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Georgian Biomedical Journal . 2017 May, Volume 1, Issue 5 The Content of Certain Hormones in Blood Serum during Diabetes Mellitus Complicated By Nephropathy T. Makharadze, M. Gvalia, J. Topuria, M. Tugushi, Kh.Tsitsiashvili The Department of Therapy Specialization at Tbilisi State Medical University, the Central Clinical Hospital, Tbilisi Abstract The results of our study has shown that: during insulin dependent or insulin dependent types of the diabetes mellitus complicated by nephropathy, in the blood serum the level of rennin is higher in the case of type I diabetes then in the case of type II. The elevation of the rennin contributes to the formation of stabile hypertension. The concentration of aldosterone in the most cases is elevated and certain correlation to the content of renin is observed. The changes of above mentioned hormone levels are as important as longer is the duration of the disease. The role of the patients age has not appeared to be is strong correlation with the levels of hormone. As for AKTH level changes, the correlation with aldosterone levels has not been observed. Keywords: diabetes mellitus, nephropathy, hormones, aldosterone Introduction A s it is known, nephropathy is one of the most frequent complications of the diabetes mellitus. Frequency of this complication during type I diabetes mellitus is 30-40%, while at type II diabetes mellitus the percentage of the nephropathies is lower. According to the data is revealed that 71% of nephropathies are accompanied by hypertonia that in most cases ends with functional failure of the kidney [1.3.4]. Some authors consider that [2] hypertonia in the patients with diabetes mellitus increases the risk of nephropathy in the case of type II - diabetes (noninsulindependent). Certain authors have studied the changes of renal functional abilities at insulin dependent (type I) diabetes mellitus patients in relation with nephropathy. In the literature we couldn't find the dates about rennin and angiotensin content in the blood serum during 210 diabetes mellitus complicated by nephropathy. About above-mentioned hormones the dates are not enough as well in the connection with the diabetes mellitus forms and the course of the disease. From all above-mentioned the aim of our study was to determine the content of rennin and aldosterone in the blood serum during the diabetes mellitus complicated of the above-mentioned hormones concentrations in the serum during insulin dependent and non-insulin dependent forms of the diabetes aggravated by nephropathy taking under the consideration the severity and the duration of the disease. Materials and Methods Serum rennin aldosterone and AKHT levels were studied by radioimmunoassay using standard tests of DSL firm. 166 patients suffered from diabetes mellitus were under our observation. The cases of type I diabetes were 90, type Ii - 76. From the cases of both ISSN 2449-3031 Georgian Biomedical Journal . 2017 May, Volume 1, Issue 5 type of the diabetes we have created the separate group comprising of 55 patients with diabetes complicated by nephropathy. In this group (with nephropathy) type I diabetes were in 34 cases, type II in 21 cases. Research and Discussion In relation with age has been observed the following pattern: 10 patients from 20 to 30 years, 17-30-40 years, 28-40-50 years. By study of rennin concentration in blood serum was revealed that in the case of type I diabetes the level of rennin is higher basically in the patients from 20 to 400 years old (should be mentioned, that the duration of disease was one years). Decrease of rennin concentration has not been established at all. In the case of type II (among studied 21 patients) the elevated levels of rennin were revealed only in 2 cases. Besides, the age of the patients was also older. Analysis of the patients data on the base of the disease duration was revealed, that the elevated levels of the rennin were observed in the patients with the 9-10 years history of the disease. The low content of rennin in blood serum was not observed at II type diabetes as well. As it was already mentioned at the type I and type II diabetes the levels of aldosterone were also studied. During type I diabetes among studied 34 patients the elevated levels of aldosterone were revealed in 2 patients. The correlation between aldosterone levels and age were not find. As for the duration of the disease the high level of the aldosterone was revealed only in one patient (28 years old) with a 1-year history of the disease. At type II diabetes the aldosterone levels were studied in 21 patients. The elevation of the hormone level was revealed only in 1 patient. In other cases aldosterone levels were in the range of norms. As it is known, rennin is the stimulator of the aldosterone secretion, therefore it was considered of high interest - either there was correlation between their concentration or not. The results of the study revealed some tendency to the elevation. There are important data about AKTH role in the secretion of aldosterone. The acrophaze of AKTH precedes them acrophase of the aldosterone secretion. Therefore the content of AKHT and aldosterone were also studied at type I and type II diabetes mellitus, but the important changes of findings were not observed. Thus, the results of our study has shown that: at insulin dependent and non-insulin dependent forms of the diabetes mellitus complicated by nephropathy, in the blood serum the levels of rennin is higher in the case of type I, than in the case of type II. The elevation of the rennin determines the formation of stabile hypertension. The concentration of aldosterone in the most cases achieves the high level. Has been mentioned the certain correlation with the rennin containing. According to our data, the character of the changes of above mentioned hormone levels is much important as longer is the duration of the diabetes and doesn't depend on time passed from onset of nephropathy. The role of the patient's age has not appeared to be in strong correlation with the levels of hormones. As for AKTH changes the correlation with aldosterone levels in our results has not been observed as well References 1. Bedd A, Camerini-Davelos R. Diabetes nephropathy. An update Arch internal med. 1990; 150(1):31-43. 2. Bell D. Hypertension in the person with diabetes. Amer J med Sci. 1989; 297:4: 228-232. 3. Noth R, Krolesk A, Kaysen G, et al. Diabetic nephropathy Hemodinamic basis and implications for disease management. Ann intern med. 1989; 110(10):795-813. 4. Murabayashi D, Baba T, Tomypima T, et al. Urinary dopamine noradreneline and adrenaline in type 2 diabetic patients with and without nephropathy. Hormone metabol Res. 1989; 21(1):27-32. ISSN 2449-3031 211