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Society for Cardiovascular Magnetic Resonance International Society for Magnetic Resonance in Medicine 2017 SCMR/ISMRM Co-Provided Workshop FINAL PROGRAM CMR for Probing Mechanisms of Heart Disease: Micro to Macro to Model February 1–2, 2017 Maryland C | Gaylord National Resort | Washington, DC USA www.scmr.org www.scmr.org • www.ismrm.org www.ismrm.org SCMR/ISMRM Jointly Sponsored Workshop SCMR/ISMRM Co-Provided Workshop Presented by the SCMR and the ISMRM Cardiac andCardiac Flow MR & Motion Quantitation Study Groups Presented by the SCMR and theMR ISMRM Study Group Accelerated Towards Comprehensive Clinical CMRCMR: for Probing Mechanisms of Heart Disease: MicroCardiovascular to Macro to Model Imaging Thursday, January 2014 February 1–2, 16, 2017 Gaylord National Resort | Washington, DC USA The Hilton New Orleans Riverside, New Orleans, Louisiana Letter from the Program Co-chairs Dear Colleagues and Friends, Letter from Organizers On behalf of the Organizing Committee, we would like welcome you to New Orleans for the SCMR / ISMRM Jointly Sponsored Workshop Accelerated CMR: Towards Comprehensive Clinical Cardiovascular Imaging presented in collaboration with the ISMRM Cardiac Imaging and Flow & Motion Quantitation Study Groups. This joint effort between the SCMR and ISMRM is the third of its kind, and we hope that this continuing cooperation enhances both research and education in cardiovascular imaging. Dear Colleagues, We are thrilled to be able to offer these exciting sessions with their excellent speakers and topics, and hope that you enjoy attending the workshop as much as we enjoyed putting it together for you. On behalf of the organizing committee, we welcome you to the 2016 Co-Provided SCMR/ISMRM Workshop entitled: The“CMR workshop is designed to provide an opportunity for researchers clinicians to discuss recent developments in rapid for Probing Mechanisms of Heart Disease: Micro to Macro toand Model”. imaging and their potential application to clinical cardiovascular MRI exams. The workshop features a one-day program of invited and proffered talks, plus poster presentations that explore new reconstruction algorithms and platforms, sequence This single track one-and-a-half-day workshop will provideMRI. an in-depth at structure andthroughout physiologythe of workshop the heart, to modifications, and protocol improvements for cardiovascular A stronglook clinical focus runs and will provide a platform to discuss CMR may best be used cardiovascular to assess pathological Theand program contains demonstrate how these new methods can how be used to accelerate existing imagingchanges. applications enable new ways to obtain information about the cardiovascular system. The scientific program comprises an introductory session four eight sessions with a mix of plenary, invited, and proffered talks. The central sessions are organized around three and topics scientific sessions, each of which focuses on a specific technical development with its corresponding potential clinical “Tissue Microstructure”, “Tissue Vitality and Mechanisms of Transport”, and “Cardiac Global and Regional Function”. The applications. We are honored to present extraordinary speakers including MRI technology leaders and distinguished clinical tissueThese of focus is human however session will also draw technologies and major findingspast fromsolutions other experts. speakers will myocardium, present content, whicheach is meant to encourage the on imaging community to reexamine example theimaging study ofand brain microstructure, and the study of cardiomyocyte in animaland models. The for areas, rapid for cardiovascular evaluate new emerging techniques to resolve opendevelopment technical challenges meet unmet clinical needs. Both clinicians and researchers should benefit from this program and both groups are encouraged to converse sessions include eminent speakers from within and from outside of our CMR community, to both challenge and broaden throughout the workshop to promote the development of techniques that can be used clinically. our perspectives. The program commences with an Opening Session featuring two Plenary Addresses by Drs. Robert Edelman and Andrew Arai, SCMR/ISMRM that is timed immediately before SCMR annual This workshopinispioneering the 6th Co-Provided both forerunners new technical developmentsWorkshop for cardiovascular imaging applications. Thisthe introductory session willscientific set the stage for the scientific sessions by reviewing past advances that have made rapid cardiovascular MRI possible sessions. Past workshops in this series have been well attended, and have been successful at enhancing theand introducing open clinical questions, which could be