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Lecture №1 Introduction to splanhnology. Digestive system SPLANCHNOLOGY (THE SCIENCE OF THE VISCERA) SOMATOLOGY • The general cover body (skin) • The skeletal system • The connection system • The muscular system SPLANCHNOLOGY • • • • The digestive system The respiratory system The urinary system The reproductive system Cavities of the body Ways to describe the topography of organs Holotopy - the projection of organs on the body surface; Skeletopy - the projection of organs the bone skeleton body; Syntopy - the position in relation to nearby organs; The position organs in relation to the serosa. Regions of the abdominal area Abdominopelvic Quadrants INTERNAL ORGANS PARENCHYMAL HOLLOW STRUCTURE OF HOLLOW ORGAN • The layer wise distribution membranes that perform different functions; • The layer wise distribution blood and lymph vessels; • The layer wise distribution neural elements. Tunica mucosa Tela submucosa Tunica muscularis Tunica adventitia / serosa STRUCTURE OF TUNICA MUCOSA The mucous membrane lining the hollow organs from their lumen. Contacting lumen mucosal surface covered with epithelium. The main functional purpose of the epithelial cells is determined by their ability to absorb and excrete metabolic products. The basis of stroma of mucosa is fibrous connective tissue with blood and lymph vessels. • • • • I – the epithelium II – the proper plate III – the muscular plate IV – the submucous layer Peculiarities of mucous membrane STRUCTURE OF MUSCULAR LAYER Muscular layer is middle layer. Regulation of traffic content in the inlet and outlet sections of digestive tube provided striated muscles. In other parts of the tube contains smooth muscle fibers forming two layers: an inner circular and outer longitudinal . Interaction of muscle fibers - contributes to the peristaltic wave, - keeping the tone of the wall, - the passage of food in portions. Sphincters of the digestive tract Serous membrane lining the abdominal wall and the organs SRTUCTURE OF PARENCHYMAL ORGANS • Parenchyma is specialized tissue, that carries out the specific function of the organ; • Stroma - connective tissue, including blood, lymph vessels and neural elements; • Division of organ into functional units: lobes segments - acinus. • Complicated system of excretory ducts. Transverse section through somite The end of the third week of embryonic development. (longitudinal section of the embryo) From the endoderm formed tube – primary gut, closed at the front and rear ends. Medial section through the head of the human embryo length of 3 mm. (4-5 week) Oral fossa is separated from the foregut by pharyngeal membrane. Anal atresia in a newborn During the 4 week the ventral wall of the primitive gut protrudes forward. Later to form the trachea, bronchi and lungs. This protrusion marks the border between the pharyngeal and the trunk guts. The trunk gut is divided into an anterior, middle and posterior guts. DYNAMICS OF THE PRIMARY INTESTINE - TORSION OF INTESTINAL LOOP DYNAMICS OF THE PRIMARY INTESTINE - TORSION OF INTESTINAL LOOP Rotate intestine is counterclockwise, 270 degrees from the original position of sagittal intestinal loop. DEVELOPMENT OF DIGESTIVE ORGANS yolk-sac cloaca 4 week 6 week 8 week 10 week Connection head gut with oral cove and the tail gut with anal cove and resorption separating their membranes; Formation of the oral cavity by separating the primary cove oral from airway (nasal cavity); Formation of the rectum and the separation of urogenital sinus from the cloaca; Rotation gastric to horizontal position; Intestinal elongation and turning it counterclockwise. At the beginning of the formation of all organs of gastro - intestinal tract surrounded on all sides by peritoneum. As a result, the turn to the next stages of development there is a shift of: changing the position of the stomach, duodenum, colon, liver movement also occurs in the right upper quadrant, and occupies the position of the pancreas in the retroperitoneal space. SPECIAL ANATOMY OF DIGESTIVE ORGANS Each of the organs of the digestive system has: • location (topography) • definite shape, • internal structure, • develops from certain source, • has a specific function in the act of digestion PHARYNX Pars nasalis Pars oralis Pars laryngea Pharynx (posterior view) Constrictions of oesophagus Pharyngeal OESOPHAGUS Parts: cervical Bronchial and aortic thoracic Diaphragmatic abdominal Topography of the stomach The stomach is situated in the epigastirum, occupying: Left hypochondric region Epigastric region (partly) Th 10-11 Epigastrium L1 Holotopy Skeletotopy and Syntopy Syntopy of stomach STOMACH Gaster, ventriculus Lesser curvature Greater curvature Parts: Walls: - anterior - posterior • Cardiac • Fundus (fornix) • Body • Pyloric Layers of the wall: •serous subserous •muscular submucous • mucous TUNICA MUCOSA M. sphincter pyloricus Gastric pits Tubular glands Pars pylorica: • pylorus • pyloric canal • pyloric antrum Stomach The surface of the mucosa is made up of gastric areas. On the surface of the gastric fields there are many openings called gastric pits. gastric pits The glands of the stomach cardiac, proper, pyloric. They consist of five types of cells: The chief (produce pepsinogen) The parietal (produce hydrochloric acid) The additional (produce mucin) The mucous The endocrine (serotonin, histamine, etc.). TUNICA MUSCULARIS Oesophagus Stratum longitudinale Circular layer Stomach Oblique layer Duodenum Pyloric sphincter The small intestine • Intestinal villi Duodenum • Jejunum • Ileum Layers of the wall: Tunica mucosa Tela submucosa Intestinal epithelium Plicae circulares Tunica muscularis: Stratum longitudinale Stratum circulare Tunica serosa Tela submucosa Intestinal glands Duodenum Bulb Pyloric sphincter Stomach Major duodenal papilla Jejunum Parts: • superior • descending • horisontal • ascending Flexure: - superior - inferior - diodenojejunal Holotopy of the large intestine • Caecum Appendix vermiformis • Colon Ascending colon Transvers colon Descending colon Sigmoid colon • Rectum Large intestine The structural features of the colon - Haustra coli - Taeniae coli - Appendices epiploicae Ilio – caecal angle Vermiform appendix Medial Ascending Ileocaecal valve Lateral Descending Alternative positions of the appendix Topography and flexure of the rectum Flexura sacralis Flexurae laterales Flexura anorectalis Ampula recti RECTUM Transverse folds Ampula recti Columnae anales Sinus anales Canalis analis Anus M. sphincter ani internus M. sphincter ani externus Layers: • Tunica mucosa Tela submucosa • Tunica muscularis • Tunica adventitia (serosa) Pancreas Pancreas and its ducts. Body Tail Ductus pancreaticus accessorius Neck Papilla duodeni minor Papilla Papilladuodeni duodenimajor major Ductus pancreaticus Head Lin. medioclavicularis Lin. parasternalis LIVER Topography Liver lies in Epigastrium, occupying - Epigastric region - Right hypochondric region - Left hypochondric region (partly) Skeletotopy Gallbladder The upper boundary : On the right - to IV intercostal space On the left – at level 6 ribs The lower bjundary: On the right - along the edge of X rib and, furthermore, the lower edge of the costal arch. Holotopy On the left – joint of cartilages of VIII and VII ribs SURFACES AND LOBES OF LIVER Lobus caudatus Left lobe Vena cava inferior Right lobe Ворота печени Left lobe Lower border Diaphragmatic surface V. porta hepatis Right lobe Lobus quadratus Visceral Lobes: Right Left Quadrate Caudate Porta hepatis Vena cava inferior Hepatic veins FUNCTIONS •exchange •detoxification Vena porta •barrier •secretory (production and secretion of bile) •deposited (for blood) Lobular branched blood vessels in the liver HEPATIC LOBULUS and bile ducts formation HEPATIC VEIN CENTRAL VEIN HEPATIC ARTERY PORTAL VEIN BILE DUCT Hepatic sinusoid BILE DUCT HEPATIC ARTERY PORTAL VEIN BILE capillary Central vein Hepatic vein Gallbladder and common bile duct Ductus cysticus Ductus hepaticus com. Vesica felea (biliaris) Ductus pancreaticus accessorius Ductus choledochus Ductus pancreaticus PERITONEUM PERITONEUM PERITONEUM PERITONEUM Position of organs in relation to the peritoneum - Intraperitoneal - Mezoperitoneal - Retroperitoneal