Download the endocrine system

THE ENDOCRINE SYSTEM
The nervous system coordinates rapid and precise responses to stimuli using action potentials. The endocrine
system maintains homeostasis and long-term control using chemical signals. The endocrine system works in
parallel with the nervous system to control growth and maturation along with homeostasis. Endocrine messages
are sent through the blood and are generally slower that nervous messages and the effects tend to last longer.
Hormones
The endocrine system is a collection of glands that secrete chemical messages we call hormones. These signals
are passed through the blood to arrive at a target organ, which has cells possessing the appropriate receptor.
Exocrine glands (not part of the endocrine system) secrete products that are passed outside the body. Sweat
glands, salivary glands, and digestive glands are examples of exocrine glands.
Steroids
Steroids are lipids derived from cholesterol. Testosterone is the male sex hormone. Estradiol, similar in
structure to testosterone, is responsible for many female sex characteristics. Steroid hormones are secreted by
the gonads, adrenal cortex, and placenta.
Endocrine Systems and Feedback
The endocrine system uses cycles and negative feedback to
regulate physiological functions. Negative feedback regulates
the secretion of almost every hormone. Cycles of secretion
maintain physiological and homeostatic control. These cycles
can range from hours to months in duration. (one positive
loop – oxytocin)
Mechanisms of Hormone Action
The endocrine system acts by releasing hormones that in turn trigger actions in
specific target cells. Receptors on target cell membranes bind only to one type
of hormone. There are two mechanisms of hormone action on all target cells.
Nonsteroid Hormones
Nonsteroid hormones (water soluble) do not enter the cell but bind to plasma
membrane receptors, generating a chemical signal (second messenger) inside
the target cell. Second messengers activate other intracellular chemicals to
produce the target cell response.
Steroid Hormones
The second mechanism involves steroid hormones, which pass through the
plasma membrane and act in a two step process. Steroid hormones bind, once
inside the cell, to the nuclear membrane receptors, producing an activated
hormone-receptor complex. The activated hormone-receptor complex binds to
DNA and activates specific genes, increasing production of proteins.
The Nervous and Endocrine Systems (T-Man)
The pituitary gland (often called the master gland) is located in a small bony cavity at the base of the brain. A
stalk links the pituitary to the hypothalamus, which controls release of pituitary hormones. The pituitary gland
has two lobes: the anterior and posterior lobes.
The hypothalamus contains neurons that control releases from the anterior pituitary. Hypothalamic hormones
are released into a portal system connecting the hypothalamus and pituitary, and cause targets in the pituitary to
release eight hormones.
Hormone
HGH
TSH
Thyroxine
Prolactin
FHS
LH
Pos/Pit
ADH
Oxytocin
Effects
Stimulates thyroid
Increase metabolism
Diseases
Gigantism, acromegaly
Hyper – too much hypo is low.
Eggs in girls, sperm in boys –
sex hormones –
Anti pee hormone – conserve water
Baby out hormone -
The Pancreas
The pancreas contains
clusters of endocrine cells
(the pancreatic islets). The
islets secrete the hormones
insulin and glucagon,
which regulate blood
glucose levels.
After a meal, blood glucose
levels rise, prompting the
release of insulin, which
causes cells to take up
glucose, and liver and
skeletal muscle cells to
form the carbohydrate
glycogen. As glucose
levels in the blood fall,
further insulin production
is inhibited. Glucagon
causes the breakdown of
glycogen into glucose, which in turn is released into the blood to maintain glucose levels within a homeostatic
range. Glucagon production is stimulated when blood glucose levels fall, and inhibited when they rise.
Diabetes results from inadequate levels of insulin. Type I diabetes is characterized by inadequate levels of
insulin secretion, often due to a genetic cause (rapid loss of insulin). Type II usually develops in adults from
both genetic and environmental causes. Loss of response of targets to insulin rather than lack of insulin causes
this type of diabetes. Diabetes causes impairment in the functioning of the eyes, circulatory system, nervous
system, and failure of the kidneys. Diabetes is the second leading cause of blindness in the US. Treatments
involve daily injections of insulin, monitoring of blood glucose levels and a controlled diet.