resolved using novel rapid imaging techniques. Each scientific session will research and education agendas of both societies. We hope this meeting continues the trend, and look forward to your begin with two invited talks by experts in the field of rapid imaging, and will include oral presentations of proffered abstracts. participation. Session I, Advances in Reconstruction Strategies, will focus on new techniques for rapid reconstruction, with special focus on developments in compressed sensing and parallel imaging. Session II, Advances in Rapid Sequences and Protocols, will cover strategies to shorten scan time for both individual measurements by improving MRI sequences and streamlining clinical Regards, protocols. Session III, Fast Imaging - Putting It Into Practice, will offer insight into using fast reconstructions and sequences in clinical practice, and will also discuss the use of novel platforms to accelerate computation for the rapid generation of MR images. Session IV, Clinical State-of-the-Art and What Lies Ahead, will be used as a starting point to envision new applications National of Health andSonia even Nielles-Vallespin, imaging paradigms, whichInstitutes could change how cardiovascular imaging is performed in the clinic. Krishna S. Nayak, University of Southern California The oral presentations will be followed by a poster session in parallel with a Wine and Cheese Reception. This time is meant Co-Chairs to provide attendees with an opportunity to discuss the topics presented in the workshop and meet colleagues interested in solving problems in cardiovascular imaging in an informal (and fun!) setting. We hope that this workshop will provide an exciting opportunity for you to explore new ideas in rapid cardiovascular MR and to engage in interesting discussions of these topics with your clinical and research colleagues. By working together as researchers and clinicians to develop more rapid imaging techniques, we can meet our goal of improving cardiovascular MRI to improve the quality of care we offer to patients around the world. Thank you to all the presenters, organizers and attendees for the effort and support put forth to make this meeting happen. We hope you enjoy your time in New Orleans! Daniel Ennis, PhD 2 Nicole Seiberlich, PhD Table of Contents Organizing and Scientific Program Committee: Welcome ................................. 2 Co-chairs: General Information .................4 Sonia Nielles-Vallespin (National Institutes of Health) Krishna Nayak (University of Southern California) Agenda ................................... 5 Disclosure Statement................ 7 Committee Members: Daniel Messroghli (Deutsches Herzzentrum Berlin) Posters ....................................8 Juliano Fernandes (Jose Michel Kalaf Research Institute — Radiologia Clinica de Campinas) Notes .....................................10 Hotel Floor Plan .......................11 www.scmr.org • www.ismrm.org 33 GENERAL INFORMATION General Information General Information Overview How are micro and macro structures related to cardiac function? How does this relation change in the presence of disease? And how can MRI help to uncover these changes? The central theme of this Workshop program seeks to provide attendees with an in-depth look at structure and physiology of the heart, and a platform to discuss how CMR may best be used to assess pathological changes thereof. To reach these goals, the program has been organized as a 1½ day Workshop on February 1 and 2 (Wednesday and Thursday) preceding the main meeting. It features keynote opening and closing sessions where a general outlook and the future of the field will be portrayed, interposed with oral abstracts and poster sessions. Each scientific session will focus on a theme linked to a particular mechanism of heart disease. Leaders in the field will introduce the general topic and will be followed by oral abstract presenters. These themes include CMR diffusion, extracellular and multi-compartment properties of the myocardium, tissue vitality and cardiac function. The workshop’s dedicated abstract sessions were planned to allow emerging and young scientists to present their work separate from the main meeting and to a more intimate and focused group. This also provides an opportunity to closely interact with the leading authorities in the field. Simultaneously, “rapid fire” poster sessions will provide the presenters with the opportunity to highlight important aspects of their work to a larger audience. This year’s topics for abstract submissions include: tissue microstructure (cardiac DTI/DWI), tissue microstructure – others, extra-cellular volume, multi-compartment perfusion, tissue vitality and mechanisms of transport, cardiac function (cine, strain and