Download Do the print media “hype” genetic research? A comparison of

LESSON PLAN
Current Genetic Research
Subject/Course: Grade 11 Academic SBI3U
Concept: Examining recent genetic research
Date: January , 2012
Time Period: 75 min.
BIG IDEA:

Research in genetics is expansive and has implications in many scientific fields
LEARNING GOALS:
 To consider the ways in which genetic research is reported in the media and the significance
 To examine current articles on genetic research, including contributions from Canadian
scientists
 To gain an appreciation for the widespread implications of genetic research in various fields
 To summarize and analyze articles in science and communicate ideas
OVERALL EXPECTATIONS:
 D1. Evaluate the importance of some recent contribution to our knowledge of genetic
processes.
 D3. Demonstrate an understanding of concepts and processes related to the transmission of
hereditary characteristics.
SPECIFIC EXPECTATIONS:
 describe and analyse examples of genetic technologies that were developed on the basis of
scientific understanding (e.g., the improvement of an experimental procedure to extract DNA
from bacterial or plant cells)
 identify and describe examples of Canadian contributions to knowledge about genetic
processes (e.g., research into cystic fibrosis) and to technologies and techniques related to
genetic processes (e.g., the invention of nuclear magnetic resonance [NMR])
PRIOR KNOWLEDGE
 Students have an understanding of terms such as gene, allele, chromosome, DNA, genome,
and mutation
 Students have knowledge of genetic processes such as mitosis and meiosis
REQUIRED MATERIALS
 Handout- Minds On article
 Science Daily articles (approximately 5 packages of 5 articles, 1 for each group)
 STSE Assignment handout
STEP BY STEP DESCRIPTION:
Step
Details
 Ask questions about the term “ genohype”
 Have students Think-Pair-Share about pros and cons of
media involvement in genetic research
Classroom Discussion
 Distribute abstract of article “Do the print media “hype”
genetic research? A comparison of newspaper stories and
peer-reviewed research papers” (Appendix B)
Assessment for
 Read the article together, using volunteer or chosen readers
learning through
classroom discussion  Discuss reactions and opinions on results and implications
of the study (Appendix A)
Minds On
Activity
Group work- Jigsaw
 Divide class into “home” groups and distribute a package
with all 5 articles
 Have each person in the home group select an article and
move into that “expert” group
 In their expert groups students read their article and make a
summary, including the main idea and implications of the
research
 After expert groups have completed their summaries (~25
min) students return to their home group and each person
shares the summary of their article (~20 min)
 Teacher will circle the room to ensure that groups stay on
task and answer any questions if needed
 As a class have students share what they found most
interesting among the articles and why it is important to
keep informed about these issues
Classroom Discussion
 Handout outline for STSE assignment (if time)
Assessment for
learning, through
classroom discussion.
Consolidation
Time
(min)
10-15 min.
45-50 min.
15 min.
ASSESSMENT FOR AND AS LEARNING:
 Informal assessment will take place throughout the classroom discussions
 Informal assessment will also take place during the group work activity.
 The main ideas of this lesson will be addressed in the STSE assignment will be evaluated
based on student’s research and presentation
Appendix A - Teacher Notes
Minds On
Any ideas what is meant by the term “genohype”?
- “hyped” portrayal of both the benefits and risks associated with genetic research and the
application of genetic technologies
Who do you think is behind “genohype”, the journalists or scientists?
- May not always be the journalists as many scientists are under pressure to "make their
research sound exciting and immediately applicable"
(clarify that scientists write journal articles and journalists report their findings in magazines,
newspapers, on the news and other forms of media)
Think-Pair-Share- Pros and Cons of media involvement of genetic research
Gather a few ideas before moving onto article
Pro- allows general public to be updated on issues related to medicine and health
Cons- exaggeration may lead public to be misinformed or have a skewed view on issues
Article- “Do the print media “hype” genetic research? A comparison of newspaper stories and peerreviewed research papers” from the Canadian Medical Association Journal (2004)
-
In this study they found that most newspaper articles are written by in-house specialist
science and technology or medical journalists
Read article summary together
What is your reaction to the findings? Are you surprised?
Do you think there is harm in reporting the benefits? Why or Why not?
-
-
sensationalization of genetics may have an adverse impact on the public’s ability to
participate in policy discussions and on the utilization of genetic services because it
creates inflated perceptions of the value of, for example, specific genetic tests (inflates
expectations for general public and special interest groups such as patients and
investors)
by reporting only benefits they leave out the risks, for instance reports on new
prescription drugs often leave out harmful side effects
Why might there be an under-representation of risks in both scientific and newspaper articles?