The Adrenal Glands
Each kidney has an adrenal gland located above it. The adrenal gland is divided into an inner medulla and an
outer cortex. The medulla synthesizes amine hormones, the cortex secretes steroid hormones. The adrenal
medulla consists of modified neurons that secrete two hormones: epinephrine and norepinephrine. Stimulation
of the cortex by the sympathetic nervous system causes release of hormones into the blood to initiate the "fight
or flight" response. The adrenal cortex produces several steroid hormones in three classes: mineralocorticoids,
glucocorticoids, and sex hormones. Mineralocorticoids maintain electrolyte balance. Glucocorticoids produce a
long-term, slow response to stress by raising blood glucose levels through the breakdown of fats and proteins;
they also suppress the immune response and inhibit the inflammatory response. (SHORT TERM VS LONG)
The Thyroid Gland
The thyroid gland is located in the neck. Almost all body cells are targets of thyroid hormones. Thyroid
hormone increases the overall metabolic rate, regulates growth and development as well as the onset of sexual
maturity. Calcitonin is secreted by parathroids in the thyroid; it plays a role in regulation of calcium.
Other disorders –
Hyperthyroidism – high thyroid hormone levels – high metabolism, weight loss. Graves
Hypothyroidism – low thyroid hormone levels – low metabolism, weight gain.
Dwarfism – symmetrical dwarfism
Gigantism – excess growth – long bones
Acromegaly – gigantism after 20’s – after long bones are fused
Cushings - high levels of cortisol - upper body obesity, rounded face, increased fat around the neck, and
thinning arms and legs. Children tend to be obese with slowed growth rates.
Addison low levels of cortisol - characterized by weight loss, muscle weakness, fatigue, low blood pressure, and
sometimes darkening of the skin in both exposed and nonexposed parts of the body.
Place loop jot notes here….
Calitonin – bone in then PTH
Page 428 – Pituitary hormones: Posterior – ADH and Oxytocin
Anterior – everything else!
Long term and Short term Stress (see page 441)
Don’t forget stress and the effects on the body – long term and short term.
UNIT 2 Reproduction Biology 3201
Binary Fission - Prokaryotes are much simpler in their organization than are
eukaryotes. The method cell division is termed binary fission. The
prokaryotic chromosome is a single DNA molecule that first replicates, then
attaches each copy to a different part of the cell membrane. Following cell
splitting (cytokinesis), there are then two cells of identical genetic
composition.
The Cell Cycle of eukaryotic cells is the sequence of growth, DNA
replication, growth and cell division that all cells go through.
Mitosis - Division of Nucleus (pro-meta-ana; coil up, line up, split up)
Mitosis deals only with the segregation of the chromosomes
and organelles into daughter cells.
Replicated chromosomes consist of two molecules of DNA
(along with their associated histone proteins) known as
chromatids. The area where both chromatids are in contact
with each other is known as the centromere the kinetochores
are on the outer sides of the centromere. Remember that
chromosomes are coiled up chromatin.
During mitosis each daughter cell receives a copy of the original DNA (if you start with 46 in the parent cell,
you should end up with 46 chromosomes in each daughter cell). Animal cells have a centriole. Plants and most
other eukaryotic organisms lack centrioles. Cells that contain centrioles also have a series of smaller
microtubules, the aster, that extend from the centrioles to the cell membrane.
(pro-meta-ana; coil up, line up, split up)
Prophase - Chromatin condenses or coils up, the nuclear envelope
dissolves, centrioles (if present) divide and migrate, kinetochores and
kinetochore fibers form, and the spindle forms.
