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University of Toronto
Cardiovascular Sciences Collaborative Program
ACTIVITY REPORT
1999 – 2000
FitzGerald Bldg., 150 College Street, Room 83D, Toronto ON M5S 3E2
Tel: 416/978-0746
Fax: 416/946-5713
E-mail: [email protected]
Web site: www.library.utoronto.ca/www/cardiosci/index.html
CONTENTS
Collaborating Departments
Executive Committee
Courses Offered
Program Sponsored Activities
- Cardiovascular Scientific Day “2000”
- Annual Student Research Day
- Lecture Series
- 3rd Annual “Cardiovascular Disease Update”
- Human Biology Student Union Career Fair
- Summer Activities
Awards
- Medtronic Travel Award
- Bigelow Book Prize
- Ontario Student Opportunity Trust Funds (OSOTF) Award
- Life Sciences Committee Summer Undergraduate Research Fellowships
Advertising Material
- World Wide Web
Program Faculty
Program Students
Convocated Students/Follow-up
Student Achievements
Director’s Comments
Publications
- Students
- Faculty
Acknowledgements
The Cardiovascular Sciences Collaborative Program has forged links with a broad base of
departments, institutes, and centres within the university providing our trainees with a rich,
diverse experience. As well, by solidifying the Program’s financial base through interest
available from endowments, industry sponsorship, and individual departmental support, the
Program is in a more secure position which has allowed further growth of the Program. We are
now better placed to provide an outstanding value added graduate training experience to those
who wish to specialize in cardiovascular sciences. For this past years’ details, please refer to the
Director’s report.
The Program office is located on campus in the FitzGerald Building. Day-to-day functions of the
Program are handled by the Program Director, Dr. C. Wittnich, and the Program Administrator,
Victoria Simpson; with the guidance of the Executive Committee.
Thanks to all of the faculty and students for another successful year leading off the millennium!
Dr. Carin Wittnich
COLLABORATING DEPARTMENTS
Faculty:
Medicine
Physical Education and Health
Clinical:
Department of Medicine
Department of Surgery
Department of Anaesthesia
Graduate:
Department of Clinical Biochemistry
Department of Community Health
Department of Exercise Sciences
Department of Medical Biophysics
Department of Pharmacology
Department of Physiology
Department of Rehabilitation Science
Institute of Medical Science
Laboratory Medicine and Pathobiology
Other:
Institute of Biomedical Engineering
EXECUTIVE COMMITTEE
The Executive Committee consists of a representative from each collaborating department as
well as two student representatives.
Dr. C. Wittnich (Director)
Dr. M. Plyley (Exercise Science)
Dr. M. Rabinovitch (Lab. Med. Pathobiology)
Dr. D.H. Osmond (Physiology)
Dr. R.D. Weisel (IMS)
Dr. R.I. Ogilvie (Pharmacology)
Dr. M. Ojha (IBME)
Dr. D. Cheng (Anaesthesia)
Dr. S. Thomas (Rehabilitation Science)
Dr. G. Wright (Medical Biophysics)
Kyle Cowan (Sr. Student Representative)
Karim Bandali (Jr. Student Representative)
COURSES OFFERED
BME1448H
EXS5508H
JEB1365H
JTC1331H
LMP1015H
LMP1407H
LMP1503H
LMP1504H
MSC3060H*
MSC3061H*
MSC3062H*
MSC3063H*
PCL1006Y
PSL1029H
PSL1038H
PSL1060H
Cardiovascular Fluid Mechanics (IBME)
Cardiovascular Disease and Exercise (Exercise Science)
Ultrasound: Theory and Applications in Biology and Medicine (IBME)
Biomaterials Science (IBME)
Vascular Pathobiology (Lab. Med. Pathobiology)
From Bench to Bedside: Design, Measurement, and Analysis for Clinical
Investigators (Lab. Med. Pathobiology)
Signal Transduction Pathways in Normal and Diseased Tissue (Lab. Med.
Pathobiology)
Biochemistry, Molecular Biology of Cardiovascular Diseases (Lab. Med.
Pathobiology)
Advanced Topics in Cardiovascular Sciences – Molecular Biology & Signal
Transduction in the Heart (IMS)
Advanced Topics in Cardiovascular Sciences – Hormones and the Cardiovascular
System (IMS)
Advanced Topics in Cardiovascular Sciences – Heart Function (IMS)
Advanced Topics in Cardiovascular Sciences – Vascular (IMS)
Cardiovascular Pharmacology (Pharmacology)
Advanced Course in Cardiovascular Regulation (Physiology)
Volume, Electrolyte and Pressure Regulation in Body Fluid Compartments
(Physiology)
Developmental Cardiovascular Physiology (Physiology)
* Core Courses for PhD Trainees
PROGRAM SPONSORED ACTIVITIES
Annual Cardiovascular Scientific Day -- May 18, 2000
The Annual Scientific Day was hosted this year by the Cardiovascular Sciences Collaborative
Program and, for the first time, the newly established Heart & Stroke/Richard Lewar Centre of
Excellence. The event was held at the Inn on the Park where 179 faculty and student/trainees
participated. The focus of the day was “Genetic Inheritance: How to Win When the Genes are
Against You!”
Following the Heart & Stroke/Richard Lewar Centre of Excellence Members-Only Strategic
Planning Meeting, the scientific day began with the Central Symposium on “The Future of
Cardiovascular Research”. This featured Mr. Rick Gallop, President and CEO, Heart & Stroke
Foundation of Ontario, who spoke on “The Heart & Stroke Foundation of Ontario and Future of
Cardiovascular Research”. Dr. David Foot, Faculty of Arts and Science, discussed “Changing
Demographics and Cardiovascular Disease: The Boomer Era”, and Dr. Steve Scherer, Centre
for Applied Genomics, Hospital for Sick Children, reviewed the “Impact of Human Genome
Project on Biomedical Research”.
Morning breakout sessions focused on two areas - “Update on Women & Heart Disease &
Stroke” and “New Tools for Cardiovascular Research and Investigation”. In the latter session,
Dr. Reed Pyeritz, MCP Hahnemann School of Medicine, Pittsburgh, PA, was featured as the
Heart & Stroke/Richard Lewar Centre of Excellence Guest Speaker. He spoke on “Genetic
Approach to the Young Person with Coronary Disease”. Presentations by key faculty were
followed by lively discussions which carried over into lunch.
The “Hyde Park” Novel Concept Session, the first time this concept has been tried, was a huge
success. Senior faculty took on the challenge and dared to share their “wildest ideas” with the
group.
Afternoon breakout sessions focussed on two areas - “Molecular Insights from Animal Models
of Human Disease” and “Future of Genetics in Diagnosis and Therapy”. These were followed by
the Isadore E. Smith Annual Lecture. This years lecture was given by Dr. Jacques Genest Jr.,
McGill University, Montreal, Quebec, who spoke on “The ABC’s of HDL Cholesterol”.
There were 24 abstracts submitted for the poster session. A panel of judges selected six poster
finalists. These finalists were asked to give a short oral presentation during a poster walkabout.
An additional hour of poster viewing was available during the breaks and over lunch. These
posters highlighted our cardiovascular trainees in their particular area of interest.
Poster prizes were awarded to:
1st Prize – Syed Zaidi (Supervisor: Dr. Rabinovitch) “Suppression of elastase activity protects
from medial/intimal thickening following carotid arterial injury in elafin overexpressing
transgenic mice”
2nd Prize – Kyle Cowan (Supervisor: Dr. Rabinovitch) “Complete reversal of fatal pulmonary
hypertension in rats by a serine elastase inhibitor”
3rd Prize – Imran Mungrue (Supervisors: Drs. Stewart & Husain) “Conditional over-expression
of human inducible nitric oxide synthase (iNOS) in the myocardium of transgenic mice”
Congratulations to the finalists, winners, and all the students for their superb efforts.
