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Society for Cardiovascular
Magnetic Resonance
International Society for
Magnetic Resonance in Medicine
2017 SCMR/ISMRM Co-Provided Workshop
FINAL PROGRAM
CMR for Probing Mechanisms of Heart Disease:
Micro to Macro to Model
February 1–2, 2017
Maryland C | Gaylord National Resort | Washington, DC USA
www.scmr.org
www.scmr.org • www.ismrm.org
www.ismrm.org
SCMR/ISMRM
Jointly
Sponsored
Workshop
SCMR/ISMRM
Co-Provided
Workshop
Presented by the SCMR and
the ISMRM
Cardiac
andCardiac
Flow MR
& Motion
Quantitation Study Groups
Presented
by the SCMR
and theMR
ISMRM
Study Group
Accelerated
Towards
Comprehensive
Clinical
CMRCMR:
for Probing
Mechanisms
of Heart Disease:
MicroCardiovascular
to Macro to Model Imaging
Thursday,
January
2014
February
1–2, 16,
2017
Gaylord
National
Resort
| Washington,
DC USA
The Hilton
New
Orleans
Riverside,
New Orleans,
Louisiana
Letter from the Program Co-chairs
Dear Colleagues and Friends,
Letter from Organizers
On behalf of the Organizing Committee, we would like welcome you to New Orleans for the SCMR / ISMRM Jointly Sponsored
Workshop Accelerated CMR: Towards Comprehensive Clinical Cardiovascular Imaging presented in collaboration with the
ISMRM Cardiac Imaging and Flow & Motion Quantitation Study Groups. This joint effort between the SCMR and ISMRM is the
third of its kind, and we hope that this continuing cooperation enhances both research and education in cardiovascular imaging.
Dear Colleagues,
We are thrilled to be able to offer these exciting sessions with their excellent speakers and topics, and hope that you enjoy
attending the workshop as much as we enjoyed putting it together for you.
On behalf of the organizing committee, we welcome you to the 2016 Co-Provided SCMR/ISMRM Workshop entitled:
The“CMR
workshop
is designed
to provide
an opportunity
for researchers
clinicians to discuss recent developments in rapid
for Probing
Mechanisms
of Heart
Disease: Micro
to Macro toand
Model”.
imaging and their potential application to clinical cardiovascular MRI exams. The workshop features a one-day program of
invited and proffered talks, plus poster presentations that explore new reconstruction algorithms and platforms, sequence
This single track
one-and-a-half-day
workshop
will provideMRI.
an in-depth
at structure
andthroughout
physiologythe
of workshop
the heart, to
modifications,
and protocol
improvements
for cardiovascular
A stronglook
clinical
focus runs
and will provide
a platform
to discuss
CMR
may best be
used cardiovascular
to assess pathological
Theand
program
contains
demonstrate
how these
new methods
can how
be used
to accelerate
existing
imagingchanges.
applications
enable
new ways
to obtain
information
about
the
cardiovascular
system.
The
scientific
program
comprises
an
introductory
session
four
eight sessions with a mix of plenary, invited, and proffered talks. The central sessions are organized around three and
topics
scientific sessions, each of which focuses on a specific technical development with its corresponding potential clinical
“Tissue Microstructure”, “Tissue Vitality and Mechanisms of Transport”, and “Cardiac Global and Regional Function”. The
applications. We are honored to present extraordinary speakers including MRI technology leaders and distinguished clinical
tissueThese
of focus
is human
however
session
will also draw
technologies
and major
findingspast
fromsolutions
other
experts.
speakers
will myocardium,
present content,
whicheach
is meant
to encourage
the on
imaging
community
to reexamine
example theimaging
study ofand
brain
microstructure,
and the
study of cardiomyocyte
in animaland
models.
The
for areas,
rapid for
cardiovascular
evaluate
new emerging
techniques
to resolve opendevelopment
technical challenges
meet unmet
clinical
needs.
Both
clinicians
and
researchers
should
benefit
from
this
program
and
both
groups
are
encouraged
to
converse
sessions include eminent speakers from within and from outside of our CMR community, to both challenge and broaden
throughout the workshop to promote the development of techniques that can be used clinically.
our perspectives.
