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BLOOD, LYMPHATIC, AND CARDIOVASCULAR SYSTEMS Slide #1 BLOOD, CARDIOVASCULAR & LYMPHATIC SYSTEMS Circulatory Systems of the body, circulating blood and lymph—transporting substances for homeostasis of the body Slide #2: What are three functions of blood? Transport, Regulation—body temp, body fluids, pH, Fight infection and protect from disease Slide #3: What is hemopoesis and where does it happen? Production of blood and it occurs in the red bone marrow Slide #4: What are the components of blood? 1—plasma, 2—red blood cells, 3— white blood cells and platelets Slide #5: What is the function of erythrocytes? Carry O2 Slide #6: Describe the erythrocyte structure. Concave, disc-like and carries O2 What makes it different than most cells? it has no nucleus What is hemoglobin? Iron and protein molecules that are on red blood cells— they carry oxygen Slide #7: What is a leukocyte? White blood cells that fight infections What are the five types of leukocytes and what are their functions? Neutrophils— phagocytes that eat pathogens (germs) Eosinophils—phagocytic removal of allergens, basophils—secrete histamines as a result of allergy response promote inflammation, lymphocytes—antibodies, monocytes—large phagocytes Slide #8: What is a thrombocyte and what is it’s function? Platelet, blood clotting or hemostasis Slide #9: Of a thrombus and embolus, which is the traveling one and which is stationary? Thrombus is stationary, embolus is traveling clot Slide #10: What is hemostasis? Blood clotting or stopping bleeding Slide #11: Match these with their definitions. Platelet plug-- Platelets change shape to stick together vascular spasm-- Smooth muscle pulls wound together coagulation. Changing fibrinogen to fibrin Slide #12: What is the difference between intrinsic and extrinsic factors? Intrinsic are reactions that take place in the blood—extrinsic are reactions that take place in the tissue during hemostasis Slide #13: What are ABO antigens and how are they different from antibodies? They are particles that determine blood types and are located on Red Blood Cells. Antibodies are found in the plasma and are formed in response to the antigens present in blood that determine blood type. Slide #14: What are the possible genotypes of Type A blood? Type O? A=A + O and A + A, O blood= O + O Slide #15: Which blood type is the universal donor? Type O Slide #16: What is polycythemia? Excessive erythrocytes RBCs Slide #17: What is hemophilia? Sex-linked genetic disorder where there are missing clotting factors. Slide #18: What is hemolytic disease of the newborn? Mother has Rh- blood. If she has a first pregnancy with baby who is Rh+ she will develop antibodies towards her baby. Second baby that is Rh+ mother may attack baby. Slide #12: What is leukemia? Cancer of the white blood cells CARDIOVASCULAR SYSTEM REVIEW Slide #20: CARDIOVASCULAR SYSTEM—Pertaining to the heart and blood vessels Slide #21: What is the primary function of the cardiovascular system? Circulation and transportation of substances. Slide #22: What is the order of the three layers of the heart and which one is the heart muscle? Epicardium, myocardium (heart muscle), endocaridium Slide #23: Which are the receiving chambers of the heart? Atria Which are the pumping chambers? Ventricles Slide #24: What are the great vessels of the heart? superior and inferior vena cava, pulmonary trunk, aorta Slide #25: Name the valves of the heart. 1. Tricuspid AV valve 2. Bicuspid AV valve 3. pulmonary semilunar valve 4. aortic semilunar valve Slide #26: Draw arrows and then write out how blood flows through the heart—superior and inferior vena cava, coronary sinus, right atrium, tricuspid valve, right ventricle, pulmonary semilunar valve, pulmonary trunk, right and left pulmonary arteries, lungs, right and left pulmonary veins, left atrium, bicuspid (mitral) valve, left ventrile, aortic semilunar valve, aorta, coronary arteries, brachiocephalic, left common ceratoid, left subclavian, descending aorta Slide #27: What makes the heart sounds heard with a stethoscope? Closing of the heart valves—lub—AV valves closing, Dub-SL valves closing Slide #28: What are the principle parts of the conduction system of the heart— SA node, AV node, Buncle of HIS, right and left bundle branches, Purkinje fibers Slide #29: Which of these is systole-- When the heart is contracting. and which is diastole-- When the heart is at rest.? Slide #30: What do these abbreviations mean? HR is heart rate X is multiplied by SV stroke volume = CO cardiac output Slide #30: What determines cardiac output? How many heartbeats per minute which is the heart rate multiplied by the