The awards ceremony, the finale of the day, also recognized outstanding students in the
Cardiovascular Sciences Collaborative Program. This years’ Bigelow Book Prize went to Dr.
Michael Borger, PhD (Supervisor: Dr. R. Weisel). Recent graduands were also awarded their
specialization certificates: MSc: Ian Coplan, Rohan Shahani, Dimitra Trambakoulos, Mohammed
Warsi, Stacy O’Blenes, and PhD: Kyle Cowan. We wish them all the best in their future
endeavours.
Lively discussions continued during the reception that followed.
Continuing medical education credits were issued for this meeting: 6.5 hours of category 1 credit
toward the AMA Physicians Recognition Award and 6.5 hours as an Accredited Group Learning
Activity under Section 1 of the Framework of CPD options for the Maintenance of Certification
Program of the Royal College of Physicians and Surgeons of Canada.
My thanks are extended to industry for their continued financial support and generosity which is
so essential to the success of this meeting. Major sponsorship included AstraZeneca, Aventis
Pharma Inc. and Merck Frosst Canada & Co. Because of their support and that of the HSRLCE,
we were able, once again, to provide an open registration and complimentary luncheon.
Plans are underway for the 2001 Scientific Day and announcements will be forthcoming. For
additional information, please go to the Collaborative Program web site or e-mail us at
[email protected].
Annual Student Research Day
On Wednesday, March 1, 2000, the Cardiovascular Sciences Collaborative Program kicked off
its 1st Annual Student Research Day in the Medical Sciences Bldg. This was a fun filled day that
was attended by CSCP trainees and faculty. Trainees began the day by giving a ten minute talk
related to their research, followed by a question/answer period as below.
SESSION I:
Jack Wallen, PhD-PSL
Gender differences in metabolic potential in hypertrophied hearts:
Role of sex hormones
Cathy Boscarino, MSc-PSL Myocardial buffering capacity & hydrogen ion accumulation
during global ischemia: Are there gender differences?
Sonia Katyal, MSc-REH
Adaptations to short term aerobic training in women: The role of
plasma volume
Nesime Askin, MSc-PSL
Metabolic response of skeletal muscle during ischemia
Patient’s adherence to prescribed therapy for coronary artery
disease
Warren Foltz, PhD-MBP
MR oximetry for ischemic heart disease
Sloane Hechter, MSc-IMS The impact of ACE inhibitors on adults with the mustard
procedure
Michelle Batthish, MSc-PSL Blockade of either chloride channels or mitochondrial ATPsensitive potassium channels abolishes the protection of
angiotensin II in rabbit ventricular myocytes
SESSION II:
Tony Lee, MSc-IMS
The role of nitric oxide in cardiovascular development and
remodeling
Nathalie Lapointe, PhD-IMS Cardioprotective effect of vasopeptidase inhibitor in the infarcted
and remodeling rat heart
Zakria Ahmed, PhD-LMP
Protein dependent increase in core aldehydes and
lysophosphatidyldchonline during high density lipoprotein (HDL)
oxidation by peroxynitrite (ONOO-)
Christie Lee, MSc-IMS
DNA vaccination confers immunity against myocarditis
Karim Bandali, PhD-PSL
Neonatal hemodynamic and metabolic responses to hyperoxia
Shona Torrance, PhD-IMS Developmental changes in myocardial beta adrenoceptors
Kyle Cowan, PhD-LMP
Complete reversal of fatal pulmonary hypertension in rats with a
serine elastase inhibitor
Michael Borger, PhD-IMS Decreased cerebral emboli during aortic arch cannulation: A
randomized clinical trial
Vaska Micevski, PhD-IMS
In the afternoon trainees were given valuable advice from Professors Peter Liu and Marlene
Rabinovitch who also shared with the students how they began their research/academic careers.
This session was followed by a discussion period in which students had an opportunity to discuss
the trials and tribulations of living a life devoted to education and research with these highly
respected and successful scientists. The day concluded with a wine and cheese reception where
students and faculty mixed and mingled, after which most of the students continued their
interactions at a student planned social event.
The Student Research Day met with resounding success and the students have made it clear this
will become an annual event. It was also unanimously decided by the students that this meeting
will be mandatory for all Program trainees. This day would not have been possible without the
Herculean efforts of the Student Reps: Karim Bandali and Kyle Cowan and their planning
committee: Sloane Hechter and Sonia Katyal. Congratulations on a job well done!
Lecture Series
For this academic year the lecture series was focused in the two main areas of “Molecular
Biology and Signal Transduction” and “Hormones and the Cardiovascular System”. A number
of interesting speakers contributed their time and knowledge. Both these areas were covered
from the perspective of whole body and organ to the molecular level including genetics, with a
particular emphasis on bridging basic science and clinical approaches to these areas.
3rd Annual “Cardiovascular Disease Update”
The 3rd Annual Cardiovascular Disease Update was successfully held on March 4, 2000 at the
Weston Prince Hotel, Toronto. This annual CME event was made possible by the generous
sponsorship of Bristol-Myers Squibb. The purpose of this half-day event is to provide clinical
insight into the diagnosis and treatment of current cardiovascular disease from a bench-tobedside perspective. This year the focus was on issues relating to women and heart disease,
hypertension, and drug therapies. Each session was accompanied by audience discussion that
continued informally during the buffet luncheon. The meeting was accredited for 4 Mainpro-MI
credits and 4 hours of the Accredited Group Learning Activity under Section 1 of the Framework
of CPD options for the Maintenance of Certification Programs of the Royal College of
Physicians & Surgeons of Canada. The meeting was attended by Family Physicians, Internists
and Specialists from across Toronto. For the first time the university mandated that we were
required to levy a fee which we kept to a minimum. This money, along with an educational grant
from industry, was used to help defray the costs of the meeting.
The speakers and topics were:
Dr. Eric Cohen, Assistant Professor of Medicine, University of Toronto
Cardiologist and Director of the Cardiac Catheterization Lab Sunnybrook & Women’s College
Health Sciences Centre
“Antiplatelet & Antithrombotic Treatment: The Full Range of Protection”
Dr. Paul Oh, Lecturer, Clinical Pharmacology, University of Toronto
Clinic Director, Cardiovascular Assessment & Risk Evaluation, Sunnybrook Health Science
Centre
“Drug: Drug Interactions – What Doctors Should Know Before Prescribing Meds”
Dr. Peter Liu, Professor of Medicine, University of Toronto
Associate Director, Division of Cardiovascular, University Health Network,
Director, Heart & Stroke/Richard Lewar Centre of Excellence
“How to Diagnose & Manage CHF & LVH”
Dr. Jean-Lucien Rouleau, Professor of Medicine, University of Toronto
Head, Division of Cardiology, University Health Network & Mount Sinai Hospital
“ACE Inhibitors, AT1 Receptor Blockers & Beyond – More Differences than Similarities!”
Human Biology Student Union Career Fair
The Cardiovascular Sciences Collaborative Program was contacted by the Human Biology
Undergraduate Student Association to participate in their Career Fair on November 30, 1999.
Various graduate programs had displays and the Collaborative Program manned a booth and
provided information to interested future graduate students.
Summer Activities
The Collaborative Program ran another very successful summer program. Applicants included
undergraduate and medical school students from the University of Toronto as well as other
universities. The Program provided a number of summer scholarships to help students who were
unable to procure funding. Over the course of the summer, seminars were presented by graduate
students currently enrolled in the Program and covered a range of topics with both clinical and
basic science relevance. As well, the summer students were given the opportunity to present
their summer work. An “end-of-summer” luncheon was held for both faculty and students.
This highly successful program is enjoyed by all who participate.
