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Investing in Biotechnology Jessica Yu Biotech 2 Company Description (Week 0 – 7) Genentech, Inc. (DNA) Genzyme Corp. (GENZ) - - - - Goals: Discovering, developing, manufacturing, and commercializing biotherapeutics in the U.S. Products: Avastin, Rituxan, Herceptin, Lucentis, Xolair, Tarvceva, Nutropin, Activase, TNKase, Cathflo Activase, Pulmozyme, Raptiva, Number of shares purchased: 7 shares Price per share at purchase: $78.30 - - - Located in the U.S. the European Union, Latin America, and Asia Pacific Consists of 5 specialized branches: Renal, Therapeutics, Transplant, Biosurgery, and Genetics Products: Renagel, Hectoral vitamin D2 prehormone products, Cerezyme/Ceredase, Fabrazyme, Thyrogen, Myozyme, Aldurazyme, Thymoglobulin, Lymphoglobuline, Synvisc, Sepra products, Number of shares purchased:7 shares Price per share at purchase: $64.07 Company Description (Week 8 - 15) Questcor Pharmaceuticals, Inc. (QSC) - - Sangamo Biosciences (SGMO) Goals: Novel therapeutics for treating diseases and diseases of the central nervous system Products: H.P. Acthar Gel, Doral Number of shares purchased: 500 shares Price per share at purchase: $1.37 - Goals: Researching and developing novel DNA-binding proteins for therapeutic gene regulation and modification Achievements: development of a class of DNA-binding proteins, called zinc finger DNA-binding proteints (ZFPs) Number of shares purchased: 19 shares Price per share at purchase: $18.86 Events Affecting Company Stocks Genentech, Inc. (-) - Alteration of a plan to discourage doctors from using Avastin to treat eye disease because of FDA concerns, but it also may have damaged Lucentis sales by angering retina specialists Genzyme Corporation (+) - the U.S. Food and Drug Administration has granted Epicel, its product for the treatment of life-threatening wounds resulting from severe burns Questcor Pharmaceuticals, Inc. (+) - U.S. shipments of its main product Acthar, a hormone used to treat swelling and allergic reactions, increased by 4 percent in December from the previous month Sangamo Biosciences (-) - Holder Kopp Investment Advisors cuts stake in Sangamo Biosciences to 7.2 percent Performance Graphs Total Stock Values for 16 Weeks Total Stock Value ($) 3000 DNA (7 shares) QSC (500 shares) GENZ (7 shares) SGMO (19 shares) 2500 2000 1500 *DNA w as sw itched w ith QSC after w eek 7 ** GENZ w as sw itched w ith SGMO after w eek 7 1000 500 0 0 2 4 6 8 Time (Weeks) Price Per Share over 16 Weeks DNA GENZ QSC SMGO Price per per Share ($)($) Price Share 80 70 60 50 *DNA w as sw itched w ith QSC after w eek 7 ** GENZ w as sw itched w ith SGMO after w eek 7 40 30 20 10 0 0 2 4 6 8 Time (Weeks) 10 12 14 16 10 12 14 Stock Investment Summary - Total Stock Value at Purchase: $996.59 - Total Stock Value after 16 Weeks: $3057.39 - Net profit: $2060.80 - Percent Increase from Original Stock Value: +206.79%