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What is Nicotine? ⢠Nicotine is a toxic colorless or yellowish oily liquid that is the chief active constituent of tobacco. ⢠It acts as a stimulant in small doses, but in larger amounts blocks the action of autonomic nerve and skeletal muscle cells. ⢠Also, it is a chemical compound that is present in tobacco. When tobacco is smoked, nicotine is absorbed through the wall lining of the small air sacs in the lungs. When sniffed or chewed, it is absorbed.