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THE ENDOCRINE SYSTEM The nervous system coordinates rapid and precise responses to stimuli using action potentials. The endocrine system maintains homeostasis and long-term control using chemical signals. The endocrine system works in parallel with the nervous system to control growth and maturation along with homeostasis. Endocrine messages are sent through the blood and are generally slower that nervous messages and the effects tend to last longer. Hormones The endocrine system is a collection of glands that secrete chemical messages we call hormones. These signals are passed through the blood to arrive at a target organ, which has cells possessing the appropriate receptor. Exocrine glands (not part of the endocrine system) secrete products that are passed outside the body. Sweat glands, salivary glands, and digestive glands are examples of exocrine glands. Steroids Steroids are lipids derived from cholesterol. Testosterone is the male sex hormone. Estradiol, similar in structure to testosterone, is responsible for many female sex characteristics. Steroid hormones are secreted by the gonads, adrenal cortex, and placenta. Endocrine Systems and Feedback The endocrine system uses cycles and negative feedback to regulate physiological functions. Negative feedback regulates the secretion of almost every hormone. Cycles of secretion maintain physiological and homeostatic control. These cycles can range from hours to months in duration. (one positive loop – oxytocin) Mechanisms of Hormone Action The endocrine system acts by releasing hormones that in turn trigger actions in specific target cells. Receptors on target cell membranes bind only to one type of hormone. There are two mechanisms of hormone action on all target cells. Nonsteroid Hormones Nonsteroid hormones (water soluble) do not enter the cell but bind to plasma membrane receptors, generating a chemical signal (second messenger) inside the target cell. Second messengers activate other intracellular chemicals to produce the target cell response. Steroid Hormones The second mechanism involves steroid hormones, which pass through the plasma membrane and act in a two step process. Steroid hormones bind, once inside the cell, to the nuclear membrane receptors, producing an activated hormone-receptor complex. The activated hormone-receptor complex binds to DNA and activates specific genes, increasing production of proteins. The Nervous and Endocrine Systems (T-Man) The pituitary gland (often called the master gland) is located in a small bony cavity at the base of the brain. A stalk links the pituitary to the hypothalamus, which controls release of pituitary hormones. The pituitary gland has two lobes: the anterior and posterior lobes. The hypothalamus contains neurons that control releases from the anterior pituitary. Hypothalamic hormones are released into a portal system connecting the hypothalamus and pituitary, and cause targets in the pituitary to release eight hormones. Hormone HGH TSH Thyroxine Prolactin FHS LH Pos/Pit ADH Oxytocin Effects Stimulates thyroid Increase metabolism Diseases Gigantism, acromegaly Hyper – too much hypo is low. Eggs in girls, sperm in boys – sex hormones – Anti pee hormone – conserve water Baby out hormone - The Pancreas The pancreas contains clusters of endocrine cells (the pancreatic islets). The islets secrete the hormones insulin and glucagon, which regulate blood glucose levels. After a meal, blood glucose levels rise, prompting the release of insulin, which causes cells to take up glucose, and liver and skeletal muscle cells to form the carbohydrate glycogen. As glucose levels in the blood fall, further insulin production is inhibited. Glucagon causes the breakdown of glycogen into glucose, which in turn is released into the blood to maintain glucose levels within a homeostatic range. Glucagon production is stimulated when blood glucose levels fall, and inhibited when they rise. Diabetes results from inadequate levels of insulin. Type I diabetes is characterized by inadequate levels of insulin secretion, often due to a genetic cause (rapid loss of insulin). Type II usually develops in adults from both genetic and environmental causes. Loss of response of targets to insulin rather than lack of insulin causes this type of diabetes. Diabetes causes impairment in the functioning of the eyes, circulatory system, nervous system, and failure of the kidneys. Diabetes is the second leading cause of blindness in the US. Treatments involve daily injections of insulin, monitoring of blood glucose levels and a controlled diet. The Adrenal Glands Each kidney has an adrenal gland located above it. The adrenal gland is divided into an inner medulla and an outer cortex. The medulla synthesizes amine hormones, the cortex secretes steroid hormones. The adrenal medulla consists of modified neurons that secrete two hormones: epinephrine and norepinephrine. Stimulation of the cortex by the sympathetic nervous system causes release of hormones into the blood to initiate the "fight or flight" response. The adrenal cortex produces several steroid hormones in three classes: mineralocorticoids, glucocorticoids, and sex hormones. Mineralocorticoids maintain electrolyte balance. Glucocorticoids produce a long-term, slow response to stress by raising blood glucose levels through the breakdown of fats and proteins; they also suppress the immune response and inhibit the inflammatory response. (SHORT TERM VS LONG) The Thyroid Gland The thyroid gland is located in the neck. Almost all body cells are targets of thyroid hormones. Thyroid hormone increases the overall metabolic rate, regulates growth and development