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Clostridium difficile - Utrecht University Repository
Clostridium difficile - Utrecht University Repository

... Willems and drs. A. Klooster) both farms were already confirmed to be positive for Clostridium difficile. The farms were especially expected to have neonatal infections of Clostridium difficile as on both farms piglets with neonatal diarrhea had colitis, which is characteristic for CDAD. All other k ...
Slide 1
Slide 1

... The clinical features of tetanus arise from the actions of a potent neurotoxin produced by the obligate Gram positive anaerobic bacteria Clostridium tetini. The toxin blocks the inhibitory action of gamma aminobutyric acid (GABA) to motor neurones, resulting in unopposed motor nerve activity. This c ...
Pathogenic Roles, Industrial Uses and Medicinal Prospects of
Pathogenic Roles, Industrial Uses and Medicinal Prospects of

... The genus Clostridium is made up of species that cause disease to both human beings and animals, with zoonotic species/strains playing critical roles in disease dynamics. Clostridial organisms posses pathogenic, therapeutic and industrial uses. Pathogenic clostridia cause lethal or life threatening ...
What`s All the Fuss About Clostridium difficile? by Peter Iwen, PhD
What`s All the Fuss About Clostridium difficile? by Peter Iwen, PhD

... antibiotics Optimal method to diagnose CDI is NOT clear Alcohol-based gels are NOT effective for hand hygiene against C. difficile spores Vancomycin is NOT the recommended initial therapy for CDI Current literature does NOT support the use of probiotics to treat for CDI CDI is NOT only a problem in ...
Toxic Weeds in Hay and the Effects on Livestock
Toxic Weeds in Hay and the Effects on Livestock

... condition is called “walking disease”. After the onset of clinical signs, the prognosis is poor. The presumptive diagnosis is based on clinical signs, and gross as well as histologic lesions (Hopper, 1978). Identification of PA-containing weeds in alfalfa and detection of PAs in forage are importan ...
Document
Document

... C. tetani can live for years as spores in animal feces and soil. As soon as it enters the human body through a major or minor wound and the conditions are anaerobic, the spores germinate and release the toxins. Tetanus may follow burns, deep puncture wounds, ear or dental infections, animal bites, a ...
Re All g as th the of reptile owners. The most significant of
Re All g as th the of reptile owners. The most significant of

... these can be passed on to the family of reptile owners. The most significant of these include: Salmonella - commonly found in all types of reptiles and can spread from reptiles to humans when something contaminated/infected with reptile faeces is placed in the mouth. It causes diarrhoea, headache, f ...
Unit 6: Bioterrorism and Infectious Diseases
Unit 6: Bioterrorism and Infectious Diseases

... Information presented to NSC members, 22 December 2002 (13 days into the epidemic). A total of 16,000 smallpox cases have been reported in 25 states (14,000 within the past 24 hours). One thousand people have died. Ten other countries report cases of smallpox believed to have been caused by internat ...
Are you prepared? - Wisconsin Association of Osteopathic
Are you prepared? - Wisconsin Association of Osteopathic

... Lethal dose for 70kg human is 1ng/kg Botulinum toxin is the most lethal neurotoxin known to man Dispersal of aerosolized toxin, 1 gm of aerosolized toxin could kill up to 1.5 million people ...
docx - BSMMU
docx - BSMMU

... Botulinum toxin is absorbed from the gut binds to receptors of presynaptic membrane of motor neurons of peripheral nervous system and cranial nerves. Proteolysis of target protein in the neurons causing inhibition of release of the acetylcholine(excitatory neurotransmitter) at the synapse. ...
Menacing Microbes: The Threat of Bioterrorism
Menacing Microbes: The Threat of Bioterrorism

... Movie will be presented showing phagocytosis by a type of white blood cell called a neutrophil. ...
Menacing Microbes: The Threat of Bioterrorism
Menacing Microbes: The Threat of Bioterrorism

... A movie will be presented showing phagocytosis by a type of white blood cell called a neutrophil. ...
Common Plants Toxic to Dogs and Cats
Common Plants Toxic to Dogs and Cats

... toxin is in the root portion of the plant. Symptoms: Include significant gastrointestinal irritation, including intense vomiting drooling and diarrhoea. Fatalities have also been reported due to heart rhythm abnormalities and seizures. Recommendation: Seek veterinary attention for symptomatic care. ...
Handout-Bioterrorism
Handout-Bioterrorism

... – Live vaccinia virus (not variola) – Vaccine site, infectious until scab heals – Newer vaccine development • S/E • Efficancy ...
Reptiles and Turtles and Infectious Diseases
Reptiles and Turtles and Infectious Diseases