AWARDS
Medtronic Travel Award
Two competitions were held (spring and fall) for the Medtronic Travel Award. This award,
established in 1995, helps to defray costs of travel for Program students presenting their research
work at recognized scientific meetings. Students supported by this award this academic year
were:
Fall 1999:
Kyle Cowan: Elastase Inhibition Induces a Smooth Muscle Cell Apoptotic Response Mediating
Reversal of Progressive Pulmonary Vascular Disease in Rats. 72nd Scientific Sessions of the
American Heart Association, November 1999 (Supervisor: Dr. Marlene Rabinovitch, LMP)
Shona Torrance: Developmental Changes in Myocardial β-Adrenoceptors. Annual Meeting of
the Canadian Cardiovascular Society, October 1999 (Supervisor: Dr. C. Wittnich, IMS)
Jack Wallen: Gender Differences in the Heart’s Metabolic Potential. Annual Meeting of the
Royal College of Physicians & Surgeons of Canada, September 1999 (Supervisor: Dr. C.
Wittnich, Physiology)
Cathy Boscarino: Hydrogen Ion Buffering Capacity in Normal Adult Hearts: Are There Gender
Differences? Annual Meeting of the Canadian Cardiovascular Society, October 1999
(Supervisor: Dr. C. Wittnich, Physiology)
Spring 2000:
Saeid Babaei: Angiogenic Actions of Lyso-Phosphatidylcholine (LPC) in the Fibrin Matrix
Model of Angiogenesis. Keystone Symposia on “Molecular & Cellular Biology” on
Experimental and Clinical Regulation of Angiogenesis”, March 2000 (Supervisor: Dr. D.
Stewart)
Bigelow Book Prize
The Bigelow Book Prize consists of 2 books written by Dr. W.G. Bigelow entitled “Cold Hearts”
and “Mysterious Heparin”. This prize was established in 1995 by the Cardiovascular Sciences
Collaborative Program to recognize and honor a pioneer clinician and scientist in the field of
cardiovascular sciences. Awardees should exemplify the personal traits of Dr. Bigelow -curiosity, drive, and scientific integrity. The award is given in every year that a qualified student
is identified. Qualifications include sustained academic scientific excellence, innovative
experimental approaches, original discoveries and good scientific productivity. Some weight is
given to work that has recognizable clinical relevance, especially that which promises to improve
patient care.
1995 – Dr. John S. Ikonomidis
1996 – Ms. Shona M. Torrance
1997 – Dr. Vivek Rao
1998 – Dr. Bryce Cowan
1999 – Dr. Gideon Cohen
2000 – Dr. Michael Borger
Ontario Student Opportunity Trust Funds (OSOTF) Award
The OSOTF award refers to a class of awards that have resulted from the Ontario government’s
“matching” program. Under the program every dollar of donation received for student assistance
has been matched by the government as well as the university on a dollar-for-dollar basis. The
Cardiovascular Sciences Collaborative Program participates in this program. There are two
major conditions for all OSOTF awards; recipients must be Ontario residents and demonstrate
financial need. However, the Program has additional eligibility criteria that must be adhered to,
including excellence in science and academic performance. One competition is held per
academic year.
The applications are handled centrally through the Faculty of Medicine’s, Research Office.
Applications pertaining to the CSCP are sent to us and are then adjudicated by a subcommittee;
chaired by Dr. D. Cheng. Committee recommendations are then forwarded to the OSOTF
Awards Committee (Faculty of Medicine) where the final decision is made. Of this years’
eligible submissions, all were deemed meritorious and the awards were allocated equitably to the
winners as follows:
Spring 2000 Competition
Karim Bandali, PhD, Dept. of Physiology
Jack Wallen, PhD, Dept. of Physiology
Cathy Boscarino, MSc, Dept. of Physiology
Life Sciences Committee Summer Undergraduate Research Fellowships
These fellowships are awarded to support research at the University of Toronto to assist
undergraduate students seeking training for graduate level research. Funds were awarded to the
Cardiovascular Sciences Collaborative Program for 8 undergraduate trainees. All candidates put
forward by the Program were awarded funding.
ADVERTISING MATERIAL
World Wide Web
The Cardiovascular Sciences Collaborative Program continues to maintain its own web site
under the Faculty of Medicine. This web site is updated regularly and is continually undergoing
expansion. Please check out our site at www.library.utoronto.ca/www/cardiosci/index.html to
learn more about cardiovascular sciences. The site is updated at faculty renewal and whenever
relevant changes occur. Links continue to be built with other relevant cardiovascular sites.
Collaborating departments are encouraged to provide hypertext links to the Collaborative
Program on their web site.
Other material that continues to give the Program exposure includes the brochure, the Scientific
Day pamphlets and posters, various industry sponsored seminars, and the Lecture Series notices
posted on campus. Collaborating departments also display and distribute the Program brochure.
PROGRAM FACULTY
Faculty are divided into 3 categories (Full, Associate, and Affiliate) depending on their SGS
status.
FULL:
U. Ackermann, L. Adamson, K. Adeli, P. Backx, C.E. Bayliss, D. Bradley, F.
Coceani, J. Coles, P. Connelly, C.R. Ethier, J.S. Floras, C. Forrest, S. Fremes,
J.M. Goodman, A.I. Gotlieb, K.W. Johnston, P.G. Kalman, F. Keeley, B.L.
Langille, H. Lenskyj, G.F. Lewis, R-K. Li, C-C. Liew, P. Liu, P. McLaughlin,
D.A.G. Mickle, L. Mickleborough, M. Ojha, D.H. Osmond, T. Parker, M.J.
Plyley, M. Rabinovitch, J-L Rouleau, M. Sefton, I. Sherman, A.S. Slutsky, M.J.
Sole, G. Steiner, D.E. Stewart, D.J. Stewart, S.G. Thomas, R.D. Weisel, G.
Wilson, C. Wittnich, G. Wright, T-W. Wu, E.L. Yeo
ASSOCIATE: M. Bendeck, D. Brooks, D. Courtman, P. Dorian, L.S. Goodman, M. Husain, J.
Irvine, T. Lindsay, M. Locke, J. Parker, N.A. Shaikh, R. Tsushima, R. Wald
AFFILIATE: J. Butany, D. Cheng, C.M. Feindel, J. Fisher, P. Murphy, R.I. Ogilvie, L.
Schwartz
We would like to wish Dr. J. Edelson all the best in his new position in Philadelphia.
Our thoughts and prayers go out to the family of Dr. Robert Burns who past away in November
1999 at the age of 48 after a lengthy illness.
PROGRAM STUDENTS
Student
Zakaria Ahmed
Akis Amfilochiadis
Nesime Askin
Saeid Babaei
Karim Bandali
Michelle Batthish
Michael Borger
Cathy Boscarino
Andrew Campbell
Gideon Cohen
Warren Foltz
Tommaso Gori
Sloane Hechter
Sonia Katyal
Nataly Kogan
Nathalie Lapointe
Christie Lee
Tony Lee
Negin Liaghati-Nasseri
Sarah McCutcheon
Vaska Micevski
Shona Torrance
Jack Wallen
Supervisor
P. Connelly
D. Osmond
C. Wittnich
D. Stewart
C. Wittnich
G. Wilson
R. Weisel
C. Wittnich
D. Stewart
R.D. Weisel
G. Wright
J. Parker
P. Liu
S. Thomas
D. Osmond
J. Rouleau
P. Liu
D. Stewart
S. Fremes
S. Thomas
D. Stewart
C. Wittnich
C. Wittnich
Degree
PhD
MSc
MSc
PhD
PhD
MSc
PhD
MSc
PhD
PhD
PhD
MSc
MSc
MSc
MSc
PhD
MSc
MSc
MSc
MSc
PhD
PhD
PhD
Department
Pathobiology
Physiology
Physiology
Pathobiology
Physiology
Physiology
IMS
Physiology
IMS
IMS
Medical Biophysics
IMS
IMS
Rehab Med
Physiology
IMS
IMS
IMS
IMS
Rehab Med
IMS
IMS
Physiology
CONVOCATED STUDENTS/FOLLOW-UP
Ian Copland, MSc, Dept. of Physiology (Supervisor, Dr. L. Adamson) has continued with his
graduate studies at the PhD level at the University of Toronto.
