Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Cholestin® Product Training Series This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited. New & Improved Cholestin® • Cholestin contains policosanol, a novel ingredient extracted from beeswax • Policosanol is clinically proven* – safe, effective, and well-tolerated • • • • Proprietary PoliSorb™ † softgel delivery Convenient once-a-day dosage Pharmanex is first to market in the US Pharmanex has exclusive rights for the network marketing channel †Policor is a trademark of Hauser, Inc. NCEP Cholesterol Guidelines Classification of LDL, Total, and HDL Cholesterol (mg/dL) LDL Cholesterol < 100 100-129 (+ 2+ RF) 130-159 (+ 0-1 RF) 160-189 > 190 Optimal Near or above optimal Borderline high High Very High Total Cholesterol < 200 200-239 > 240 Desirable Borderline high High HDL Cholesterol < 40 > 60 Low High From: Third report of the National Cholesterol Education Program Expert Panel, May 2001 NCEP Cholesterol Guidelines Using NCEP guidelines, about 65 million Americans should make dietary and lifestyle changes to maintain cardiovascular health Cholestin® : Health Benefits • Maintains existing normal cholesterol levels* – – – – Total & LDL-Cholesterol HDL-Cholesterol LDL/HDL Ratio Triglycerides • Helps prevent oxidation of LDL cholesterol* • Promotes normal blood fluidity* * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. History of Policosanol Early 90’s: Beeswax policosanol initially sourced in Cuba Mid 90’s: Sugar cane policosanol suggested as more economical source Cuban government Sugarcane policosanol clinically tested and commercialized in Cuba Pedro P. Perez revives R&D work in US for beeswax policosanol Perez teams up with top-quality pharmaceutical company; now supplier 2001: Pharmanex launches Cholestin® beeswax policosanol Cholestin Composition Primary Active Constituent: • Policosanol from Beeswax (PolicorTM )† – Novel ingredient - “Cholesterol Breakthrough” – Extracted from white NF-grade beeswax (GRAS) – Patent granted to supplier in October 2001 (for use, composition and process) Pharmanex has been granted exclusivity for Network Marketing Channel †Policor is a trademark of Hauser, Inc. Standardization C32 - 6.517 mV 40.00 • Guaranteed minimum 40% policosanol • Reproducible fingerprint of 5 primary aliphatic longchain alcohols C30 - 5.937 50.00 C28 - 5.440 C24 - 4.647 C26 - 5.012 60.00 30.00 20.00 10.00 0.00 2.00 4.00 6.00 8.00 Minutes 10.00 12.00 14.00 PoliSorb™ † Proprietary Delivery PoliSorb softgels have over 10 times better dissolution than policosanol capsules or tablets • Policosanol delivery can be problematic: – naturally a fat-soluble, waxy substance – remains solid at body temperature – tablets & capsules have poor dissolution • Pharmanex PoliSorb™ proprietary delivery: – overcomes solubility problems – emulsified with lecithin phospholipids • natural cell membrane components †Policor is a trademark of Hauser, Inc. Policosanol: Clinical Data Policosanol (sugar cane wax), double-blind clinical trials:** • Blood lipids: 13 studies (total of 1,378 subjects) • Platelet aggregation: 6 studies • LDL-oxidation: 1 study Policosanol from beeswax may be more effective: • Main constituent in sugar cane wax, octacosanol, is not very active in rats (Kato S, Br J Nutr 1995;73:433) Beeswax policosanol clinical trials: • Two open-label pilot studies * Summarized in Healthcare Professionals Product Guide Clinical Data - Summary Research with policosanol has shown the following results (10-20 mg/day):* • Benefits after 8-12 weeks, maximum effect evident after 12 months • Excellent safety & side effect profile * Summarized in Healthcare Professionals Product Guide Policosanol Safety Beeswax policosanol has excellent safety data: • Clinical data: few & mild side effects* • Made from purified, white NF-grade beeswax • GRAS (FDA-Approved) for food & drug use * Summarized in Healthcare Professionals Product Guide Drug Interactions • No clinical reports of drug interactions* • Preliminary contraindications: – high-dose aspirin therapy – anticoagulants (warfarin, coumadin, etc.) – discontinue within 2 weeks of surgery * Summarized in Healthcare Professionals Product Guide Summary • • • • • • • • Cholestin maintains existing normal cholesterol levels* Provides 15 mg per softgel of policosanol Policosanol is clinically proven Proprietary PoliSorb™ softgel delivery Convenient once-a-day dosage Safe & well tolerated Pharmanex is first to market in the US Pharmanex has exclusive rights for the network marketing channel * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.