Download Assembly Line Biosynthesis of Polyketide Antibiotics

Ryckman Lecture
Assembly Line
Biosynthesis of
Polyketide Antibiotics
speaker
Chaitan Khosla
Wells H. Rauser and Harold M. Petiprin
Professor in the School of Engineering;
Professor of Chemical Engineering,
Chemistry, and Biochemistry
Friday, Nov. 18, 2016
Lecture: 3:00 p.m. • Whitaker 100 Auditorium
Reception to follow • Brauer 2nd floor lobby
Abstract: Many complex natural products are
synthesized by multi-enzyme systems that
operate as assembly lines. Their apparently
modular architecture has opened the door
to biosynthetic engineering of new natural
products by rationally manipulating the DNA
encoding these megasynthases. Understanding
the structures and mechanisms of these
assembly lines represents a challenging and
exciting frontier in multifunctional catalysis.
Stanford University
eece.wustl.edu