Kyle Cowan, PhD, Laboratory Medicine & Pathobiology (Supervisor: Dr. M. Rabinovitch) has
been accepted into medical school at the University of Toronto.
Dimitra Trambakoulos, MSc, Dept. of Physiology (Supervisor: Dr. D. Osmond) has been
accepted into medical school at the University of Ottawa.
Stacy O’Blenes, MSc, Laboratory Medicine & Pathobiology (Supervisor: Dr. M. Rabinovitch)
has returned to residency in Cardiac Surgery at the University of Toronto.
Mohammed Warsi, MSc, Institute of Medical Science (Supervisor: Dr. P. Liu) has been accepted
into medical school at the University of Toronto.
Rohan Shahani, MSc, Institute of Medical Science (Supervisor: Dr. T. Lindsay) has been
accepted into medical school at the University of Toronto.
STUDENT ACHIEVEMENTS
Nesime Askin
Saeid Babaei
Karim Bandali
Michelle Batthish
Michael Borger
Government of Ontario/Heart & Stroke Foundation of Ontario Graduate
Scholarship in Science & Technology.
Doctoral Fellowship, Medical Research Council of Canada
Postgraduate Award: Edward Christie Prize, University of Toronto
MRC/BioContact 99 Competition, 2nd Prize, Quebec
Young Investigator Award, Canadian Cardiovascular Society, Quebec
Best Presentation, 4th Annual Symposium on Advances in Laboratory
Medicine, The Hospital for Sick Children, University of Toronto
National Science and Engineering Research Council (NSERC-PGSB)
Scholarship
Ontario Student Opportunity Trust Fund (OSOTF) Award, Cardiovascular
Sciences Collaborative Program, University of Toronto
Ontario Graduate Scholarship in Science and Technology (OGSST) declined
1st Place, Poster Presentations, 4th Annual Symposium on Advances in
Laboratory Medicine, The Hospital for Sick Children
Ontario Graduate Scholarship: Ministry of Training, Colleges and
Universities
Research Training Competition Studentship: The Hospital for Sick
Children
1st Place, Oral Presentations, Samuel Lunenfeld Summer Student
Symposium, The Hospital for Sick Children
Santalo Scholarship for Graduate Studies: Department of Physiology,
University of Toronto
Edward Christie Stevens Fellowship, University of Toronto
Soobiah Javenthey Award, University of Toronto
CSCI Award for Excellence in Research Research, Medical Research
Council of Canada
Canadian Cardiovascular Society Student Award for Clinical Research
Wilfred G. Bigelow Book Prize, Cardiovascular Sciences Collaborative
Program, University of Toronto
Catherine Boscarino Heart & Stroke/Richard Lewar Centre of Excellence Fellowship,
University of Toronto
Ontario Student Opportunity Funds (OSOTF) Award, Cardiovascular
Sciences Collaborative Program, University of Toronto
Warren Foltz
Heart & Stroke Foundation of Canada Research Traineeship, University of
Toronto
Tommaso Gori
Arrangement Grant between the Universities of Siena and Toronto
Sloane Hechter
University of Toronto Open Entry Scholarship, Institute of Medical
Science, University of Toronto
Golden Key National Honor Society, Faculty of Education, McGill
University
Sonia Katyal
Scholarship Recipient, Canadian Association of Cardiac Rehabilitation
University of Toronto Open Scholarship, Department of Rehabilitation
Science, University of Toronto
Nataly Kogan
Member of the Dean’s Honour List
Tony Lee
Institute of Medical Science Roncari Book Prize, University of Toronto
Institute of Medical Science Merit Scholarship, University of Toronto
CHS-Pfizer-MRC/PMAC Health Program Studentship Award, IMS,
University of Toronto
Shona Torrance
Medtronic Travel Award, Cardiovascular Sciences Collaborative Program
Jack Wallen
Ontario Student Opportunity Trust Funds (OSOTF) Award, University of
Toronto
Medtronic Travel Award, Cardiovascular Sciences Collaborative Program
Medical Research Council/K.M. Hunter Doctoral Research Award
Research Trainee Award, Canadian Society for Clinical Investigation,
Royal College of Physicians and Surgeons of Canada
DIRECTOR’S COMMENTS:
In its’ eighth year, the Cardiovascular Sciences Collaborative Program (CSCP) continues to grow
and evolve. The CSCP also continues to develop new liaisons with other departments and
faculties who express an interest in cardiovascular sciences. We welcome the Department of
Medical Biophysics as our newest participating department.
We also welcome the opportunity to interact with the new Heart & Stroke/Richard Lewar Centre
of Excellence (HSRLCE) which was established at the University of Toronto in 1998. The
purpose of this Centre is primarily to bring cutting edge cardiovascular research together at the
University and to become an international leader. It focuses on the prevention and cure of
atherosclerosis, heart failure and congenital heart disease using cutting edge tools such as
molecular genetics to evolve diagnostic, prognostic and therapeutic innovations. Immediate
benefits to our trainees has been access to new monies in the form of a Fellowship program and
OGSST scholarships. As well, the HSRLCE Distinguished Visiting Professor Seminar Series
has provided Program trainees a wonderful forum to meet and hear international scientists/
clinicians. Thus, combining the CSCP’s role in education and the HSRLCE’s role in research,
our efforts together could provide an outstanding second to none cardiovascular initiative on
campus. This relationship continues to be explored and we anticipate exciting times in the years
ahead.
The following graph represents enrolment figures. It can be seen that during the current academic
year we had 17 Masters and 12 PhD trainees active in the program. Once again, we had a
significant number of our trainees who completed and convocated which was counterbalanced by
new recruits. The ability to recruit the numbers that we convocated and actually increase our
enrolment is a reflection of a number of initiatives (eg. 1st Annual Student Research Day,
increased student representation (1junior/1senior) on the Executive Committee) that focus on
increasing student capture in the CSCP. This has resulted in more student activity promotion and
a higher Program profile with the trainees.
CSCP Student Enrolment:
35
30
25
20
15
10
5
0
MSc
PhD
Total
1992
1993
1994
1995
1996
1997
1998
1999
This past year was the first that we benefited from a fully committed administrative individual
which allowed us to pursue a number of activities that previously were not possible. In the
upcoming year the initiatives already launched will be furthered and their impact on student
enrolment is expected to increase.
This years’ annual student interviews illustrated an unprecedented level of satisfaction with the
program. The increase in events targeted specifically for students has resulted in more effective
student participation and this has further elevated satisfaction with the Program. The postgraduate follow-up illustrates that the graduates of this past year have once again gone on to
pursue either academic or research careers (see Convocated section). As part of the ongoing
tradition, bound copies of each graduating student’s thesis is kept in the Program office. We now
have 16 MSc and 9 PhD theses available for anyone interested in perusing.
The CSCP award programs have again helped support a number of our trainees. The Medtronic
Travel Award monies made it possible for a number of students to attend scientific meetings and
present their work. As well, the OSOTF bursary monies provided much needed financial relief
to a number of deserving students in the Collaborative Program. These funds are available on an
annual basis to help those with demonstrated academic and research excellence that are in
financial need. It is interesting to note that perhaps as a sign of the outstanding quality of
students in the Program, despite well advertised bursaries and funds available for travel, these
funds are not in as high demand as one would expect. This has as a side benefit that students
who apply have a very good chance of success. Corporate sponsors such as Bristol-Myers
Squibb, Merck Frosst Canada & Co., and more recently Solvay Pharma are to be recognised,
once again, for their outstanding annual support of education in the cardiovascular sciences at the
University of Toronto.
