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BIOGRAPHICAL SKETCH
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NAME
POSITION TITLE
Paul J. Converse, Ph.D.
Research Associate
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Ohio University, Athens, Ohio
Univ. of Durham, Durham, England
Johns Hopkins Univ., Baltimore, MD
Johns Hopkins Univ., Baltimore, MD
DEGREE
(if applicable)
B.A.
M.Sc.
MHS
Ph.D.
YEAR(s) FIELD OF STUDY
1968
1977
1980
1984
Government cum laude
Human Genetics
Tropical Medicine
Immunol.&Inf. Dis
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment,
experience, and honors. Include present membership on any Federal Government public advisory committee. List, in chronological order, the
titles, all authors, and complete references to all publications during the past three years and to representative earlier publications pertinent to
this application. If the list of publications in the last three years exceeds two pages, select the most pertinent publications. DO NOT EXCEED
TWO PAGES.
Professional Experience and Honors
1979,81-84 Johns Hopkins University, Scholarships
1980
Delta Omega, Public Health Honor Society
Sigma Xi, The Scientific Research Society
1991 Board Member Damien-Dutton Society for Leprosy Aid, Inc.
1980 - 84
Graduate Research Assistant, Res. Assoc., Research Fellow, Bone Marrow Transplant
Unit, Oncology Center, Johns Hopkins Univ., School of Medicine
1984 - 88
Senior Scientist, Acting Director (1985-1986), Armauer Hansen Research Institute, Addis
Ababa, Ethiopia
1984 - 90
Research Associate, Dept. of Immunology & Infectious Diseases, The Johns Hopkins
University, School of Hygiene and Public Health.
1988 - 90
Visiting Scientist, Department of Infectious Diseases, Roslagstull Hospital, Karolinska
Institute, Stockholm, Sweden
1990 Assistant Professor, Associate, Dept. of Molecular Microbiology & Immunology
(formerly
named Immunology & Infectious Diseases,) The Johns Hopkins School of Public Health.
1997 - 1999 Project Scientist, IGEN Int’l, Inc., Gaithersburg, MD
1999 Science Writer, OMIM, Johns Hopkins University/NIH-NCBI
2002 Research Associate, Center for Tuberculosis Research, Johns Hopkins University
1991
Johns Hopkins University Faculty Development Award, Heiser Program for Research in
Leprosy, National Foundation for Infectious Diseases Young Investigators Award, Damien
Dutton Society for Leprosy Aid, Inc., "A SCID Mouse Model of Leprosy".
1992 - 95
NIH AI 27165, Co-Principal Investigator "Tuberculosis: Histopathology, CMI, DTH and
cytokines.
1994 - 99
NIH AI 35195, Co-Principal Investigator "Tuberculosis Vaccine Development".
Publications
Converse, P.J., Hess, A.D., Tutschka, P.J., and Santos, G.W. Effect of cyclosporine on the
response of normal human lymphocytes to cytomegalovirus in vitro. Infect. Immun. 41:1226-1233,
1983.
Converse, P.J. and Hess, A.D. The effect of cyclosporine and interleukin-2 on the restoration of
in vitro immune responses to cytomegalovirus. Scand. J. Immunol. 21: 109-118, 1985.
Vogelsang, G.B., Hess, A.D., Berkman, A.W., Tutschka, P.J., Farmer, E.R., Converse, P.J., and
Santos, G.W. An in vitro test for graft versus host disease in patients with genotypic HLA-identical
bone marrow transplants. New Engl. J. Med. 313: 645-650, 1985.
Converse, P.J. and Bjune, G. NK cell activity and reversal reaction in leprosy. Int. J. Lepr. 55:
503-509, 1986.
Ottenhoff, T.H.M., Converse, P.J., Bjune, G., and de Vries, R.R.P. HLA antigens and reversal
reactions in Ethiopian borderline tuberculoid leprosy patients. Int. J. Lepr. 56: 261-266,1987.
Converse, P.J., Mshana, R.M., and Bjune, G. Cimetidine inhibits suppressor factor production
in Ethiopian lepromatous leprosy patients. Int. J. Lepr. 56:548-551, 1987.
Converse, P.J., Ottenhoff, T.H.M, Gebre, N., Ehrenberg, J.P., and Kiessling, R. Cellular,
humoral, and gamma interferon responses to Mycobacterium leprae and BCG antigens in healthy
individuals exposed to leprosy. Scand. J. Immunol. 27: 515-525, 1988.
Ottenhoff, T.H., Converse, P.J., Ehrenberg, J.E., Gebre, N., and Kiessling, R. T cell responses to
fractionated Mycobacterium leprae antigens in leprosy. The lepromatous nonresponder defect can be
overcome in vitro by stimulation with high molecular weight M. leprae components. Eur. J. Immunol.
19: 707-713, 1989.
