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The Human Cardiovascular System *In preparation for a pig’s heart dissection Larry M. Frolich, Ph.D.,Human Anatomy Location of Heart in Thorax CV System Function: Circulate blood through entire body for • • • • Transport of oxygen to cells Transport of CO2 away from cells Transport of nutrients (glucose) to cells Movement of immune system components (cells, antibodies) • Transport of hormones How? • Heart is pump • Diffusion in capillaries Veins = Return Arteries = Away Artery/Vein Differences Arteries Direction Blood Away from of flow Heart Pressure Higher Veins Blood to Heart Walls Lumen THICKER: Tunica media thicker than tunica externa Smaller THINNER: Tunica externa thicker than tunica media Larger Valves No valves Valves (see next) Lower Capillaries • Microscopic: 1 cell thick • Network • Entire goal of C-V system is to get blood into capillaries where diffusion takes place GREAT VESSELS •Aorta •IVC, SVC •Pulmonary Trunk •Pulmonary Veins 2 Circulatory Paths heartarteries arterioles veinsvenules capillaries Systemic Pulmonary Heart Chambers and Valves Larry M. Frolich, Ph.D.,Human Anatomy Right Heart Chambers: Pulmonary Circuit • Right Atrium (forms most of posterior of heart) – Receives O2-poor blood from body via IVC, SVC, Coronary sinus • Right Ventricle – Receives O2-poor blood from right atrium through tricuspid valve – Pumps blood to lungs via Pulmonary Semilunar Valve in pulmonary trunk – Septum Left Heart Chambers: Systemic Circuit • Left Atrium – Receives O2-rich blood from 4 Pulmonary Veins • Left Ventricle (forms apex of heart) – Receives blood from Left Atrium via bicuspid valve – Pumps blood into aorta via Aortic Semilunar Valve to body Heart Valves: Lub*-Dub** • *Tricuspid Valve: Right AV valve – 3 Cusps (flaps) made of endocardium and CT – Flow of blood pushes cusps open – When ventricle in diastole (relaxed), cusps hang limp in ventricle – Ventricular contraction increases pressure and forces cusps closed • *Bicuspid (Mitral) Valve: Left AV valve – 2 cusps anchored in Lft. Functions same as Rt. AV valve • **Semilunar valves: prevents backflow in lg arteries -Pulmonary Semilunar Valve: RV & Pulmonary Trunk -Aortic Semilunar Valve: LV & Aorta -3 cusps: blood rushes past they’re flattened, as it settles they’re pushed down (valve closed) Chamber contraction/relaxation Blood supply to heart wall