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NASHUA COMMUNITY COLLEGE COURSE OUTLINE FORM Course Title: General Biology I Credit Hours: 4 Course Prefix & Lecture Hours: 3 Lab Hours: 3 No.:SCIN103 Department: Science, Engineering Technology and Mathematic Program: Life Science and Chemistry Prerequisites/ Co-requisites: Successful completion (C or higher) of college preparatory Biology and Chemistry within the past five years Required Accuplacer Score: Reading 80 or above; Sentence Skills 70 or above; Mathematics 85 or higher Entrance Skills: “ Excellent reading skills are mandatory for this course. Strong math abilities are also desirable. Creative problem-solving, ability to work in teams and a strong background in college-preparatory math and science will increase success. Catalog Description: Biology I for majors is designed for students pursuing a career in the sciences or advanced health sciences. It is an in-depth exploration of biochemistry, cell structure and function, genetics, and evolution. Labs will provide opportunities to explore topics using hands-on methodologies and critical thinking in a project-based learning environment. Course Competencies Competency (Knowledge and Skills) Critical Thinking Skills Students will be able to: Themes in the study of life Identify the common themes that unify all living things Recognize that evolution accounts for unity and diversity in life Describe biological inquiry as a process of formulating and testing hypotheses based on observations Explain the scientific method Differentiate between theories and hypotheses Analyze, criticize, examine, experiment, question, compose, design, formulate, write, conclude, explain, predict, summarize Chemical context of life and role of water Describe the concepts of matter and energy and the major forms of energy Demonstrate and understanding of the atoms and its structure Compare and contrast molecular bonds Recognize that chemical reactions make and break chemical bonds Describe the mechanisms by which water’s intramolecular and intermolecular bonds contribute to water’s properties Carbon and Macromolecules Describe and compare the building blocks, general structures, and biological functions of carbohydrates, lipids, proteins, and nucleic acids Identify the role of dehydration synthesis and hydrolysis in the formation and break down of organic molecules Cell Structure and Function Describe how microscopes are used in the study of living organisms Describe the chemical composition of the plasma membrane and relate it to membrane functions Analyze, compare, contrast, diagram, explain, relate, write, justify Breakdown, distinguish, relate, explain, choose, describe, evaluate. Identify, illustrate, calculate, collect, design, devise, explain, generate, plan, support, interpret, predict. Describe and explain the form and function of organelles found within various types of cells across the three domains of life Name the key components of the endomembrane system and describe its role in regulating protein traffic and metabolism in the cell. Recognize that both the cytoskeleton and extracellular components support the cell’s physical structure, communication, and functions Membrane structure and function Illustrate, model, diagram, explain, compare, Describe the molecular basis of the fluid contrast, describe mosaic model Compare and contrast the mechanisms of active, passive, and bulk transport Describe the role of the plasma membrane in cell signaling Metabolism Explain the role of ATP in cellular metabolism Explain enzyme activity, its effect on activation energy, and metabolic controls Explain how metabolic processes transform energy and matter Evaluate the spontaneity of a reaction based on its free energy changes Respiration and Fermentation Describe how catabolic pathways yield energy by oxidizing organic fuels Describe the 3 stages of cellular respiration in the complete oxidation of glucose Describe the interconnected nature of the reactants and products formed within the complete oxidation of glucose Identify the conditions under which cells utilize aerobic and anaerobic respiration and fermentation to produce ATP Describe how glycolysis and the citric Diagram, examine, question, point out, explain, conclude, estimate, plan, predict, summarize, synthesize, support Explain, plan, predict, analyze, conclude, generate, relate, support, justify acid cycle connect to many other pathways Photosynthesis Recognize that photosynthesis converts chemical energy to food Compare and contrast the light reactions and the Calvin cycle with a detailed understanding of the net projects of each set of reactions The Cell Cycle Explain how normal cell division results in genetically identical cells Explain the cellular changes that occur through each phase of the cell cycle Explain how regulation is employed throughout the cell cycle Meiosis and sexual life cycles Explain how genetic information is passed from parent to offspring Explain the cellular changes that occur through each phase of meiotic cell division Recognize that fertilization and meiosis alternate throughout the sexual reproduction Differentiate between diploid and haploid life cycles Describe how genetic variation is produced during sexual reproduction Mendelian genetics and the chromosomal basis of inheritence Describe how Mendel used scientific inquiry to identify the two laws of inheritance Describe Mendel’s law of segregation and law of independent assortment Predict the outcome of monohybrid and dihybrid crosses Recognize the complexity of inheritance patterns in living organisms as compared to theoretical inheritance patterns Relate patterns of Mendelian genetics to