volume of blood with each heart pump and equals the cardiac output Slide #32: What is the difference between the pulmonary and systemic circulation Pulmonary goes from the heart to the lungs and systemic goes from the heart to the body Slide #33: What is blood pressure and how do you measure it? When the heart contracts it exerts force on the arterial wall—systole, when the heart is at rest, force exerted on the walls—dyastole, measured with a blood pressure cuff What is the most accurate way to measure blood pressure? Using a recently calibrated blood pressure cuff and listening to the sounds with a stethoscope What does 120/80 mean? Average adult blood pressure What is the name of the cuff used to measure blood pressure? sphygmomanometer Slide #34: What is pulse and where can you feel it? Force exerted on arterial walls with each heart beat—you can feel the pulse where arteries are close to surface and bone. Carotid, radial, brachial, pedal, temporal Slide #35: What are 3 major similarities and differences between arteries, veins, and capillaries? Similarities: veins and arteries have three layers, all carry blood and transport substances, veins and arteries have a lumen differences: arteries carry blood away from heart, veins carry it toward, arteries carry oxygenated blood except pulmonary, veins carry deoxygenated blood except pulmonary, veins have valves, capillaries have one layer, area of exchange Slide #36: What is an aneurysm? Weak area of artery that balloons out Slide #37: What is angina pectoris? Heart pain (pain in the chest) Slide #38: What is an arrythmia? Irregular heartbeat Slide #39: What is atherosclerosis? Hardening of the arteries Slide #40: What is CAD coronary artery disease and CVA—cerebral vascular accident (stroke) Slide #41: What is a myocardial infarction? Heart attack—a portion of the heart dies due to a blocked coronary artery and causes the heart to stop LYMPHATIC SYSTEM Slide #42: LYMPAHTIC SYSTEM—Returns fluid to blood and helps fight infection (immune system) Slide 43: What and where are the tonsils—lymphoid tissue--pharyngeal tonsiladenoids are in the nasal cavity, palatine are at the back of the throat and lingual are down the throat a little ways, spleen—largest lymphoid organ that filters out germs, recycles blood cells parts and is located in left upper quadrant inferior to the left lung, thymus—T cell maturation takes place here and located posterior to the sternum, lymph nodes—small lymphoid organs located in clusters by lymphatic vessels, bone marrow in spongy bone where white blood cells are made and lymph vessels which transport lymph and are closely associated with the cardiovascular system Slide #44: What are two functions of the spleen? Filter blood and fight infection, blood reservoir, recycles red blood cell parts Slide #45: Why does the thymus get smaller as we age? Our T-cells learn how to fight infections we are exposed to and over time we have been exposed to a lot of antigens, therefore, we don’t need the Thymus as much as we did when we were younger and not exposed to much Slide#46: What is M.A.L.T? Mucosa Associated lymphoid tissue Slide #47: Whatare two things that help lymph travel through the body?-- Pressure gradients caused by breathing. Skeletal muscle contractions, One way valves. Slide #48: What is the difference between an antigen and an antibody? Antigens are foreign particles that enter the body, Antibodies are proteins (B cells) that target antigens for destruction Slide #49: Match these cells with their function, helper T-cell-- These are the generals of the immune repsponse., cytoxic T cell-- These poison antigens., suppressor T cell-- These stop the immune response, memory T-cell-- These remember the antigen in case there is a future attack. Slide #50: Describe the difference between the two types of B cells. Plasma cells, sometimes referred to as B-plasma cells, make and secrete large numbers of antibodies that target antigens and help with eliminating them, Memory Bcells help in the response to a second exposure to the same antigens Slide #51: What is the definition of an autoimmune disease? Where the body attacks itself—the immune system does damage to healthy cells in the body Slide #52 What are mumps and why do we not see this anymore? Viral infection that attacks the paratoid salivary gland and causes it to swell—can cause infertility in males—vaccination available now Slide #53: What is polio? A viral disease that attacks the white matter in the spinal cord—caused by a virus—there is a vaccination for it now Slide #54 What are allergies? Body has an immune response to substances that are not harmful to the body such as pollen or certain foods