Download zzz - pharm 1st retake 2010.1 - SAMIT - kasiula264

zzz - pharm 1st retake 2010.1.doc
(73 KB) Pobierz
Pharm 1st retake (version B)
1. Which of the following is contraindication for the use of morphine?
a.
Obstetrical pain (give meperidine)
b. Acute pulmonary edema
c.
MI
d. Cardiac surgery
e.
Premedication before general anesthesia
2. Legionella infections are best treated by?
a.
Penicillin
b. Erythromycin
c.
Chloramphenicol
d. Tetracycline
e.
Amphotericin B
3. Which of the following cephalosporins are very resistant to chromosomal -lactamase?
a.
Cephalexin
b. Cefazolin
c.
Ceftazidime
d. Ceforaxim
e.
Cefepime (4th generation)
4. Which of the following drugs has no activity against G+ bacteria and anaerobes?
a.
Azithromycin
b. Aztreonam (monobactam drug)
c.
Doxycycline
d. Chloramphenicol
e.
Sulphamethoxazole
5. Which of the following combination will not extend antibacterial effects?
a.
Clavulanic acid + amoxicillin
b. Tetracycline + penicillin
c.
Sulbactam + ampicillin
d. Tazzabactam + piperacillin
TMP – SMX
e.
6. Please indicate which of the following combination is NOT true?
a.
Glucorticosteroides – decrease of vessels permeability
b. 2 agonist – inhibit of histamine release from the mast cells
c.
theophylline – weak anti-inflammatory action
d. theophylline – blockade of adenosine receptors
e.
glucocorticosteroids – prevent and treat hypocalcemiac (it causes osteoporosis)
Match the drug below with description and toxicity most commonly attributed to it?
a. Ciprofloxacin
b. Amphotericin B
c. Caspofungin
d. Flucytosine
e. Ketoconazole
7. An inactive pro-drug which is converted to its active metabolite by fungal enzyme but
not mammalian enzyme? Flucytosine
8. Cannot be used with antacids? Fluoroquinolone (and tetracyclines)
9. Direct detergent-like effect on cell membrane?Amphotericin B
10. Inhibit cell wall glucan synthesis? Caspofungin
11. Which of the following drug is used with mifepristone for induce abortion?
a.
Oxytocin
b. Ergonovine
c.
PGF 2A
d. Prostin E2
e.
Methylergonovine
12. Which of the following inhibits platelets aggregation by increase of cAMP
levels?
a.
Aspirin
b. Ticlopidine (uses ADP)
c.
Norepinephrine
d. Clopidogrel (used ADP)
e.
Epoprostenol
13. The following statements about aspirin are correct EXCEPT for?
a.
Should be given to patients who have survived MI
b. Is used to treat DVT for unstable angina
c.
With other antiplatelets agents improves the potency rates of arterial grafts
d. Should be given to patients with TIA
e.
Acts by inhibition of tromboxane synthesis
14. In the process of fibrinolysis indicate wrong answer?
a.
Plasminogens is a precursor of plasmin
b. Streptokinase acts as an indirect inhibitor of plasmin formation
c.
Alteplase acts as a tissue
d. Tranexemic acid blocks plasmin formation
e.
Plasmin formation take place on the fibrin surface but not within the circulation
blood
15. Which of the following is NOT a physiologic effect of insulin
a.
Stimulate of gluconeogenesis
b. Stimulation of glucogen synthesis
c.
Stimulation of lipid synthesis
d. Stimulation of triglyceride synthesis
e.
Stimulation of protein synthesis
16. Antiviral drugs that inhibit fusion of HIV virus with CD4 cell membrane?
a.
Amantadine and yidarabine
b. Efavirenz and neviraphe
c.
Rifampicin and idoxuridine
d. Enuvirtide and maraviroc (GP41 CCR5)
e.
Interferon and maraviroc
17. Bacterial resistance to fluoroquinolones is often mediated by?
a.
Enzyme that degrade fluoroquinolones
b. Enzymes that inactivate fluorquinolones
c.
Amplification of bacterial dihydrofolate reductase
d. Reduced level the porins in bacterial membrane
e.
Changes in bacterial cell wall peptidoglycan.
