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BIOGRAPHICAL SKETCH Fei, Baowei NAME: eRA COMMONS USER NAME: BAOWEIFEI Assistant Professor Georgia Cancer Coalition Distinguished Scholar POSITION TITLE: EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY Case Western Reserve University, Ohio Doctor of Philosophy Systems Engineering Case Western Reserve University, Ohio Master of Science Computer Science Shanghai Jiao Tong University, Shanghai Doctor of Engineering Biomedical Engineering Xi’an Jiaotong University, Xi’an Master of Engineering Biomedical Engineering Xi’an Jiaotong University, Xi’an Bachelor of Science Biomedical Engineering & Instrumentation A. Personal Statement Currently, I lead the Quantitative BioImaging Laboratory (QBIL) at Emory University. I have experience of leading NIH and DoD sponsored projects when I worked at Case Western Reserve University in Cleveland, Ohio. I received comprehensive training in biomedical engineering, computer science, and radiology, which includes two doctor degrees and two Master degrees. In 2006, my work entitled “New Imaging Method Provides a „Before and After‟ Snapshot of the Prostate” was highlighted by the U.S. Department of Defense Congressionally Directed Medical Research Program. In 2009, I was selected as a Georgia Cancer Coalition Distinguished Scholar. In summary, I have a demonstrated record of successful and productive research projects. In summary, I have a demonstrated record of successful and productive research projects in an area that has significant impact on prostate cancer management that affect 1 in 6 men, and my expertise and experience have prepared me to lead the proposed project. B. Positions and Honors 2009Assistant Professor, Department of Radiology, Emory University, Atlanta, GA 2009Assistant Professor, Department of Biomedical Engineering, Georgia Institute of Technology 2005-2008 Assistant Professor, Radiology/Biomedical Engineering, Case Western Reserve University, Ohio 2005-2008 Member of Case Comprehensive Cancer Center, Case Western Reserve University, Ohio 2002-2004 Senior Research Associate, Biomedical Engineering, Case Western Reserve University, 2000-2001 Research Associate, Biomedical Engineering, Case Western Reserve University 1998-2000 Research Fellow, Biomedical Engineering, Nanyang Technological University, Singapore 1995-1998 Research Assistant, Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 1993-1995 Principal Engineer, Department of Research & Development, Zhuhai Biolight Co. Guangdong 1990-1993 Engineer, Research Institute of Shanghai Medical Electronics Co. LTD., Shanghai 2009 2008-2009 2007-2009 2007-2009 2003-2009 National Institute of Health (NIH) Study Section ZRG1 SBIB US Army Medical Research and Materiel Command (USAMRMC) Study Section Maryland Technology Development Corporation (TEDCO) Grant Reviewer Editorial Board of Clinical Medicine: Urology Associate Editor, Medical Physics; Honors (Selected from 18 awards/Honors) 2009 2006 Georgia Cancer Coalition Distinguished Cancer Scholar – Georgia State, USA http://www.georgiacancer.org/res-dist-baowei_fei.php Research work entitled “New imaging method provides a „before and after‟ snapshot of the prostate” is highlighted on the US Department of Defense (DoD) Congressionally Directed Medical Research Programs (CDMRP) website homepage (http://cdmrp.army.mil/highlights/2006.htm#2 ) 2003 2001 1997 1990 Research work on molecular imaging for prostate cancer was included in the 2003 Annual Report of US Department of Defense (DoD) Congressionally Directed Medical Research Programs (CDMRP). http://cdmrp.army.mil/annreports/2003annrep/pdf/4_pcrp.pdf