The program commences with an Opening Session featuring two Plenary Addresses by Drs. Robert Edelman and Andrew Arai,
SCMR/ISMRM
that is timed
immediately
before
SCMR annual
This
workshopinispioneering
the 6th Co-Provided
both
forerunners
new technical
developmentsWorkshop
for cardiovascular
imaging
applications.
Thisthe
introductory
session
willscientific
set the stage
for
the
scientific
sessions
by
reviewing
past
advances
that
have
made
rapid
cardiovascular
MRI
possible
sessions. Past workshops in this series have been well attended, and have been successful at enhancing theand
introducing open clinical questions, which could be resolved using novel rapid imaging techniques. Each scientific session will
research and education agendas of both societies. We hope this meeting continues the trend, and look forward to your
begin with two invited talks by experts in the field of rapid imaging, and will include oral presentations of proffered abstracts.
participation.
Session
I, Advances in Reconstruction Strategies, will focus on new techniques for rapid reconstruction, with special focus on
developments in compressed sensing and parallel imaging. Session II, Advances in Rapid Sequences and Protocols, will cover
strategies
to shorten scan time for both individual measurements by improving MRI sequences and streamlining clinical
Regards,
protocols. Session III, Fast Imaging - Putting It Into Practice, will offer insight into using fast reconstructions and sequences in
clinical practice, and will also discuss the use of novel platforms to accelerate computation for the rapid generation of MR
images. Session IV, Clinical State-of-the-Art and What Lies Ahead, will be used as a starting point to envision new applications
National
of Health
andSonia
even Nielles-Vallespin,
imaging paradigms,
whichInstitutes
could change
how cardiovascular imaging is performed in the clinic.
Krishna S. Nayak, University of Southern California
The oral presentations will be followed by a poster session in parallel with a Wine and Cheese Reception. This time is meant
Co-Chairs
to provide attendees with an opportunity to discuss the topics presented in the workshop and meet colleagues interested in
solving problems in cardiovascular imaging in an informal (and fun!) setting.
We hope that this workshop will provide an exciting opportunity for you to explore new ideas in rapid cardiovascular MR and
to engage in interesting discussions of these topics with your clinical and research colleagues. By working together as researchers
and clinicians to develop more rapid imaging techniques, we can meet our goal of improving cardiovascular MRI to improve
the quality of care we offer to patients around the world.
Thank you to all the presenters, organizers and attendees for the effort and support put forth to make this meeting happen. We
hope you enjoy your time in New Orleans!
Daniel Ennis, PhD
2
Nicole Seiberlich, PhD
Table of Contents
Organizing and Scientific
Program Committee:
Welcome ................................. 2
Co-chairs:
General Information .................4
Sonia Nielles-Vallespin
(National Institutes of Health)
Krishna Nayak
(University of Southern California)
Agenda ................................... 5
Disclosure Statement................ 7
Committee Members:
Daniel Messroghli
(Deutsches Herzzentrum Berlin)
Posters ....................................8
Juliano Fernandes
(Jose Michel Kalaf Research Institute —
Radiologia Clinica de Campinas)
Notes .....................................10
Hotel Floor Plan .......................11
www.scmr.org • www.ismrm.org
33
GENERAL INFORMATION
General Information
General Information Overview
How are micro and macro structures related to cardiac function? How does this relation change in the presence of disease? And how can MRI
help to uncover these changes?
The central theme of this Workshop program seeks to provide attendees with an in-depth look at structure and physiology of the heart, and
a platform to discuss how CMR may best be used to assess pathological changes thereof.
To reach these goals, the program has been organized as a 1½ day Workshop on February 1 and 2 (Wednesday and Thursday) preceding the
main meeting. It features keynote opening and closing sessions where a general outlook and the future of the field will be portrayed, interposed
with oral abstracts and poster sessions. Each scientific session will focus on a theme linked to a particular mechanism of heart disease. Leaders
in the field will introduce the general topic and will be followed by oral abstract presenters. These themes include CMR diffusion, extracellular and multi-compartment properties of the myocardium, tissue vitality and cardiac function.