Metaphase follows Prophase. The chromosomes line up a the equator of
the spindle, where the spindles attach to the kinetochore fibers.
Anaphase begins with the separation of the centromeres, and the pulling
of chromosomes to opposite poles of the spindle.
Telophase is when the chromosomes reach the poles of their respective
spindles, the nuclear envelope reforms, chromosomes uncoil into
chromatin form, and the nucleolus (which had disappeared during
Prophase) reform. Where there was one cell there are now two smaller
cells each with exactly the same genetic information.
Cytokinesis is the process where one cell splits off from its sister cell.
This is quite different in plants and animals cells
Meiosis - Sexual reproduction occurs only in eukaryotes. During the formation of gametes, the number of
chromosomes is reduced by half, and returned to the full amount when the two gametes fuse during fertilization.
Haploid and diploid are terms referring to the number of sets of chromosomes in a cell. Diploid organisms are
those with two (di) sets of chromosomes. Human beings (except for their gametes), most animals and many
plants are diploid. We abbreviate diploid as 2n. Ploidy is a term referring to the number of sets of chromosomes.
Haploid organisms/cells have only one set of chromosomes, abbreviated as n. Organisms with more than two
sets of chromosomes are termed polyploid. Chromosomes that carry the same genes are termed homologous
chromosomes. Humans receive one set of homologous chromosomes from each parent.
Meiosis is a special type of nuclear division which segregates one copy of each homologous chromosome into
each new "gamete”. Meiosis, on the other hand, reduces the number of sets of chromosomes by half, so that
when fertilization occurs the ploidy of the parents will be reestablished.
Most cells in the human body are produced by mitosis. These are the somatic cells. Cells that become gametes
are referred to as germ line cells. The vast majority of cell divisions in the human body are mitotic, with meiosis
being restricted to the gonads.
Phases of Meiosis - Two successive nuclear divisions occur, Meiosis I and Meiosis II. Meiosis produces 4
haploid cells.
Prophase I has a unique event -- the pairing of homologous chromosomes. Synapsis is the process of linking
of the replicated homologous chromosomes. The resulting chromosome is termed a tetrad, being composed of
two chromatids from each chromosome, forming a thick (4-strand) structure. Crossing-over may occur at this
point. During crossing-over chromatids break and may be reattached to a different homologous chromosome.
This doubles the variability of gamete genotypes.
Events of Prophase I are similar to those in Prophase of mitosis: chromatin condenses into chromosomes, the
nucleolus dissolves, nuclear membrane is disassembled, and the spindle apparatus forms but THEN TETRADS
form (Tetrads coil up).
Metaphase I is when tetrads line-up along the equator of the spindle. Spindle fibers attach to the centromere
region of each homologous chromosome pair. (Tetrads line up)
Anaphase I is when the tetrads separate, and are drawn to opposite poles by the spindle fibers. The centromeres
in Anaphase I remain intact. (Tetrads separate)
Telophase I is similar to Telophase of mitosis, except that only one set of (replicated) chromosomes is in each
"cell". Depending on species, new nuclear envelopes may or may not form. Some animal cells may have
division of the centrioles during this phase. (Tetrads uncoil)
Meiosis II is just like mitosis. During Prophase II, nuclear envelopes (if they formed during Telophase I)
dissolve, and spindle fibers reform and chromosomes coil up. (Coil up, line up, split up)
Metaphase II is similar to mitosis, with spindles moving chromosomes into equatorial area and attaching to the
opposite sides of the centromeres in the kinetochore region.
During Anaphase II, the centromeres split and the former chromatids (now chromosomes) are segregated into
opposite sides of the cell.
Telophase II is identical to Telophase of mitosis. Cytokinesis separates the cells.
Sexual reproduction produces offspring that are genetically different from their parents. Asexual reproduction
produces offspring genetically identical to their parent. Fission, budding, fragmentation, and the formation of
rhizomes and stolons are some of the mechanisms that allow organisms to reproduce asexually.