... potentially very dangerous bugs so must be handled carefully. People most at risk of developing illness include babies and small children, pregnant women, the elderly and people with serious disease such as cancer. The most worrying diseases carried by reptiles are: Salmonella: these bacteria are co ...
Pathogen and Outbreak Cards - University of Colorado Denver
Pathogen and Outbreak Cards - University of Colorado Denver

... toxins.  These  toxins  can  cause  two  types  of  illness:  one  type   characterized  by  diarrhea  and  the  other,  called  emetic  toxin,  by   nausea  and  vomiting.   These  bacteria  are  present  in  foods  and  can  multiply ...
33. Botulinum Toxins
33. Botulinum Toxins

... more suggestive of a massive pulmonary embolism, yet his heart and lungs were said to be normal.1 • Heydrich’s death is not especially suggestive of botulism. The clinical course of wound botulism (albeit with a more-rapid onset) probably comes close to what should have happened if Heydrich’s wound ...
Microbial interactions
Microbial interactions

... Clostridium produces extremely dangerous neurotoxins Normally a spore-forming soil anaerobe Accidental pathogen in man Clostridium botulinum Produces most potent toxin known Seven grams (one teaspoon) enough to kill the entire human population Toxin produced under anaerobic conditions Improperly can ...
Preparing for and Responding to Bioterrorism
Preparing for and Responding to Bioterrorism

... 2. A bioterrorist attack with botulinum toxin is most likely to be via aerosol (inhalational botulism), or possibly through contamination of the food supply. Botulism is caused by botulism toxin, a zinc protease produced by Clostridium botulinum. C. botulinum, a ubiquitous soil bacteria, ...
Introduction - Food Standards Agency
Introduction - Food Standards Agency

... are seven subtypes of C. botulinum, each expressing a different toxin, known as A-G. These subtypes tend to be geographically distributed, probably reflecting climate and soil type as well as geographical separation. Subtypes A, B and E are associated with human botulism, C and D with animal illness ...
There are two types of food poisoning
There are two types of food poisoning

... who ingest them will be symptomatic. • Point source' outbreaks, in which nomber of cases all become symptomatic following ingestion, classically occur after school or canteen lunches where meat stews are served. ...
acute diarrhoea
acute diarrhoea

... – C1 and D are coded by phage genes that are lysogenic in C. botulinum. – Types A, B and E cause almost all human botulism. – All toxins are proteins of 150,000 molecular weight – prevent release of acetylcholine at the neuro-muscular junction causing a flaccid paralysis ...
Wanted: Disease-causing Bacteria Due Date Choose ONE
Wanted: Disease-causing Bacteria Due Date Choose ONE

... c) Organism's M.O. (police jargon for how the organism attacks and spreads) d) Hideout of the culprit (where it is most likely to be found) e) Why/how is it considered “armed and dangerous”? (Most common injury/injuries done to victim) f) Most common victims and number of victims g) Most effective w ...
Preparing and Responding to Bioterrorism: Information for
Preparing and Responding to Bioterrorism: Information for

... Clostridium Botulinum Pathogenesis  Toxin ...
Clostridium Clostridium is a genus of Gram
Clostridium Clostridium is a genus of Gram

... Clostridium consists of around 100 species [3] that include common freeliving bacteria as well as important pathogens.[4] There are five main species responsible for disease in humans:  C. ...
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Botulism



Botulism US /ˈbɒtʃʉlɪzəm/ UK /ˈbɒtjʊlɪzəm/ (Latin, botulus, a sausage) is a rare and potentially fatal illness caused by a toxin produced by the bacterium Clostridium botulinum. The disease begins with weakness, trouble seeing, feeling tired, and trouble speaking. This may then be followed by weakness of the arms, chest muscles, and legs. The disease does not usually affect consciousness or cause a fever.Botulism can occur in a few different ways. The bacterial spores that cause it are common in both soil and water. They produce botulinum toxin when exposed to low oxygen levels and certain temperatures. Foodborne botulism happens when food containing the toxin is eaten. Infant botulism happens when the bacteria develops in the intestines and releases toxin. Typically this only happens in children less than six months of age as after that protective mechanisms develop. Wound botulism is found most often among those who inject street drugs. In this situation spores enter a wound and, in the absence of oxygen, release toxin. It is not passed directly between people. The diagnosis is confirmed by finding the toxin or bacteria in the person in question.Prevention is primarily by proper food preparation. The toxin, though not the organism, is destroyed by heating to more than 85 °C (185 °F) for longer than 5 minutes. Honey can contain the organism, and for this reason honey should not be fed to children of under 12 months. Treatment is with an antitoxin. In those who lose their ability to breathe on their own, mechanical ventilation, potentially for months may be required. Antibiotics may be used for wound botulism. Death occurs in 5 to 10% of people. Botulism can affect many other animals.
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