The Bigelow Book Prize is awarded in recognition of an outstanding graduate student in the
Program and is the most prestigious student award given. A plaque has been designed to
commemorate this annual event and we will be having an unveiling reception in the near future.
Due to the popularity of the original courses MSC 3060/3061, they have now been redesigned
into 4 half credit courses which were approved by the School of Graduate Studies. Thus, there
are now 4 courses on “Advanced Topics in Cardiovascular Sciences” for our trainees to select.
These are MSC3060 – cellular and molecular mechanisms, MSC3061 – hormones in the
cardiovascular system; MSC3062 – heart function; and MSC3063 – vascular. Ongoing and
frequent review of these courses continues to ensure that leading edge technologies and research
foci are represented. This is considered critical if they are to serve as our flagship courses for our
trainees. Enrolment continues to be strong in these courses and their popularity is reflected in the
strong reviews by the students.
The 3rd Annual Cardiovascular Update was again jointly run with the generous support of
Bristol-Myers Squibb in the form of an educational grant. This half-day event provided a clinical
update and insights to interested trainees, specialists and general practitioners in the
cardiovascular field. As this CME event is offered to general practitioners, the university
required us to charge a registration fee. This was kept to a minimum in order to encourage
attendance and the educational grant allowed this to be so. Details of this meeting are in the
appropriate section of this report.
This past year we welcomed a new corporate sponsor, Solvay Pharma. The Program was pleased
to be a part of a series of workshops focused on systolic hypertension that was offered to both
G.P.’s, specialists and trainees. The “Cardi-Active: Systolic Hypertension Workshop” was held
at the Glenn Abbey Golf Course on May 6th and at Niagara-on-the-Lake on June 13th. These
were very well attended and those present all felt the time well spent. It is hoped that together
with Solvay a Canada-wide CME event may be created to promote the dissemination of current
information on the management of systolic hypertension. A panel of experts in the field from
across the country has been formed and discussions are ongoing.
For the 2000-2001 academic year, we plan to continue our current activities and pursue the
following priorities:
1.
2.
3.
4.
5.
6.
7.
Create a Student Guidebook with course listings to help selection.
Obtain a much more user friendly sub-domain name for the web site.
Development of a student section in the Program web site.
Actively recruit students to the program.
Further develop CME programs in cardiovascular sciences.
Firm up a 5-year plan for the program.
Recruit clinical residents doing 1-2 years of research into a formal graduate program where
appropriate.
8. Continue developing endowments to provide permanent infrastructure support.
PUBLICATIONS – STUDENTS
Belanger MP, Wallen WJ, Wittnich C: Special feeding and care of senescent spontaneously
hypertensive rats (Lead Article). Contemp Topics Lab Animal Sci, 1999;38:7-11.
Borger MA, Fremes SE, Weisel RD, Rao V, Cohen G, Lindsay TF, Naylor CD: Coronary
artery bypass and carotid endarterectomy: Does a combined approach increase risk? A
metaanalysis. Ann Thorac Surg, 1999;68:14-21.
Borger MA, Taylor RL, Weisel RD, Kularni G, Benaroia M, Rao V, Cohen G, Fedorko L,
Feindel CM: Cannulation of the distal aortic arch results in less cerebral microemboli than
cannulation of the ascending aorta: A randomized clinical trial. J Thorac Cardiovasc Surg,
1999;118:740-745.
Borger MA, Wei KS, Weisel RD, Ikonomidis JS, Rao V, Cohen G, et al: Myocardial perfusion
during antegrade and retrograde cardioplegia: A contrast echo study. Ann Thorac Surg,
1999;68:955-961.
Borger MA, Weisel RD: Myocardial Protection. IN: Perioperative Care in Cardiac Anesthesia
and Surgery (Eds, Cheng DCH, David TE). Landes Bioscience, Austin, Texas 1999:106-110.
Cohen G, Borger MA, Weisel RD, Rao V: Intraoperative myocardial protection: Current trends
and future perspectives. Ann Thorac Surg, 1999;68:1995-2001.
Cohen G, Shirai T, Weisel RD, Rao V, Merante F, Tumiati LC, Mohabeer MK, Borger MA, Li
RK, Mickle DA: Optimal myocardial preconditioning in humans. Ann NY Acad Sci,
1999;874:306-319.
Foltz WD, Merchant N, Downar E, Stainsby JA, Wright GA: Coronary venous oximetry using
MRI. Magnetic Resonance in Medicine, 1999;42:837-848.
Lee TC, Zhao YD, Courtman DW, Stewart DJ: Abnormal aortic valve development in mice
lacking endothelial nitric oxide synthase. Circulation, 2000;101:2345-2348.
Najm HK, Wallen WJ, Belanger MP, Williams WG...Wittnich C: Does the degree of cyanosis
affect myocardial adenosine triphosphate levels and ventricular function in children undergoing
congenital heart surgery? J Thorac Cardiovasc Surg, 2000;119:515-524.
Taylor RL, Borger MA, Weisel RD, Fedorko L, Feindel CM: Cerebral microemboli during
cardiopulmonary bypass: Increased emboli during perfusionist interventions. Ann Thorac Surg,
1999;68:89-93.
Torrance SM, Belanger MP, Wallen WJ, Wittnich C: Neonatal pig hearts’ metabolic and
functional response to the development of ischemic contracture – is recovery possible? Pediatric
Res, 2000;48:1-9.
Wittnich C, Wallen WJ, Belanger MP, Ikonomidis JS: Extracellular calcium concentration
affects susceptibility to global ischemic injury in newborn but not adult hearts. J Heart Lung
Trans, 1999;18:675-683.
PUBLICATIONS – FACULTY
Adamson SL, Kingdom J: Antenatal betamethasone and fetoplacental blood flow. The Lancet,
1999;354:255-256.
Afroze T, Husain M: C-Myb binding sites medite G1/S-associated repression of the plasma
membrane Ca2+ ATPase-1 promoter. J Biol Chem, 2000;275:9062-9069.
Akong T, Gotlieb AI: Reduced in vitro repair in endothelial cells harvested from the intercostal
ostia of porcine thoracic aorta. Arterioscl Thromb Vasc Biol, 1999;19:665-671.
Arellano R, Jiang M, O’Brien W, Hossain I, Boylen P, Demajo W, Cheng DCH: Acute graded
hypercapnia increases collateral coronary blood flow in a swine model of chronic coronary artery
obstruction. Crit Care Med, 1999;27:2729-2734.
Azevedo ER, Newton GE, Floras JS, Parker JD: Reducing cardiac filling pressure lowers
norepinephrine spillover in patients with chronic heart failure. Circulation, 2000;101:2053-2059.
Azevedo ER, Newton GE, Parker AB, Floras JS, Parker JD: Sympathetic responses to atrial
natriuretic peptide in patients with congestive heart failure. J Cardiovasc Pharma, 2000;35:129135.
Babensee JE, Sefton MV: Viability of HEMA-MMA microencapsulated model hepatoma cells
in rats and the host response. Tiss Eng, 2000;6:165-182.
Bandali KS, Ackermann U: Are prostaglandins involved in ANP mechanisms of cardiovascular
control? Can J Physiol Pharmacol, 1999;77:211-215.
Bartfay WJ...Sole MP...Liu PP: A biochemical, histochemical and electron microscopic study
on the effects of iron-loading on the hearts of mice. Cardiovasc Pathol, 1999;8(6):305.