The workshop’s dedicated abstract sessions were planned to allow emerging and young scientists to present their work separate from the
main meeting and to a more intimate and focused group. This also provides an opportunity to closely interact with the leading authorities in
the field. Simultaneously, “rapid fire” poster sessions will provide the presenters with the opportunity to highlight important aspects of their
work to a larger audience. This year’s topics for abstract submissions include: tissue microstructure (cardiac DTI/DWI), tissue microstructure
– others, extra-cellular volume, multi-compartment perfusion, tissue vitality and mechanisms of transport, cardiac function (cine, strain and
others) and novel technologies for probing mechanisms of heart disease.
The program is meant to foster in-depth interactions among attendees, not only during the scientific presentations but also during the six
breaks in between sessions as well as during the reception and poster viewing hour that is scheduled at the end of Day 1.
Target Audience
The workshop targets professionals seeking an in-depth view of basic cardiac microstructure, compartments and function and its
characterization by CMR. This includes basic researchers in imaging methods and cardiac translational sciences, PhD students and postdocs,
clinicians (cardiologists, radiologists), CMR technologists and members of different ISMRM Study Groups (Cardiac MR, Diffusion, ElectroMagnetic Tissue Properties (SWI), MR Elastography (MRE), MR Flow and Motion Quantitation, and Perfusion).
Educational Objectives
At the conclusion of this workshop, participants will be better able to:
1. Summarize the microstructure of the myocardium, its relation to cardiac function, and its changes in the presence of disease.
2. Examine the basic principles and technical challenges of cardiac diffusion magnetic resonance imaging.
3. Describe recent studies in cardiac Diffusion MRI and evaluate the potential of this technique as a diagnostic tool.
4. Define compartment models of the heart and how CMR can assess the correlations among them using perfusion, ECV, 13C imaging,
CEST and BOLD.
5. Examine global and regional myocardial function mechanics and the application of stiffness imaging, elastography, and tissue tracking.
Continuing Medical Education Credits
The Society for Cardiovascular Magnetic Resonance is accredited by the Accreditation Council for Continuing Medical Education to provide
continuing medical education for physicians. Detailed information can be found on the 2017 SCMR meeting website at www.scmr2017.org.
The Society for Cardiovascular Magnetic Resonance designates this live activity for a
maximum of 9.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit
commensurate with the extent of their participation in the activity.
4
4
SCMR/ISMRM
Jointly
Sponsored
Workshop
• February
4-5, 2015
SCMR/ISMRM
Co-Provided
Workshop
• February
1–2, 2017
Agenda
Wednesday, February 1, 2017
Cardiac Microstructure #2
11:15 am – 12:30 pm
Opening Session
8:00 am – 9:15 am
8:00 am
Moderators:
Sonia Nielles-Vallespin, PhD, MSc (National
Institute of Health) and Krishna Nayak, PhD
(University of Southern California)
Welcome/Introduction
Sonia Nielles-Vallespin, PhD, MSc (National
Institute of Health)
Krishna Nayak, PhD (University of Southern
California)
8:10 am
Characterizing the spectrum of heart
failure
Sean Pinney, MD (Mount Sinai Hospital)
8:40 am
Probing Microstructure of the Brain
Carlo Pierpaoli, MD, PhD (NIBIB/NIH)
9:15 am
BREAK
11:15 am
CMR Diffusion Models
Andrew Scott, PhD (The Royal Brompton
Hospital)
11:35 am
CMR Diffusion Clinical Translation
