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Transcript
Magnetic nanoparticle clusters as a nanomedicine for site-specific delivery/imaging LiFang Wang, ShuoLi Sun, YuLun Lo, JiaJyun Lin, and JyunHan Ke Department of Medicinal & Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan One-pot synthesized polyacrylic acid-coated iron oxide (Fe3O4) was used to further decorate with a polymer, a fluorescent dye via either chemical or physical bonding. Superparamagnetic iron oxide nanoparticles (SPION) possess specific magnetic properties in the presence of an external magnetic field, which endow them an attractive platform as contrast agents for magnetic resonance imaging (MRI) and as carriers for drug delivery. In this talk, I am going to present how to synthesize a multifunctional SPION that combines several beneficial approaches specifically targeting tumor sites. This new designed SPION can be served as a co-delivery carrier for chemotherapy and gene therapy agents as well as a dual-modality nanoprobe for cancerous theragnostics.