Kaplan, G., Kiessling, R., Hancock, G., Teklemariam, S., Sheftel, G., Job, C.K., Converse, P.,
Ottenhoff, T.H., Becx-Bleumink, M., Dietz, M., and Cohn, Z.A. The reconstitution of cell mediated
immunity in the cutaneous lesions of lepromatous leprosy by rIL-2. J. Exp. Med. 169: 893-907, 1989.
Ottenhoff, T.H.M., Kiessling, R., Converse, P.J., Li, S.G., and de Vries, R.R.P. Antigen
specific T cell nonresponsiveness in man: lepromatous leprosy, a model disease. In: F. Melchers et al.,
eds., Progress in Immunology VII, 890-893, Springer-Verlag, Berlin, 1989.
Converse, P., Ottenhoff, T.H.M., Teklemariam, S.W., Hancock, G.E., Dietz, M., BecxBleumink, M., Wondimu, A., Kiessling, R., Cohn, Z.A., and Kaplan, G. Intradermal recombinant
interleukin 2 enhances peripheral blood T-cell responses to mitogen and antigens in patients with
lepromatous leprosy. Scand. J. Immunol. 32: 83-91, 1990.
Kaleab, B., Kiessling, R., Converse, P., Halapi, E., Tadesse, G., Rottenberg, M., and Ottenhoff,
T. Mycobacterial-induced cytotoxic T cells as well as nonspecific killer cells derived from healthy
individuals and leprosy patients. Eur. J. Immunol. 20: 2651-2659, 1990.
Converse, P.J., Fehniger, T.E., Ehrnst, A., Strannegård, Ö. and Britton S. Immune responses to
fractionated cytomegalovirus (CMV) antigens after HIV infection. Loss of cellular and humoral
reactivity to antigenic fractions recognized by HIV-, CMV+ individuals. Clin. Exp. Immunol. 82:559566. 1990.
Öhman, R., Walford, C., Converse, P., and Ridell, M. Reactions to antigens from Actinomycetes
including Mycobacterium leprae in leprosy patients. Int. J. Leprosy. 59:320-322. 1991.
Converse, P.J., Haines, V., Wondimu, A., Craig, L., and Meyers W.M. Infection of SCID mice
with Mycobacterium leprae and control with antigen-activated "immune" human PBMC. Infect. Immun.
63: 1047-1054, 1995.
Converse, P.J.Su, W.-J., Howard, N.S. RT/PCR to detect cytokines in a rabbit model of
tuberculosis. Procs. Bovine TB Symposium (in press).
Esa, A.H. and Converse, P.J. Nordihydroguaiaretic acid blocks IL-2 independent lymphocyte
proliferative responses but enhances responses to tuberculin. Scand. J. Immunol. 43: 127-133, 1996.
Converse, P.J., Dannenberg, A.M. Jr., Estep, J.E., Sugisaki, K., Abe, Y., Schofield, B.H., Pitt,
M.L. Cavitary Tuberculosis Produced In Rabbits By Aerosolized Virulent Tubercle Bacilli. Infect.
Immun. 64: 4776-4787 (1996).
Converse, P.J., Jones, S.L., Astemborski, J., Vlahov, D., N.M. Graham. Comparison of a
tuberculin interferon-gamma assay with the tuberculin skin test in high-risk adults: effect of
human immunodeficiency virus infection. J Infect Dis. 176:144-50 (1997).
Sugisaki, K., Dannenberg, A.M. Jr., Abe, Y., Tsuruta, J., Su, W.J., Said, W., Feng, L.,
Yoshimura, T., Converse, P.J., Mounts, P. Nonspecific and immune-specific up-regulation of
cytokines in rabbit dermal tuberculous (BCG) lesions. J Leukoc Biol. 63:440-50 (1998).
Converse, P.J., Dannenberg, A.M. Jr., Shigenaga, T., McMurray, D. N., Phalen, S.W., Stanford,
J.L., Rook, G.A., Koru-Sengul, T. Abbey, H., Estep, J.E., Pitt, M.L. Pulmonary bovine-type tuberculosis
in rabbits: bacillary virulence, inhaled dose effects, tuberculin sensitivity, and Mycobacterium vaccae
immunotherapy. Clin Diagn Lab Immunol. 5:871-81 (1998).
Kimura, M., Converse, P.J., Astemborski, J., Rothel, J.S., Vlahov, D., Comstock, G.W.,
Graham, N.M.H., Chaisson, R.E. and Bishai, W.R Comparison between a whole blood interferon-g
release assay and tuberculin skin testing for the detection of tuberculosis infection among patients at risk
for tuberculosis exposure. J. Infect. Dis. 179:1297-1300 (1999).
Sheen, P., Converse, P.J., et al. Lack of Sensitivity and Specificity in a PPD-based whole blood
gamma interferon test for Tuberculosis in a highly endemic Peruvian population. Submitted 2002.