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AP Biology Pre-Discussion Questions: Molecular Genetics 6- Genetics: A Systems Perspective Instructions: Topic Presentation: Supplementary Resources: “Crash Course: Biology” Videos: Videos By Paul Anderson: Part 1: Developmental Genetics Questions to answer: Things you should make sure you understand: Part 2: Genomics Questions to answer: Things you should make sure you understand: Instructions: ● ● ● ● ● ● Open the presentation. Watch the embedded video clips and move through the embedded content. Answer the “Questions to answer”. Make sure you understand the “Things you should make sure you understand”. Feel free to view the “Supplementary Resources”. Write down any questions that you have about the material. Topic Presentation: click here Supplementary Resources: “Crash Course: Biology” Videos: Videos By Paul Anderson: Part 1: Developmental Genetics Questions to answer: 1. Define the term “differentiation.” 2. Explain the function of each of the following as relates to the process of differentiation: a. cytoplasmic determinants b. cellular induction 3. 4. 5. 6. c. cellular determination Why does determination have to precede differentiation? How do cells acquire positional information about their location in a developing embryo? Explain the function of bicoid. What are the homeobox genes? What do they do in a developing animal? Things you should make sure you understand: (feel free to ask questions about them in class) Part 2: Genomics Questions to answer: 1. Explain the purpose of the Human Genome Project (HGP). 2. Compare the approaches to genome sequencing taken by the public human genome project, and Craig Venter’s private initiative. 3. Explain why the HGP finished sequencing four years ahead of schedule. 4. What is bioinformatics and why is it a necessary and important field of study? 5. Is there any particular pattern among genomes and the organisms who have them? 6. Explain what transposable elements are and give an overview of their function. 7. On a percentage basis, what type of sequence comprises the most of the human genome? What type of sequence comprises the least? 8. What is a gene family? How do they evolve? 9. Compare identical-sequence and non-identical sequence gene families. 10. Explain the types of signatures that have been left in the human genome when looking at our split from rodents and from chimpanzees. 11. Why does duplication of genetic sequences typically precede divergence of those sequences? Things you should make sure you understand: (feel free to ask questions about them in class)