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MEDICAL BIOLOGY AND GENETICS I Dr. Mehmet Ozdemir COURSE EVALUATION CRITERIA Method Quantity Participation 1 Quiz 2 Midterm Exam(s) 1 Laboratory 1 Lab/Practical Exam(s) 1 Final Exam 1 Percentage (%) 5 5 30 5 10 40 100 Examinations: Essay Questions True-False Fill in the Blank Multiple Choices Short Answers Matching First Topic : Historical Concept and Development of Organisms/Scope of Biology/ Classification/The Medical Importance of the Six Kingdoms of Living Organisms What is Biology Biology - The study of Life Biology is a branch of science, which deals with the study of life. It is concerned with the study of living organisms, which are immeasurably diverse and complex than the non-living matter. Hence, biology is also described as life science or natural science Development Is the process through which an embryo becomes an adult organism and eventually dies. Or The progressive changes in size, shape, and function during the life of an organism by which its genetic potentials(genotype)are translated into functioning mature systems(phenotype) Video Presentation Organization of Life Atom- smallest unit of matter that maintains the properties of an element Molecule- group of atoms held together by covalent bonds; make up cells Organelle Cells- living thing that has a membrane to keep it apart from others; makes up tissues Tissues- material which organs are made of Organs- a group of assorted tissues which makes up the organ system and performs bodily functions Organ System- the processes which allow an organism and its related parts to function properly Organism- one individual, one body of the population Population- all organisms of one particular species in a community Community- all living organisms in a certain ecosystem that interact Ecosystem- all biotic and abiotic factors in a certain area Biosphere- all the ecosystems on earth Characteristics of Life Each individual living thing is called an organism. All organisms have the following characteristics. 1-Living things are highly organized and contain many complex chemical substances. 2-Living things are made up of one or more cells Characteristics of Life 3-Living things use energy 4-Living things have a limited life span 5-Living things grow (Growth) 6-Living things respond to changes in the environment 7-Living things reproduce (Recroduction) 8-Living things respire (Respiration 9-Living things excrete (Excretion) 10-Living things feed (Feeding) Characteristics of living things: Change in position by the action of muscles in animals, and slow growth movements in plants Movement process by which living cells release Respiration The energy from organic molecules The ability to detect and respond to changes Sensitivity in the environment either inside or outside the organism Growth Increase in size and mass Creation of new organisms that are Reproduction the same species as the parents Removal of wastes from the organism’s body. Excretion Supplies an organism with the food it Nutrition needs to respire, grow, repair and reproduce. The Life Processes Living things carry on certain activities that are also characteristics of life. We will briefly describe the function or processes that organisms perform in order to stay alive.These life processes are Nutrition Transport Respiration Synthesis and Assimilation Growth The Life Processes Excretion Regulation Reproduction Metabolism Nutrition -Organisms feed is called nutrition There are two types of nutrition a-Autotrophic nutrition. Autotrophic organisms can make their own food. For example: green plants(Photosynthesis) b-Heterotrophic nutrition Heterotrophic organisms obtain food from the bodies of other organisms. -Carnivors,such as cats and foxes,eat the flesh of animal -Herbivores, such as horses and rabbits, eat plants -Omnivors, such as human, eat both plants and animals -Parasites, such as fleas and tapeworms, live on or another living organism(host) Metabolism All the chemical reaction occurring within the cells of an organism are called its metabolism. There are two different types of metabolism: Catabolism (breaking down): is a process in which complex substances are broken down into simpler ones, resulting in the release of energy. Respiration is an important example of catabolism in living things. Anabolism (Building up): is a process in which simple raw materials are used to build up complex compounds. This type of reaction requires a supply of energy Examples of anabolism are Photosynthesis, and all cases of growth and repair in the bodies of organisms. Both catabolic (breaking down) and anabolic (building up) processes occur in living things. i.e. All living things born, grow, develop, reproduce, and dies. This process is called Life cycle. Respiration All the life processes require a constant supply of energy. Organisms obtain their energy by releasing the chemical energy stored in certain nutrients. The process by which this is accomplished is called respiration. Respiration involves a complex series of chemical reactions. There are two types Aerobic respiration (It requires oxygen from the air) Anaerobic respiration( It does not requires oxygen) Growth Growth is the process by which living organism increase in size. Excretion: The removal of waste substances from the body is called excretion. Reproduction Reproduction is the process by which living organism produce new organisms of their own kind. Unlike the other life processes, reproduction is not necessary for the continued life of an individual organism. However, it is necessary for the continued existence of that kind of organisms. There are two types of reproduction. Asexual reproduction( only one parent and all offspring are identical to the parent.) Sexual reproduction(two parents and offspring are not identical to either parent) Homework