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Quiz 2 MCB 4211
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___________________________________________
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1. Identify the TRUE statement about the Major Histocompatibility Complex of
genes
a. Neutrophils recognize antigen in much the same way as T cells and B cells.
b. The MHC gene complex includes both MHC class I, class II and class III
molecules.
c. The MHC gene complex encodes all of the minor histocompatibility antigens
that together cause rapid rejection of transplanted tissue.
d. The MHC genes are not members of the immunoglobulin supergene family.
e. All of the above are true.
2. Rearrangement of the TcR alpha and beta genes occurs
a. Using the same enzymatic processes that are employed by Heavy chain
and Light chain genes
b. Using the same sequences of DNA that produce antibody, just rearranged
differently
c. Using the same J chain elements
d. All of the above are true
e. None of the above are true
3. Which of the following is true regarding the gut-associated lymphoid tissue
(GALT) as described in Dr. Debbie Laukens’ guest lecture?
a. The GALT is composed of primary lymphoid tissue.
b. The GALT is required for defense to pathogens and the induction of oral
tolerance.
c. The small intestine and colon are sterile and do not contain commensal
microbes.
d. All of the above are true
e. Only A and B are correct
4. Signal transduction cascades are responsible for converting ligand-receptor
binding events into biochemical signals that
a. Ultimately result in cell apoptosis.
b. Produce proliferative responses.
c. Activate differentiation events.
d. Alter the transcription profile of the cell.
e. All of the above are true
5. An example of a biochemical event that is associated with signaling events is
a. The binding of activated enzymes to immunoreceptor tyrosine-based
activation motifs.
b. The release of calcium stores from the endoplasmic reticulum and the
downstream activation of other enzymatic processes.
c. The enzymatic digestion of inositol phosphate PIP3 to produce DAG and
IP3
d. The activation of calcineurin and the conversion of inactive NF-AT to
active transcription factor.
e. All of the above are true.
Quiz 2 MCB 4211
Name
___________________________________________
Student ID number _______________________________
6. T cell killing requires that the cytosolic granules do something. What is it?
a. They must burst in the cytosol of the T cell to release their contents.
b. They much produce complement.
c. They must produce a calcium burst as part of the killing mechanism.
d. They must divide to produce more granules.
e. They must fuse with the plasma membrane to release perforin and
serine proteases.
7. The endogenous pathway of antigen presentation is essential to
a. Anti-viral responses.
b. Antibody production.
c. Th1 activation.
d. Complement activation.
e. All of the above depend on the endogenous pathway.
8. The reason for the difference in MHC class I and MHC class II antigen
presentation is that
a. The binding events of MHC presentation are determined by
cytokine/receptor interactions.
b. The stage at which these membrane proteins encounter antigen in
their path to the exterior surface of the plasma membrane is
different.
c. The two classes of MHC belong to different supergene families.
d. The antigens bound by classical class I and class II molecules are different
in their fundamental biochemistry.
e. None of the above are true.
9. The MHC is one of the most polymorphic genetic regions known in mammals.
This is partly due to the multiple MHC class I genes that are found in that region.
How might you destabilize the MHC and produce a mouse that cannot make MHC
class I on its plasma membranes?
a. Activate several complement genes simultaneously.
b. Knock out the J chain gene.
c. Disrupt the beta-2 microglobulin gene.
d. Kill all antigen presenting cells.
e. All of the above experimental approaches will succeed.
10. What is one result of Fas/FasL ligand/receptor interactions?
a. Complement activation.
b. MAMP expression.
c. Apoptosis.
d. Granule exocytosis.
e. None of the above result from Fas/FasL interactions.