Bayliss CE: Edith. Case #1, Structure/Function. UofT Faculty of Medicine, 42 pages, 1999.
Bayliss CE: Mrs. Lively. Case #2, Structure/Function. UofT Fac of Medicine, 50 pages, 1999.
Bayliss CE: Bart Giamatti. Case #3, Structure/Function. UofT Fac of Medicine, 42 pages, 1999.
Bayliss CE: Week 11 Syllabus. Structure/Function, UofT Faculty of Medicine, 107 pages, 1999.
Bayliss CE: Week 12 Syllabus. Structure/Function, UofT Faculty of Medicine, 83 pages, 1999.
Bayliss CE: Week 13 Syllabus. Structure/Function, UofT Faculty of Medicine, 97 pages, 1999.
Bayliss CE: Week 14 Syllabus. Structure/Function, UofT Faculty of Medicine, 45 pages, 1999.
Belanger MP, Wallen WJ, Wittnich C: Special feeding and care of senescent spontaneously
hypertensive rats. Contemporary Topics in Laboratory Animal Science, 1999;38(4):7-11.
Bendeck MP, Irvin C, Reidy M, Smith L, et al: Smooth muscle cell matrix metalloproteinase
production is stimulated via αvβ3 integrin. Arteriosclerosis, Throm Vasc Biol, 2000;20:14671472.
Borger MA, Fremes SE, Weisel RD, Cohen G, Rao V, Lindsay TF, Naylor CD: Coronary
bypass and carotid endarterectomy: does a combined approach increase risk? A meta analysis.
Ann Thorac Surg, 1999;68:14-21.
Borger MA, Taylor R, Weisel RD...Feindel CM: Decreased cerebral emboli during distal aortic
arch cannulation: a randomized clinical trial. J Thorac Cardiovasc Surg, 1999;118:740-745.
Borger MA, Wei KS, Weisel RD, Ikonomidis JS, Rao V, Cohen G, et al: Myocardial perfusion
during warm antegrade and retrograde cardioplegia: a contrast echo study. Ann thorac Surg,
1999;68:955-961.
Bradley TD: Continuous positive airway pressure for the treatment of congestive heart failure.
Can Med Assoc J, 2000;162:535-536.
Bradley TD, Floras JS: Pathophysiological interactions between sleep apnea and congestive heart
failure. IN: Sleep Apnea: Implications in Cardiovascular and Cerebrovascular Disease. (Eds. T.D.
Bradley, J.S. Floras), Marcel Dekker, NY, 2000:385-414.
Brooks D, Lacasse Y, Goldstein RS: Pulmonary rehabilitation programs in Canada: National
survey. Can Respir J, 1999;6:55-63.
Brooks D, Solway BS, Downes L, Graham I, Carter M: A survey of suctioning practices among
physical therapists, respiratory therapists and nurses. Can Respir J, 1999;6:513-520.
Butany J, Gotlieb AI: Native valvular heart disease. IN: Atlas of Cardiovascular Pathology
(Eds. B.M. McManus, E. Braunwald), Current Medicine, 1999;93:157-166.
Campbell AIM, Kuliszewski MA, Stewart DJ: Cell-based gene transfer to the pulmonary
vasculature. Am J Respir Cell Mol Biol, 1999;21:567-575.
Carpentier A, Mittelman SD, Lamarche B, Bergman RN, Giacca A, Lewis GF: Acute
enhancement of insulin secretion by free fatty acids in humans is lost with prolonged FFA
elevation. Am J Physiol, 1999;276:E1055-E1066.
Carpentier A, Mittelman SD, Lamarche B, Bergman RN, Giacca A, Lewis GF: Free fatty acids
induce pancreatic beta cell failure in obese non-diabetic humans but not in those with Type 2
diabetes. Diabetes, 2000;49:399-408.
Case P, Lemieux S, Kennedy SH, Lewis GF: Elevated plasma lipids in patients with binge
eating disorder are found only in those who are anorexic. Int. J. Eating Disorders,
1999;25(2):187-193.
Challis DE, Pfarrer CD, Ritchie JWK, Koren G, Adamson SL: Glucose metabolism is elevated
and vascular resistance and maternofetal transfer is normal in perfused placental cotyledons from
severely growth-restricted human fetuses. Pediatric Res, 2000;47:309-315.
Chen JC, Moriarty JA, Derbyshire JA...Wright GA, et al: Prostate cancer: MR imaging and
thermometry during microwave thermal ablation-initial experience. Radiology, 2000;214:290297.
Cheng DCH, Byrick RJ, Knobel E: Structural models for intermediate care areas. Crit Care
Med, 1999;27:2266-2271. (Accompanied by an editorial – Gerber DR: Structural models for
intermediate care areas: one size does not fit all. Crit Care Med, 1999;27:2321-2323.)
Chin C, Feindel CM, Cheng DCH: Duration of preoperative amiodarone treatment may
associate with postoperative hospital mortality in patients undergoing heart transplantation. J
Cardiothorac Vasc Anesth, 1999;13:562-566.
Cho HC, Tsushima RG, Nguyen TT, Guy HR, Backx PH: Two critical cysteine residues
implicated in disulfide bond formation and proper folding of Kir2.1. Biochemistry,
2000;39:4649-4657.
Cohen G, Borger M, Weisel RD, Rao V: Intraoperative myocardial protection: current trends
and future perspectives. Ann thorac Surg, 1999;68:1995-2001.
Connolly SJ, Gent M, Roberts RS, Dorian P, Roy D, et al: Canadian Implantable Defibrillator
Study (CIDS): A randomized trial of the implantable cardioverter defibrillator against
amiodarone. Circulation, 2000;101(11):1297-1302.
Couch GG, Johnston KW, Ojha M: An in vitro comparison of the hemodynamics of two
inferior vena cava filters. J Vasc Surg, 2000;31:539-549.
Cowan KN, Heilbut A, Lam C, Ito S, Rabinovitch M: Reversal of severe pulmonary
hypertension by a serine elastase inhibitor. Nat Med, 2000;6:698-702.
Cowan KN, Jones PL, Rabinovitch M: Elastase and matrix metalloproteinase inhibitors induce
regression and tenascin-C antisense prevents progressive vascular disease. J Clin Invest,
2000;105:21-34.
Crawford B, Stewart DE, Meana M: Treatment decision making in mature adults: gender
differences. Health Care for Women International, 2000;21:91-104.
Current Opinion in Cardiology, 9:Suppl 1: Heart failure resolved? An interactive debate. Satellite
symposium to the Third International Forum for the Evaluation of Cardiovascular Care, Monte
Carlo, Monaco, 19 Jan 1994. Edited by Michael J. Sole.
Djaiani GN, Cheng DCH, Carroll JA, Yudin M, Karski JM: Fast-track cardiac anesthesia in
patients with sickle cell abnormalities. Anesth Analg, 1999;89:598-603.
Dorian P: Amiodarone and defibrillation threshold: A clinical conundrum. J Cardiovasc
Electrophysiol, 2000;11(7):741-743.
Dorian P, Philippon F: Chapter 3: The management of acute ventricular tachycardia or
fibrillation. Can J Cardiol, 2000;16(Suppl C):16C-19C.
Dupuis J, Schwab AJ, Simard A, Cernacek P, Stewart DJ, Goresky CA: Kinetics of endothelin1 binding in the dog liver microcirculation in vivo. Am J Physiol, 1999;277(Gastrointest Liver
Physiol 40):G905-G914.
Ethier CR, Prakash S, Steinman DA, Leask RL, Couch GG, Ojha M: Steady flow separation
patterns in a 45 degree junction. J Fluid Mechanics, 2000;400:1-38.