Explain, analyze, plan, predict, generate, analyze, conclude, defend, describe, create Model, explain, conclude, diagram, relate Diagram, arrange, assemble, predict, diagram, differentiate, compare, contrast, model, question, conclude, analyze Analyze, explain, model, diagram, summarize, tell, write, predict the physical patterns of chromosomes Explain how sex-linked genes and linked genes affect patterns of inheritance Explain the chromosomal basis of genetic disorders Molecular basis of inheritence State that DNA is the genetic material Describe the proteins associated with DNA replication and repair Describe chromosomal structure on a molecular level Protein synthesis Describe the process of protein manufacturing from gene to polypeptide, including the steps of transcription, mRNA modification, and translation Evaluate the effects of chromosomal mutation upon gene expression Discuss the universality of the gene as the basis for life Regulation of gene expression Describe how bacteria alter their gene expression with respect to environmental changes Explain how eukaryotic gene expression is regulated and results in different cell types in a multicellular organism Explain the chromosomal basis of cancer Viruses Describe the physical structure of virus, prions, and viroids Describe the process of viral replication and the life cycle of a virus Biotechnology Outline the steps involved in DNA cloning Differentiate between various techniques used in biotechnology Evaluate potential applications of current biotechnology methods Defend the use of cloning in treating Model, diagram, explain, analyze, support, tell, write Explain, analyze, conclude, predict, identify, question, relate Plan, predict, evaluate, conclude, analyze, diagram, explain, support, write Model, diagram, explain Explain, plan, predict, analyze, conclude, interpret, support, set up, tell, synthesize, summarize environmental and human ailments Genomes and evolution Explain how scientists use bioinformatics to analyze and sequence genomes Discuss the variations seen in genomes, including size, number of genes, and gene density Recall that multicellular eukaryotes contain significant amounts of noncoding DNA Explain how the genomic sequence is the molecular basis for evolution and that duplication, rearrangement, and mutation are mechanisms for change Darwinian evolution Explain the historical context within which Darwin developed the theory of evolution Outline the process of natural selection by which populations evolve Express that the theory of evolution is supported by multiple, verifiable scientific studies and explorations Synthesize, analyze, explain, compare, contrast, defend, develop, criticize Population evolution Explain why genetic variation makes evolution possible Employ the Hardy-Weinberg equation to evaluate evolution in a population Relate changes in allele frequencies in a population to natural selection, genetic drift, and gene flow Relate natural selection as the only mechanism responsible for adaptive evolution The origin of the species Explain that the biological species concept emphasizes reproductive isolation. Relate how speciation can take place with or without geographic speciation Calculate, predict, analyze, summarize, explain, synthesize, evaluate, estimate Synthesize, criticize, justify, judge, predict, explain, support Compare, contrast, evaluate, explain, appraise, model, outline, relate Describe the role of hybrid zones in causing reproductive isolation Explain how speciation can occur at different rates form changes in genes. The history of life on earth Describe the conditions on Earth that made the origin of life possible. Relate how the fossil record documents that history of life. Discuss key events in life’s history, such as the origins of single-celled and multicelled organisms. Explain how the rise and fall of groups of organisms reflect differences in speciation and extinction rates. Describe how major changes in body form can result from genetic changes. State that evolution is not goal-oriented, and explain. Relate, explain, analyze, construct, defend, judge, criticize, support, tell, write Course Outline: Content Topic Subtopics ( a., b., etc.) Themes in the Study of Life a. Scientific inquiry b. Unifying nature of the themes of biology c. Evolution as the core unifying theme The Chemistry of Life a. The Chemical Context of Life b. Water and Life c. Carbon and the Molecular Diversity of Life d. The Structure and Function of Large Biological Molecules The Cell Genetics Mechanisms of Evolution a. b. c. d. e. f. g. a. b. c. d. e. f. g. h. i. a. b. c. d. A Tour of the Cell Membrane Structure and Function Metabolism Cellular Respiration and Fermentation Photosynthesis Cell Communication The Cell Cycle Meiosis and Sexual Life Cycles Mendelian Genetics The Chromosomal Basis of Inheritence The Molecular Basis of Inheritence From Gene to Protein Regulation of Gene Expression Viruses Biotechnology Genomes and Their Evolution Descent with Modification The Evolution of Populations The Origin of Species The History of Life on Earth Performance Evaluation Formative Assessments Summative Assessments -Chapter Quizzes (in class) -Mastering Biology activities (web-based) -Lab activities (data collection, experimental design, answering questions) -Individual presentation of current research -Entrance and Exit Exam (standardized, based on national standards) -3 Unit Exams, consisting of both objective and subjective items, as well as a comprehensive final exam -A number of required laboratory reports to be written throughout the semester Method of Instruction: Lectures, class discussions and debates, weekly laboratory activities, library research, field trips, guest speakers, regular assessments.