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Cholestin®
Product Training Series
This material has been prepared by Pharmanex to be used in
conjunction with general educational events and activities only.
Alterations or modifications of this presentation without the
express approval of Pharmanex is prohibited.
New & Improved Cholestin®
• Cholestin contains policosanol, a novel ingredient
extracted from beeswax
• Policosanol is clinically proven*
– safe, effective, and well-tolerated
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Proprietary PoliSorb™ † softgel delivery
Convenient once-a-day dosage
Pharmanex is first to market in the US
Pharmanex has exclusive rights for the
network marketing channel
†Policor is a trademark of Hauser, Inc.
NCEP Cholesterol Guidelines
Classification of LDL, Total, and HDL Cholesterol (mg/dL)
LDL Cholesterol
< 100
100-129 (+ 2+ RF)
130-159 (+ 0-1 RF)
160-189
> 190
Optimal
Near or above optimal
Borderline high
High
Very High
Total Cholesterol
< 200
200-239
> 240
Desirable
Borderline high
High
HDL Cholesterol
< 40
> 60
Low
High
From: Third report of the National Cholesterol
Education Program Expert Panel, May 2001
NCEP Cholesterol Guidelines
Using NCEP guidelines,
about 65 million Americans
should make dietary and lifestyle changes
to maintain cardiovascular health
Cholestin® : Health Benefits
• Maintains existing normal cholesterol levels*
–
–
–
–
Total & LDL-Cholesterol
HDL-Cholesterol
LDL/HDL Ratio
Triglycerides
• Helps prevent oxidation of LDL cholesterol*
• Promotes normal blood fluidity*
* These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
History of Policosanol
Early 90’s: Beeswax
policosanol initially
sourced in Cuba
Mid 90’s: Sugar cane
policosanol suggested as
more economical source
Cuban government
Sugarcane policosanol
clinically tested and
commercialized in Cuba
Pedro P. Perez
revives R&D work
in US for beeswax
policosanol
Perez teams up
with top-quality
pharmaceutical
company; now
supplier
2001: Pharmanex
launches Cholestin® beeswax policosanol
Cholestin Composition
Primary Active Constituent:
• Policosanol from Beeswax (PolicorTM )†
– Novel ingredient - “Cholesterol Breakthrough”
– Extracted from white NF-grade beeswax (GRAS)
– Patent granted to supplier in October 2001
(for use, composition and process)
Pharmanex has been granted exclusivity
for Network Marketing Channel
†Policor is a trademark of Hauser, Inc.
Standardization
C32 - 6. 517
mV
4 0 .0 0
• Guaranteed minimum
40% policosanol
• Reproducible fingerprint
of 5 primary aliphatic longchain alcohols
C30 - 5. 937
5 0 .0 0
C28 - 5. 440
C24 - 4. 647
C26 - 5. 012
6 0 .0 0
3 0 .0 0
2 0 .0 0
1 0 .0 0
0 .0 0
2 .0 0
4 .0 0
6 .0 0
8 .0 0
Min u te s
1 0 .0 0
1 2 .0 0
1 4 .0 0
PoliSorb™ † Proprietary Delivery
PoliSorb softgels have over 10 times better
dissolution than policosanol capsules or tablets
• Policosanol delivery can be problematic:
– naturally a fat-soluble, waxy substance
– remains solid at body temperature
– tablets & capsules have poor dissolution
• Pharmanex PoliSorb™ proprietary delivery:
– overcomes solubility problems
– emulsified with lecithin phospholipids
• natural cell membrane components
†Policor is a trademark of Hauser, Inc.
Policosanol: Clinical Data
Policosanol (sugar cane wax), double-blind clinical trials:**
• Blood lipids: 13 studies (total of 1,378 subjects)
• Platelet aggregation: 6 studies
• LDL-oxidation: 1 study
Policosanol from beeswax may be more effective:
• Main constituent in sugar cane wax, octacosanol, is not very active in
rats (Kato S, Br J Nutr 1995;73:433)
Beeswax policosanol clinical trials:
• Two open-label pilot studies
* Summarized in Healthcare Professionals Product Guide
Clinical Data - Summary
Research with policosanol has shown
the following results (10-20 mg/day):*
• Benefits after 8-12 weeks, maximum effect
evident after 12 months
• Excellent safety & side effect profile
* Summarized in Healthcare Professionals Product Guide
Policosanol Safety
Beeswax policosanol has excellent safety data:
• Clinical data: few & mild side effects*
• Made from purified, white NF-grade beeswax
• GRAS (FDA-Approved) for food & drug use
* Summarized in Healthcare Professionals Product Guide
Drug Interactions
• No clinical reports of drug interactions*
• Preliminary contraindications:
– high-dose aspirin therapy
– anticoagulants (warfarin, coumadin, etc.)
– discontinue within 2 weeks of surgery
* Summarized in Healthcare Professionals Product Guide
Summary
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Cholestin maintains existing normal cholesterol levels*
Provides 15 mg per softgel of policosanol
Policosanol is clinically proven
Proprietary PoliSorb™ softgel delivery
Convenient once-a-day dosage
Safe & well tolerated
Pharmanex is first to market in the US
Pharmanex has exclusive rights for the
network marketing channel
* These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.