as well as the onset of sexual maturity. Calcitonin is secreted by parathroids in the thyroid; it plays a role in regulation of calcium. Other disorders – Hyperthyroidism – high thyroid hormone levels – high metabolism, weight loss. Graves Hypothyroidism – low thyroid hormone levels – low metabolism, weight gain. Dwarfism – symmetrical dwarfism Gigantism – excess growth – long bones Acromegaly – gigantism after 20’s – after long bones are fused Cushings - high levels of cortisol - upper body obesity, rounded face, increased fat around the neck, and thinning arms and legs. Children tend to be obese with slowed growth rates. Addison low levels of cortisol - characterized by weight loss, muscle weakness, fatigue, low blood pressure, and sometimes darkening of the skin in both exposed and nonexposed parts of the body. Place loop jot notes here…. Calitonin – bone in then PTH Page 428 – Pituitary hormones: Posterior – ADH and Oxytocin Anterior – everything else! Long term and Short term Stress (see page 441) Don’t forget stress and the effects on the body – long term and short term. UNIT 2 Reproduction Biology 3201 Binary Fission - Prokaryotes are much simpler in their organization than are eukaryotes. The method cell division is termed binary fission. The prokaryotic chromosome is a single DNA molecule that first replicates, then attaches each copy to a different part of the cell membrane. Following cell splitting (cytokinesis), there are then two cells of identical genetic composition. The Cell Cycle of eukaryotic cells is the sequence of growth, DNA replication, growth and cell division that all cells go through. Mitosis - Division of Nucleus (pro-meta-ana; coil up, line up, split up) Mitosis deals only with the segregation of the chromosomes and organelles into daughter cells. Replicated chromosomes consist of two molecules of DNA (along with their associated histone proteins) known as chromatids. The area where both chromatids are in contact with each other is known as the centromere the kinetochores are on the outer sides of the centromere. Remember that chromosomes are coiled up chromatin. During mitosis each daughter cell receives a copy of the original DNA (if you start with 46 in the parent cell, you should end up with 46 chromosomes in each daughter cell). Animal cells have a centriole. Plants and most other eukaryotic organisms lack centrioles. Cells that contain centrioles also have a series of smaller microtubules, the aster, that extend from the centrioles to the cell membrane. (pro-meta-ana; coil up, line up, split up) Prophase - Chromatin condenses or coils up, the nuclear envelope dissolves, centrioles (if present) divide and migrate, kinetochores and kinetochore fibers form, and the spindle forms. Metaphase follows Prophase. The chromosomes line up a the equator of the spindle, where the spindles attach to the kinetochore fibers. Anaphase begins with the separation of the centromeres, and the pulling of chromosomes to opposite poles of the spindle. Telophase is when the chromosomes reach the poles of their respective spindles, the nuclear envelope reforms, chromosomes uncoil into chromatin form, and the nucleolus (which had disappeared during Prophase) reform. Where there was one cell there are now two smaller cells each with exactly the same genetic information. Cytokinesis is the process where one cell splits off from its sister cell. This is quite different in plants and animals cells Meiosis - Sexual reproduction occurs only in eukaryotes. During the formation of gametes, the number of chromosomes is reduced by half, and returned to the full amount when the two gametes fuse during fertilization. Haploid and diploid are terms referring to the number of sets of chromosomes in a cell. Diploid organisms are those with two (di) sets of chromosomes. Human beings (except for their gametes), most animals and many plants are diploid. We abbreviate diploid as 2n. Ploidy is a term referring to the number of sets of chromosomes. Haploid organisms/cells have only one set of chromosomes, abbreviated as n. Organisms with more than two sets of chromosomes are termed polyploid. Chromosomes that carry the same genes are termed homologous chromosomes. Humans receive one set of homologous chromosomes from each parent. Meiosis is a special type of nuclear division which segregates one copy of each homologous chromosome into each new "gamete”. Meiosis, on the other hand, reduces the number of sets of chromosomes by half, so that when fertilization occurs the ploidy of the parents will be reestablished. Most cells in the human body are produced by mitosis. These are the somatic cells. Cells that become gametes are referred to as germ line cells. The vast majority of cell divisions in the human body are mitotic, with meiosis being restricted to the gonads. Phases of Meiosis - Two successive nuclear divisions occur, Meiosis I and Meiosis II. Meiosis produces 4 haploid cells. Prophase I has a unique event -- the pairing of homologous chromosomes. Synapsis is the process of linking of the replicated homologous chromosomes. The resulting chromosome is termed a tetrad, being composed of two chromatids from each chromosome, forming a thick (4-strand) structure. Crossing-over may occur at this point. During crossing-over chromatids break and may be reattached to a different homologous chromosome. This doubles the variability of gamete genotypes. Events of Prophase I are similar to those in Prophase of mitosis: chromatin condenses into chromosomes, the nucleolus dissolves, nuclear membrane is disassembled, and the spindle apparatus forms but THEN TETRADS form (Tetrads coil up). Metaphase I is when tetrads line-up along the equator