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Frank E. Barber, Ph.D. 4003 Pintail Cove Oxford Mississippi 38655 662-236-4226 [email protected] Education 1976 Ph.D. University of Washington, Seattle, WA, Electrical & Biomedical Engineering. Major area of study: Electromagnetic Fields and Waves. Dissertation: "Ultrasonic Microprobe: for modeling and measuring the angle distribution of echoes from diseased arterial tissues" 1969 M.S. Northeastern University, Electrical Engineering 1966 A.B. Dartmouth College Honors and Awards 1982 Distinguished Lecturer, IEEE Group on Sonics and Ultrasonics 1980 Research Career Development Award, National Cancer Institute, National Institutes of Health 1975 Sigma Xi 1975 Tau Beta Pi Professional Experience April 2004 to present Senior Scientist for Biomedical Acoustics, National Center for Physical Acoustics, University of Mississippi, Oxford, MS. June 1994 to May 2004 President and General Manager, Sound Products International, Inc., Brattleboro VT; owned and operated a small company. June, 1991 - June 1994 Senior Technology Analyst, Pfizer, Inc., Medical Devices Division, Hospital Products Group, New York, N.Y. For Pfizer Corporate Headquarters: monitored research technology & management, and new product acquisition & development for Pfizer and its Medical Devices subsidiary companies: Valleylab, Boulder CO - electrosurgical instruments, ultrasonic surgery, minimally invasive surgery Schneider Labs., Minneapolis MN - Catheters & stents for cardiac angiography and angioplasty American Medical Systems, Minneapolis MN - Urological devices, prostheses, prostate surgery Strato Medical (&Infusaid) Beverly, MA - Implantable pumps, infusion ports, vascular access devices 81955913 8/11/2017 1:46 AM Page 1 of 6 Howmedica, E. Rutherford, NJ - Hip and knee prostheses, fixation devices, maxillofacial implants Biomedical Sensors (England) - in-vivo blood gas sensors Advisor to and technical liaison between Pfizer and subsidiary Shiley, Inc. regarding research program to minimize the problems associated with Shiley's heart valve malfunction Developed technology analysis and transfer program between Pfizer and David Sarnoff Research Center, Princeton, NJ, in areas of optics and electro-optics, and micromachine and nanomachine technology. April, 1990 - June, 1991 Director, Research & Engineering, Life Sciences, Inc., West Lebanon NH 1987-April, 1990 Senior Scientist, Institute of Applied Physiology & Medicine, Seattle, WA; and; 1989-1990 Affiliate Associate Professor of Electrical Engineering, University of Washington, Seattle Ultrasound imaging and tissue characterization Clinical research: contrast venography & duplex ultrasound for deep venous thrombosis. 1975-1987 Harvard Medical School, Department of Radiology; with staff appointments at the Brigham and Women's Hospital and the Dana Farber Cancer Institute, Boston, MA 1980-1987 Assistant Professor of Radiology (Physics) 1977-1980 Instructor in Radiology (Physics) 1975-1977 Associate in Radiology (Physics) Founded & directed Harvard Medical School's Ultrasound Physics Program Conceived and developed the Scanning Acoustic Microprobe (SCAMP) - unique echo sampling and Fourier reconstruction methods for imaging fine scale tissue structure Recipient of major National Cancer Institute grants for ultrasonic characterization of normal and diseased tissues in breast cancer Recipient of major National Heart Lung & Blood Institute contracts for ultrasonic detection and characterization of atherosclerotic lesions Collaborated in clinical research: hyperthermia, cardiology and cardiovascular disease, cancer Taught in both medical, and physics and engineering curricula, and supervised graduate students at Harvard and MIT. Initiated and directed the physics portion of a National Cancer Institute training program in imaging methods in cancer. 1984-1985 Division of Ultrasound, Elscint Inc., Boston MA-on leave of absence from Harvard May 1984 - Dec. 1984 Senior Scientist and Director, Probe Division Jan. 1985 - Apr. 1985 Director of R & D Responsible for new product research and development new production prototypes, manufacturing methods; production & quality control planning 81955913 8/11/2017 1:46 AM Page 2 of 6 phased and linear array transducers; protocols and procedures for FDA regulatory compliance pulse-Doppler, duplex instruments for vascular and cardiovascular diagnosis Assisted with the return of Elscint Ultrasound from Boston to Haifa and Jerusalem, Israel. 1970-1975 Engineer, Center for Bioengineering, Univ. of Washington, Seattle, WA Conceived, designed and developed for clinical use the first Duplex pulse-echo, pulseDoppler systems for ultrasonic diagnosis - coined the term "Duplex Ultrasound" Principal Investigator for all imaging and duplex Doppler projects for the Cardiovascular Instrumentation Research and Development Program, National Heart, Lung and Blood Institute. Created the ultrasound imaging system that directly elevated ultrasonography from a clinical research tool to the status of accepted medical practice Developed computer methods for three dimensional mapping of ultrasonic images of the heart Performed and published the first measurements to characterize acoustic scattering from atherosclerotic plaque. 1966-1970 Staff Associate, Bioengineering Department, Forsyth Dental Institute, Boston, MA With Dr. Sidney Lees, founded the first Bioengineering Program in dental research Developed ultra-high resolution ultrasound transducers for non-destructive testing First to produce accurate measurements of the ultrasonic properties of hard dental tissues. 