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PHC 471: MEDICINAL CHEMISTRY IV (2 + 1) Prereq.: PHC 371 Course Description The study of the structures, nomenclatures, synthesis, interaction of drugs with the receptor sites, structure-activity relationship, metabolism of the different chemical classes of the following medicinal agents. No. of Lectures A. Chemotherapy i. Introduction to chemotherapy Theory of selective toxicity Synthetic antimalarials Sulfonamides Antimycobacterium agents Antiamoebic agents Anthelmintic agents Antiviral and antifungal agents Cancer chemoterapy (Antineoplastic agents): a) Introduction b) Antimetabolites b) Alkylating agents d) Miscellaneous antineoplastic agents ii. iii. iv. v. vi. vii. viii. 1 3 3 1 2 2 1 1 2 2 1 B. Diagnostic agents 3 C. Hypoglycemic agents 2 D. Thyroid and antithyroid agents 2 E. Two Examinations. 2 _________ Total 28 ======== PHC 471: PRACTICAL The course is designed to expose the student to the verification of the chemical purity of the drug products using the pharmacopoeial monographs as well as various spectrometric methods. Lab. No. 1 1. 2. 3. a) Aminophylline Tablet Identification Assay for theophylline (U.V. Assay). Assay for ethylenediamine (Acid-base titration). 1. 2. 3. a) Aspirin Tablets (Acetylsalicylic acid tablet) Identification. Limit test for salicylic acid. Assay according to British Pharmacopeia. b) 1. Ascorbic Acid (Vit. C) Tablet Assay (Redox titration). 1. 2. a) Chloramphenicol Capsules Identification. Assay (U.V. Assay). b) 1. 2. Phenylephrine Eye Drops Identification. Assay (by U.V.). 1. 2. a) Methyl Dopa (Aldomet) Tablet: Identification. Assay (visible or colorimetric assay). b) 1. 2. Calcium Lactate Tablet Identification. Assay (complexometric titration). a) 1. 2. Indomethacin Suppositories Identification. Assay (U.V.). b) 1. 2. Frusemide Injection Identification. Assay (U.V.). 2 3 4 5&6 7 Practical Examination No. 1. 8 a) 1. 2. Lab. No. Tolbutamide Tablet Identification. Assay (Acid-base titration). b) 9 Paracetamol Tablet 1. Identification. 2. Assay (U.V. assay). a) 1. 2. b) 10 Grisofulvin Tablet 1. Identification. 2. Assay (U.V. assay). a) 1. 2. 3. 4. b) 11 12 Dextrose Intravenous Infusion Identification. Assay (polarimetry). Chloroquine Phosphate Tablet 1. Identification. 2. Assay. a) 1. 2. b) Compound Sodium Lactate Intravenous Infusion Identification. Assay for total Cl. Assay for CaCl2. Assay for lactic acid. Hydroxocobalamine Injection 1. Identification. 2. Assay (U.V.) a) 1. 2. b) Hydroquinone Ointment Identification (T.L.C.). Assay (Redox titration). Sodium Chloride Eye Lotion Identification. Assay (preciptimetric titration). Busulphan Tablet 1. Identification. 2. Assay. 13 Revision 14 Practical Exam. No. 2. ________________ 14 Total ==========