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BIOGRAPHICAL SKETCH Provide the following information for the key personnel in the order listed on Form Page 2. Photocopy this page or follow this format for each person. NAME POSITION TITLE Paul J. Converse, Ph.D. Research Associate EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION Ohio University, Athens, Ohio Univ. of Durham, Durham, England Johns Hopkins Univ., Baltimore, MD Johns Hopkins Univ., Baltimore, MD DEGREE (if applicable) B.A. M.Sc. MHS Ph.D. YEAR(s) FIELD OF STUDY 1968 1977 1980 1984 Government cum laude Human Genetics Tropical Medicine Immunol.&Inf. Dis RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and honors. Include present membership on any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the past three years and to representative earlier publications pertinent to this application. If the list of publications in the last three years exceeds two pages, select the most pertinent publications. DO NOT EXCEED TWO PAGES. Professional Experience and Honors 1979,81-84 Johns Hopkins University, Scholarships 1980 Delta Omega, Public Health Honor Society Sigma Xi, The Scientific Research Society 1991 Board Member Damien-Dutton Society for Leprosy Aid, Inc. 1980 - 84 Graduate Research Assistant, Res. Assoc., Research Fellow, Bone Marrow Transplant Unit, Oncology Center, Johns Hopkins Univ., School of Medicine 1984 - 88 Senior Scientist, Acting Director (1985-1986), Armauer Hansen Research Institute, Addis Ababa, Ethiopia 1984 - 90 Research Associate, Dept. of Immunology & Infectious Diseases, The Johns Hopkins University, School of Hygiene and Public Health. 1988 - 90 Visiting Scientist, Department of Infectious Diseases, Roslagstull Hospital, Karolinska Institute, Stockholm, Sweden 1990 Assistant Professor, Associate, Dept. of Molecular Microbiology & Immunology (formerly named Immunology & Infectious Diseases,) The Johns Hopkins School of Public Health. 1997 - 1999 Project Scientist, IGEN Int’l, Inc., Gaithersburg, MD 1999 Science Writer, OMIM, Johns Hopkins University/NIH-NCBI 2002 Research Associate, Center for Tuberculosis Research, Johns Hopkins University 1991 Johns Hopkins University Faculty Development Award, Heiser Program for Research in Leprosy, National Foundation for Infectious Diseases Young Investigators Award, Damien Dutton Society for Leprosy Aid, Inc., "A SCID Mouse Model of Leprosy". 1992 - 95 NIH AI 27165, Co-Principal Investigator "Tuberculosis: Histopathology, CMI, DTH and cytokines. 1994 - 99 NIH AI 35195, Co-Principal Investigator "Tuberculosis Vaccine Development". Publications Converse, P.J., Hess, A.D., Tutschka, P.J., and Santos, G.W. Effect of cyclosporine on the response of normal human lymphocytes to cytomegalovirus in vitro. Infect. Immun. 41:1226-1233, 1983. Converse, P.J. and Hess, A.D. The effect of cyclosporine and interleukin-2 on the restoration of in vitro immune responses to cytomegalovirus. Scand. J. Immunol. 21: 109-118, 1985. Vogelsang, G.B., Hess, A.D., Berkman, A.W., Tutschka, P.J., Farmer, E.R., Converse, P.J., and Santos, G.W. An in vitro test for graft versus host disease in patients with genotypic HLA-identical bone marrow transplants. New Engl. J. Med. 313: 645-650, 1985. Converse, P.J. and Bjune, G. NK cell activity and reversal reaction in leprosy. Int. J. Lepr. 55: 503-509, 1986. Ottenhoff, T.H.M., Converse, P.J., Bjune, G., and de Vries, R.R.P. HLA antigens and reversal reactions in Ethiopian borderline tuberculoid leprosy patients. Int. J. Lepr. 56: 261-266,1987. Converse, P.J., Mshana, R.M., and Bjune, G. Cimetidine inhibits suppressor factor production in Ethiopian lepromatous leprosy patients. Int. J. Lepr. 56:548-551, 1987. Converse, P.J., Ottenhoff, T.H.M, Gebre, N., Ehrenberg, J.P., and Kiessling, R. Cellular, humoral, and gamma interferon responses to Mycobacterium leprae and BCG antigens in healthy individuals exposed to leprosy. Scand. J. Immunol. 