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THE GASTRO-INTESTINAL SYSTEM MODULE )SYS 328( Credit Hours : 5 INTRODUCTION The gastrointestinal system is a complex, multi-organ structure that performs many vital functions, including ingestion, digestion, movement, absorption and elimination. The tubular gastrointestinal tract includes the mouth, esophagus, stomach, small intestine, large intestine, rectum, and anus. The luminal surface along much of this tract is lined with cells that is in continuous regeneration and secrete substances that aid in breaking down ingested food or absorb nutrients and water into the bloodstream for distribution throughout the body. The layers of muscles and associated nerves that surround the lumen propel food and waste through the system for eventual elimination. The pancreas secretes enzymes into the small intestine to help break down proteins, fat, and carbohydrates. The liver and biliary system secrete bile into the small intestine to aid in the digestion of fat. In addition, the liver processes nutrients absorbed by the small intestine into forms that can be used by the body and detoxifies potentially harmful substances. Adequate function of the digestive system requires proper control of both the nervous and endocrine systems. Dysfunction of the gastrointestinal tract, may result not only in one of the many digestive system disorders, but also to illnesses in any system of the body, such as the nervous system or the immune system. In this module the students will link the basic science knowledge with the clinical science and skills. They will learn the causes, pathogenesis, prognosis and the most important clinical features of some gastrointestinal and hepatobilliary diseases. The students will learn how to approach a diagnosis and or the differential diagnosis of these lesions. The implementation of this knowledge will be fundamental in their future clinical science. It is necessary to look at this module from different aspects including the normal process carried out by the involved cells/organs and abnormalities that can affect the system and their consequences. The structure / function relationship is emphasized in this module rather than the classical teaching of isolated topics of anatomy, physiology, biochemistry, pathology, parasitology and pharmacology.