Christopher Nguyen, PhD (Cedars-Sinai
Medical Center)
11:55 am
W003 Cardiac Diffusion Tensor Imaging
— Comparison of In Vivo Systolic and
Diastolic Cardiomyocyte Orientations
Patrick Magrath, M.S. (University of
California, Los Angeles)
12:05 pm
W004 Automatic detection of corrupted
frames in cardiac DTI with machine
learning
Pedro Ferreira, PhD (Cardiovascular
Biomedical Research Unit, The Royal
Brompton Hospital, Sydney Street, London,
SW3 6NP, UK)
Cardiac Microstructure #1
9:30 am – 10:45 am
9:30 am
Moderators:
PedroFerreira, PhD
(The Royal Brompton Hospital) and David
Sosnovik, MD (Harvard Medical School —
Massachusetts General Hospital)
Microstructural organization of the Heart
Dudley Pennell, MD (Royal Brompton
Hospital)
9:50 am
CMR Diffusion Pulse Sequences
Christian Stoeck, PhD (University and ETH
Zurich)
10:10 am
CMR Diffusion Analysis and Interpretation
Daniel Ennis, PhD (University of California,
Los Angeles)
10:30 am
W001 Validation of DTI in Whole
Myocardium with Structure Tensor
Synchrotron Radiation Imaging
Irvin Teh, PhD (University of Oxford)
10:38 am
W002 An in-vivo comparison of STEAM
and motion compensated spin-echo
imaging in cardiac DTI
Andrew Scott, PhD (The Royal Brompton
Hospital)
10:45 am
BREAK
Moderators:
Daniel Ennis, PhD (University of California,
Los Angeles) and Martin Froeling (UMC
Utrecht)
AGENDA
Maryland C
Tissue Vitality & Mechanisms of Transport #1
1:30 pm – 2:45 pm
Moderators:
Edward DiBella, PhD (University of Utah)
Martin Ugander, MD, PhD (Karolinska
Institutet)
1:30 pm
The Cardiomyocyte and Its local
Environment
David Sosnovik, MD (Massachusetts General
Hospital)
1:50 pm
ECV (technique and translation)
Peter Kellman, Ph.D. (National Heart, Lung,
and Blood Institute)
2:10 pm
Multi-compartment Perfusion Modeling
Michael Jerosch-Herold, PhD (Department of
Radiology, Brigham and Women’s Hospital)
www.scmr.org
www.scmr.org •• www.ismrm.org
www.ismrm.org
55
Agenda
Tissue Vitality & Mechanisms of Transport #2
Thursday, February 2, 2017
3:30 pm – 4:45 pm Moderators:
Edward DiBella, PhD (University of Utah)
Dara L. Kraitchman, DVM, PhD (Johns
Hopkins University School of Medicine)
Cardiac Global & Regional Function #1
AGENDA
3:30 pm
Moderators:
Alistair Young, PhD (The University of
Auckland) and Pierre Croisille, MD, PhD
(University Lyon, UJM-Saint-Etienne)
8:00 am
From physiology to function; changes in
the presence of disease
Juliano de la Fernandes, MD, PhD, MBA
(Jose Michel Kalaf Research Institute)
3:40 pm
13C
Damian Tyler, PhD (University of Oxford)
3:50 pm
CEST
Sebastian Kozerke, PhD (ETH Zurich; King’s
College London)
8:25 am
Quantitative CMR of Regional Function
Frederick Epstein, PhD (University of
Virginia)
4:00 pm
BOLD
Rohan Dharmakumar, PhD (Cedars-Sinai
Medical)
8:50 am
Mechanics and Stiffness (w/pressure) FEM
Martyn Nash, PhD (Auckland Bioengineering
Institute, University of Auckland)
4:08 pm
W005 Vasodilator Response in Heart
Transplant Recipients using T1-based
Myocardial Blood Volume Mapping
Krishna Nayak, PhD (University of Southern
California)
9:15 am
BREAK
4:16 pm
W006 Assessing The Repeatability
of ECV Mapping Without Hematocrit
Measurement at 3T
Michael Blatt, B.S. (University of Utah)
4:24 pm
W007 Hemorrhage alters remote
myocardial response following acute
myocardial infarction: A T2-BOLD and T1ECV study
Nilesh Ghugre, PhD (Sunnybrook Research
Institute, University of Toronto)
4:32 pm
6
Targeted Probes
Zahi Fayad, PhD (Icahn School of Medicine
at Mount Sinai)
8:00 am – 9:15 am
W008 Myocardial T1 and T2 mapping
in severe aortic stenosis: novel insights
into the pathophysiology of myocardial
remodeling?