Feldman RD, Campbell N, Larochelle P, Bolli P, Burgess ED, Carruthers SG, Floras JS, et al for
the Task Force for the Development of the 1999 Canadian Recommendations for the
Management of Hypertension. 1999 Canadian recommendations for the management of
hypertension. Can Med Assoc J, 1999;161(12 Suppl):S1-S17.
Ferreira IM, Brooks D, Lacasse Y, Goldstein RS: Nutritional support for individuals with
chronic obstructive pulmonary disease: A meta-analysis. Chest, 2000;117:672-678.
Floras JS: Modulation of blood pressure, heart rate, and sympathetic nerve activity in healthy
humans and in heart failure. Therapeutic Research, 2000;21:75-80.
Floras JS: The RESOLVD Investigators: Effects of metoprolol CR in patients with ischemic
and dilated cardiomyopathy. The Randomized Evaluation of Strategies for Left Ventricular
Dysfunction Pilot Study. Circulation, 2000;101:378-384. (Member of Steering Committee)
Foltz WD, Merchant N, Downar E, Stainsby JA, Wright G: Coronary venous oximetry using
MRI. Magnetic Resonance in Med, 1999;42:837-848. (Finalist, W.S. Moore Award, ISMRM)
Gloviczki P, Baker WH, Kalman PG, Han D: The management of primary aortocaval and ilioiliac arteriovenous fistulae. Perspectives in Vasc Surg, 1999;12:133-148.
Goodman L: Chest-mounted left ventricular nuclear monitoring technologies (Science and
Technology Watch). Aviat Space Environ Med, 2000;71(6):659.
Goodman LS, Banks RD, Grissett JD, Saunders PL: Heart rate and blood pressure responses to
+Gz following varied-duration –Gz. Aviat Space Environ Med, 2000;71(2):137-141.
Gordon MJ, Chu KC, Margaritis A, Martin AJ, Ethier CR, Rutt BK: Measurement of GdDTPA diffusion through tissue-substitute PVA hydrogel using MR imaging. Biotechnology and
Bioengineering, 1999;65:476-484.
Gotlieb AI, Benditt EP, Schwartz SM: Blood Vessels. IN: Pathology 3rd Edition (Eds, E. Rubin,
J.L. Farber), J.B. Lippincott, PA, 1999.
Gotlieb AI, Lee TYJ: Endothelial Repair in Atherosclerosis. IN: Current Topics in Pathology.
Tissue Repair and Fibrosis (Eds. A. Desmouliere, B. Tuchweber), 1999;93:157-166.
Hou G, Gronska M, Bendeck MP: Type VIII collagen stimulates smooth muscle cell migration
and MMP synthesis after arterial injury. Am J Pathology, 2000;156:467-476.
Irvine J, Baker B, Smith J....Gent M, Dorian P: Poor adherence to placebo or amiodarone
therapy predicts mortality: results from the CAMIAT study. Canadian Amiodarone Myocardial
Infarction Arrhythmia Trial. Psychosom Med, 1999;61(4):566-575.
Irvine J, Basinski A, Baker B...Gent M, Dorian P: Depression and risk of sudden cardiac death
after acute myocardial infarction: testing for the confounding effects of fatigue. Psychosom Med,
1999;61(6):729-737.
Jeejeebhoy FM, Dorian P, Newman D: Panic disorder and the heart – a cardiology perspective.
J Psychosom Res, 2000;48(5):393-403.
Kalman PG, Johnston KW: Reply letter to editor regarding "The value of late computed
tomographic scanning in identification of vascular abnormalities after abdominal aortic aneurysm
repair". J Vasc Surg, 1999;30:961-962.
Kalman PG, Pope M, Bhola C, Richardson R, Sniderman KW: A practical approach to vascular
access for hemodialysis and predictors of success. J Vasc Surg, 1999;30:727-733.
Kalman PG, Rappaport DC, Merchant N, Clarke K, Johnston KW: The value of late computed
tomographic scanning in identification of vascular abnormalities after abdominal aortic aneurysm
repair. J Vasc Surg, 1999;29:442-450.
Kalman PG: Stent-graft repair of abdominal aortic aneurysms. Can Med Assoc J,
1999;161:1133.
Kalman PG: Thoracofemoral bypass: proximal exposure and tunneling. Seminars in Vascular
Surgery, 2000;13:65-69.
Karski JM, Mathieu M, Cheng DCH, Carroll J, Scott GJ: Etiology of preoperative anemia in
patients undergoing scheduled cardiac surgery. Can J Anesth, 1999;46:979-982.
Keith M, Jeejeebhoy KN, Sole MJ: The role of oxidative stress in congestive heart failure. Heart
Failure, 1999;15:3-4.
Kip KE, Bourassa MG, Jacobs AK, Schwartz L, Feit F, et al: Influence of pre-PTCA strategy
and initial PTCA result in patients with multivessel disease. The BARI Study. Circulation,
1999;100:910-917.
Kirpalani A, Park H, Johnston KW, Butany J, Ojha M: Velocity and shear stress patterns in
the human right coronary artery. J Biomech Engin, 1999;121:370-375.
Krunic N, Adamson SL, Ackerley C, Okita RT, Coceani F: Perinatal changes in choroidal 15hydroxy prostaglandin dehydrogenase:implications for prostaglandin removal from brain. Dev
Brain Res, 2000;121:144-155.
Krunic N, Adamson SL, Coceani F: Differential uptaker and catabolism of prostaglandin (PG)
E2 versus PGF2α in the sheep choroid plexus during development. Dev Brain Res, 2000;119:1119.
Lacasse Y, Brooks D, Goldstein RS: Trends in the epidemiology of chronic obstructive
pulmonary disease in Canada, 1980-1995. Chest, 1999;116:306-313.
Lahooti S, Sefton MV: Effect of an immobilization matrix and capsule membrane permeability
on the viability of encapsulated HEK cells. Biomaterials, 2000,21:987-995.
Lahooti S, Sefton MV: Microencapsulation of normal and transfected L292 fibroblasts in a
HEMA-MMA cololymer. Tiss Eng, 2000;6:139-149.
Lamarche B, Carpentier A, Uffelman KD, Steiner G, Barrett PHR, Lewis GF: Triglyceride
enrichment of HDL enhances the in vivo metabolic clearance of HDL-associated apolipoprotein
A-1 in healthy humans. J. Clin. Invest, 1999;103:1191-1199.
Lamarche B, Shirya R, Lewis GF: HDL metabolism in hypertriglyceridemic states. An
overview. Clin Chim Acta, 1999;286:145-161.
Lane D, Motolko M, Yan DB, Ethier CR: A comparison of the effects of sodium hyaluronate
and chondroitin-sulfate sodium hyaluronate on outflow facility in human cadaver eyes. J Cat
Refract Surg, 2000;26:277-281.
Langleben D, Barst RJ, Badesch D...Stewart DJ, Long W: Continuous infusion of epoprostenol
improves the net balance between pulmonary edothelin-1 clearance and release in primary
pulmonary hypertension. Circulation, 1999;99:3266-3271.
Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam K, Liu Y, Osmond DH, et al:
Characterization of apelin, the ligand for the APJ receptor. J Neurochem, 2000;74:34-41.
Lee SD, Dorian P, Geist M, Davies E, et al: Validation of a non-invasive measure of local
myocardial repolarization in a conscious human model: the adaptation of repolarization to
changes in rate. J Cardiovasc Electrophysiol, 1999;10(9):1171-1179.
Lee TC, Zhao YD, Courtman DW, Stewart DJ: Abnormal aortic valve development in mice
lacking endothelial nitric oxide synthase. Circulation, 2000;101:2345-2348.
Lee TYJ, Gotlieb AI: Early stages of endothelial wound repair: Conversion of quiescent to
migrate endothelial cells involves tyrosine phosphorylation and actin microfilament
reorganization. Cell and Tissue Res, 1999;297:435-450.
