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Digestive System- Hormones Several hormones help to regulate digestion: â¢_________ produced by cells in the lining of the stomach when food reaches the stomach. Enters the blood stream and stimulates the stomach to make gastric juices. â¢__________ produced by cells lining the duodenum when food enters. Stimulates the pancreas to secrete bicarbonate, that neutralizes the acidity of the chyme moving from the stomach to the small intestine. â¢____________(CCK)- produced by the small intestine to stimulate the gallbladder to release bile and the pancreas to release its enzymes into the small intestine.