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53rd Annual Meeting of The American Society of Human Genetics November 4 - 8, 2003 Los Angeles, California ______________________________________________________________________ PROPOSED SESSION TITLE A Comprehensive Genomics Approach to Complex Disease: The NHLBI Programs for Genomic Applications A major focus in health care in the new millennium will be to link genomic information to pathophysiology. The National Heart, Lung, Blood Institute (NHLBI) has pioneered a Program for Genomic Applications (PGA) (http://www.nhlbi.nih.gov/resources/pga/), a major initiative to advance functional genomic research related to heart, lung, blood, and sleep health and disorder. The program, consisting of 11 PGAs, develops information, tools, and resources to link genes to biological function on a genomic scale. All the information, reagents, and tools developed in the PGAs are freely available to the research community. This workshop will provide information on how to utilize the resources developed by the PGAs, including animal models, DNA variations (SNPs), Gene Expression (Microarrays), and Bioinformatics. The purpose of this session is to familiarize investigators with state of the art approaches and technologies designed to understand the genetic contribution of complex diseases involving heart, lung, blood, and sleep. To introduce and demonstrate public resources available to study complex disease from benchside to bedside. SPEAKERS 1. Howard J Jacob, Ph.D (animal models of HLBS disorders) 2. Chris O’Donnell, MD, M.P.H. (human HLBS disorders, e.g. variation, expression) 3. Jan-Fang Cheng, Ph.D (web tour)