-
Scientists do not want to emphasize costs or risks because they have their own agenda too
Are there any limitations to this study?
-
Researchers only looked at print media (and only those related to peer reviewed articles
and published abstracts)
This study looked only at articles in respected newspapers, such as the Globe and Mail, Wall Street
Journal, Guardian, etc. How might this affect the results and implications of the study?
-
These papers may have more journalists with science backgrounds affects the results and
given that they are not circulated as highly as other tabloids may not be representative of
what the public is reading
Don’t take everything you see or read as the absolute truth and be sure to analyze where information
comes from. Bear in mind that a few exaggerated articles may discredit all others in the public’s
opinion. Try to understand that genetics is a relatively new field of study and it will take time to fully
understand the complexity of many genetic issues. With that in mind it is an exciting field with
advancements occurring in technology and implications for many other areas of science (health,
environment, evolution, etc.)
Appendix B- Mind’s On Article
Do the print media “hype” genetic research? A comparison of
newspaper stories and peer-reviewed research papers
Tania M. Bubela, Timothy A. Caulfield
1. From the Health Law Institute (Bubela, Caulfield), the Faculty of Law and the
Faculty of Medicine and Dentistry (Caulfield), University of Alberta, Edmonton,
Alta. Timothy Caulfield is Canada Research Chair in Health Law and Policy and
is Research Director at the Health Law Institute. 2004
Abstract
Background: The public gets most of its information about genetic research from the media. It has
been suggested that media representations may involve exaggeration, called “genohype.” To
examine the accuracy and nature of media coverage of genetic research, we reviewed the reporting of
single-gene discoveries and associated technologies in major daily newspapers in Canada, the United
States, Great Britain and Australia.
Methods: We used neutral search terms to identify articles about gene discoveries and associated
technologies hosted on the Dow Jones Interactive and Canadian NewsDisk databases from January
1995 to June 2001. We compared the contents, claims and conclusions of the scientific journal article
with those of the associated newspaper article.
Coders subjectively assigned the newspaper articles to 1 of 3 categories: moderately to highly
exaggerated claims, slightly exaggerated claims or no exaggerated claims. We used classification
tree software to identify the variables that contributed to the assignment of each newspaper article to
1 of the 3 categories: attention structure (positioning in the newspaper and length of the article),
authorship, research topic, source of information other than the scientific paper, type and likelihood
of risks and benefits, discussion of controversy, valuation tone (positive or negative), framing (e.g.,
description of research, celebration of progress, report of economic prospects or ethical perspective),
technical accuracy (either omissions or errors that changed the description of the methods or
interpretation of the results) and use of metaphors.
Results: We examined 627 newspaper articles reporting on 111 papers published in 24 scientific and
medical journals. Only 11% of the newspaper articles were categorized as having moderately to
highly exaggerated claims; the majority were categorized as having no claims (63%) or slightly
exaggerated claims (26%).
The classification analysis ranked the reporting of risks as the most important variable in determining
the categorization of newspaper articles. Only 15% of the newspaper articles and 5% of the scientific
journal articles discussed costs or risks, whereas 97% of the newspaper articles and 98% of the
scientific journal articles discussed the likelihood of benefits of the research.
Interpretation: Our data suggest that the majority of newspaper articles accurately convey the
results of and reflect the claims made in scientific journal articles. Our study also highlights an
overemphasis on benefits and under-representation of risks in both scientific and newspaper articles.
The cause and nature of this trend is uncertain.
Appendix C- Articles
(#1) DNA Mismatch Repair Happens Only During a Brief Window of
Opportunity
ScienceDaily (Dec. 22, 2011) — In eukaryotes -- the group of organisms that include
humans -- a key to survival is the ability of certain proteins to quickly and accurately repair
genetic errors that occur when DNA is replicated to make new cells.
In a paper published in the December 23, 2011 issue of the journal Science, researchers at
the Ludwig Institute for Cancer Research and the University of California, San Diego School
of Medicine have solved part of the mystery of how these proteins do their job, a process
called DNA mismatch repair (MMR).
"One of the major questions in MMR is how MMR proteins figure out which base in a DNA
mispair is the wrong one," said Ludwig Institute assistant investigator Christopher D.
Putnam, PhD, an adjunct assistant professor of medicine at UC San Diego. "For example, if
guanine (G) is inappropriately in a base-pair with thymine (T), is the G or the T the error?
