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ZHAO Yufen
( Prof. )
Yu-Fen Zhao Ph.D
Professor of Chemistry
Academician of ChineseAcademy Science.
1971 B.S., NationalTsinghuaUniversity in Taiwan
1975 Ph.D., StateUniversity of New York at Stony Brook,
Advisor: Prof. Fausto Ramirez.
1975-1979 Postdoctoral Associate,
StateUniversity of New York at Stony Brook and New York
University,
1979-1988 Associate Professor, Professor,
Institute of Chemistry Academia Sinica, Beijing
1988- Present Professor,
Department of Chemistry, TsinghuaUniversity, Beijing
1993-present Director, Bioorganic Phosphorus Chemistry Laboratrory.
1994-present Vice-Dean, School of Life Science & Engineering,TsinghuaUniversity,
Beijing
1991 was elected as the youngest Member of Chinese Academy of Sciences, councilor
of the Chinese Chemical Society, Full Member of the Academy of Creative Endeavors of
Russia
Research: Field: Organic Phosphorus Chemistry , Bioorganic Chemistry, Origin of Life,
Medicinal Chemistry.
Achievement:
1. Medicine chemistry
Invented a new method to synthesize the skeleton of the Celphalatoxine,which is an
anti-cancer reagent. Developed a new type of non-toxic compounds, which are highly
effective for curing theschistosomiasis.
2. RNA and DNA cleavage reagents
Discovered that the N-phospho-histidine could cleave RNA and DNA by hydrolysis on
the phospho-diester bond, Also found that N-phospho-serine in histidine could cleave
DNA and RNA by a bio-mimic mechanism Cooperated with OhioUniversity for site
specific cleavage of RNA and DNA.
3. Auto-catalysis of the N-phospho-amino acids:
It was found that N-phospho-amino acids could not only self-assemble into
oligo-peptides in organic and aqueous condition from pH 2 to 9, at the temperature
0-80oC, but also phosphorylate the nucleosides into nucleotides and oligo-nucleotides.
Therefore, N-phospho-amino acids could produce the peptide library,nucleotide library
and the peptide-nucleotide conjugated library in one pot reaction.
4. Origin of Life
N-phospho-amino acids also could form the LB-membrane and lipsome structure,
together with auto-catalysis for peptide and nucleotides formation, it was proposed as
the minimum evolved system.
SELECTED PUBLICATIONS:
1. Xin Chen, Nan-Jiang Zhang and Yu-Fen Zhao, Bioorganic Chemistry, 1997, 25 ,
23-31, “Reaction Kinetics of Oxyphosphoranes with Model Compounds of Nucleosides”
2. Yan-Mei Li, Ming Wei, Yu-Fen Zhao, Jian-Yuan Yu, Qun Zhou, Spectroscopy Letters,
1999, 32 (2), 197-203, “Investigations on the Effects of cAMP on Membrane
Phospholipid of Human Erythrocytes by Laser Raman Spectroscopy”
3. Yu-Fen Zhao, Yong Ju, Yan-Mei Li Qian Wang, Yin-Wu Yin, Bo Tan, Int. J. Of Peptide
and Protein Res., 1995, 1-5 , 514-518, “Self-Activation of N-Phosphoamino Acids and
N-Phosphodipeptides in Oligopeptide Formation”
4. Yu-Fen Zhao, Qing-Jin Yan, Qian Wang, Int. J. Of Peptide and Protein Res., 1996,
46 , 276-281. “Phosphoryl Transfer Reaction Regulated by Amino Acid Side Chains: A
Model for Phosphorproteins”
5. Yong-Fang Li, Yao-Wu Sha, Yuan Ma, Yu-Fen Zhao, Biochemical Biophysical
Research Communication, 1995, 213 (3), 875-880, “Cleavage of DNA by N-Phosphoryl
Histidine”
6. Yu-Fen Zhao and Pei-Sheng Cao, J. Chela-Flores and F. Raulin (eds.), Chemical
Evolution: Physics of the Origin and Life, 1996, 279-285, Kluwer Academic Publishers,
Printed in the Netherland, “Basic Models of Chemical Evolution of Life: The Minimum
Evolving System”
7. Wei-Hua Zhou, Yong Ju, Yu-Fen Zhao, Qing-Gang Wang and Guo-an Luo, Origins of
Life and Evolution of the Biosphere, 1996, 26 , 547-560, “Simultaneous Fomation of
Peptides and Nucleotides from N-Phosphothreonine”
8. Hua Fu, Zhao-Long Li, Yu-Fen Zhao, Guang-Zhong Tu, J. Am. Chem. Soc., 1999,
121 , 291-295, “Oligomerization of N,O-Bis(trimethylsilyl)-a-amino Acids into Peptides
Mediated by o-Phenylene Phosphorochloridate”
9. Nan-Jing Zhang, Hai-Yan Lu, Xin Chen, Yu-Fen Zhao, Synthesis, 1998, 376-378 , “A
Facile Synthesis of Acylaminotetraoxyspirophosphoranes”
10. Hua Fu, Guang-Zhong Tu, Zhao-Long Li, Yu-Fen Zhao, Synthesis, 1998, 855-858 ,
“Synthesis
of
5
2-Phenoxy-2,7 -spirol[1,3,2-benzodioxaphosphole-2,2’-1,3,2-oxazophospholan]-5’-ones”