others) and novel technologies for probing mechanisms of heart disease. The program is meant to foster in-depth interactions among attendees, not only during the scientific presentations but also during the six breaks in between sessions as well as during the reception and poster viewing hour that is scheduled at the end of Day 1. Target Audience The workshop targets professionals seeking an in-depth view of basic cardiac microstructure, compartments and function and its characterization by CMR. This includes basic researchers in imaging methods and cardiac translational sciences, PhD students and postdocs, clinicians (cardiologists, radiologists), CMR technologists and members of different ISMRM Study Groups (Cardiac MR, Diffusion, ElectroMagnetic Tissue Properties (SWI), MR Elastography (MRE), MR Flow and Motion Quantitation, and Perfusion). Educational Objectives At the conclusion of this workshop, participants will be better able to: 1. Summarize the microstructure of the myocardium, its relation to cardiac function, and its changes in the presence of disease. 2. Examine the basic principles and technical challenges of cardiac diffusion magnetic resonance imaging. 3. Describe recent studies in cardiac Diffusion MRI and evaluate the potential of this technique as a diagnostic tool. 4. Define compartment models of the heart and how CMR can assess the correlations among them using perfusion, ECV, 13C imaging, CEST and BOLD. 5. Examine global and regional myocardial function mechanics and the application of stiffness imaging, elastography, and tissue tracking. Continuing Medical Education Credits The Society for Cardiovascular Magnetic Resonance is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Detailed information can be found on the 2017 SCMR meeting website at www.scmr2017.org. The Society for Cardiovascular Magnetic Resonance designates this live activity for a maximum of 9.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 4 4 SCMR/ISMRM Jointly Sponsored Workshop • February 4-5, 2015 SCMR/ISMRM Co-Provided Workshop • February 1–2, 2017 Agenda Wednesday, February 1, 2017 Cardiac Microstructure #2 11:15 am – 12:30 pm Opening Session 8:00 am – 9:15 am 8:00 am Moderators: Sonia Nielles-Vallespin, PhD, MSc (National Institute of Health) and Krishna Nayak, PhD (University of Southern California) Welcome/Introduction Sonia Nielles-Vallespin, PhD, MSc (National Institute of Health) Krishna Nayak, PhD (University of Southern California) 8:10 am Characterizing the spectrum of heart failure Sean Pinney, MD (Mount Sinai Hospital) 8:40 am Probing Microstructure of the Brain Carlo Pierpaoli, MD, PhD (NIBIB/NIH) 9:15 am BREAK 11:15 am CMR Diffusion Models Andrew Scott, PhD (The Royal Brompton Hospital) 11:35 am CMR Diffusion Clinical Translation Christopher Nguyen, PhD (Cedars-Sinai Medical Center) 11:55 am W003 Cardiac Diffusion Tensor Imaging — Comparison of In Vivo Systolic and Diastolic Cardiomyocyte Orientations Patrick Magrath, M.S. (University of California, Los Angeles) 12:05 pm W004 Automatic detection of corrupted frames in cardiac DTI with machine learning Pedro Ferreira, PhD (Cardiovascular Biomedical Research Unit, The Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK) Cardiac Microstructure #1 9:30 am – 10:45 am 9:30 am Moderators: PedroFerreira, PhD (The Royal Brompton Hospital) and David Sosnovik, MD (Harvard Medical School — Massachusetts General Hospital) Microstructural organization of the Heart Dudley Pennell, MD (Royal Brompton Hospital) 9:50 am CMR Diffusion Pulse Sequences Christian Stoeck, PhD (University and ETH Zurich) 10:10 am CMR Diffusion Analysis and Interpretation Daniel Ennis, PhD (University of California, Los Angeles) 10:30 am W001 Validation of DTI in Whole Myocardium with Structure Tensor Synchrotron Radiation Imaging Irvin Teh, PhD (University of Oxford) 10:38 am W002 An in-vivo comparison of STEAM and motion compensated spin-echo imaging in cardiac DTI Andrew Scott, PhD (The Royal Brompton Hospital) 10:45 am BREAK Moderators: Daniel Ennis, PhD (University of California, Los Angeles) and Martin Froeling (UMC Utrecht) AGENDA Maryland C Tissue Vitality & Mechanisms of Transport #1 1:30 pm – 2:45 pm Moderators: Edward DiBella, PhD (University of Utah) Martin Ugander, MD, PhD (Karolinska Institutet) 1:30 pm The Cardiomyocyte and Its local Environment David Sosnovik, MD (Massachusetts General Hospital) 1:50 pm ECV (technique and translation) Peter Kellman, Ph.D. (National Heart, Lung, and Blood Institute) 2:10 pm Multi-compartment Perfusion Modeling Michael Jerosch-Herold, PhD (Department of Radiology, Brigham and Women’s Hospital) www.scmr.org www.scmr.org •• www.ismrm.org www.ismrm.org 55 Agenda Tissue Vitality & Mechanisms of Transport #2 Thursday, February 2, 2017 3:30 