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ST Segment Elevation Myocardial Infarction following Valve Replacement Surgery: An Unusual Presentation Venkataramanan Gangadharan, MD Shafeeq Ahmed, MD Brian Zagol, MD George Vetrovec, MD Case Presentation • 35 year old man with history of HIV presented with fever and chills to an outside hospital • Patient was found to be bacteremic and subsequent TEE revealed infective endocarditis with a large vegetation on the mitral valve severe mitral regurgitaton. • Pre-operative cardiac catheterization revealed an anomalous left coronary artery from the right Sinus of Valsalva but no obstructive coronary artery disease. Pre-Operative Coronary Angiogram Case Presentation • Patient underwent a successful pericardial tissue valve replacement with a 29 mm Edwards mitral valve through an open sternotomy. • 24 hours post procedure the patient began experience severe chest pain and diagnosed with an ACUTE Lateral ST Segment Elevation with troponin peaking at 30. ECG Coronary Angiogram LAO Caudal showing no new disease in the left coronary system Occluded Anomalous Left Circumflex from Right Sinus of Valsalva Coronary Intervention Balloon Angioplasty to the occluded Left Circumflex No significant improvement to flow post balloon angioplasty Contrast injection through balloon Coronary Intervention Post 3.0 x 12 mm INTEGRITY bare metal stent placement Post overlapping 2.75 x 12 mm INTEGRITY bare metal stent placement Discussion • Ischemic iatrogenic coronary lesions can complicate mitral valve surgery - either valve replacement or annuloplasty • Commonly affected vessels include the left circumflex or posterior descending artery due to their proximity to the mitral valve • Risk of ischemic insults usually depend on anatomic relationships between the coronary artery and posterior mitral annulus – rarely further complicated in patients with anomalous coronary origins. Discussion • Coronary Injury post mitral valve replacement is a known complication although the mechanism of injury has been sparingly identified through isolated case reports. • Injury can be divided into those due to direct mechanical compression/distortion of the vessel, coronary artery embolization (air embolization, silcone material embolization or suture material), or injury to the coronary endothelium caused by ablative procedures (MAZE) done in conjunction with surgery. • Clinically patients can present intra-operatively or in the post-operative period with typical manifestations Discussion • Intra-operative - recurrent ventricular arrhythmias, subtle but new wall motion abnormalities or even STelevation on cardiac monitoring can indicate vessel compromise – Rapid treatment can be achieved performing emergency saphenous vein graft bypass to the compromised vessel. • Post-operative – patient can present with typical symptoms, persistent ventricular arrhythmias, ST Elevation and even sudden hemodynamic compromise – Treatment can be achieved percutaneously with intervention to the culprit vessel. Conclusion • Potential risk of iatrogenic coronary artery injury does exist with mitral valve surgery • Percutaenous and surgical options are available for treatment and valve integrity should be evaluated in cases secondary to mechanical compression. • Appropriate pre-operative visualization of the coronary circulation especially with regards to anatomy and course can help to avoid such complications during surgery. References 1. 2. 3. 4. 5. 6. 7. Somekh NN, Haider A, Makaryus AN, Katz S, Bello S, Hartman A. Left circumflex coronary artery occlusion after mitral valve annuloplasty: “a stitch in time”. Texas Heart Inst J 2012;39(1):104-7. Postorino S, Buja P, Grassi G, Millosevich P, Barbierato M, Venturini A, Zanchettin C, Polesel E, Di Pede F, Raviele A. Mitral valve repair complicated by iatrogenic coronary artery lesion treated with percutaneous coronary intervention. J Cardiovasc Med (Hagerstown) 2011 Mar;12(3):180-1. Grande AM, Fiore A, Massetti M, Vigano M. Iatrogenic circumflex coronary lesion in mitral valve surgery: case report and review of literature. Tex Heart Inst J 2008;35(2):179-83. Ender J, Singh R, Nakahira J, Subramanian S, Thiele H, Mukherjee C. Echo didactic: visualization of the circumflex artery in the perioperative setting with transesophageal echocardiography. Anesth Analg 2012 Jul;115(1):22-6. Sheth H, Swamy RS, Shah AP. Acute myocardial infarction and cardiac arrest due to coronary artery perforation after mitral valve surgery: successful treatment with a covered stent. Cardiovasc Revasc Med 2012 Jan-Feb;13(1):62-5. Schyma C, Kernback-Wighton G, Madea B. Kinking of a coronary artery as a rare complication in mitral valve replacement. Forensic Sci Int 2012 Sept 10;221(1-3). Sangha R, Hui P. Intravascular ultrasound imaging and percutaneous intervention in a patient with post mitral valve replacement circumflex coronary artery occlusion. J Invasive Cardiol 2004 Jun;16(6):351-2.