Download PHC 471: MEDICINAL CHEMISTRY IV (2 + 1)

PHC 471: MEDICINAL CHEMISTRY IV (2 + 1)
Prereq.: PHC 371
Course Description
The study of the structures, nomenclatures, synthesis, interaction of drugs with the
receptor sites, structure-activity relationship, metabolism of the different chemical classes
of the following medicinal agents.
No. of
Lectures
A.
Chemotherapy
i.
Introduction to chemotherapy
Theory of selective toxicity
Synthetic antimalarials
Sulfonamides
Antimycobacterium agents
Antiamoebic agents
Anthelmintic agents
Antiviral and antifungal agents
Cancer chemoterapy (Antineoplastic agents):
a) Introduction
b) Antimetabolites
b) Alkylating agents
d) Miscellaneous antineoplastic agents
ii.
iii.
iv.
v.
vi.
vii.
viii.
1
3
3
1
2
2
1
1
2
2
1
B.
Diagnostic agents
3
C.
Hypoglycemic agents
2
D.
Thyroid and antithyroid agents
2
E.
Two Examinations.
2
_________
Total 28
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PHC 471: PRACTICAL
The course is designed to expose the student to the verification of the chemical purity of
the drug products using the pharmacopoeial monographs as well as various spectrometric
methods.
Lab. No.
1
1.
2.
3.
a)
Aminophylline Tablet
Identification
Assay for theophylline (U.V. Assay).
Assay for ethylenediamine (Acid-base titration).
1.
2.
3.
a)
Aspirin Tablets (Acetylsalicylic acid tablet)
Identification.
Limit test for salicylic acid.
Assay according to British Pharmacopeia.
b)
1.
Ascorbic Acid (Vit. C) Tablet
Assay (Redox titration).
1.
2.
a)
Chloramphenicol Capsules
Identification.
Assay (U.V. Assay).
b)
1.
2.
Phenylephrine Eye Drops
Identification.
Assay (by U.V.).
1.
2.
a)
Methyl Dopa (Aldomet) Tablet:
Identification.
Assay (visible or colorimetric assay).
b)
1.
2.
Calcium Lactate Tablet
Identification.
Assay (complexometric titration).
a)
1.
2.
Indomethacin Suppositories
Identification.
Assay (U.V.).
b)
1.
2.
Frusemide Injection
Identification.
Assay (U.V.).
2
3
4
5&6
7
Practical Examination No. 1.
8
a)
1.
2.
Lab. No.
Tolbutamide Tablet
Identification.
Assay (Acid-base titration).
b)
9
Paracetamol Tablet
1.
Identification.
2.
Assay (U.V. assay).
a)
1.
2.
b)
10
Grisofulvin Tablet
1.
Identification.
2.
Assay (U.V. assay).
a)
1.
2.
3.
4.
b)
11
12
Dextrose Intravenous Infusion
Identification.
Assay (polarimetry).
Chloroquine Phosphate Tablet
1.
Identification.
2.
Assay.
a)
1.
2.
b)
Compound Sodium Lactate Intravenous Infusion
Identification.
Assay for total Cl.
Assay for CaCl2.
Assay for lactic acid.
Hydroxocobalamine Injection
1.
Identification.
2.
Assay (U.V.)
a)
1.
2.
b)
Hydroquinone Ointment
Identification (T.L.C.).
Assay (Redox titration).
Sodium Chloride Eye Lotion
Identification.
Assay (preciptimetric titration).
Busulphan Tablet
1.
Identification.
2.
Assay.
13
Revision
14
Practical Exam. No. 2.
________________
14 Total
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