Download CHM 421 Master Syll - Central Michigan University

Central Michigan University
College of Arts & Sciences
Course Syllabus
CHM
Desg.
I.
421
No.
______Survey of Biochemistry_________________3(3-0)
__
Title
Credit(Mode)
Bulletin Description
Introductory course in biochemistry. Intended for students in biology, chemistry, allied
health, dietetics, public health and food preparation. No credit toward major.
II.
Prerequisites
CHM 120 or 132 and 342 or 346
III.
Rationale for Course Level
The course enrolls junior and senior students and has 300-level prerequisites.
IV.
Textbooks and Other Materials To Be Furnished by the Student
Campbell “Biochemistry” or equivalent.
V.
Special Requirements of the Course
None
VI.
General Methodology Used in Conducting the Course
Lecture and discussion.
VII.
Course Objectives
This is a one-semester Biochemistry course that has the following objectives:
1.
2.
3.
4.
The student should know the structure and function of various subcellular
components of a prokaryotic and a eukaryotic cell.
The student should understand the structure and chemistry of amino acids and
proteins, carbohydrates, lipids, nucleotides and nucleic acids.
The student should be able to use the Henderson-Hasselbach equation to calculate
and predict the different ionized forms of a biomolecule or biochemical such as a
buffer.
The student should understand the mechanism by which enzymes accelerate rates
of reactions.
5.
6.
7.
8.
9.
10.
VIII.
The student should be able to perform calculations on enzyme kinetics and
determine Vmax and Km by the use of statistics (preferably on a PC).
The student should be able to apply basic thermodynamics in understanding the
bioenergetics of reactions in a cell.
The student should understand the design of metabolic pathways in a cell and the
functions of each pathway.
The student should be familiar with the important reactions in the metabolism (i.e.
synthesis and degradation) of carbohydrates, lipids, proteins, and nucleotides and
the role that vitamins play.
The student should be able to relate the various metabolic pathways to the
production of energy (in the form of ATP) via biological oxidation in the Kreb’s
cycle and electron transport chain. The student should be able to determine the
amount of free energy available in biological redox reactions.
The student should understand the field of molecular biology through a
comprehension of the structure of DNA and RNA and their synthesis.
Course Outline
Week 1
Introduction to biochemistry
Cells and organelles
Week 2
Water, acids, bases, and buffers
Carbohydrates and monosaccharides
Discaccharides and polysaccharides
Week 3
Nucleotide structure
Amino Acids
Structure and function of peptides
Week 4
Protein structure
Protein function
Examination I on Chapters 1-4, 6-1, and 10
Week 5
Enzyme nomenclature
Vitamins and coenzymes
Enzyme catalysis and assay of activity
Week 6
Enzyme kinetics and inhibition
Regulation of enzymes
Fatty acids and phosphoglycerides
Week 7
Sphingolipids and cholesterol
Terpenes and fat-soluble vitamins
Membrane structure and function
Week 8
ATP and bioenergetics
Introduction to metabolism
Examination II on Ch. 5, 11, 12 and 13-1
Week 9
Glycolysis
Gluconeogenesis
Pentose phosphate pathway
Week 10
The citric acid cycle
Regulation of carbohydrate metabolism
Respiratory chain of electron transport
Week 11
Oxidative phosphorylation
Photosynthesis
Week 12
Fatty acid oxidation
Biosynthesis of fatty acids
Cholesterol and steroid metabolism
Week 13
Examination III on chapters 13-17
Amino acid synthesis and degradation
The urea cycle
Week 14
Nucleotide metabolism
Regulation of nitrogen metabolism
Nucleic acid structure
Week 15
Transcription and gene expression
DNA replication and recombinant DNA
Protein biosynthesis
Week 16
Final examination, comprehensive with emphasis on Chapters 6-9 and 18
IX.
Evaluation
100 points for Examination I
100 points for Examination II
100 points for Examination III
200 points for the Final Examination
108 points for Class Participation
608 total points in the course
X.
Bibliography
A.
Textbooks
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
Biochemistry by Stryer (3rd edition) (on reserve at library)
Principles of Biochemistry by Lehninger (on reserve)
Biochemistry by Rawn (1983 edition) (on reserve)
Biochemistry by Armstrong (3rd edition)
Biochemistry by Zubay (2nd edition)
Harper’s Biochemistry by Martin, et al (22nd edition)
Principles of Biochemistry by Smith, et al (7th edition)
Biochemistry by Kuchel and Ralston (Shaum’s Outline Series)
Biochemistry by Voet and Voet
Outlines of Biochemistry by Conn, et al (5th edition)
11.
12.
B.
References
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
C.
Chemical Abstracts
Biological Abstracts
Titles
1.
2.
3.
4.
F.
Science
Chemical and Engineering News
Nature
Scientific American
Science News
Trends in Biological Sciences
Abstracts
1.
2.
E.
Annual Review of Biochemistry
CRC Handbook of Biochemistry
Comprehensive Biochemistry
Methods in Enzymology
Advances in Enzymology
Advances in Enzyme Regulation
The Enzymes
Vitamins and Hormones
Advances in Protein Chemistry
The Proteins
Advances in Lipid Research
Progress in Nucleic Acid Research and Molecular Biology
Periodicals
1.
2.
3.
4.
5.
6.
D.
Human Biochemistry by Orten and Newhaus (10th edition)
Biochemistry by Mathews and van Holde
Current Contents
Biological and Agricultural Index
Chemical Titles
Index Medicus
Journals
1.
2.
3.
4.
5.
Journal of Biological Chemistry
Proceedings of the National Academy of Science
Biochemistry
Biochemistry Journal
International Journal of Biochemistry
6.
7.
8.
9.
10.
12.
13.
Books:
Syllabus Prepared By:
Archives of Biochemistry and Biophysics
Biochimica et Biophysica Acta
Analytical Biochemistry
Biochemistry and Biophysics Research Communication
Canadian Journal of Biochemistry and Cell Biology
Journal of Lipid Research
Journal of Molecular Biology
A large variety are located on the 4th floor of Park Library in Sections
QD, QH, and QP.
Ajit Sharma______________________________
Name
________________________________________
Signature
November 30, 1995
Date
______________________