Bettina Baeßler, M.D. (University Hospital of
Cologne, Department of Radiology)
Cardiac Global & Regional Function #2
9:30 am – 10:45 am Moderators:
Frederick Epstein, PhD (University of
Virginia) and Sebastian Kelle, MD, PhD
(German Heart Institute Berlin)
9:30 am
Elastography
Arunak Kolipaka, PhD (The Ohio State
University Wexner Medical Center)
9:40 am
Feature Tracking
Andreas Schuster, MD PhD MBA FESC
FACC (Department of Cardiology and
Pneumology, University Medical Center
Göttingen, Germany)
9:50 am
Tissue Phase Mapping
Daniela Föll, MD (Cardiology and Angiology
I, University Heart Center Freiburg- Bad
Krozingen)
10:00 am
W009 Quantitative Cardiac Mechanics
using In Vivo Cine DENSE, Cardiac
Diffusion Tensor Imaging, and a
Continuum Mechanics Model
Ilya Verzhbinsky (University of California,
Los Angeles)
SCMR/ISMRM Co-Provided Workshop • February 1–2, 2017
Disclosure Statement
10:08 am
10:16 am
10:24 am
10:32 am
W010 MRI-Based Estimates of Passive
Cardiac Mechanics Using A Finite Element
Framework
Luigi Perotti, PhD (UCLA)
W011 Cine DENSE MRI of cardiac
activation: application to cardiac
resynchronization therapy Daniel Auger,
Ph.D (University of Virginia)
W012 Improved free-breathing cine
DENSE using image-based navigators with
motion compensation and compressed
sensing: development and initial evaluation
Xiaoying Cai, BS (University of Virginia)
BREAK
Closing
11:15 am – 12:30 pm
Moderators:
Sonia Nielles-Vallespin, PhD, MSc (National
Institute of Health) and Krishna Nayak, PhD
(University of Southern California)
11:15 am
Pathohistologic Techniques for Validation
Katharina Wassilew, MD (University Hospital
of Copenhagen)
11:35 am
Experimental Design for Validation
Jurgen Schneider, PhD (University of Leeds)
11:55 am
Workshop Highlights and Reflections
Robert Balaban, PhD (NHLBI NIH)
12:25 pm
Closing
Sonia Nielles-Vallespin, PhD, MSc (National
Institute of Health) and Krishna Nayak, PhD
(University of Southern California)
DISCLOSURE STATEMENT
The SCMR and ISMRM are committed to:
• Ensuring balance, independence, objectivity and scientific rigor in all Continuing Medical Education
(CME) programs; and
• Presenting CME activities that promote improvements or quality in healthcare and are independent of
commercial interests.
Therefore it is the policy of both societies that any person who has influence over the content of a program designated
for AMA PRA Category 1 Credits™ must disclose any real or apparent financial interest or other relationship (i.e.,
grants, research support, consultant, honoraria) that the individual may have with the manufacturers, distributors
or providers of any commercial products or services that may be discussed in the presentation.
Such financial interests or relationships must be identified in advance so that potential conflicts can be resolved
before the program, and participants at the CME activity may have these facts fully disclosed at the outset.
Neither the ISMRM nor the SCMR implies that such financial interests or relationships are inherently improper or
that such interests or relationships would prevent the speaker or organizer from making an objective contribution.
However, it is imperative that such financial interests or relationships be identified so that potential conflicts can be
resolved before the program, and participants at the CME activity may have these facts fully disclosed in advance.
It then remains for the audience to determine whether an individual’s outside interests may reflect a possible bias in
either the exposition or the conclusions presented. Specific faculty disclosure information for each speaker, course
director, and planning committee member will be shared with the audience prior to the speaker’s presentation. A
complete list of disclosures is available on the SCMR 2017 meeting website.
