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Transcript
Salmonella - pathogenesis ⢠Systemic disease, host-adapted serotypes are more invasive and tend to cause systemic disease in their hosts. S.Typhi, S.Paratyphi A,B and C. ⢠Typhoid fever has incubation period from 3 to 56 days, usually between10 and 20 days. ⢠Invasive salmonellas penetrate the intestinal epithelium and are then carried by the lymphatics to the mesentheric lymph nodes. After multiplication in the macrophages, they are released to drain the blood stream, and disseminate around the body. ⢠They are removed from the blood by macrophages but continue to multiply within them. This kills the macrophages which then release large numbers of bacteria into the blood causing septicaemia.
