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Heredity and the Origin of Life Genes and Cell Division • ____________________ – the cell’s “blueprints”; • they contain the information needed to build ___________ and cell products. • Genes are stored in the __________________________ (just like blueprints would be stored in a filing cabinet in a factory). • _______________________ (like filing cabinets) - are found in the ___________________ (like in the file room). • • Each cell contains a ___________________ set of all the organism’s genes. ______________ Division – aka “binary fission”, occurs when one cell (parent cell) divides to produce __________ new cells (daughter cells). • • Can be compared to building a new factory exactly like the old one. • In order to build, you have to have a plan and an order of steps. A cell goes through __________________ stages to prepare and finally divide into two new cells • Three stages of cell division • • First Stage: _________________________ • Stage where genes are copied • Genes are on long, thin chromosomes • Sister ____________________________ – two identical strands Second Stage: _________________________ • The equal distribution of the parent cell’s genes Four phases of ______________________: • • ____________________ • Membrane around nucelus disappears • Sister chromatids attached and spindle fibers form ____________________ • • ____________________ • • All chromosomes line up in middle Each pair separates and move to opposing ends ____________________ • Reach each end and begin to uncoil; form two new nuclei Third Stage: ________________________ • ________________ stage of cell division • Divides each daughter cell with some cytoplasm and organelles • The parent cell pinches in between the two nuclei until cytoplasm divides The purpose of mitotic cell division is to insure that each new daughter cell has genes __________________________ to those in the parent cell. Asexual Reproduction: A result of mitotic cell division • ________________________ reproduction – reproduction by ____________________ cell divisions. • Types of asexual reproduction: • __________________ – a method of asexual reproduction illustrated by yeast • • __________________ – process of re-growing missing parts. • • The bulge is called a “bud” Examples: planarians, lizard tail, starfish arms. __________________ – a cell surrounded by a protective coating • Example: Bread mold Sexual Reproduction • Occurs when ________________ organisms each give a complete copy of their genes to form a new organism. • ______________________ - when copies of genetic information during sexual reproduction are produced • During meiosis, the genetic material is _________________________ just as in mitosis, but there is an additional step, where the daughter cells divide, making _____________ total instead of _______________. Heredity and the Origin of Life How Genes Function • There is a specific “________________________” of genes. • In this language, four symbols are called ___________________________. Adenine, Thymine, Guanine, Cytosine – A, T, C, G – in DNA Adenine, Uracil, Guanine, Cytosine – A, U, C, G – in RNA • Letters are made out of ________ nucleotides and are called __________ Example codon: AGC • Words made from the __________ are called _____________. • These “words” can even be translated into another language – the language of protein. • Symbols A,T,G,C (_________________________) • Letters (________________) • Words (________________) • Four main points to keep in mind: • _________________________ (symbols) are arranged into __________________ (words) • ________________ are arranged into ___________________(words) • Genes are _________________________ for making proteins • During reproduction, a _________________________ copy is made of all genes and is given to ______________ new organism DNA is coded messages • 1953 __________________________________________ – discovered and worked out the model for ________________ (deoxyribonucleic acid) • ______________ – looks like a twisted ladder and it is made up of units called nucleotides • There are four different________________________ and EACH contains a ______________, phosphate, and _________________ • • _________________ • _________________ • _________________ • _________________ In DNA, _______________________are arranged so that the sugars and phosphates form the sides of the ladder while the bases make up the rungs of the ladder (See page 86-87 in your text) • ____ always pairs up with T • ____ always pairs up with G • ___________________ – they are specific sections of DNA • _____________________________ – the process by which one DNA molecule forms two DNA molecules • This occurs before a cell divides • See p. 87 for process (and handout) RNA helps decode the messages • DNA contains genetic information in a _________________ • The code is an arrangement of _____________ in the DNA molecule • When a cell needs a certain protein, the section of __________ (gene) for that protein makes ribonucleic acid (__________) • RNA is different from DNA in its bases; _______________ is replaced by ______________ • _________ – messenger RNA; because the RNA contains a copy of the DNA’s coded message • ______________________ – process of making mRNA molecule The Decoded messages are Proteins • After mRNA is made in the ________________, it carries a working copy of DNA’s coded message to a _____________________ in the cytoplasm • Ribosome reads the ____________ to make a protein • ________________ synthesis – the manufacturing of proteins inside a cell • _______________ – transfer RNA – involved in protein synthesis • Within one cell, there are over ________ different kinds of tRNA molecules • Various tRNA molecules carry _________________________ to the ribosome and mRNA • During protein synthesis, the nucleotide ___________________ of the mRNA determines which amino acids to use. • ________________ – group of three bases; codes for a specific amino acid • A protein contains at least one chain of ________________________ • ________________ molecules bring amino acids to the mRNA and line them up according to the RNA’s sequence Heredity and the Origin of Life The origin of modern genetics • __________________________ – the study of inheritance (passing from parents to offspring) of traits • Gregor _____________________ – Roman catholic monk, highly educated; experimented with ____________ plants • • He observed traits (_____________ and pod color) of pea plants. ___________________ – organism in which the traits remain the same for many generations • • Example: TT or tt (both alleles the same) ___________________ – when the ancestors are not alike • Example: Tt (both alleles not the same; a “carrier”) • Cross – mating specific organisms to