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Transcript
Model accounting for the mechanisms linking epipodophyllotoxin therapy, MLL fusion proteins, cell cycle progression, and the relaxation of cell cycle checkpoints, leading to reduced levels of apoptosis in myeloid progenitor cells after genotoxic chemotherapy (hence increased survival of cells with damaged DNA). The accelerated acquisition of additional genetic lesions in clonogenic preleukemic cells eventually culminates in overt myeloid leukemia. See text for further explanation. (Adapted from Downing and Look.575 Used with permission). Source: Genes Altered by Chromosomal Translocations in Leukemias and Lymphomas, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: http://mhmedical.com/ Accessed: August 03, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