Picking the wrong base results in mutations, not fixes."
Using Saccharomyces cerevisiae, or baker's yeast, as their model organism, the
researchers, led by Richard D. Kolodner, PhD, Ludwig Institute investigator and UCSD
professor of medicine and cellular and molecular medicine, discovered that newly replicated
DNA produces a temporary signal for 10 to 15 minutes after replication which helps identify
it as new -- and thus a potential subject for MMR.
The actual signal was not identified, but Putnam said it might be tell-tale nicks in singlestranded DNA or certain proteins associated with replication. The scientists are working to
pinpoint the precise signal.
The findings, combined with earlier, published work that visualized MMR in a living cell for
the first time, more fully explains how eukaryotes eliminate DNA replication errors, which
can result in defects and the development of cancers.
"How eukaryotes identify the newly synthesized strand of DNA is a mystery that has
persisted for at least 30 years," said Putnam. "These findings really change our ideas of
how MMR works," said Putnam.
Co-authors include Hans Hombauer and Anjana Srivatsan of the Ludwig Institute for
Cancer Research, UCSD Departments of Medicine and Cellular and Molecular Medicine,
Institute of Genomic Medicine and UC San Diego Moores Cancer Center.
Funding for this research came from the National Institutes of Health.
(#2) Frogs Use Calls to Find Mates With Matching Chromosomes; Tree
Frogs That Look Similar Hear Chromosome Difference in Calls
ScienceDaily (Dec. 27, 2011) — When it comes to love songs, female tree frogs are pretty
picky. According to a new study from the University of Missouri, certain female tree frogs
may be remarkably attuned to the songs of mates who share the same number of
chromosomes as they do. The discovery offers insight into how new frog species may have
evolved.
Carl Gerhardt, Curators Professor of Biological Sciences in the MU College of Arts and
Science and doctoral student Mitch Tucker studied two closely related species of grey tree
frogs that live in Missouri, the eastern grey tree frog (Hyla versicolor) and the Cope's grey
tree frog (H. chrysoscelis).
"To the naked eye -- human and frog -- the two frogs look exactly alike," Gerhardt said.
"The frogs differ only in the number of chromosomes. The eastern grey tree frog has double
the number of chromosomes."
To the ears of potential mates, the two species differ in their vocal performances.
"The males are both singing the same love song -- just one frog is singing it slower. It's kind
of like the difference between Eric Clapton's original and unplugged versions
of Layla," Tucker said.
In previous studies, the scientists found that tree frogs with more sets of chromosome have
larger cell sizes, which slows down the trill rate. What was not known was whether the
calling preferences of females are similarly linked to chromosome number.
To answer this question, Tucker simulated the chromosome duplication event by replicating
spring temperatures early in the frog development. Females were grown to maturity and
then exposed to computer-generated, synthetic male calls that differed by trill rate. They
found that the females hopped toward the calls with the trill rate of the males with matching
chromosome numbers, which indicates female preference.
"This shows that chromosome number alone can control the behavior that keeps the
species separate," Gerhardt said. "In turn, as chromosome number increases, so does the
size of cells, which is probably the immediate cause of the changes in calls and
preferences."
In animals, the origin of species is often associated with geographic barriers. A large body
of water or range of mountains, for example, splits a large population and prevents mating.
The eastern grey tree frog, according to Gerhardt, may represent a rare case of rapid
evolution occurring by chromosome duplication, changes in behavior and reproductive
isolation.
The report, titled "Parallel changes in mate-attracting calls and female preferences in
autotriploid tree frogs," was published by the journal Proceedings of the Royal Society BBiological Sciences. The study was supported by funding from the National Science
Foundation, National Institutes of Health, and the University of Missouri Research Board.
(#3) Major breast cancer breakthrough announced at BC Cancer Agency
VANCOUVER, Oct. 7, 2009 /PRNewswire/ - For the first time in history, BC Cancer
Agency scientists in British Columbia, Canadahave decoded all of the three billion letters in
the DNA sequence of a metastatic lobular breast cancer tumour, a type of breast cancer
which accounts for about 10 per cent of all breast cancers, and have found all of the
mutations, or "spelling" mistakes that caused the cancer to spread.
The landmark study, which will be published October 8th as the cover story in the
prestigious international science journal Nature, helps unlock the secrets of how cancer
begins and spreads, thus pointing the way to the development of new breast cancer
treatment targets and therapies.