www.scmr.org • www.ismrm.org
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Posters
Poster Directory
POSTERS
SCMR/ISMRM Co-Provided Workshop - Posters
8
W013
Simulating the Effect of Motion Induced by Systolic Variability in cDTI using STEAM
Andrew Scott, PhD (NIHR Cardiovascular Biomedical Research Unit, The Royal Brompton Hospital,
Sydney Street, London, SW3 6NP, UK)
W014
Nonlinear Fitting Improves Precision in Biexponential Joint T2 and Apparent Diffusion Coefficient
Mapping in the Heart
Eric Aliotta, M.S. (UCLA)
W015
Bringing the T1 mapping sequences together: A study of the T2 and magnetization transfer effects in
ex vivo pig hearts
Tarik Hafyane, MSC (Montreal Heart Institute)
W016
The Influence of the Analysis Technique on Myocardial T1 Measurement Using CMR
El-Sayed Ibrahim, PhD (University of Michigan)
W017
CMR Tissue Characterization for Identifying Obesity Phenotypes in Metabolic Syndrome
Jadranka Stojanovska, MD (University of Michigan)
W018
Bright-blood T2STIR-bSSFP has Higher Diagnostic Accuracy Than the Bright-blood T2 pre-bSSFP
for Assessment of Area-at-risk in Acute Myocardial Infarction: A New Proposed Bright-blood T2weighted MRI
Dan Yang, msci (West China Hospital,Sichuan University)
W019
Software-based evaluation algorithms for dynamic oxygenation-sensitive CMR studies
Thomas Bertrand, B.Sc. (Hons), M.Sc. Student (MUHC)
W020
Cardiac viability in the peri-infarct region quantified by T1 mapping following manganese-enhanced
MRI (MEMRI) is associated with LV remodeling post-myocardial infarction (MI)
Yuko Tada, MD, PhD (Stanford University School of Medicine)
W021
3D Real-Time Cardiac MRI: Preliminary Results on Sheep
Jing Liu, Ph.D. (University of California, San Francisco)
SCMR/ISMRM Co-Provided Workshop • February 1–2, 2017
W022
Displacement encoding with Stimulated echoes (DENSE) is superior to feature tracking and
tagging to detect abnormal left ventricular wall function by analyzing circumferential strain.
Johan Kihlberg, MSc (CMIV, Linkoping University)
W023
Tissue Tagging Reveals Maternal Nutrient Restriction Induced Alteration of Cardiac Mechanics in
the Male Baboon Offspring, Paralleling Effects of Aging
Anderson Kuo, MD (University of Texas Health Science Center at San Antonio)
W024
Accurate and rapid longitudinal strain imaging by cine DENSE using one-dimensional longitudinal
displacement encoding
Xiaoying Cai, BS (University of Virginia)
W025
MAPSE and TAPSE for the evaluation of left and right ventricular function in cardiac MR and
functional cardiac CT.
Asik Ali Mohamed Ali, MD (Vancouver General Hospital - University of British Columbia)
W026
Stress CMR using Fast-SENC CMR for Predicting Regional Function Abnormalities
El-Sayed Ibrahim, PhD (University of Michigan)
W027
CMR tagging pattern for 3D tracking: Radial-zSPAMM
Abbas Nasiraei Moghaddam, PhD (Amirkabir University of Technology)
W028
Anisotropic Myocardial Stiffness in HFpEF Porcine Hearts: Initial Feasibility
Prateek Kalra, MS (Department of Radiology, The Ohio State University Wexner Medical Center)
W029
Measuring Left Ventricular Myocardial stiffness using transient intrinsic torsional shear wave
propagation: Initial results from phantom study and volunteers
Jessica Webb, BM BCh MRCP (King’s College London)
W030
A multi-scale investigation of structural and functional remodelling in heart failure
Vicky Wang, PhD (Auckland Bioengineering Institute, University of Auckland)
W031
Feasibility of Cardiac Cine MRI at 0.35T
Shams Rashid, Ph.D. (Department of Radiological Sciences, UCLA)
W032
Towards reducing the confounding effect of intra-myocardial blood volume on native T1: Purelysystolic T1 mapping using an ungated spoiled steady-state approach
Behzad Sharif, PhD (Cedars-Sinai Medical Center, Los Angeles)
www.scmr.org • www.ismrm.org
POSTERS
Posters
9
Notes
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SCMR/ISMRM Co-Provided Workshop • February 1–2, 2017
Gaylord National Resort FLOOR PLAN
www.scmr.org • www.ismrm.org
11
CMR 2018
A Joint EuroCMR/SCMR Meeting
January 31 – February 3, 2018
BA RCELON A , SPA IN