Postdoctoral Traineeship Award, US Department of Defense Prostate Cancer Research Program. Title: “Molecular Imaging for SPECT/MRI-guided Minimally Invasive Treatment of Prostate Cancer” http://cdmrp.army.mil/search.aspx The Outstanding Young Investigator Award in Biomedical Engineering of the Year 1997 in Shanghai, The Society of Biomedical Engineering of Shanghai. Admitted to the Extraordinary Youth Program of Xi’an Jiaotong University at 14 years of age in 1986 and obtained the B.S. Degree in Biomedical Engineering at the age of 18 in 1990. C. Selected peer-reviewed publications (Select from 33) 1. B Fei, JL Duerk, DB Sodee, DL Wilson. “Three-dimensional semiautomatic warping registration of the prostate and pelvis”, Academic Radiology, Vol. 12, pp. 815-824, 2005. PMID: 16039535 2. B Fei, JL Duerk, DT Boll, JS Lewin, DL Wilson, “Slice to volume registration and its potential application to interventional MRI-guided radiofrequency thermal ablation of prostate cancer,” IEEE Transactions on Medical Imaging, Vol. 22, No. 4, pp. 515-525, 2003. PMID: 12774897 3. B Fei, C Kemper, DL Wilson, A comparative study of warping and rigid body registration for the prostate and pelvic MR volumes, Computerized Medical Imaging and Graphics, Vol. 27, pp.267-281, 2003. PMID: 12631511 4. B Fei, JL Duerk, DL Wilson, “Automatic 3D registration for interventional MRI-guided treatment of prostate cancer,” Computer Aided Surgery, Vol. 7, No.5, pp. 257-267, 2002. PMID: 12582978 5. B Fei, A Wheaton, Z Lee, JL Duerk, DL Wilson, “Automatic MR volume registration and its evaluation for the pelvis and prostate,” Physics in Medicine and Biology, Vol. 47, pp. 823-838, 2002. PMID: 11931473 6. B Fei, WS Ng, S Chauhan, CK Kwoh, “The safety issues of medical robotics,” Reliability Engineering and System Safety, Vol. 73, No. 2, pp. 183-192, Jul. 2001. 7. B Fei, H Wang, C Wu, M Chiu, Choline PET Imaging for Monitoring Early Tumor Response to Photodynamic Therapy, Journal of Nuclear Medicine, 51(1): 130-138, 2010. PMID: 20008981 8. Wang H, Fei B (corresponding author). “A modified fuzzy C-means classification method using a multiscale diffusion filtering scheme”. Medical Image Analysis. 13(2):193-202, 2009. PMID: 18684658 9. Cheng Y, C Samia, Meyers JD, Panagopoulos I, Fei B (co-corresponding author), Burda C. “Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer”. Journal of American Chemical Society (JACS), 30(32):10643-7. 2008. PMCID: PMC2719258 10. B Fei, H Wang, JD Meyers, D Feyes, NL Oleinick, JL Duerk, “High-Field Magnetic Resonance Imaging of the Response of Human Prostate Cancer to Pc 4-based Photodynamic Therapy in an Animal Model”, Lasers in Surgery and Medicine, 39(9):723-30, 2007. PMCID: PMC2719260 11. X Chen, RC Gilkeson, B Fei (corresponding author), “Automatic 3D-to-2D registration for ct and dualenergy digital radiography for Calcification Detection”, Medical Physics, 34(12):4934-43, 2007. PMCID: PMC2743028 12. B Fei, HS Wang, RF Muzic, CA Flask, DL Wilson, JL Duerk, DK Feyes, NL Oleinick, Deformable and rigid registration of microPET and high-resolution MR images for photodynamic therapy of cancer in mice, Medical Physics, vol. 33, No. 3, pp. 753-760, 2006. PMID: 16878577 13. B Fei, Z Lee, JL Duerk, JS Lewin, DB Sodee, DL Wilson, “Registration and fusion of SPECT, high resolution MRI, and interventional MRI for thermal ablation of the prostate cancer,” IEEE Transactions on Nuclear Science, Vol. 51, No.1, pp. 177-183, 2004. 