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Prenatal Period • Begins with conception and continues until the birth • Cleavage and implantation (Figure 33-6) – Once zygote is formed, it immediately begins to divide – Morula • Solid mass of cells formed from zygote • Takes approximately 3 days; continues to divide (Figure 33-7) – Blastocyst • Hollow ball of cells that implants into uterine lining (Figure 33-9) • Approximately 10 days pass from fertilization until implantation in uterine lining • Ovum has a store of nutrients that support this embryonic development until implantation has occurred Prenatal Period • Blastocyst – Trophoblast • Outer wall of blastocyst • Forms the support structures – Amniotic cavity – Chorion – Inner cell mass • As blastocyst develops, yolk sac and amniotic cavity are formed (Figure 33-9) • In humans, yolk sac’s functions are largely nonnutritive…production of blood cells • Eventually forms the tissues of the body Prenatal Period • Cleavage and implantation (cont.) – Placenta (Figure 33-11) • • • • • Structural anchor Nutritive bridge Excretory organ Respiratory organ Endocrine organ – Secretes large amounts of human chorionic gonadotropin (HCG), which stimulates the corpus luteum to continue its secretion of estrogen and progesterone (Figure 33-12). This prevents mensturation and allows for successful implantation and development. • Placental tissue normally separates maternal and fetal blood supplies Prenatal Period • Periods of development (Figures 33-13 through 3315) – Gestation period • Approximately 39 weeks • Divided into three 3-month segments called trimesters – – – – First trimester – weeks 1 through 12 Second trimester - weeks 12 through 28 Third trimester - week 28 until birth Zygote, morula, blastocyst, embryo, fetus • 35 Days – Heart beats – 3/8 inch long – Eyes and limb buds visible • 49 Days – Heart beats – 3/8 inch long – Eyes and limb buds visible • End of first trimester – 3 inches long – Facial features are apparent – Limbs are complete – Sex can be identified • At four months – All organ systems are formed and functioning to some extent Prenatal Period • Formation of the primary germ layers – Three layers of specialized cells develop early in first trimester of pregnancy – Cells of embryonic disk differentiate and form each of the three primary germ layers – Each primary germ layer gives rise to specific organs and systems of the body (Figure 33-16) – There are three primary germ layers: • Endoderm—inside layer • Ectoderm—outside layer • Mesoderm—middle layer Prenatal Period • Endoderm – Linings of various tracts and several glands • • • • Respiratory and GI tract Pancreatic and hepatic ducts Urinary tract Glandular epithelium of many glands • Ectoderm – Structures around periphery of the body • Epidermis • Enamel • Cornea – Brain and spinal cord • Mesoderm – Most organs between those formed by the endoderm and ectoderm – Dermis, muscles, bones, many glands, kidneys, gonads, circulatory system Prenatal Period • Histogenesis and organogenesis – Histogenesis • Process by which primary germ layers develop into different kinds of tissues – Organogenesis • Arrangement of tissues into organs – Differentiation, multiplication, growth, rearrangement take place in a definite and orderly sequence – After 4 months, development is mainly a matter of growth Prenatal Period • Changes during pregnancy – Large size of uterus affect normal function of mother’s body • Center of gravity is shifted forward • Uterus presses on the rectum and may affect intestinal motility – Constipation – Hemorrhoids • Pressure on the bladder reduces its storing capacity • Upward pressure pushes the abdominal organs against the diaphragm – Hiatal hernia