see how the traits are inherited • Mendel’s Theories: • Traits are controlled by __________________; each offspring has ________ factors for each trait, one from each parent) • The same factors (alleles) _______________; different – ____________ • Each factor in the set of two is either dominant or recessive • __________________ – has more influence on a trait • __________________ – the “hidden” or masked factor • Mendel discovered that when both factors were dominant (TT) the plant showed the ________________________ trait. • When both factors were recessive (tt), the plant showed the __________________ trait • When had one dominant and one recessive trait, showed the ______________________________ trait (Tt) • __________________ – TT or tt • __________________ – Tt • __________________ – the physical characteristics of an organism • __________________ – specific factors (or alleles) an organism possess • __________________ – when pollen and eggs united; when two gametes form a union • Later Discoveries: • Mendel published a paper describing his experiments and stating his theories • His paper sat unnoticed for _________ years, in which scientists discovered mitosis and meiosis. • Then scientists began to make connections as they further studied genetics. Heredity and the Origin of Life Genes, Chromosomes, and Heredity • Not all chromosomes have the same number of _________________ • Chromosome number is different for different organisms, but in humans = _________. • Chromosomes occur in _____________; thus, humans have ________ pairs of chromosomes • Each member of a pair of chromosomes has the same type of ___________________ (ex. eye color and eye color) • Each type of gene comes from each _______________ – one from mother and one from father • Today, Mendel’s “__________________” are called “_________________” which are made of ___________ Punnett Squares • _____________________squares are a visual way to understanding how Mendel’s theories work. • Use symbols to represent ________________ (factors) • Symbols represent _________ genes because genes are normally paired • However, when they form gametes, they will have one gene from each pair • To illustrate Mendel’s cross, you can use a Punnett Square • Practice the Punnett Square under “What do you think?” on page 99 Variations in Mendel’s Theories • If all were either dominant or recessive, it would be easy; however, not all traits are either dominant or recessive • ______________________ dominance – two traits combine or ______________ together to produce a different Trait • Example: RR x WW (crossing red and white flowers) • Because both are dominant – when they cross they will produce ________________ flowers • _________________________ – Dominant AND recessive traits are both expressed. • Example: BB x WW (crossing black and white chickens) will produce chickens with both black AND white traits. • ___________________ gene inheritance – more than two genes are responsible for producing a single trait • Example: scientists believe that _____________ color may be controlled by as many as 12 different genes (which explains why all hair is different from another!) Inheritance of Sex Chromosomes • Normal humans have ________ pairs of chromosomes • The 23rd pair determines the ______ of the individual • • In females, the pair is _________ • In males, the pair is _________ The ______ chromosome is smaller than the _____ chromosome and has very few genes • It is the _____________ who determines the sex of the child. Sex-linked traits • ___________________ trait – an inherited trait that has a gene on the ________ chromosome but no corresponding gene on the Y chromosome. • In this case, an unpaired gene of the X chromosome of the male will automatically express the trait. • With females, only the dominant trait will express itself • • Example: red-green ________________________________ _________________ – people who have the gene for that trait but do not express the trait themselves Inherited Disorders • These are _________________________ traits that are passed on through genes • Why does God allow a person to be born with an inherited disorder? • God has a purpose; it is NOT _________________________ Heredity and the Origin of Life Mutations • ________________________ – any change in an organism’s genetic material • Can occur in a ___________ base pair, a whole _____________________________, or a whole set of chromosomes • Most are almost always _______________________(i.e. lethal mutations – mutations that cause death) • Types of mutations: ______________ and _____________________ Gene Mutations • ________________ mutation – due to the change in the sequence of bases of a segment of DNA that makes up a gene. • When ___________________ comes to translate the mutated section of DNA, it gets the wrong message! • Some gene mutations affect the _________________ organism; other do not affect the organism at all. What is the harmful nature of gene base-pair mutations? “THE SHY BOY SAW THE MAD DOG EAT THE FAT HAM TOO” Somatic and Germ Mutations • ______________________ mutations (body cells – do not make gametes) – are not passed on to future generations • _______________________ mutations – mutations that occur in the gametes or cells that form gametes – can be passed on to future generations • It may not affect the organism in which it occurs, but can affect the offspring Chromosomal Changes • ____________________ Change – involving the number of chromosomes or the number or location of genes on a chromosome • Can be _______________ or affect the ________________ • Does not involve the formation of ___________________, unlike gene mutations • Chromosomes normally occur in sets • Most people have _________ sets and are called __________________ – humans have 23 sets (pairs) • __________________– an unusual number of chromosomes (number of sets of chromosomes) • Example: down syndrome (3 of the twenty-first pair instead of 2) Applied Genetics • Mankind has used genetics principles for thousands of years. • ___________________________________ – choosing organisms with desirable traits and breeding them in hopes of offspring having those traits • __________________________ – a form of selective breeding; mating of an organism with its close relatives, in hopes of getting purebred organisms • ___________________ – a group of organisms • _________________________________ – another method used to produce animals and plants with desirable traits; breeding individuals from different varieties to produce offspring with traits from both parents • __________________________________ – uses living organisms to make new, more desirable organism or products • _________________________________ – using special techniques to control the genetic makeup of an organism • cloning