Lemieux S, Lewis GF, Ben-Chetrit A, Steiner G, Greenblatt EM: Correction of
hyperandrogenemia by laparoscopic ovarian cautery in women with polycystic ovarian syndrome
is not accompanied by improved insulin sensitivity or lipid-lipoprotein levels. J Clin Endocrinol
Metab, 1999;84:4278-4282.
Lemieux S, Patterson B, Carpentier A, Klein S, Lewis GF, Steiner G: A novel stable isotope
method using a [2H5]-glycerol bolus to measure VLDL-TG kinetics in humans. J Lipid Res,
1999;40:2111-2117.
Lent B, Phillips S, Richardson B, Stewart DE: Promoting parental leave for physicians. Can
Med Assoc J, 2000;162:1575-1576.
Leung RS, Bradley TD: Long-term treatment of refractory congestive heart failure by continuous
positive airway pressure. Can J Cardiol, 1999;15:1009-1012.
Lewis GF, Carpentier A, Bilinski D, Giacca A, Vranic M: Counterregulatory response to
insulin-induced hypoglycemia differs according to the insulin delivery route. J Clin Endocrinol
Metab, 1999;84:1037-1046.
Lewis GF, Carpentier A, Vranic M, Giacca A: Resistance to insulin's acute direct hepatic effect
in suppressing steady state glucose production in individuals with Type 2 diabetes mellitus.
Diabetes, 1999;48:570-576.
Lewis GF (Expert committee Member): Canadian Diabetes Association, “Guidelines for the
Nutritional Management of Diabetes Mellitus in the New Millennium”. Can J Diabetes Care,
1999;23(3):56-69.
Lewis GF: Lipid metabolism, bimonthly update. Curr Opinion in Lipidol, 1999;9:171-173
(Editorial/review), 1999;10:475-477.
Li KCP, Dalman RL, Wright GA: In vivo flow independent T2 measurements of superior
mesenteric vein blood in diagnosis of chronic mesenteric ischemia: A preliminary evaluation.
Acad Radiology, 1999;6:530-534. (Stauffer Award for Best Clinical Paper, 1999)
Li RA, Tsushima RG, Himmeldirk K, Dime DS, Backx PH: Local anesthetic anchoring to
cardiac sodium channels: Implications into tissue-selective drug targeting. Circ Res, 1999;85:8898.
Li R-K, Jia Z-Q, Weisel RD, Mickle DAG, Choi A, Yau TM: Survival and function of
bioengineered cardiac grafts. Circulation, 1999;100(Suppl II):63-69.
Li R-K, Weisel RD, Mickle DAG, Jia ZQ, Kim EJ, Sakai T, Tomita S, Schwartz L, Iwanochko
M, Husain M, Cusimano RJ, Burns RJ, Yau TM: Autologous porcine heart cell transplantation
improved heart function after a myocardial infarction. J Thorac Cardiovasc Surg, 2000;119:6268.
Li R-K, Yau TM, Weisel RD, Mickle DAG, et al: Construction of a bioengineered graft. J
Thorac Cardiovasc Surg, 2000;119:368-375.
Liu P, Mak S, Stewart DJ: Potential role of the microvasculature in the progression of heart
failure. Am J Cardiol, 1999;19(84-4A):23L-26L.
Liu P, Sole MJ: What is the relevance of apoptosis to the cardiac myocardium? Can J Cardiol,
1999;15(supppl. B):8B-10B.
Locke M: Heat shock factor activation and Hsp72 accumulation in aged skeletal muscle. Cell
Stress and Chaperones, 2000;5:45-51.
Lorenzi-Filho G, Dajani HR, Leung RST, Floras JS, Bradley TD: Entrainment of blood
pressure and heart rate oscillations by periodic breathing. Am J Respir Crit Care Med,
1999;159:1147-1154.
Lorenzi-Filho G, Rankin F, Bies I, Bradley TD: Effects of inhaled CO2 and O2 on CheyneStokes respiration in patients with heart failure. Am J Respir Crit Care Med, 1999;159:14901498.
Mason CAE, Chang P, Fallery C, Rabinovitch M: Nitric oxide mediates LC-3 dependent
regulation of fibronectin synthesis in ductus arteriosus smooth muscle cells. FASEB J,
1999;13:1423-1434.
Mason TM, Goh T, Tchipashvili V, Sandhu H, Gupta N, Lewis GF, Giacca A: A prolonged
elevation of plasma free fatty acids desensitises the insulin secretory response to glucose in vivo
in rats. Diabetes, 1999;48:524-530.
McKelvie RS, Yusuf S, Pericak D, Avezum A, Burns RJ...Rouleau J, et al: Comparison of
candesartan, enalapril, and their combination in congestive heart failure. Randomized Evaluation
of Strategies for Left Ventricular Dysfunction (RESOLVD) Pilot Study. Circulation,
1999;100:1056-1064. (Floras JS – Member of Steering Committee)
Meana M, Stewart DE, Lickrish GM, Murphy J, Rosen N: Patient preference for the
management of mildly abnormal PAP smears. J Women’s Health Gender Based Med,
1999;8:941-947.
Mehta S, Liu PP, Fitzgerald FS, Allidina Y, Bradley TD: Effects of continuous positive airway
pressure on cardiac volumes in patients with ischemic and dilated cardiomyopathy. Am J Respir
Crit Care Med, 2000;161:128-134.
Melo LG, Pang SC, Ackermann U: Atrial natriuretic peptide: Regulator of chronic blood
pressure and fluid-electrolyte balance. NIPS, 2000;15:143-149.
Melo LG, Steinhelper ME, Pang SC, Tse Y, Ackermann U: ANP in regulation of arterial
pressure and fluid-electrolyte balance: Lessons from genetic mouse models. Am J Physiol
Physiol Genomics, 2000;278:45-58.
Melo LG, Veress AT, Ackermann U, Pang SC, Flynn TG, Sonnenberg H: Chronic hypertension
in ANP knockout mice: Contribution of peripheral resistance. Reg Peptides, 1999;79:109-115.
Melo LG, Veress AT, Ackermann U, Steinhelper M, Pang SC, Tse Y, Sonnenberg H: Chronic
regulation of arterial blood pressure in ANP transgenic and knockout mice: Role of
cardiovascular sympathetic tone. Cardiovasc Res, 1999;43:437-444.
Melo LG, Veress AT, Chong CK, Ackermann U, Sonnenberg H: Salt-sensitive hypertension in
ANP knockout mice is prevented by AT?1 receptor antagonist Losartan. Am J Physiol,
1999;277:R624-R630.
Meneilly GS, Battistini B, Floras JS: Lack of effect of sodium nitroprusside on insulinmediated blood flow and glucose disposal in the elderly. Metabolism, 2000;49:373-378.
Mitani Y, Zaidi SHE, Dufourcq P, Thompson K, Rabinovitch M: Nitric oxide reduces vascular
smooth muscle cell elastase activity through cGMP-mediated suppression of ERK
phosphorylation and AML1B nuclear partitioning. FASEB J, 2000;14:805-814.
Moore JA, Yin K, Karlik S, Rutt BK, Steinman DA, Ethier CR: Computational blood flow
modeling based on in vivo measurements. Ann Biomed Engineering, 1999;27:627-640.
Najm JH, Wallen J, Belanger MP, Coles JG...Wittnich C: Does the degree of cyanosis affect
myocardial adenosine triphosphate levels and function in children undergoing surgical
procedures for congenital heart disease? J Thorac Cardiovasc Surg, 2000;119:515-524.
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ACKNOWLEDGEMENTS:
The Cardiovascular Sciences Collaborative Program would like to thank the following industry
sponsors for their generous support.
Bristol-Myers Squibb
Medtronic Canada
Merck Frosst Canada & Co.
Solvay Pharma