pm – 4:45 pm Moderators: Edward DiBella, PhD (University of Utah) Dara L. Kraitchman, DVM, PhD (Johns Hopkins University School of Medicine) Cardiac Global & Regional Function #1 AGENDA 3:30 pm Moderators: Alistair Young, PhD (The University of Auckland) and Pierre Croisille, MD, PhD (University Lyon, UJM-Saint-Etienne) 8:00 am From physiology to function; changes in the presence of disease Juliano de la Fernandes, MD, PhD, MBA (Jose Michel Kalaf Research Institute) 3:40 pm 13C Damian Tyler, PhD (University of Oxford) 3:50 pm CEST Sebastian Kozerke, PhD (ETH Zurich; King’s College London) 8:25 am Quantitative CMR of Regional Function Frederick Epstein, PhD (University of Virginia) 4:00 pm BOLD Rohan Dharmakumar, PhD (Cedars-Sinai Medical) 8:50 am Mechanics and Stiffness (w/pressure) FEM Martyn Nash, PhD (Auckland Bioengineering Institute, University of Auckland) 4:08 pm W005 Vasodilator Response in Heart Transplant Recipients using T1-based Myocardial Blood Volume Mapping Krishna Nayak, PhD (University of Southern California) 9:15 am BREAK 4:16 pm W006 Assessing The Repeatability of ECV Mapping Without Hematocrit Measurement at 3T Michael Blatt, B.S. (University of Utah) 4:24 pm W007 Hemorrhage alters remote myocardial response following acute myocardial infarction: A T2-BOLD and T1ECV study Nilesh Ghugre, PhD (Sunnybrook Research Institute, University of Toronto) 4:32 pm 6 Targeted Probes Zahi Fayad, PhD (Icahn School of Medicine at Mount Sinai) 8:00 am – 9:15 am W008 Myocardial T1 and T2 mapping in severe aortic stenosis: novel insights into the pathophysiology of myocardial remodeling? Bettina Baeßler, M.D. (University Hospital of Cologne, Department of Radiology) Cardiac Global & Regional Function #2 9:30 am – 10:45 am Moderators: Frederick Epstein, PhD (University of Virginia) and Sebastian Kelle, MD, PhD (German Heart Institute Berlin) 9:30 am Elastography Arunak Kolipaka, PhD (The Ohio State University Wexner Medical Center) 9:40 am Feature Tracking Andreas Schuster, MD PhD MBA FESC FACC (Department of Cardiology and Pneumology, University Medical Center Göttingen, Germany) 9:50 am Tissue Phase Mapping Daniela Föll, MD (Cardiology and Angiology I, University Heart Center Freiburg- Bad Krozingen) 10:00 am W009 Quantitative Cardiac Mechanics using In Vivo Cine DENSE, Cardiac Diffusion Tensor Imaging, and a Continuum Mechanics Model Ilya Verzhbinsky (University of California, Los Angeles) SCMR/ISMRM Co-Provided Workshop • February 1–2, 2017 Disclosure Statement 10:08 am 10:16 am 10:24 am 10:32 am W010 MRI-Based Estimates of Passive Cardiac Mechanics Using A Finite Element Framework Luigi Perotti, PhD (UCLA) W011 Cine DENSE MRI of cardiac activation: application to cardiac resynchronization therapy Daniel Auger, Ph.D (University of Virginia) W012 Improved free-breathing cine DENSE using image-based navigators with motion compensation and compressed sensing: development and initial evaluation Xiaoying Cai, BS (University of Virginia) BREAK Closing 11:15 am – 12:30 pm Moderators: Sonia Nielles-Vallespin, PhD, MSc (National Institute of Health) and Krishna Nayak, PhD (University of Southern California) 11:15 am Pathohistologic Techniques for Validation Katharina Wassilew, MD (University Hospital of Copenhagen) 11:35 am Experimental Design for Validation Jurgen Schneider, PhD (University of Leeds) 11:55 am Workshop Highlights and Reflections Robert Balaban, PhD (NHLBI NIH) 12:25 pm Closing Sonia Nielles-Vallespin, PhD, MSc (National Institute of Health) and Krishna Nayak, PhD (University of Southern California) DISCLOSURE STATEMENT The SCMR and ISMRM are committed to: • Ensuring balance, independence, objectivity and scientific rigor in all Continuing Medical Education (CME) programs; and • Presenting CME activities that promote improvements or quality in healthcare and are independent of commercial interests. Therefore it is the policy of both societies that any person who has influence over the content of a program designated for AMA PRA Category 1 Credits™ must disclose any real or apparent financial interest or other relationship (i.e., grants, research support, consultant, honoraria) that the individual may have with the manufacturers, distributors or providers of any commercial products or services that may be discussed in the presentation. Such financial interests or relationships must be identified in advance so that potential conflicts can be resolved before the program, and participants at the CME activity may have these facts fully disclosed at the outset. Neither the ISMRM nor the SCMR implies that such financial interests or relationships are inherently improper or that such interests or relationships would prevent the speaker or organizer from making an objective contribution. However, it is