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ZHAO Yufen ( Prof. ) Yu-Fen Zhao Ph.D Professor of Chemistry Academician of ChineseAcademy Science. 1971 B.S., NationalTsinghuaUniversity in Taiwan 1975 Ph.D., StateUniversity of New York at Stony Brook, Advisor: Prof. Fausto Ramirez. 1975-1979 Postdoctoral Associate, StateUniversity of New York at Stony Brook and New York University, 1979-1988 Associate Professor, Professor, Institute of Chemistry Academia Sinica, Beijing 1988- Present Professor, Department of Chemistry, TsinghuaUniversity, Beijing 1993-present Director, Bioorganic Phosphorus Chemistry Laboratrory. 1994-present Vice-Dean, School of Life Science & Engineering,TsinghuaUniversity, Beijing 1991 was elected as the youngest Member of Chinese Academy of Sciences, councilor of the Chinese Chemical Society, Full Member of the Academy of Creative Endeavors of Russia Research: Field: Organic Phosphorus Chemistry , Bioorganic Chemistry, Origin of Life, Medicinal Chemistry. Achievement: 1. Medicine chemistry Invented a new method to synthesize the skeleton of the Celphalatoxine,which is an anti-cancer reagent. Developed a new type of non-toxic compounds, which are highly effective for curing theschistosomiasis. 2. RNA and DNA cleavage reagents Discovered that the N-phospho-histidine could cleave RNA and DNA by hydrolysis on the phospho-diester bond, Also found that N-phospho-serine in histidine could cleave DNA and RNA by a bio-mimic mechanism Cooperated with OhioUniversity for site specific cleavage of RNA and DNA. 3. Auto-catalysis of the N-phospho-amino acids: It was found that N-phospho-amino acids could not only self-assemble into oligo-peptides in organic and aqueous condition from pH 2 to 9, at the temperature 0-80oC, but also phosphorylate the nucleosides into nucleotides and oligo-nucleotides. Therefore, N-phospho-amino acids could produce the peptide library,nucleotide library and the peptide-nucleotide conjugated library in one pot reaction. 4. Origin of Life N-phospho-amino acids also could form the LB-membrane and lipsome structure, together with auto-catalysis for peptide and nucleotides formation, it was proposed as the minimum evolved system. SELECTED PUBLICATIONS: 1. Xin Chen, Nan-Jiang Zhang and Yu-Fen Zhao, Bioorganic Chemistry, 1997, 25 , 23-31, “Reaction Kinetics of Oxyphosphoranes with Model Compounds of Nucleosides” 2. Yan-Mei Li, Ming Wei, Yu-Fen Zhao, Jian-Yuan Yu, Qun Zhou, Spectroscopy Letters, 1999, 32 (2), 197-203, “Investigations on the Effects of cAMP on Membrane Phospholipid of Human Erythrocytes by Laser Raman Spectroscopy” 3. Yu-Fen Zhao, Yong Ju, Yan-Mei Li Qian Wang, Yin-Wu Yin, Bo Tan, Int. J. Of Peptide and Protein Res., 1995, 1-5 , 514-518, “Self-Activation of N-Phosphoamino Acids and N-Phosphodipeptides in Oligopeptide Formation” 4. Yu-Fen Zhao, Qing-Jin Yan, Qian Wang, Int. J. Of Peptide and Protein Res., 1996, 46 , 276-281. “Phosphoryl Transfer Reaction Regulated by Amino Acid Side Chains: A Model for Phosphorproteins” 5. Yong-Fang Li, Yao-Wu Sha, Yuan Ma, Yu-Fen Zhao, Biochemical Biophysical Research Communication, 1995, 213 (3), 875-880, “Cleavage of DNA by N-Phosphoryl Histidine” 6. Yu-Fen Zhao and Pei-Sheng Cao, J. Chela-Flores and F. Raulin (eds.), Chemical Evolution: Physics of the Origin and Life, 1996, 279-285, Kluwer Academic Publishers, Printed in the Netherland, “Basic Models of Chemical Evolution of Life: The Minimum Evolving System” 7. Wei-Hua Zhou, Yong Ju, Yu-Fen Zhao, Qing-Gang Wang and Guo-an Luo, Origins of Life and Evolution of the Biosphere, 1996, 26 , 547-560, “Simultaneous Fomation of Peptides and Nucleotides from N-Phosphothreonine” 8. Hua Fu, Zhao-Long Li, Yu-Fen Zhao, Guang-Zhong Tu, J. Am. Chem. Soc., 1999, 121 , 291-295, “Oligomerization of N,O-Bis(trimethylsilyl)-a-amino Acids into Peptides Mediated by o-Phenylene Phosphorochloridate” 9. Nan-Jing Zhang, Hai-Yan Lu, Xin Chen, Yu-Fen Zhao, Synthesis, 1998, 376-378 , “A Facile Synthesis of Acylaminotetraoxyspirophosphoranes” 10. Hua Fu, Guang-Zhong Tu, Zhao-Long Li, Yu-Fen Zhao, Synthesis, 1998, 855-858 , “Synthesis of 5 2-Phenoxy-2,7 -spirol[1,3,2-benzodioxaphosphole-2,2’-1,3,2-oxazophospholan]-5’-ones”