, Prasugrel, and/or Vorapaxar: Should We Use Single or Dual Antiplatelet Therapy? BWH: Deepak L. Bhatt, MD, MPH 2:20 pm – 2:30 pmDiscussion/Q&A IS 120 mm Hg SYSTOLIC THE OPTIMAL TARGET BLOOD PRESSURE? 2:30 pm – 2:55 pm The SPRINT Trial: 120 mm Hg Systolic versus 140 mm Hg Systolic as the Target Blood Pressure BWH: Marc Pfeffer, MD, PhD 2:55 pm – 3:20 pm Can Renal Artery Denervation rather than Three Antihypertensive Medications Achieve the Target Blood Pressure? Mayo: Rajiv Gulati, MD 3:20 pm – 3:40 pmDiscussion/Q&A STATINS, EZETIMIDE, AND PCSK9 INHIBITORS: PARADIGMS AND GUIDELINES FOR THE NEW ERA OF LIPID MANAGEMENT 3:40 pm – 4:05 pm Integrated Management of Elevated Lipid Levels Mayo: Iftikhar Kullo, MD 4:05 pm – 4:30 pm PCSK9 and Its Inhibition: A New Era in LDL Therapeutics and Cardiovascular Risk Reduction BWH: Jorge Plutzky, MD 4:30 pm – 4:50 pmDiscussion/Q&A ACUTE MYOCARDIAL INFARCTION 4:50 pm – 5:15 pm Pathophysiology of Acute Myocardial Infarction: Beyond Plaque Rupture and Evolving Therapeutic Implications BWH: Peter Libby, MD 5:15 pm – 5:25 pmDiscussion/Q&A ACUTE PULMONARY EMBOLISM 5:25 pm – 5:50 pm Ideal Management of Acute Pulmonary Embolism: Important Updates and Advances BWH: Samuel Z. Goldhaber, MD 5:50 pm – 6:00 pmDiscussion/Q&A 6:00 pm – 6:30 pm NETWORKING RECEPTION KEYNOTE LECTURE AND DINNER 6:30 pm – 7:15 pm The Epidemic of Cardiovascular Disease in the Developing World: Global Implications and What It Means for You Mayo: Bernard J. Gersh, MBChB, DPhil 7:15 pm – 7:30 pmDiscussion/Q&A 7:30 pm – 8:30 pmDinner 8:30 pm Adjourn for the evening Program changes/substitutions may be made without notice. To view the most up-to-date version of the course program, please visit the course website. cine 2016 Saturday, October 22 7:30 am – 8:15 am Continental Breakfast 8:15 am – 8:30 amSeating ADVANCED HEART FAILURE: NOVEL AND INNOVATIVE MEDICAL AND MECHANICAL THERAPIES 8:30 am – 8:55 am Novel and Innovative Medical Therapies: Advanced Heart Failure Mayo: Brooks Edwards, MD 8:55 am – 9:20 am Novel and Innovative Mechanical Therapies: Advanced Heart Failure BWH: Mandeep Mehra, MD 9:20 am – 9:40 amDiscussion/Q&A SPECIAL LECTURE BY PATRICK O’GARA, MD 9:40 am – 10:05 am What’s Coming Next in Cardiovascular Medicine—A Special Update BWH: Patrick O’Gara, MD (recent Past President of the American College of Cardiology) 10:05 am – 10:15 amDiscussion/Q&A 10:15 am – 10:45 am Coffee Break IDIOPATHIC PULMONARY HYPERTENSION 10:45 am – 11:10 am Updates in Pathophysiology, Genetics, and Medical Management of Idiopathic Pulmonary Hypertension BWH: Aaron Waxman, MD, PhD 11:10 am – 11:20 amDiscussion/Q&A HEART FAILURE WITH PRESERVED EJECTION FRACTION 11:20 am – 11:45 am Novel Concepts, Pathophysiology, and Best Practices for the Medical Management of Heart Failure with Preserved Ejection Fraction Mayo: Barry Borlaug, MD 11:45 am – 11:55 amDiscussion/Q&A MANAGEMENT OF STRUCTURAL HEART DISEASE IN THE CARDIAC CATHETERIZATION LABORATORY 11:55 am – 12:20 pm Improving Patient Outcomes in Transcatheter Aortic Valve Replacement and Mitral Valve Repair Mayo: Charanjit S. Rihal, MD 12:20 pm – 12:30 pmDiscussion/Q&A 12:30 pm – 1:20 pm Networking Luncheon 1:20 pm – 1:30 pm Seating for Afternoon Sessions STROKE PREVENTION IN ATRIAL FIBRILLATION 1:30 pm – 1:55 pm Stroke Prevention in Atrial Fibrillation: Biomarkers, Genomics, and Anticoagulant Therapy BWH: Christian T. Ruff, MD, MPH 1:55 pm – 2:20 pm When To Recommend Left Atrial Appendage Occlusion: Current and Future Status Mayo: Paul Friedman, MD 2:20 pm – 2:40 pmDiscussion/Q&A VASCULAR MEDICINE UPDATE 2:40 pm – 3:15 pm Vascular Medicine Quiz: Multi-Modality Imaging, Inflammatory Illnesses, Dermatologic Mysteries, and More BWH: Gregory Piazza, MD, MS 3:15 pm – 3:35 pm Refreshment Break CARDIOVASCULAR GENOMICS AND GENETICS: PRACTICAL APPLICATIONS 3:35 pm – 4:00 pm Application of Cardiovascular Genomics at the Bedside: Are We There Yet? Mayo: Richard Weinshilboum, MD 4:00 pm – 4:25 pm Best Practices to Integrate Cardiovascular Genetics into Daily Clinical Practice BWH: Calum MacRae, MD, PhD 4:25 pm – 4:45 pmDiscussion/Q&A 4:45 pm – 5:00 pm Wrap-up and Adjourn Calum MacRae, MD, PhD; Course Directors Registration Information Register at CardiovascularMedicine2016.com Cardiovascular Medicine 2016 • October 21–22 • Boston, MA Course Tuition Register after September 15, 2016 Register on or before September 15, 2016 $345 $295 (Save $50) Fees shown in USD. Your tuition includes the networking reception and dinner on October 21, breakfast and lunch on October 22, coffee and snack breaks on both days, an online syllabus, and the printed program book. Registration Mayo Clinic Cardiovascular CME has implemented an online conference registration system. If this is your first time using the online system, you will need to create a profile and login account. The system will guide you through the profile and login process. An e-mail address is required upon registration. A letter of confirmation will be forwarded to this address upon receipt of payment and submitted registration. Present this letter of confirmation when checking in at the meeting registration desk. Although it is not Mayo Clinic Division of Cardiovascular Diseases policy to limit the number of registrants for a course, conference room facilities may necessitate closing of enrollment; therefore, early registration is advised. Enrollment for this program is limited. Cancellation Policy If you cancel your participation in this course, your registration fee, less a $75 administrative fee, will be refunded when written notification is received by Mayo Clinic Cardiovascular CME before October 7, 2016 (email: cvcme@ mayo.edu). No refunds will be made on or after October 7, 2016. Canceled registrations are non-transferable. Mayo Clinic Division of Cardiovascular Diseases reserves the right to cancel or postpone any course due to unforeseen circumstances. In the unlikely event Mayo Clinic Division of Cardiovascular Diseases must cancel or postpone this course, Mayo Clinic Division of Cardiovascular Diseases will refund the registration fee, but is not responsible for any related costs, charges, or expenses to participants, including fees assessed by airline/travel/lodging agencies. Venue Joseph B. Martin Conference Center at Harvard Medical School 77 Avenue Louis Pasteur • Boston, MA 02115 Located within the New Research Building at Harvard Medical School, the Joseph B. Martin Conference Center offers a new standard of technical and architectural excellence to conference participants. Its convenient location in the heart of Boston’s Longwood Medical Area puts you within walking distance of historic Fenway Park, the Emerald Necklace Conservancy, and the MBTA’s Longwood stop—which brings all of Boston within easy reach. Complimentary internet is provided in the meeting room. Accommodations Hyatt Regency Boston • One Avenue de Lafayette • Boston, Massachusetts, 02111 • Tel: +1 617 912 1234 A limited number of rooms have been reserved at the Hyatt Regency Boston Hotel until September 29, 2016. When calling the hotel, be sure to specify that you are enrolled in this activity to receive a reduced room rate of $249 per person single occupancy and $269 per double occupancy. Hotel arrangements can also be made online before September 29 by visiting the course website at www.CardiovascularMedicine2016.com and using the course-specific reservation link on the Venue page. Inquiries Cardiovascular Continuing Education, 200 First Street SW - Gonda 6-472, Rochester, MN 55905 E-mail: [email protected] • Phone: 800-283-6296 HARVARD MEDICAL SCHOOL TEACHING HOSPITAL Cardiovascular Medicine 2016 MC4111-184 October 21–22, 2016 | Boston MA Timely and important updates for: • Single vs. dual antiplatelet therapy • Blood pressure management • Renal denervation • Lipid control • Heart attack prevention • Heart failure with preserved injection fraction • Acute pulmonary embolism • Idiopathic pulmonary hypertension • Transcatheter valve replacement and repair • Stroke prevention in atrial fibrillation • Left atrial appendage occlusion • Cardiovascular genomics and genetics Register at CardiovascularMedicine2016.com Mayo Clinic 200 First Street SW Rochester, MN 55905