Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Hyaluronic Acid in Ear, Nose and Throat (ENT) Hyaluronic acid and the respiratory system Hyaluronic acid is universally recognised as being the main molecular component of the extracellular matrix. In the respiratory apparatus it is synthesized by rhinopharyngeal and pulmonary interstitial fibroblasts, the tracheobronchial submucosal glands, and the goblet cells of the lining epithelium, which add it to the mucus that covers and protects the respiratory airways. As a result of this distribution, hyaluronic acid has a central role to play in respiratory physiology, and is involved in many homeostatic mechanisms. Hyaluronic acid administered via inhaler penetrates rapidly and becomes integrated in the pulmonary interstice, preventing diffusion of macromolecules and regulating the migration of the cell populations involved in phlogistic reactions. Its highly hydrophobic properties also allows it to hydrate the entire respiratory tree, facilitating removal of catabolites and allergens. As a result of its ability to form part of the glycoprotein component covering the upper respiratory mucosa it is involved in regulating mucociliary clearance by disrupting potential impairing allergenic or inflammatory factors, either from the environment or endogenous. THE IBSA TREATMENT PROPOSAL (YABRO®) The IBSA range offers an innovative, effective and safe approach for phlogistic pathologies in the ENT field, aimed at restoring and maintaining the physiological conditions of the damaged interstice and pulmonary mucous membranes occurring in chronic bronchial phlogosis, assisting with disorders of the upper respiratory airways and improving restoration of the functions of the mucous membrane in the post-operative phase of endonasal interventions, together with therapeutic treatments which have already been prescribed. This is a medical device containing a sterile, isotonic solution of 0.3% hyaluronic acid salt, to be administered by nebulizer.