18. Which of the following drugs is used to treat infection caused by aerobic and anaerobic
G- bacilli?
a.
Pen G
b. Cefamandel
c.
Cefotetan
d. Erythromycin
e.
Tetracycline
19. All of the following antibiotics may produce ototoxicity EXCEPT for?
a.
Erythromycin (does cause)
b. Vancomycin
c.
Clindamycin
d. Gentamycin
e.
Tobramycin
Match the following description with indicated compounds;
a. Vit. A
b Vit. K
c. Vit. B12
d. Folate
e. Iron
20. It is a cofactor for carboxylase of factors II, VII, IX, X. Vitamin K
21. Absorption occurs in the duodenum and involves intracellular binding protein.
Iron
22. Absorption requires deconjugation of polyglutamyl form to a monoglutamyl one. Folate
23. Which of the following statements correctly pairs a commonly used anticoagulant with
its MOA?
a.
Heparin acts to cleave the covalent linkage between fibrin monomers.
b. Tissue plasminogen activator acts by irreversibly inhibiting thrombin.
c.
Streptokinase is a bacterial product that causes platelets lysis, therefore inhibiting
platelet aggregation.
d. Streptokinase acts by the enzymatic cleavage of inactive plasminogen to
active one.
e.
Aspirin irreversibly binds fibrinogen, which decreases pool of available fibrin
monomers that can participate in clot formation.
24. AE attributed to the progestin component of oral contraceptives include all of the
following EXCEPT for?
a.
Sodium and fluid retention
b. Increased appetite and weight gain
c.
Acne
d. Hirsutism
e.
Increased growth of endometrium (previously breast engorgement)
25. The MOA of mebendazole in susceptible parasite is;
a.
Blockade of neuromuscular junction
b. Inhibition of dehydrofolate reductase
c.
Inhibition of glucose uptake
d. Inhibition microtubules synthesis
e.
Stimulation of chloride channels
26. A 19-y.o patient is brought to the emergency room with respiratory depression
hypotension and loss of consciousness induced by overdose of methadon. Appropriate
treatment of his condition would be?
a.
Flumazenil
b. Naltrexone
c.
Naloxone
d. Nalorphine
e.
Dexamethasone
27. Which of the following statement about antimycobacterial drugs is not correct?
a.
Peripheral neuropathy is the major toxic effect of INH
b. Peripheral neuritis and visual disturbance are most common AE of ethambutol
c.
Hyperuricemia
d. Rifampin decreases the elimination rate of many drugs
e.
The liver metabolism of INH is under genetic control
28. All of the following statements about antiviral drugs are correct EXCEPT?
a.
Didanosine causes dose dependent peripheral neuropathy and pancreatic
dysfunction
b. At the initiation of therapy with the acyclovir most patients experience a flulike syndrome
c.
Initial phosphorylation by viral thymidine kinase of acyclovir is involved in
bioactivation of drug
d. Clinical use unterferon include treatment of Kaposi’s sarcoma, hairy-cell
leukemia and hepatitis B virus
e.
Foscarnet is active against resistant herpes strains that are thymidine kinasedeficient
29. Please point out the WRONG ANSWER; in congestive heart failure we should not
administer?
a.
Drugs increasing L-ventricular and diastolic pressure
b. Drugs increasing the myocardial contraction
c.
Drugs decreasing the pre- and after-load
d. Drugs increasing sympathetic system activity
e.
Drugs decreasing the after-load
30....
Plik z chomika:
kasiula264
Inne pliki z tego folderu:

zzz - pharm 1st retake 2010.1.doc (73 KB)
Inne foldery tego chomika:

Zgłoś jeśli naruszono regulamin







Strona główna
Aktualności
Kontakt
Dla Mediów
Dział Pomocy
Opinie
Program partnerski




Regulamin serwisu
Polityka prywatności
Ochrona praw autorskich
Platforma wydawców
Copyright © 2012 Chomikuj.pl
__MACOSX