Download Nanomedicine Research at OU

Nanomedicine Research at OU
Roger Harrison, Ph.D.
Professor
School of Biomedical Engineering
School of Chemical, Biological and Materials Engineering
OU Health Sciences Center Biomedical Engineering Symposium
March 24, 2017
What Is Nanomedicine?
• Nanomedicine is the medical application of nanotechnology.
• Nanomedicine ranges from the medical applications of nanomaterials and
biological devices, to nanoelectronic biosensors, and even future applications
of molecular nanotechnogy such as biological machines.
• Current problems for nanomedicine involve understanding the issues related
to toxicity and environmental impact of nanoscale materials.
• Distinct from the field of Molecular Medicine, a broad field where physical,
chemical, biological, bioinformatics and medical techniques are used to
describe molecular structures and mechanisms, identify fundamental
molecular and genetic errors of disease, and to develop molecular
interventions to correct them.
Nanomedicine Researchers at OU
• OU-Norman - include:
• Michael Detamore – Biomedical Engineering
Nanoparticles in tissue engineering
• Roger Harrison – Biomedical Engineering, and Chemical, Biological
and Materials Engineering
Targeted single-walled carbon nanotubes for photothermal therapy
of cancer and targeted gold nanoparticles for imaging tumors
• Chaunbin Mao – Chemistry and Biochemistry
Phage nanomedicine for various applications
• Vassilios Sikavitsas – Biomedical Engineering
Nano- and micro-scale features of tissue scaffolds for tissue
engineering
Nanomedicine Researchers at OU
• OU Health Sciences Center - include:
• Priyabrata Mukherjee – Pathology and Stephenson Cancer Center
Nanoparticles for cancer therapy, including gold nanoparticles
• Rajagopal Ramesh – Pathology and Stephenson Cancer Center
Nanoparticles for gene and drug delivery for cancer treatment and
exosomes for cancer therapy
Detamore Research Group
• Nanoparticles for tissue engineering:
• Hydrogel precursor solutions
• Tissue matrix – for example, cartilage particles
Harrison Research Group
• Single-walled carbon nanotubes for
cancer therapy:
• Modes of heating:
• Near-infrared light
• Radiofrequency field
• Bladder cancer
• Breast cancer
• Melanoma
• Eye cancer
• Brain cancer
• Prostate cancer
• Gold nanoparticles for imaging:
• Breast cancer
Sikavitsas Research Group
•
Nano- and micro-scale materials for
tissue engineering:
Orthopedic tissue engineering, including
for tendons and bones
Polylactic acid scaffolds
Heparin functionalized
PLLA fiber
Mao Research Group
• Phage nanomedicine applications:
• Gene/drug delivery
• Vaccines
• Tissue regeneration
• Directing the fate of stem cells
• Templating materials
• Self assembly
Mukherjee Research Group
• Gold nanoparticles for cancer therapy:
• Inhibition of growth and metastasis
• Modulation of trafficking and mechanism
of antibody-induced receptor
endocytosis
• Effect of nanoparticle surface charge at
the plasma membrane
Ramesh Research Group
• Exosomes as drug delivery vehicles for cancer
therapy (“nanosomes”)
Y
Imaging agent
Targeting Ligand
Gene
therapeutic
Y
• Multifunctional nanoparticles for tumortargeted delivery and imaging:
• Lipids
• Polymers
• Gold
• Applications for lung, breast, ovarian, and
melanoma
Nanosomes
Chemodrug