"One in nine women is expected to develop breast cancer, and breast cancer accounts for
29 per cent of all cancer diagnoses for B.C. women," said Health Services Minister Kevin
Falcon. "As a result of the efforts of the scientists behind the study, this breakthrough
finding gives further hope to the thousands of women with this terrible disease."
"I never thought I would see this in my lifetime," said Dr. Samuel Aparicio, head of the
breast cancer research program at the BC Cancer Agency, an agency of the Provincial
Health Services Authority (PHSA). "This is a watershed event in our ability to understand
the causes of breast cancer and to develop personalized medicines for our patients. The
number of doors that can now be opened to future research is considerable."
Partnering with the BC Cancer Agency's Genome Sciences Centre, Dr. Aparicio's team
used the latest in next-generation DNA sequencing technology to study the evolution of a
single patient's lobular breast cancer tumour over a nine-year interval. They found 32
mutations in the metastatic cancer tumour and then looked to see how many of those same
spelling mistakes were present in the original tumour. The result was surprising - only five
of the 32 could have been present in all of the cells of the primary tumour, thus fingering
them as the criminals that caused the disease to get started in the first place. These five
mutations were previously unknown to researchers as playing a role in cancer.
"This study demonstrates the remarkable capacity of next-generation DNA sequencing
technology," says Dr. Marco Marra, Director, BC Cancer Agency's Genome Sciences
Centre. "The project that decoded the first human genome in 2001 took years and an
enormous amount of funding. We were able to sequence the breast cancer genome in
weeks and at a fraction of the cost."
"Through our research at the BC Cancer Agency, we are dedicated to finding new and
novel ways to detect cancer earlier and to develop more enhanced treatments," said Brian
Schmidt, Interim President, BC Cancer Agency and Senior Vice President, Provincial
Services, Population and Public Health, PHSA. "This discovery is a wonderful example of
how investment in research is helping to pave the way toward better outcomes for cancer
patients in the future."
The discovery is not only a major scientific milestone for the BC Cancer Agency, an
acknowledged world leader in cancer research care, but also a significant testimony to the
power of philanthropy invested in science to fuel cancer research and drive new
discoveries.
"The BC Cancer Foundation, as the fundraising arm of the agency, has raised over $15
million to support breast cancer research at the BC Cancer Agency across the province,
including Dr. Aparicio's program, through its Weekend to End Breast Cancer walk," said BC
Cancer Foundation President and CEO Douglas Nelson. "We are very grateful to the many
thousands of British Columbians who have walked, donated and supported The Weekend
to End Breast Cancer over the past six years. To everyone who has walked or contributed
we can confidently say your efforts have made a difference - you are a partner in this
remarkable achievement."
The BC Cancer Foundation founded the BC Cancer Agency's Genome Sciences Centre,
the Centre for Translational and Applied Genomics at the BC Cancer Agency, and the BC
Cancer Agency's Breast Cancer Outcomes Unit, all of which played a key role in the study.
The research was conducted in the BC Cancer Agency's research centre in Vancouver,
which was constructed by the BC Cancer Foundation, with donor and provincial and federal
government funding.
The Canadian Breast Cancer Foundation, BC/Yukon Region supported a key member of
Dr. Aparicio's research team through a bioinformatics fellowship. Other funders and
supporters include the Canadian Institutes for Health Research, Genome Canada and
Genome BC, the Canadian Foundation for Innovation, and the Michael Smith Foundation
for Health Research.
Dr. Aparicio was recruited in 2005 from Cambridge University, UK to develop a breast
cancer research program in British Columbia at the BC Cancer Agency. He holds the Nan
and Lorraine Robertson Chair in Breast Cancer Research at theUniversity of British
Columbia (UBC), the Canada Research Chair in Molecular Oncology and is a professor in
the Department of Pathology and Laboratory Medicine at UBC.
The BC Cancer Agency is committed to reducing the incidence of cancer, reducing the
mortality from cancer and improving the quality of life of those living with cancer. It provides
a comprehensive cancer control program by working with community partners to deliver a
range of oncology services, including prevention, early detection, diagnosis and treatment,
research, education, supportive care, rehabilitation and palliative care. The BC Cancer
Foundation raises funds to support research and enhancements to patient care at the BC
Cancer Agency throughout B.C.
(#4) Cold Cases Gone Hot: Researchers Solve Decades-Old Medical
Mysteries Using Genetics
ScienceDaily (Jan. 28, 2011) — The mystery began in 1976. Adolfo Pampena was diagnosed
with a rare form of cancer that caused a strange combination of symptoms and was associated
with the occurrence of multiple tumours in his stomach and colon. His medical team was
stumped and was unable to answer the most important questions for him and his family: the
cause of his disease and the risk for future generations.