Regulation Homeostasis Classification of Living Things Diversity of Life Classification of Living Things Diversity of Life What is classification? Classification is the grouping of things according to characteristics The branch of biology that deals with classification and naming of living things is taxonomy. WHY CLASSIFY? In order to more easily study the unity and diversity of living organisms in an organized manner, biologists classify organisms This means that they group organisms together based on their common characteristics Physical structure is often the primary basis for biological classification BIONOMIAL NOMENCLATURE Carolus Linneaus devised binomial nomenclature (2 names in Latin) Genus-Species ex. scientific name of humans ..... Homo sapiens Homo is the genus name .... sapiens is the species name Both have to be printed in italics or MODERN CLASSIFICATION SYSTEM: KINGDOM PHYLLUM CLASS ORDER FAMILY GENUS SPECIES KINGDOMS: The 5 Kingdom System is based on the following criteria: 1. Presence or absence of a nuclear membrane 2. Unicellularity versus multicellularity 3. Type of nutrition Living Thinks Questions What is classification? Why is classifying living things important? What is taxonomy? Describe binomial nomenclature. Monera Monera are single-celled organisms that don’t have a nucleus. Bacteria make up the entire kingdom. There are more forms of bacteria than any other organism on Earth. Some bacteria are beneficial to us, such as the ones found in yogurt. Others can cause us to get sick. Three basic types of bacteria Three basic types of bacteria CoccusBaccillusSpirillum- Structure of Bacteria Bacterial cells, like plant cells, are surrounded by a cell wall. However, bacterial cells walls are made up of polysaccharide chains linked to amino acids, While plant cell walls are made up of……………………. Many bacteria secrete a slimy capsule around the outside of the cell wall. The capsule provides additional protection for the cell Structure of Bacteria Inside the cell wall and capsule is the cell membrane. Cytoplasm (ribosomes and DNA) Some of the bacteria have flagella which are used for locomotion in water. Life function of bacteria Most bacteria are heterotrophic as Saprobes : Do not cause disease. why? Parasites: Live on or living organisms, and may cause disease. Life function of bacteria A few bacteria are autotrophic which are either photosynthetic or chemosynthetic. Photosynthetic………… Chemosynthetic bacteria obtain energy by oxidizing inorganic substances such as compounds of iron or sulfur, nitrites, and ammonia. The energy is used for the synthesis of organic compounds from carbon dioxide. Bacteria generally reproduce asexually by binary fission. The genetic material replicates, and the parent cell divides in two equal daughter cells. A few bacteria reproduce sexually like conjugation which are transfer of chromosomes or chromosomal parts does occur occasionally Small group of bacteria are harmful but generally bacteria are benefit (useful). Useful bacteria are used in the production of yoghurt and cheese. Most bacteria are harmless, and , in fact, are necessary for the continuance of life. Why? The bacteria of decay break down the tissues of dead animals and plants, and return oxygen, carbon, nitrogen, phosphorus, and sulfur to the air, soil and water. These elements can then be used by other living things. The role of bacteria in the recycling of materials. Some bacteria cause diseases. This type of bacteria is called phatogenic bacteria. Phatogenic bacteria cause disease such as tuberculosis, cholera, diptheria, pneumonia, typhoid and teeth decay. Kingdom Protista Characteristics of Protists Mainly unicellular or very simple multicellular They are eukaryotic, which means they have a nucleus. Most have mitochondria. They can be parasites. They all prefer aquatic or moist environments. Examples of protists include some algae, paramecium, and amoeba. Classification of Protists For classification, the protists are divided into three groups: Animal-like protists, which are heterotrophs and have the ability to move. Plant-like protists, which are autotrophs that photosynthesize. Fungi-like protists, which are heterotrophs, and they have cells with cell walls and reproduce by forming spores. Ex: Euglena Euglena likes animals because it can move. It also likes plants because it has chloroplast in its structure. KINGDOM FUNGI *multicellular *have nuclei *mainly do not move from place to place *heterotrophic (food is digested outside of fungus) *examples - They include mushrooms, molds, and yeasts Reproduce by budding and spores. Most fungi grow best in warm, moist places. They may be microscopic or large multicellular organism. They cause diseases in plants and animals especially they irritate our skin. but some are useful, used in the production of cheese,wine and beer Mushroom is a food source. Decompose dead organism and help recycling of nutrients. of some medicines especially antibiotics for example;penicillin Production KINGDOM PLANTAE (plants) *multicellular *have nuclei *do not move *autotrophic *examples - multicellular algae, mosses, ferns, flowering plants (dandelions, roses, etc.), trees, etc Plants Plants contain chlorophyll, a green pigment necessary for photosynthesis, a process in which plants convert energy from sunlight into food. Their cell walls are made sturdy by a material called cellulose, and they are fixed in one place. Plants are divided into two groups: flower- and fruit-producing plants and those that don’t produce flowers or fruits. They include garden flowers, agricultural crops, grasses, shrubs, ferns, mosses, and conifers. KINGDOM ANIMALIA (animals ) *multicellular *have nuclei *do move *heterotrophic * They are divided into vertebrates and invertebrates and include mammals, amphibians, reptiles, birds and fish.