imperative that such financial interests or relationships be identified so that potential conflicts can be resolved before the program, and participants at the CME activity may have these facts fully disclosed in advance. It then remains for the audience to determine whether an individual’s outside interests may reflect a possible bias in either the exposition or the conclusions presented. Specific faculty disclosure information for each speaker, course director, and planning committee member will be shared with the audience prior to the speaker’s presentation. A complete list of disclosures is available on the SCMR 2017 meeting website. www.scmr.org • www.ismrm.org 7 Posters Poster Directory POSTERS SCMR/ISMRM Co-Provided Workshop - Posters 8 W013 Simulating the Effect of Motion Induced by Systolic Variability in cDTI using STEAM Andrew Scott, PhD (NIHR Cardiovascular Biomedical Research Unit, The Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK) W014 Nonlinear Fitting Improves Precision in Biexponential Joint T2 and Apparent Diffusion Coefficient Mapping in the Heart Eric Aliotta, M.S. (UCLA) W015 Bringing the T1 mapping sequences together: A study of the T2 and magnetization transfer effects in ex vivo pig hearts Tarik Hafyane, MSC (Montreal Heart Institute) W016 The Influence of the Analysis Technique on Myocardial T1 Measurement Using CMR El-Sayed Ibrahim, PhD (University of Michigan) W017 CMR Tissue Characterization for Identifying Obesity Phenotypes in Metabolic Syndrome Jadranka Stojanovska, MD (University of Michigan) W018 Bright-blood T2STIR-bSSFP has Higher Diagnostic Accuracy Than the Bright-blood T2 pre-bSSFP for Assessment of Area-at-risk in Acute Myocardial Infarction: A New Proposed Bright-blood T2weighted MRI Dan Yang, msci (West China Hospital,Sichuan University) W019 Software-based evaluation algorithms for dynamic oxygenation-sensitive CMR studies Thomas Bertrand, B.Sc. (Hons), M.Sc. Student (MUHC) W020 Cardiac viability in the peri-infarct region quantified by T1 mapping following manganese-enhanced MRI (MEMRI) is associated with LV remodeling post-myocardial infarction (MI) Yuko Tada, MD, PhD (Stanford University School of Medicine) W021 3D Real-Time Cardiac MRI: Preliminary Results on Sheep Jing Liu, Ph.D. (University of California, San Francisco) SCMR/ISMRM Co-Provided Workshop • February 1–2, 2017 W022 Displacement encoding with Stimulated echoes (DENSE) is superior to feature tracking and tagging to detect abnormal left ventricular wall function by analyzing circumferential strain. Johan Kihlberg, MSc (CMIV, Linkoping University) W023 Tissue Tagging Reveals Maternal Nutrient Restriction Induced Alteration of Cardiac Mechanics in the Male Baboon Offspring, Paralleling Effects of Aging Anderson Kuo, MD (University of Texas Health Science Center at San Antonio) W024 Accurate and rapid longitudinal strain imaging by cine DENSE using one-dimensional longitudinal displacement encoding Xiaoying Cai, BS (University of Virginia) W025 MAPSE and TAPSE for the evaluation of left and right ventricular function in cardiac MR and functional cardiac CT. Asik Ali Mohamed Ali, MD (Vancouver General Hospital - University of British Columbia) W026 Stress CMR using Fast-SENC CMR for Predicting Regional Function Abnormalities El-Sayed Ibrahim, PhD (University of Michigan) W027 CMR tagging pattern for 3D tracking: Radial-zSPAMM Abbas Nasiraei Moghaddam, PhD (Amirkabir University of Technology) W028 Anisotropic Myocardial Stiffness in HFpEF Porcine Hearts: Initial Feasibility Prateek Kalra, MS (Department of Radiology, The Ohio State University Wexner Medical Center) W029 Measuring Left Ventricular Myocardial stiffness using transient intrinsic torsional shear wave propagation: Initial results from phantom study and volunteers Jessica Webb, BM BCh MRCP (King’s College London) W030 A multi-scale investigation of structural and functional remodelling in heart failure Vicky Wang, PhD (Auckland Bioengineering Institute, University of Auckland) W031 Feasibility of Cardiac Cine MRI at 0.35T Shams Rashid, Ph.D. (Department of Radiological Sciences, UCLA) W032 Towards reducing the confounding effect of intra-myocardial blood volume on native T1: Purelysystolic T1 mapping using an ungated spoiled steady-state approach Behzad Sharif, PhD (Cedars-Sinai Medical Center, Los Angeles) www.scmr.org • www.ismrm.org POSTERS Posters 9 Notes ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ ______________________________________________________________________________________________________________________ 10 SCMR/ISMRM Co-Provided Workshop • February 1–2, 2017 Gaylord National Resort FLOOR PLAN www.scmr.org • www.ismrm.org 11 CMR 2018 A Joint EuroCMR/SCMR Meeting January 31 – February 3, 2018 BA RCELON A , SPA IN