Now, 35 years later, the answers are at hand thanks to a genetic study led by investigators at
the Research Institute of the McGill University Health Centre (RI MUHC), the McGill Program in
Cancer Genetics at the Gerald Bronfman Centre for Clinical Research in Oncology and the
Lady Davis Institute for Medical Research at the Jewish General Hospital. The study was
recently published in The New England Journal of Medicine (NEJM).
The researchers were able to pinpoint the gene responsible for the disease (BUB1B), which is
involved in the regulation of chromosomal separation. Instability during cell division can result in
chromosomes ending up in the wrong place, which can lead to the development of tumours.
"The general significance of this discovery is that individuals can be seen at our genetic clinic
with an unknown condition and end up with a diagnosis that is relevant to patients and their
families," said Dr. William Foulkes, senior author of the study and a researcher in genetics at
the RI MUHC, the Lady Davis Institute.
"My father and family were relieved that the cancer risk for other family members is much less
than we thought," said Mary Pampena, Adolfo's daughter. "Now we know more about my
father's genetic history and the cancers he had. We know what screening test to do in the
future. This is important information for us, our children and future generations."
In another study published in the January, 2011 Journal of the American Medical Association
(JAMA). Dr. Foulkes details a second solved mystery involving five families with a long history
of nontoxic multinodular goiter (MNG). Goiter is a thyroid disease which can lead to extreme
swelling of the neck or larynx. The most common form of the disease is not genetic and is due
to iodine insufficiency. However, this form of MNG was known to be genetic, but to date, no one
had ever localized the specific gene or mutation responsible. Dr. Foulkes, Dr. Marc Tischkowitz
(from the Program in Cancer Genetics and the Lady Davis Institute) and their team finally
succeeded, and found the mutation in a surprising place.
As it turns out, the mutation, in a gene called DICER1, was extremely unusual, Foulkes said,
who is also James McGill Professor of Medicine, Human Genetics and Oncology and Director
of the Program in Cancer Genetics at McGill University. "It changes the protein in only one
place, and that single change is enough to trigger multinodular goiter. Generally speaking,
when you have a mutation in a disease gene, it causes a multitude of problems, not just one
illness. But in this case, we have no evidence that it causes anything except goiter.
Intriguingly, women in three of the families had been diagnosed with an unusual type of ovarian
tumor called Sertoli-Leydig Cell Tumor and thus Foulkes and his colleagues were able confirm
that there is a genetic link between multi-nodular goiter and these rare tumors. This link had first
been postulated in 1974.
"In the future, our challenge as researchers is to be able to help people with an unknown
condition by finding out rather quickly what the genetic cause of their problem is" explained
Foulkes. "We can hope in the long-term to have an impact on treatment, diagnosis and other
aspect of management."
(#5) Coffee Drinking in Your Genes? Genetic Variants in Two Genes
Linked With Caffeine Intake
ScienceDaily (Apr. 6, 2011) — Two genes in which variation affects intake of caffeine, the
most widely consumed stimulant in the world, have been discovered. A team of
investigators from the National Cancer Institute, Harvard School of Public Health, Brigham
and Women's Hospital, and the University of North Carolina at Chapel Hill examined
genetic variation across the entire genome of more than 47,000 individuals from the U.S.,
as described in the open-access journal PLoS Genetics.
The genes identified were CYP1A2, which has previously been implicated in the
metabolism of caffeine, and AHR, involved in the regulation of CYP1A2. Individuals with the
highest-consumption genotype for either gene consumed ~40 mg more caffeine than those
with the lowest-consumption genotype, equivalent to the amount of 1/3 cup of caffeinated
coffee, or 1 can of cola.
Caffeine is implicated in numerous physiological and medical conditions; it affects sleep
patterns, energy levels, mood, and mental and physical performance. The identification of
genes that have an impact on daily consumption offers opportunities to better understand
these conditions. Further exploration of the identified genetic variants may provide insight
into the speed of caffeine metabolism, how long caffeine circulates in the blood, or how
strong the physiological effects of consuming a given amount of caffeine are.
Apart from smoking, genetic determinants of lifestyle behaviors have generally not been
consistently described. This study is among the first to examine the entire genome for a
relationship between genetics and caffeine intake, a lifestyle behavior relevant to over 90%
of U.S. adults. The study's success also suggests that additional genetic determinants of
dietary and lifestyle behaviors may be identified in the future using a similar genome-based
research strategy.