1965 (Summer) Research Assistant, Radio-physics Department, Dartmouth College. Military: 1960-1963 - U.S. Army, Honorable discharge. Consulting Assignments Advanced Technology Laboratories, Inc., Seattle WA A.D. Little Company, Inc., Cambridge MA Technicare Ultrasound, Denver CO Johnson & Johnson Company NJ Recurrent Solutions, Inc., Cambridge MA National Cancer Institute National Heart Lung & Blood Institute Elscint, Inc., Boston MA & Haifa Israel Gordon Products, Inc., Groton CT Institute of Applied Physiology and Medicine, Seattle WA New York Institute of Technology, New York NY SRI International (Stanford Research Institute), Menlo Park, CA Palo Alto Research Center (PARC), Xerox Corp, Palo Alto, CA Law Firm of Weil, Gotshal & Manges, New York NY Law Firm of Allen Rubenstein, New York NY 81955913 8/11/2017 1:46 AM Page 3 of 6 National Science Foundation, Bethesda MD Continental Can Company, Chicago IL Whitaker Foundation, Boston MA Children's Hospital Medical Center, Boston MA NTR Systems, Inc., Seattle WA Dentron, Inc., Lincoln NB Law Firm of Costello and Mabie, Brattleboro VT Pfizer Inc., Hospital Products Group, New York NY Professional Activities & Affiliations (memberships & various offices held) American Association of Physicists in Medicine Association for the Advancement of Medical Instrumentation Consultant Editor, Medical Ultrasound. Acoustical Society of America American Institute of Ultrasound in Medicine Institute of Electrical and Electronics Engineers Engineering in Medicine and Biology Society Ultrasonics, Ferroelectrics and Frequency Control Society Selected Bibliography 1. Lees S, Barber FE. Looking into teeth with ultrasound. Science. August 1968; 161:477-478. 2. Barber FE, Baker DW, Nation AWC, Strandness DE Jr., Reid JM. Ultrasonic duplex echoDoppler scanner. IEEE Trans. Bio-Medical Engineering, March 1974; BME-21, 2:109-113. 3. Barber FE, Baker DW, Strandness DE Jr, Ofstad JM, Mahler GD. Duplex Scanner II: for simultaneous imaging of artery tissues and flow. 1974 Ultrasonics Symposium Proceedings, IEEE Press, 1974; 744-748. 4. Barber FE. Development of instrument for non-invasive detection of atherosclerotic lesions. NHLBI Devices and Technology Branch Contractors Conf. Proc., Bethesda MD, p.151, Dec. 1976. 5. Felix WR, Barber FE, Silverman A, Segal B, O'Hara J. Measurement of arterial blood flow using duplex Doppler ultrasound & sound spectral analysis. Proc. Symp. on Hemodynamics of Blood 1979, pp. 71-77. 6. Reuter KL, D'Orsi CJ, Raptopoulow VD, Barber FE, Moss LJ. Sono-graphic pseudoasymmetry of the prenatal cerebral hemispheres, 26th Annual Convention of the AIUM, San Francisco, CA, August 1981. 7. Barber FE, Griffice CP. Power deposition for ultrasound hyperthermia. In: Nussbaum GH. ed., Physical Aspects of Hyperthermia, American Institute of Physics, New York, 1982:209-230. 81955913 8/11/2017 1:46 AM Page 4 of 6 8. Patriquin HB, DiPietro M, Barber FE, Teele RL. Sonography of thickened gallbladder wall: Causes in Children. Am. J. Radiology 1983; 141:57-60. 9. Klepper, JR, Barber FE, and Spencer MP. Improved instrumentation for the diagnosis of venous thrombosis. Presented at the Devices and Technology Branch Contractors Meeting, Bethesda, MD, December 5-7, 1988. 10. Barber, FE. The Scanning Acoustic Microprobe: I. Analysis and synthesis of a spherically symmetric point spread function; and II. Application to the measurement and characterization of a piston reflector. J. Acous. Soc. Am. January, 1991. 11. Barber, FE and X Yang, Real-time detection of HIFU-induced changes in focal attenuation from B-mode compound scan data. Prog. & Abstracts, 5th Intl. Symp. on Therapeutic Ultrasound, Oct. 27-29, Boston, MA. 12. Yang, X, Barber FE, and Church CC, The activation of tissue factors by high intensity focused ultrasound-a pathway to acoustic-biochemical hemostasis. Prog. & Abstracts, 5th Intl. Symp. on Therapeutic Ultrasound, Oct. 27-29, Boston, MA. Teaching Experience & Principal Invited Lectureships Brigham and Women's Hospital, Boston Harvard School of Public Health, Boston Harvard-MIT Program in Health Sciences and Technology, Boston Harvard Medical School, Boston Northeastern University, Department of Electrical Engineering, Boston Massachusetts Institute of Technology, Department of Electrical Engineering, Cambridge Boston University, Department of Biomedical Engineering, Boston American Association for the Advancement of Science American Association of Physicists in Medicine New England Roentgen Ray Society Atherosclerosis Research Center, MIT & Mass. General Hospital Children's Hospital Medical Center, Boston Latin American Radiological Society Indianapolis Center for Advanced Research International Conf. on Information Processing in Medical Imaging, Stanford U., Palo Alto, CA New England Deaconess Hospital, Boston Hewlett Packard Co., Palo Alto, CA SRI International (Stanford Research Institute), Menlo Park, CA Varian Associates, Palo Alto, CA IBM, Thomas J. Watson Laboratories, Yorktown Heights, NY Philips Laboratories, Briarcliff Manor, NY Sigma Xi Society Pennsylvania State University 81955913 8/11/2017 1:46 AM Page 5 of 6 Washington University, St. Louis, MO Marquette University, Milwaukee WI American Society for Nondestructive Testing Institute of Electrical & Electronics Engineers: Ultrasonics Ferroelectrics and Frequency Control Society Engineering in Medicine & Biology Society National Cancer Institute's Training Program in Imaging Methods in Cancer University of Louisiana, Lafayette 81955913 8/11/2017 1:46 AM Page 6 of 6