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UNIVERSITY OF SOUTHERN PHILIPPINES FOUNDATION Salinas Drive, Lahug Cebu City COLLEGE OF PHARMACY SYLLABUS IN BIOPHARMACEUTICS AND PHARMACOKINETICS I. Course Code : Pharm 6 II. Course Title : Biopharmaceutics and Pharmcokinetics III. Course Outline : 3 units (3 hours lecture per week) IV. Course Description : This course deals with the Liberation, Absorption, Distribution, Metabolism, Elimination, Response, (LADMER) or the fate of drug in living human or animal body. It monitors the movement of a drug in a living cell and the rate of eliminating through the different organs of elimination. V. General Objectives of the course: During and after the course the students are expected to: Cognitive discuss the principles of liberation, absorption, distribution, metabolism and excretion and the factors that affect these processes and define relevant pharmacokinetic terminologies; Psychomotor demonstrate how changes in the physiologic state including disease states affect drug behavior; apply knowledge of biopharmaceutics and pharmacokinetics in the design of a rational drug therapy and regimen; Affective interpret raw data and derive pharmacokinetic models and parameters that best describe the pharmacokinetic behavior of drugs in the body. SPECIFIC LEARNING OBJECTIVES CONTENT During and after the class sessions for the Prelims the students are expected to: PRELIM PERIOD TIME ALLOTMENT TEACHING STRATEGIES EVALUATION I. Orientation 1. review and familiarize USPF’s and CoPh’s VMG as well as be oriented with the course requirements, college policies and the regarding system; 2. state the meaning and importance of the LADER system; 3. identify the different cells I the body organs responsible for drug assimilation; 4. discuss and illustrate the drug receptor interaction; 5. demonstrate the different absorption/transport mechanism; 6. relate the dissociation constant and degree of ionization of drugs with the body fluids of the target organ. 1 hour Socialized discussion 1.1 USPF’s and CoPh’s VMG and Core Values 1. 2 Course Requirements, College Policies and Grading System Quizzes Lecture discussion II. LADMER System III. Organs, cells, Tissues IV. Cell membrane V. Drug Receptor Interaction VI. Absorption Transport Mechanism VII. PKA and Degree of Ionization 2 hours 2 hours 2 hours 2 hours 2 hours Chart presentation Use of OPH Graded Recitation Class Interaction 2 hours Prelim Examination Assignment Mastery Eaxm 1 hour Periodic Examination SPECIFIC LEARNING OBJECTIVES CONTENT TIME ALLOTMENT TEACHING STRATEGIES EVALUATION During and after the class sessions for the Midterm, the students are expected to: MIDTERM I. Lipid / Water Partition Coefficient 3 hours Lecture-discussion Quizzes 1. solve problems meet by drugs due to lipid/water partition coefficient; 2. discuss the physio-chemical factors altering the biological performance of drugs. 3. trace the route and describe the movement of drugs along the GIT; 4. demonstrate the route of the circulatory system; 5. predict the interaction of drugs with the receptor organ and explained the distribution of protein binding to drug distribution bioavailability. II. Physio-chemical Factors Altering Biological Performance of Drugs 3 hours Presentation of Chart Assignment III. Biopharmaceutical data of the GIT 3 hours Use of OPH IV. The Circulatory System 2hours Lecture Demonstration V. Binding of Drugs to Biological Material 2 hours Midterm Examination 1 hour Graded Recitation Mastery Exam Periodic Examination SPECIFIC LEARNING OBJECTIVES CONTENT During and after the class sessions for the Semi-final, the students are expected to: SEMI-FINAL PERIOD 1. define and describe drug metabolism; 2. identify and differentiate compartment models; 3. compute problems on arte constant using different compartment models involving intravascular and extravascular administration; 4. compare the volume of distribution in the different organs of the body; 5. recognize and differentiate the organs of excretion with their functional tests. 1. Drug Metabolism 2. Compartment Models 3. Determination of Rate Constants 4. Volume of Distribution 5. Organs of Excretion 6. Function of Test of the Excretory Organs TIME ALLOTMENT TEACHING STRATEGIES EVALUATION 3 hours Insightful Discussion Quizzes 3 hours Lecture Demonstration Report ratings 3 hours Group reporting Graded Recitation 3 hours Chart presentation Mastery Exam Semi-final Examination 1 hour Periodic Examination SPECIFIC LEARNING OBJECTIVES CONTENT During and after the class sessions for the Final, the students are expected to: FINAL PERIOD 1. describe and predict the clearance of drugs I the body; 2. demonstrate the process of recycling; 3. determine and explain the elimination rate constant of a drug 4. relate the blood level of the drug with the time curve; 5. design a pharmaceutical dosage form after knowing the different pharmacokinetic parameters. 1. Clearance of Drugs 2. Urinary and Biliary Recycling 3. Cumulative Urinary Excretion 4. Area under the Blood Level Time Curve 5. Pharmacokinetics of Drug Dosing Final Examination TIME ALLOTMENT TEACHING STRATEGIES EVALUATION 3 hours Insightful Discussion Quizzes 3 hours Lecture Demonstration Graded Recitation 3 hours Group reporting Mastery Exam 3 hours Group dynamics Report ratings 1 hour Periodic Examination VI. COURSE REQUIREMENTS 1. Class attendance 2. Quizzes 3. Four major examinations Prelim, midterm, semi final and final 4. Presentation of report through power point Grading system (For prelim, midterm, semi final and final) A. Class standing ------------------------------------------- 60% (includes quizzes, seat work, oral recitation, reports) Periodic examination results ---------------------------- 40% B. Current initial grade --------------------------------------60% Previous grade ------------------------------------------- 40% VII. INSTRUCTIONAL RESOURCES: A. Books Birkett, Donald J. Pharacokinetics Made Easy Australia: Mc Graw – Hill Book Company, 1998. Dhillon Clinical Pharmacokinetics, 2006 Ritschel, W. A. Biopharmaceutics and Pahrmacokinetics. New York: Academic Press, 1988. Shargel Leon an dAndrew B.C. / Yu. Applied Biopharmaceutics and pharmcokinetics. Third Edition. U.S.A. Prentice Hall International. 1999.