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National Imaging Associates, Inc. Clinical guidelines MUGA (Multiple Gated Acquisition) Scan CPT Codes: 78472, 78473, 78494, +78496 Guideline Number: NIA_CG_027 Responsible Department: Clinical Operations Original Date: Page 1 of 4 Last Review Date: Last Revised Date: Implementation Date: September 1997 August 2016 August 2016 January 2017 INTRODUCTION: Multiple-gated acquisition (MUGA) scanning is a radionuclide ventriculography technique to evaluate the pumping function of the ventricles of the heart. During this noninvasive nuclear test, radioactive tracer is injected into a vein and a gamma camera detects the radiation released by the tracer, providing moving images of the heart. From these images, the health of the heart’s pumping chamber, the left ventricle, can be assessed. It is used to evaluate the left ventricular ejection fraction (LVEF), a measure of overall cardiac function. It may also detect areas of poor contractility following an ischemic episode and it is used to evaluate left ventricular hypertrophy. Initial Clinical Reviewers (ICRs) and Physician Clinical Reviewers (PCRs) must be able to apply criteria based on individual needs and based on an assessment of the local delivery system. INDICATIONS FOR MULTIPLE-GATED ACQUISITION (MUGA) SCAN: To evaluate left ventricular (LV) function at baseline before chemotherapy or cardiotoxic therapy; may be repeated prior to subsequent chemotherapy cycles until a total cardiotoxic dose has been reached. To evaluate ejection fraction in a patient with congestive heart failure (CHF), when prior cardiac imaging has proven inadequate for an accurate determination of ejection fraction. To evaluate patient, who is obese or who has chronic obstructive pulmonary disease (COPD), for coronary artery disease (CAD). As an alternative form of stress imaging instead of echocardiography or myocardial perfusion imaging, based upon similar necessity criteria for the evaluation of coronary or valvular heart disease. COMBINATION OF STUDIES WITH MUGA: Abdomen CT/Pelvis CT/Chest CT/Neck MRI/Neck CT with MUGA – known tumor/cancer for initial staging or evaluation before starting chemotherapy or radiation treatment. ADDITIONAL INFORMATION RELATED TO MUGA: Request for a follow-up study - A follow-up study may be needed to help evaluate a patient’s progress after treatment, procedure, intervention or surgery. Documentation requires a medical reason that clearly indicates why additional imaging is needed for the type and area(s) requested. 1— MUGA 2017 Proprietary MUGA Scan Monitoring during Chemotherapy – Chemotherapeutic drugs that are used in cancer treatment may be toxic to the heart muscle. To minimize the risk of damaging the heart muscle with these drugs, the patient’s cardiac function may be monitored with the MUGA scan before and during administration of the drug. Before the first dose of the drug, a MUGA scan may be performed to establish a baseline left ventricle ejection fraction (LVEF). It may then be repeated after cumulative doses. If the LVEF begins to decrease, cardio toxicity risk must be considered if continuing the treatment. 2— MUGA 2017 Proprietary REFERENCES ACC/AHA/AATS/PCNA/SCAI/STS 2014 Focused Update of the Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Journal of the American College of Cardiology, 2014, 7, doi:10.1016/j.jacc.2014.07.017. Retrieved from http://content.onlinejacc.org/article.aspx?articleid=1891717. ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 Multimodality Appropriate Use Criteria for the Detection and Risk Assessment of Stable Ischemic Heart Disease A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. Journal of the American College of Cardiology, 2014, 63(4), 380-406. doi:10.1016/j.jacc.2013.11.009. Retrieved from http://content.onlinejacc.org/article.aspx?articleid=1789799 Anagnostopoulos, C., Harbinson, M., Kelion, A., Kundley, K., Loong, C.Y., Notghi, A., . . . Underwood, S.R. (2004). Procedure guidelines for radionuclide myocardial perfusion imaging. Heart, 90, 1i010. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876307/pdf/v090p000i1.pdf Berman, D.S., Kang, X, Hayes, S.W., Friedman, J.D., Cohen, I., Abidov, A., . . . Hachamovitch, R. (2003). Adenosine myocardial perfusion single-photon emission computed tomography in women compared with men: Impact of diabetes mellitus on incremental prognostic value and effect on patient management. Journal of the American College of Cardiology, 41, 1125-1133. Retrieved from http://content.onlinejacc.org/cgi/reprint/41/7/1125.pdf Fatima, N., Zaman, M.U., Hashmi, A., Kamal, S., & Hameed, A. (2011). Assessing adriamycin-induced early cardiotoxicity by estimating left ventricular ejection fraction using technetium-99m multiple-gated acquisition scan and echocardiography. Nucl Med Commun, 32(5), 381-385. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21346663 Hachamovitch, R., Hayes, S.W., Friedman, J.D., Cohen, I., & Berman, D.S. (2004). Stress myocardial perfusion single-photon emission computed tomography is clinically effective and cost effective in risk stratification of patients with a high likelihood of coronary artery disease (CAD) but no known CAD. Journal of the American College of Cardiology, 43, 200-208. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/14736438 Hacker, M., Jakobs, T., Matthiesen, F., Vollmer, C., Nikolaou, K., Becker, C., & Tiling, R. (2005). Comparison of spiral multidetector CT angiography and myocardial perfusion imaging in the noninvasive detection of functionally relevant coronary artery lesions: 3— MUGA 2017 Proprietary First clinical experiences Journal of Nuclear Medicine, 46, 1294-1300. Retrieved from http://jnm.snmjournals.org/content/46/8/1294.full.pdf+html Hakeem, A., Bhatti, S., Dillie, K.S., Cook, J.R., Samad, Z., Roth-Cline, M.D., & Chang, S.M. (2008) Predictive value of myocardial perfusion single-photon emission computed tomography and the impact of renal function on cardiac death. Circulation, 118, 25402549. Retrieved from http://circ.ahajournals.org/content/118/24/2540.abstract Karkos, C.D., Thomson, G.J., Hughes, R., Hollis, S., Hill, J.C., & Mukhopadhyay, U.S. (2002). Prediction of cardiac risk before abdominal aortic reconstruction: Comparison of a revised Goldman Cardiac Risk Index and radioisotope ejection fraction. Journal of Vascular Surgery, 35(5), 943-949.Retrieved from http://www.jvascsurg.org/article/S0741-5214(02)23579-X/abstract Krahn, A.D., Hoch, J.S., Rockx, M.A., Leong-Sit, P., Gula, L.J., Yee, R., . . . Klein, G.C. (2008). Cost of preimplantation cardiac imaging in patients referred for a primaryprevention implantable cardioverter-defibrillator. American Journal of Cardiology, 102(5), 588-592. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/18721517 Marcassa, C., Bax, J.J., Bengel, F., Hesse, B., Petersen, C.L., Reyes, E., & Underwood, R. (2008) Clinical value, cost-effectiveness, and safety of myocardial perfusion scintigraphy: a position statement. European Heart Journal, 29, 557-63. Retrieved from http://eurheartj.oxfordjournals.org/content/29/4/557.full.pdf+html Metz, L.D., Beattie, M., Hom, R., Redberg, R., Grady, D., & Fleischmann, K.E. (2007).The prognostic value of normal exercise myocardial perfusion imaging and exercise echocardiography: A meta-analysis. Journal of the American College of Cardiology, 49, 227-237. Retrieved from http://content.onlinejacc.org/cgi/reprint/49/2/227.pdf Mitra D, Basu S. (2012) Equilibrium radionuclide angiocardiography: Its usefulness in current practice and potential future applications, World J Radiol. 2012 Oct 28; 4(10): 421–430. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495989/ Shureiqi, I., Cantor, S.B., Lippman, S.M., Brenner, D.E., Chernew, M.E., & Fendrick, A.M. (2002). Clinical and economic impact of multiple gated acquisition scan monitoring during anthracycline therapy. British Journal of Cancer, 86, 226-232. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375190/pdf/86-6600037a.pdf Yancy CW., Jessup M., Bozkurt B., Butler J., Casey DE., Drazner MH., Fonarow GC., et al. 2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive summary. A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2013; 128:1810. http://circ.ahajournals.org/content/128/16/1810 4— MUGA 2017 Proprietary