of the spindle. Spindle fibers attach to the centromere region of each homologous chromosome pair. (Tetrads line up) Anaphase I is when the tetrads separate, and are drawn to opposite poles by the spindle fibers. The centromeres in Anaphase I remain intact. (Tetrads separate) Telophase I is similar to Telophase of mitosis, except that only one set of (replicated) chromosomes is in each "cell". Depending on species, new nuclear envelopes may or may not form. Some animal cells may have division of the centrioles during this phase. (Tetrads uncoil) Meiosis II is just like mitosis. During Prophase II, nuclear envelopes (if they formed during Telophase I) dissolve, and spindle fibers reform and chromosomes coil up. (Coil up, line up, split up) Metaphase II is similar to mitosis, with spindles moving chromosomes into equatorial area and attaching to the opposite sides of the centromeres in the kinetochore region. During Anaphase II, the centromeres split and the former chromatids (now chromosomes) are segregated into opposite sides of the cell. Telophase II is identical to Telophase of mitosis. Cytokinesis separates the cells. Sexual reproduction produces offspring that are genetically different from their parents. Asexual reproduction produces offspring genetically identical to their parent. Fission, budding, fragmentation, and the formation of rhizomes and stolons are some of the mechanisms that allow organisms to reproduce asexually. Human Reproduction and Development In sexual reproduction new individuals are produced by the fusion of haploid gametes to form a diploid zygote. Sexual reproduction offers the benefit of generating genetic variation among offspring, which enhances the chances of the population's survival. The Male Reproductive System Testes are suspended outside the abdominal cavity by the scrotum, (for an optimal temperature for sperm development). Seminiferous tubules are inside each testis, and are where sperm are produced by meiosis. Spermatocytes inside the tubules divide by meiosis to produce spermatids that in turn develop into mature sperm. Sperm production begins at puberty at continues throughout life, with several hundred million sperm being produced each day. Once sperm form they move into the epididymis, where they mature and are stored. Male Sex Hormones The anterior pituitary produces folliclestimulating hormone (FSH) and luteinizing hormone (LH). Action of LH is controlled by the gonadotropinreleasing hormone (GnRH). LH stimulates cells in the seminiferous tubules to secrete testosterone, which has a role in sperm production and developing male secondary sex characteristics. FSH acts on cells to help in sperm maturation. Negative feedback by testosterone controls the actions of GnRH. Sexual Structures Sperm pass through the vas deferens and connect to a short ejaculatory duct that connects to the urethra. The urethra passes through the penis and opens to the outside. Secretions from the seminal vesicles add fructose and prostaglandins to sperm as they pass. The prostate gland secretes a milky alkaline fluid. The Cowpers gland secretes a mucus-like fluid that provides lubrication for intercourse. Sperm and secretions make up semen. The Female Reproductive System The ovary contains many follicles composed of a developing egg surrounded by an outer layer of follicle cells. Each egg begins oogenesis as a primary oocyte. At birth each female carries a lifetime supply of developing oocytes, each of which is in Prophase I. A developing egg (secondary oocyte) is released each month from puberty until menopause, a total of 400-500 eggs. Ovarian Cycles After puberty the ovary cycles between a follicular phase (maturing follicles) and a luteal phase (presence of the corpus luteum). These cyclic phases are interrupted only by pregnancy and continue until menopause, when reproductive capability ends. The ovarian cycle lasts usually 28 days. During the first phase, the oocyte matures within a follicle. At midpoint of the cycle, the oocyte is released from the ovary in a process known as ovulation. Following ovulation the follicle forms a corpus luteum which synthesizes and prepares hormones to prepare the uterus for pregnancy. The uterus has an inner layer, the endometrium, in which a fertilized egg implants. At the lower end of the uterus the cervix connects the uterus to the vagina. Hormones and Female Cycles (FSH, LH – pituitary progesterone, estrogen – ovarian) The ovarian cycle is hormonally regulated in two phases. The follicle secretes estrogen before ovulation; the corpus luteum secretes both estrogen and progesterone after ovulation. The ovarian cycle covers events in the ovary; the menstrual cycle occurs in the uterus. The menstrual cycles’ first day of blood flow (day 0) known as menstruation. During menstruation the uterine lining is broken down and shed as menstrual flow. FSH and LH are secreted on day 0, beginning both the menstrual cycle and the ovarian cycle. Both FSH and LH stimulate the maturation of a single follicle in one of the ovaries and the secretion of estrogen. Rising levels of estrogen in the blood trigger secretion of LH, which stimulates follicle maturation and ovulation (day 14, or midcycle). LH stimulates the remaining follicle cells to form the corpus luteum, which produces both estrogen and progesterone. Estrogen and progesterone stimulate the development of the endometrium and preparation of the uterine inner lining for implantation of a zygote. If pregnancy does not occur, the drop in FSH and LH cause the corpus luteum to disintegrate. The drop in hormones also causes the sloughing off of the inner lining of the uterus by a series of muscle contractions of the uterus.