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Central Michigan University College of Arts & Sciences Course Syllabus CHM Desg. I. 421 No. ______Survey of Biochemistry_________________3(3-0) __ Title Credit(Mode) Bulletin Description Introductory course in biochemistry. Intended for students in biology, chemistry, allied health, dietetics, public health and food preparation. No credit toward major. II. Prerequisites CHM 120 or 132 and 342 or 346 III. Rationale for Course Level The course enrolls junior and senior students and has 300-level prerequisites. IV. Textbooks and Other Materials To Be Furnished by the Student Campbell “Biochemistry” or equivalent. V. Special Requirements of the Course None VI. General Methodology Used in Conducting the Course Lecture and discussion. VII. Course Objectives This is a one-semester Biochemistry course that has the following objectives: 1. 2. 3. 4. The student should know the structure and function of various subcellular components of a prokaryotic and a eukaryotic cell. The student should understand the structure and chemistry of amino acids and proteins, carbohydrates, lipids, nucleotides and nucleic acids. The student should be able to use the Henderson-Hasselbach equation to calculate and predict the different ionized forms of a biomolecule or biochemical such as a buffer. The student should understand the mechanism by which enzymes accelerate rates of reactions. 5. 6. 7. 8. 9. 10. VIII. The student should be able to perform calculations on enzyme kinetics and determine Vmax and Km by the use of statistics (preferably on a PC). The student should be able to apply basic thermodynamics in understanding the bioenergetics of reactions in a cell. The student should understand the design of metabolic pathways in a cell and the functions of each pathway. The student should be familiar with the important reactions in the metabolism (i.e. synthesis and degradation) of carbohydrates, lipids, proteins, and nucleotides and the role that vitamins play. The student should be able to relate the various metabolic pathways to the production of energy (in the form of ATP) via biological oxidation in the Kreb’s cycle and electron transport chain. The student should be able to determine the amount of free energy available in biological redox reactions. The student should understand the field of molecular biology through a comprehension of the structure of DNA and RNA and their synthesis. Course Outline Week 1 Introduction to biochemistry Cells and organelles Week 2 Water, acids, bases, and buffers Carbohydrates and monosaccharides Discaccharides and polysaccharides Week 3 Nucleotide structure Amino Acids Structure and function of peptides Week 4 Protein structure Protein function Examination I on Chapters 1-4, 6-1, and 10 Week 5 Enzyme nomenclature Vitamins and coenzymes Enzyme catalysis and assay of activity Week 6 Enzyme kinetics and inhibition Regulation of enzymes Fatty acids and phosphoglycerides Week 7 Sphingolipids and cholesterol Terpenes and fat-soluble vitamins Membrane structure and function Week 8 ATP and bioenergetics Introduction to metabolism Examination II on Ch. 5, 11, 12 and 13-1 Week 9 Glycolysis Gluconeogenesis Pentose phosphate pathway Week 10 The citric acid cycle Regulation of carbohydrate metabolism Respiratory chain of electron transport Week 11 Oxidative phosphorylation Photosynthesis Week 12 Fatty acid oxidation Biosynthesis of fatty acids Cholesterol and steroid metabolism Week 13 Examination III on chapters 13-17 Amino acid synthesis and degradation The urea cycle Week 14 Nucleotide metabolism Regulation of nitrogen metabolism Nucleic acid structure Week 15 Transcription and gene expression DNA replication and recombinant DNA Protein biosynthesis Week 16 Final examination, comprehensive with emphasis on Chapters 6-9 and 18 IX. Evaluation 100 points for Examination I 100 points for Examination II 100 points for Examination III 200 points for the Final Examination 108 points for Class Participation 608 total points in the course X. Bibliography A. Textbooks 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Biochemistry by Stryer (3rd edition) (on reserve at library) Principles of Biochemistry by Lehninger (on reserve) Biochemistry by Rawn (1983 edition) (on reserve) Biochemistry by Armstrong (3rd edition) Biochemistry by Zubay (2nd edition) Harper’s Biochemistry by Martin, et al (22nd edition) Principles of Biochemistry by Smith, et al (7th edition) Biochemistry by Kuchel and Ralston (Shaum’s Outline Series) Biochemistry by Voet and Voet Outlines of Biochemistry by Conn, et al (5th edition) 11. 12. B. References 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. C. Chemical Abstracts Biological Abstracts Titles 1. 2. 3. 4. F. Science Chemical and Engineering News Nature Scientific American Science News Trends in Biological Sciences Abstracts 1. 2. E. Annual Review of Biochemistry CRC Handbook of Biochemistry Comprehensive Biochemistry Methods in Enzymology Advances in Enzymology Advances in Enzyme Regulation The Enzymes Vitamins and Hormones Advances in Protein Chemistry The Proteins Advances in Lipid Research Progress in Nucleic Acid Research and Molecular Biology Periodicals 1. 2. 3. 4. 5. 6. D. Human Biochemistry by Orten and Newhaus (10th edition) Biochemistry by Mathews and van Holde Current Contents Biological and Agricultural Index Chemical Titles Index Medicus Journals 1. 2. 3. 4. 5. Journal of Biological Chemistry Proceedings of the National Academy of Science Biochemistry Biochemistry Journal International Journal of Biochemistry 6. 7. 8. 9. 10. 12. 13. Books: Syllabus Prepared By: Archives of Biochemistry and Biophysics Biochimica et Biophysica Acta Analytical Biochemistry Biochemistry and Biophysics Research Communication Canadian Journal of Biochemistry and Cell Biology Journal of Lipid Research Journal of Molecular Biology A large variety are located on the 4th floor of Park Library in Sections QD, QH, and QP. Ajit Sharma______________________________ Name ________________________________________ Signature November 30, 1995 Date ______________________