27: 515-525, 1988. Ottenhoff, T.H., Converse, P.J., Ehrenberg, J.E., Gebre, N., and Kiessling, R. T cell responses to fractionated Mycobacterium leprae antigens in leprosy. The lepromatous nonresponder defect can be overcome in vitro by stimulation with high molecular weight M. leprae components. Eur. J. Immunol. 19: 707-713, 1989. Kaplan, G., Kiessling, R., Hancock, G., Teklemariam, S., Sheftel, G., Job, C.K., Converse, P., Ottenhoff, T.H., Becx-Bleumink, M., Dietz, M., and Cohn, Z.A. The reconstitution of cell mediated immunity in the cutaneous lesions of lepromatous leprosy by rIL-2. J. Exp. Med. 169: 893-907, 1989. Ottenhoff, T.H.M., Kiessling, R., Converse, P.J., Li, S.G., and de Vries, R.R.P. Antigen specific T cell nonresponsiveness in man: lepromatous leprosy, a model disease. In: F. Melchers et al., eds., Progress in Immunology VII, 890-893, Springer-Verlag, Berlin, 1989. Converse, P., Ottenhoff, T.H.M., Teklemariam, S.W., Hancock, G.E., Dietz, M., BecxBleumink, M., Wondimu, A., Kiessling, R., Cohn, Z.A., and Kaplan, G. Intradermal recombinant interleukin 2 enhances peripheral blood T-cell responses to mitogen and antigens in patients with lepromatous leprosy. Scand. J. Immunol. 32: 83-91, 1990. Kaleab, B., Kiessling, R., Converse, P., Halapi, E., Tadesse, G., Rottenberg, M., and Ottenhoff, T. Mycobacterial-induced cytotoxic T cells as well as nonspecific killer cells derived from healthy individuals and leprosy patients. Eur. J. Immunol. 20: 2651-2659, 1990. Converse, P.J., Fehniger, T.E., Ehrnst, A., Strannegård, Ö. and Britton S. Immune responses to fractionated cytomegalovirus (CMV) antigens after HIV infection. Loss of cellular and humoral reactivity to antigenic fractions recognized by HIV-, CMV+ individuals. Clin. Exp. Immunol. 82:559566. 1990. Öhman, R., Walford, C., Converse, P., and Ridell, M. Reactions to antigens from Actinomycetes including Mycobacterium leprae in leprosy patients. Int. J. Leprosy. 59:320-322. 1991. Converse, P.J., Haines, V., Wondimu, A., Craig, L., and Meyers W.M. Infection of SCID mice with Mycobacterium leprae and control with antigen-activated "immune" human PBMC. Infect. Immun. 63: 1047-1054, 1995. Converse, P.J.Su, W.-J., Howard, N.S. RT/PCR to detect cytokines in a rabbit model of tuberculosis. Procs. Bovine TB Symposium (in press). Esa, A.H. and Converse, P.J. Nordihydroguaiaretic acid blocks IL-2 independent lymphocyte proliferative responses but enhances responses to tuberculin. Scand. J. Immunol. 43: 127-133, 1996. Converse, P.J., Dannenberg, A.M. Jr., Estep, J.E., Sugisaki, K., Abe, Y., Schofield, B.H., Pitt, M.L. Cavitary Tuberculosis Produced In Rabbits By Aerosolized Virulent Tubercle Bacilli. Infect. Immun. 64: 4776-4787 (1996). Converse, P.J., Jones, S.L., Astemborski, J., Vlahov, D., N.M. Graham. Comparison of a tuberculin interferon-gamma assay with the tuberculin skin test in high-risk adults: effect of human immunodeficiency virus infection. J Infect Dis. 176:144-50 (1997). Sugisaki, K., Dannenberg, A.M. Jr., Abe, Y., Tsuruta, J., Su, W.J., Said, W., Feng, L., Yoshimura, T., Converse, P.J., Mounts, P. Nonspecific and immune-specific up-regulation of cytokines in rabbit dermal tuberculous (BCG) lesions. J Leukoc Biol. 63:440-50 (1998). Converse, P.J., Dannenberg, A.M. Jr., Shigenaga, T., McMurray, D. N., Phalen, S.W., Stanford, J.L., Rook, G.A., Koru-Sengul, T. Abbey, H., Estep, J.E., Pitt, M.L. Pulmonary bovine-type tuberculosis in rabbits: bacillary virulence, inhaled dose effects, tuberculin sensitivity, and Mycobacterium vaccae immunotherapy. Clin Diagn Lab Immunol. 5:871-81 (1998). Kimura, M., Converse, P.J., Astemborski, J., Rothel, J.S., Vlahov, D., Comstock, G.W., Graham, N.M.H., Chaisson, R.E. and Bishai, W.R Comparison between a whole blood interferon-g release assay and tuberculin skin testing for the detection of tuberculosis infection among patients at risk for tuberculosis exposure. J. Infect. Dis. 179:1297-1300 (1999). Sheen, P., Converse, P.J., et al. Lack of Sensitivity and Specificity in a PPD-based whole blood gamma interferon test for Tuberculosis in a highly endemic Peruvian population. Submitted 2002.