Human Reproduction and Development
In sexual reproduction new individuals are produced by the fusion of haploid gametes to form a diploid zygote.
Sexual reproduction offers the benefit of generating genetic variation among offspring, which enhances the
chances of the population's survival.
The Male Reproductive System
Testes are suspended outside the abdominal cavity by the scrotum, (for an optimal temperature for sperm
development). Seminiferous tubules are inside each testis, and are where sperm are produced by meiosis.
Spermatocytes inside the tubules divide by meiosis to produce spermatids that in turn develop into mature
sperm.
Sperm production begins at puberty at continues throughout life, with several hundred million sperm being
produced each day. Once sperm form they move into the epididymis, where they mature and are stored.
Male Sex Hormones
The anterior pituitary produces folliclestimulating hormone (FSH) and
luteinizing hormone (LH). Action of LH
is controlled by the gonadotropinreleasing hormone (GnRH). LH
stimulates cells in the seminiferous
tubules to secrete testosterone, which
has a role in sperm production and
developing male secondary sex
characteristics. FSH acts on cells to help
in sperm maturation. Negative feedback
by testosterone controls the actions of
GnRH.
Sexual Structures
Sperm pass through the vas deferens and connect to a short ejaculatory duct that connects to the urethra. The
urethra passes through the penis and opens to the outside. Secretions from the seminal vesicles add fructose and
prostaglandins to sperm as they pass. The prostate gland secretes a milky alkaline fluid. The Cowpers gland
secretes a mucus-like fluid that provides lubrication for intercourse. Sperm and secretions make up semen.
The Female Reproductive System
The ovary contains many follicles
composed of a developing egg
surrounded by an outer layer of
follicle cells. Each egg begins
oogenesis as a primary oocyte. At
birth each female carries a lifetime
supply of developing oocytes, each of
which is in Prophase I. A developing
egg (secondary oocyte) is released
each month from puberty until
menopause, a total of 400-500 eggs.
Ovarian Cycles
After puberty the ovary cycles between a follicular phase (maturing follicles) and a luteal phase (presence of the
corpus luteum). These cyclic phases are interrupted only by pregnancy and continue until menopause, when
reproductive capability ends. The ovarian cycle lasts usually 28 days. During the first phase, the oocyte matures
within a follicle. At midpoint of the cycle, the oocyte is released from the ovary in a process known as
ovulation. Following ovulation the follicle forms a corpus luteum which synthesizes and prepares hormones to
prepare the uterus for pregnancy. The uterus has an inner layer, the endometrium, in which a fertilized egg
implants. At the lower end of the uterus the cervix connects the uterus to the vagina.
Hormones and Female Cycles (FSH, LH – pituitary
progesterone, estrogen – ovarian)
The ovarian cycle is hormonally regulated in two phases. The follicle secretes estrogen before ovulation; the
corpus luteum secretes both estrogen and progesterone after ovulation. The ovarian cycle covers events in the
ovary; the menstrual cycle occurs in the uterus. The menstrual cycles’ first day of blood flow (day 0) known as
menstruation. During menstruation the uterine lining is broken down and shed as menstrual flow. FSH and LH
are secreted on day 0, beginning both the menstrual cycle and the ovarian cycle. Both FSH and LH stimulate the
maturation of a single follicle in one of the ovaries and the secretion of estrogen. Rising levels of estrogen in the
blood trigger secretion of LH, which stimulates follicle maturation and ovulation (day 14, or midcycle). LH
stimulates the remaining follicle cells to form the corpus luteum, which produces both estrogen and
progesterone. Estrogen and progesterone stimulate the development of the endometrium and preparation of the
uterine inner lining for implantation of a zygote. If pregnancy does not occur, the drop in FSH and LH cause the
corpus luteum to disintegrate. The drop in hormones also causes the sloughing off of the inner lining of the
uterus by a series of muscle contractions of the uterus.