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Chapter 16 - Nutrition and Metabolism Nutrition - food (nutrients) we eat Need balance - carbohydrates, fats, proteins (vitamins & minerals) Malnutrition - deficiency or imbalance in consumption of nutrients Metabolism - the “use of foods,” after they have been digested, absorbed, & circulated to cells Use food products in two ways energy source building blocks for complex chemical compounds Assimilation - occurs when food molecules enter cells & undergo chemical changes Catabolism - chemical reactions that release energy from food body’s only source of energy Anabolism - chemical reactions that build food molecules into more complex chemical compounds Role of the Liver Bile -secreted to help move fats (lipids) Help maintain normal glucose conc. Synthesize blood proteins (plasma proteins prothrombin, fibrinogen, albumin) Detoxifies bacterial products & some drugs Stores iron, Vitamin A & D Blood flow from GI tract goes to liver 1st Carbohydrate Metabolism Preferred energy source Compound made of glucose which body likes to use 1st for energy Three series of chemical reactions that occur in sequence for catabolism of glucose: 1. Glycolysis - changes glucose to pyruvic acid (in cytoplasm), anaerobic, energy is released 2. Citric acid cycle - pyruvic acid to carbon dioxide (in mitochondria), aerobic, energy is released 3. Electron transfer system • Located in mitochondria • Transfers most of glucose energy to ATP (adenosine triphosphate), some as heat • ATP - served as direct energy source for cellular work in all living organisms • ATP - not stored - used almost immediately • When ATP used - it changes to a reusable form (ADP) & releases energy - ADP attached to more carbohydrate breakdown products > forms more ATP • Only enough ATP is produced to met cellular Glycogenesis - glucose anabolism Occurs in liver & muscle cells Process of joining glucose molecules together > glycogen (animal starch) Constant Glucose Blood Levels Stays between 70 - 110 mg / 100ml blood (even if we have or have not eaten) Hormones help regulate carbohydrate metabolism to control blood glucose • Insulin - helps glucose into cells (< blood levels) Fat Metabolism Also primary source of energy Used if glucose not available - fats can goes into citric acid cycle for energy If not needed - anabolized to form triglycerides stored in adipose tissue Protein Metabolism Used for energy only in very small amounts (normally) Anabolism - amino acids (20) used to make proteins (Essential - must be in diet, Nonessentialcan be missing from diet, body can make) Vitamins Organic compounds needed in small amt. for normal metabolism throughout the body Make enzymes work properly Most are not made in body (must come from diet) Body stores fat-soluble Vit. -A, D, E, K in the liver Water-soluble (Vit. Bs, C) - need continuous supply from diet Avitaminosis - deficiency of vitamins • Scurvy - deficiency Of Vit. C, < collagen fiber production & maintenance = body falls apart (connective tissue problems) Hypervitaminosis - vitamin excess • Vit. A - Hair loss, skin dry, anoxexia, vomiting • More common with fat-soluble vit. Minerals - inorganic elements or salts found naturally in the earth - proper amt. Enzymes activation, many chemical reactions (Na & Ca: muscle & nerve conduction) Metabolic Rates Basal metabolic rate (BMR) - rate at which food is catabolized under basal conditions (resting but awake, not digesting food, not adjusting to temp.) Number of calories of heat that must be produced per hour by catabolism to keep body alive, awake, & comfortably warm Total metabolic rate (TMR) - total amt. of energy used by body / day Calories = TMB (no weight gain) Body Temperature 60% energy from food > heat (not ATP) Hypothalamus regulates body temp.by negative feedback mechanisms (^ temp. > more blood to skin) Normal 97-100 degrees F Heat lost from skin: • Radiation - flow of heat away from blood • Conduction - transfer to skin > external envir. • Convection - transfer to air(flowing away from skin) • Evaporation - water (sweat) vaporization Heat Conserved - vasoconstriction