14. B Fei, Z Lee, DT Boll, JL Duerk, JS Lewin, DL Wilson, “Image registration and fusion for interventional MRI-guided thermal ablation of the prostate cancer,” Peer-reviewed paper in Lecture Notes in Computer Science Vol. 2879, pp. 364-372, Springer-Verlag Berlin Heidelberg, 2003. D. Research Support Georgia Cancer Coalition Distinguished Clinicians and Scientists Award (PI: Fei) Source: Georgia Cancer Coalition – Georgia State 7/01/2009 – 6/30/2014 The major goal of this award to develop in vivo imaging technology for cancer research Role: PI P50CA128301 (PI: Meltzer, Hu, Goodman) 9/24/08-8/31/13 NIH/NCI Emory Molecular and Translation Imaging Center (P50) The goal is to create In vivo Cancer Molecular Imaging Center (ICMIC) at Emory University Project 1 (PI: Schuster): Characterization of Prostate Cancer with FACBC PET/CT Core C (Core Director: Votaw): Quantitative image and statistical analysis Role: Co-investigator 1 RO1 CA 129356-01 (PI: Schuster) 09/1/07-08/31/12 NIH 18F-FACBC PET-CT for the Detection and Staging of Recurrent Prostate Carcinoma The major goal of this research is to determine if PET imaging with anti-[18F]FACBC will lead to improved patient care in the diagnosis and staging of prostate cancer and to elucidate the mechanism of its uptake within malignant cells. Role: Co-investigator 1P20CA128301-01 (PI: Bremner) 07/01/07-06/30/13 NIH Neural Circuits in Women with Abuse and PSTD The major goal of this project is to measure changes in brain function that occur during stress and the way these may affect myocardial ischemia in patients with CVD and depression. Role: Co-investigator R01 MH073886 (PI: Bremner) 09/01/08-08/31/13 NIH/NIMH Mechanisms of Depression in CVD This project uses SPECT imaging of myocardial perfusion and PET imaging of brain blood flow during a cognitive stress challenge in patients with heart disease with and without depression. Role: Co-investigator Completed Research Support R21CA120536 (PI: Fei) 4/1/06-12/31/08 NIH/NCI: Multimodality in vivo Molecular Imaging for Prostate PDT The objective is to perform PDT of prostate cancer in a mouse model and to develop small animal imaging. Role: PI R21 MH080208-02 (PI: Bremner) 08/31/07-07/31/09 NIH Benzodiazepine Receptor in PTSD The major goal of this study is to use imaging of the benzodiazepine receptor in women with PTSD, hypothesizing a reduction in benzodiazepine receptor binding in prefrontal cortex in women with abuse and PTSD compared to women with abuse without PTSD and normal women. Role: Co-investigator Translational Research Program (PI: Fei) 7/15/08-12/31/08 Coulter Foundation Dual-energy digital radiography for early detection of cardiac disease The objective is to develop dual-energy digital radiography techniques as a screen tool for cardiac diseases. Role: PI Presidential Research Initiative (PI: Fei) 7/1/07-12/31/08 Case Western Reserve University In Vivo Imaging for Nanoparticle-based Cancer Therapy The goal is to evaluate nanoparticles for cancer treatment and to develop imaging to monitor the therapy. Role: PI Cancer Center Project (PI: Fei) 3/1/06-8/30/07 Case Comprehensive Cancer Center Multimodality in vivo Imaging for photodynamic therapy of prostate cancer This application proposes to test a second-generation photosensitizing drug for photodynamic therapy of prostate cancer in an animal model. Longitudinal images will be acquired to monitor tumor changes after therapy. Role: PI Department of Defense (PI: Fei) 4/25/02-4/24/04 Department of Defense (DoD) Molecular Imaging for MRI-guided Minimally Invasive treatment for Prostate Cancer The overall goal of this project is to develop multimodality imaging for interventional MRI-guided radiofrequency thermal ablation treatment for prostate cancer. Role: PI