Download UNIVERSITY OF SOUTHERN PHILIPPINES FOUNDATION

UNIVERSITY OF SOUTHERN PHILIPPINES FOUNDATION
Salinas Drive, Lahug Cebu City
COLLEGE OF PHARMACY
SYLLABUS IN
BIOPHARMACEUTICS AND PHARMACOKINETICS
I. Course Code
:
Pharm 6
II. Course Title
:
Biopharmaceutics and Pharmcokinetics
III. Course Outline
:
3 units (3 hours lecture per week)
IV. Course Description
:
This course deals with the Liberation, Absorption, Distribution, Metabolism, Elimination, Response, (LADMER) or the fate of
drug in living human or animal body. It monitors the movement of a drug in a living cell and the rate of eliminating through
the different organs of elimination.
V. General Objectives of the course:
During and after the course the students are expected to:
Cognitive
 discuss the principles of liberation, absorption, distribution, metabolism and excretion and the factors that affect these
processes and define relevant pharmacokinetic terminologies;
Psychomotor
 demonstrate how changes in the physiologic state including disease states affect drug behavior;
 apply knowledge of biopharmaceutics and pharmacokinetics in the design of a rational drug therapy and regimen;
Affective
 interpret raw data and derive pharmacokinetic models and parameters that best describe the pharmacokinetic behavior of drugs
in the body.
SPECIFIC LEARNING OBJECTIVES
CONTENT
During and after the class sessions for
the Prelims the students are expected to:
PRELIM PERIOD
TIME ALLOTMENT
TEACHING STRATEGIES
EVALUATION
I. Orientation
1. review and familiarize USPF’s and
CoPh’s VMG as well as be oriented
with the course requirements, college
policies and the regarding system;
2. state the meaning and importance
of the LADER system;
3. identify the different cells I the
body organs responsible for drug
assimilation;
4. discuss and illustrate the drug
receptor interaction;
5. demonstrate the different
absorption/transport mechanism;
6. relate the dissociation constant and
degree of ionization of drugs with the
body fluids of the target organ.
1 hour
Socialized discussion
1.1 USPF’s and CoPh’s VMG and
Core Values
1. 2 Course Requirements, College
Policies and Grading System
Quizzes
Lecture discussion
II. LADMER System
III. Organs, cells, Tissues
IV. Cell membrane
V. Drug Receptor Interaction
VI. Absorption Transport Mechanism
VII. PKA and Degree of Ionization
2 hours
2 hours
2 hours
2 hours
2 hours
Chart presentation
Use of OPH
Graded Recitation
Class Interaction
2 hours
Prelim Examination
Assignment
Mastery Eaxm
1 hour
Periodic
Examination
SPECIFIC LEARNING OBJECTIVES
CONTENT
TIME ALLOTMENT
TEACHING STRATEGIES
EVALUATION
During and after the class sessions for
the Midterm, the students are expected
to:
MIDTERM
I. Lipid / Water Partition Coefficient
3 hours
Lecture-discussion
Quizzes
1. solve problems meet by drugs due
to lipid/water partition coefficient;
2. discuss the physio-chemical
factors altering the biological
performance of drugs.
3. trace the route and describe the
movement of drugs along the GIT;
4. demonstrate the route of the
circulatory system;
5. predict the interaction of drugs
with the receptor organ and explained
the distribution of protein binding to
drug distribution bioavailability.
II. Physio-chemical Factors Altering
Biological Performance of Drugs
3 hours
Presentation of Chart
Assignment
III. Biopharmaceutical data of the GIT
3 hours
Use of OPH
IV. The Circulatory System
2hours
Lecture Demonstration
V. Binding of Drugs to Biological
Material
2 hours
Midterm Examination
1 hour
Graded Recitation
Mastery Exam
Periodic
Examination
SPECIFIC LEARNING OBJECTIVES
CONTENT
During and after the class sessions for
the Semi-final, the students are expected
to:
SEMI-FINAL PERIOD
1. define and describe drug
metabolism;
2. identify and differentiate
compartment models;
3. compute problems on arte constant
using different compartment models
involving intravascular and
extravascular administration;
4. compare the volume of
distribution in the different organs of the
body;
5. recognize and differentiate the
organs of excretion with their functional
tests.
1. Drug Metabolism
2. Compartment Models
3. Determination of Rate Constants
4. Volume of Distribution
5. Organs of Excretion
6. Function of Test of the Excretory
Organs
TIME ALLOTMENT
TEACHING STRATEGIES
EVALUATION
3 hours
Insightful Discussion
Quizzes
3 hours
Lecture Demonstration
Report ratings
3 hours
Group reporting
Graded Recitation
3 hours
Chart presentation
Mastery Exam
Semi-final Examination
1 hour
Periodic
Examination
SPECIFIC LEARNING OBJECTIVES
CONTENT
During and after the class sessions for
the Final, the students are expected to:
FINAL PERIOD
1. describe and predict the clearance of
drugs I the body;
2. demonstrate the process of recycling;
3. determine and explain the elimination
rate constant of a drug
4. relate the blood level of the drug with
the time curve;
5. design a pharmaceutical dosage form
after knowing the different
pharmacokinetic parameters.
1. Clearance of Drugs
2. Urinary and Biliary Recycling
3. Cumulative Urinary Excretion
4. Area under the Blood Level Time
Curve
5. Pharmacokinetics of Drug Dosing
Final Examination
TIME ALLOTMENT
TEACHING STRATEGIES
EVALUATION
3 hours
Insightful Discussion
Quizzes
3 hours
Lecture Demonstration
Graded Recitation
3 hours
Group reporting
Mastery Exam
3 hours
Group dynamics
Report ratings
1 hour
Periodic
Examination
VI. COURSE REQUIREMENTS
1. Class attendance
2. Quizzes
3. Four major examinations
Prelim, midterm, semi final and final
4. Presentation of report through power point
Grading system (For prelim, midterm, semi final and final)
A. Class standing ------------------------------------------- 60%
(includes quizzes, seat work, oral recitation, reports)
Periodic examination results ---------------------------- 40%
B. Current initial grade --------------------------------------60%
Previous grade ------------------------------------------- 40%
VII. INSTRUCTIONAL RESOURCES:
A. Books
Birkett, Donald J. Pharacokinetics Made Easy Australia: Mc Graw – Hill Book Company, 1998.
Dhillon Clinical Pharmacokinetics, 2006
Ritschel, W. A. Biopharmaceutics and Pahrmacokinetics. New York: Academic Press, 1988.
Shargel Leon an dAndrew B.C. / Yu. Applied Biopharmaceutics and pharmcokinetics. Third Edition. U.S.A. Prentice Hall International. 1999.