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Nepafenac Ophthalmic Suspension 0.1%
(NEVANAC®)
Advantages over conventional NSAID in
treating ocular inflammation and CME:
 Smaller dose to reach thrapeutic levels (One drop
TID one day pre-op, DOS, 14 days post-op) ïƒ minimizes side effects
 Physiologic pH (7.4) ïƒ and reduced burning &
irritation
 Only Ophthalmic NSAID prodrugïƒ better
penetration and less ocular surface sideeffects and
high selectivity in CME.
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Prodrug .Structure:
Metabolic
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w Conversion
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Nepafenac
Amfenac
 Nepafenac is converted to a potent
cyclooxygenase inhibitor, Amfenac, by
intraocular hydrolases
Ke TL, Graff G, Spellman JM, Yanni JM. Nepafenac, a unique nonsteroidal prodrug with potential utility in the
treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular
barriers. Inflammation. 2000;24:371-84.
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