Download DECIDE presentation

Project participants:
Consortium GARR (IT), CNR (IT), Consorzio COMETA (IT),
Fatebenefratelli (IT), University San Raffaele (IT),
University of Genoa (IT), University of Foggia (IT), Fondazione SDN (IT),
MAAT France (FR), Imperial College (UK), Uniwersytet Warszawski (PL),
Centre Hospitalier Universitaire de Toulouse (FR), Alzheimer Europe (LU)
EC Call: FP7-INFRAS-2010-2 – VRC
Contract n: RI-261593
Project type: CP-CSA
Duration: 24 months
Total budget: 2.580.558 €
EC Funding: 2.399.998 €
DECIDE:
an Integrated e-Infrastructure and eService for Research and Early Diagnosis
of Alzheimer Disease
DECIDE in a Nutshell
Creation of a e-Infrastructure and service dedicated to research and early
diagnosis of AD and other neurodegerative diseases
AD is one of EU’s greatest challanges for the next few years
Intended not only for research purposes, but for the exploitation into
clinical practice
Started on: 1st September 2010
Duration: 24 Months
Requested EC contribution: ~2.4 M€
Co-ordinated by GARR, the Italian R&E network, COMETA has the technical
coordination
Scientific Coordination by the neuGRID Principal Investigator
Involves 13 European Partners + European NoE of research and healthcare
centres specialised on AD + the European network of patient advocate
societies
All stakeholders involved, from the network layer to end-users
Project Objectives
To provide the Neuroscientific and Medical community with a
dedicated e-Infrastructure
relying on GÉANT, EGI and NeuGrid
To deploy a secure and user-friendly service for the early diagnosis
and research on dementia and other brain diseases
linking large distributed DBs of multi-modal neuro-images
To validate the e-Infrastructure and the service
with real patient cases
To propose a business model to ensure the sustainability of the
infrastructure after the end of the project
and facilitate its extension to new communities and pathologies
To disseminate the results and provide training programmes
promoting the adoption of the DECIDE infrastructure and service
The Project Workplan at a Glance
Networking
Activities
Creation stable liaisons with relevant
stakeholders in the scientific and eInfrastructure domains
Dissemination of results and reaching out to
the medical community
Service
Activities
Network and GRID provisioning and
management
Exposing the medical database to the
applications running on the e-Infrastructure
Joint
Research
Activities
Porting of the diagnostic algorithms
Design of the diagnostic service
User validation and Testing
The Project Consortium
A vertical approach to e-Health, targeting the needs of neuroscientists
community through the provisioning of an e-Infrastructure aimed at supporting
them in the daily execution of the diagnosis
CONSORTIUM GARR - Italy
CONSORZIO COMETA – Italy
Network & GRID Layer
Infrastructure Partners
CNR - Italy
UNIVERSITY OF GENOA - UNIGE Italy
UNIVERSITY OF FOGGIA - UNIFG Italy
MAAT FRANCE - maat G - France
IMPERIAL COLLEGE – United Kingdom
UNIWERSYTET WARSZAWSKI - Poland
Application Layer
Partners
IRCCS FATEBENEFRATELLI - Italy
UNIVERSITY SAN RAFFAELE - Italy
FONDAZIONE SDN - Italy
CENTRE HOSPITALIER UNIVERSITAIRE DE
TOULOUSE - France
ALZHEIMER EUROPE - Luxembourg
Research & Healthcare Layer
Partners
DECIDE e-Infrastructure Layers
The DECIDE Service Concept
Masking complexity for the end user
Web interface for ease of use and access from everywhere
Distributed
reference DBs
Multiple quantitative algorithms for research and diagnosis
Secure exploitation of large multimodal reference databases of
normal subjects and patients
How DECIDE Works
Different user profiles with different workflows and authorization levels
«Neurologist»: can upload patient images, ask for diagnostic tests to be performed, and get the report
«Physician»: can set some attributes and perform diagnostic tests
«Scientist»: can modify paramethers for research purposes
All profiles need to attend a dedicated course and qualify in order to get access to the system
DECIDE e-Infrastructure Architecture
DECIDE Applications
DECIDE User Profiles
Authentication & Authorization
Training
Robot Certificates server
Applications’ GUI
Repository platform GUI
Grid e-Infrastructure API
Test Environment
Production Environment
Job management (WMS, LB)
Data management (LFC, AMGA)
Information system (BDII)
Robot certificates
VOMS server
DECIDE Applications
GridSPM: specifically designed for SPECT and PET neurological
clinical images provides an SPM analysis for the early diagnosis of
Alzheimer Disease
GridMRISeg: implements an automatic algorithm for the subcortical
segmentation of MRI brain images for hippocampal volume
estimation, using the auto context model (ACMAdaboost) developed
by LONI
GridEEG: implements EEG processing algorithms with the aim of
detecting early symptoms of Alzheimer Disease and distinguishing
different forms of degenerative impairment
GridANN4ND: concerns the analysis of PET biomarkers in
Neurological and Psychiatric Disorders and provides a classification
of suspected patients through an Artificial Neural Network
Project Status
The DECIDE distributed e-infrastructure and
service is up and running. It is being released
for user testing by a panel of selected early
adopters, who will undergo dedicated training
sessions to allow them to make the best use of
the tool. Their feedback will result in further
improvements to the four applications deployed
by the project.
Next steps
In addition, DECIDE can serve as a testing
environment for new potential applications to be
ported on the infrastructure. In the long term,
this infrastructure could be extended to cover
algorithms relating to other diseases of the brain
and other organs, involving the whole life
science research community.
Thank you
for your kind attention!
Find more about DECIDE at www.eu-decide.eu
or contact us for questions and collaboration
opportunities at [email protected]