Download Organic syntheses HSCP

UNIVERSITY OF NIŠ
Faculty of Science and Mathematics
Course Unit Descriptor Faculty
Department of Chemistry
GENERAL INFORMATION
Study program
Chemistry
Study Module (if applicable)
High school chemistry professor
Course title
Organic syntheses
Level of study
☐ Bachelor
 Master’s
Type of course
 Obligatory
☐ Elective
Semester
 Autumn
☐Spring
Year of study
first
Number of ECTS allocated
8
Name of lecturer/lecturers
Niko Radulović
 Lectures
Teaching mode
☐ Doctoral
☐Group tutorials
☐ Individual tutorials
 Laboratory work ☐ Project work
☐ Seminar
☐Distance learning ☐ Blended learning
☐ Other
PURPOSE AND OVERVIEW (max. 5 sentences)
The course introduces the student to the disconnection approach to organic synthesis, i.e. retrosynthetic analysis. With
this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create
simpler molecule; reversing this process gives a synthetic route to the target molecule from simpler starting materials.
Lectures on the synthesis of given types of molecules alternate with strategy lectures in which the methods just learnt
are placed in a wider context. The synthesis lectures cover many ways of making each type of molecule starting with
simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional
groups. The strategy lectures cover questions of selectivity, protection, stereochemistry, and develop more advanced
thinking via reagents specifically designed for difficult problems.
SYLLABUS (brief outline and summary of topics, max. 10 sentences)
The course is aimed at teaching the skills needed to design total synthesis of organic molecules. Both the knowledgebase of reactions which can be used, and the strategy of their employment will be covered. The course typically follows
the organization indicated below. Introduction: Planning Organic Syntheses; Synthons and Reagents: Aromatic
Compounds; Strategy I: The Order of Events; One-Group C-X Disconnections; Chemoselectivity; Two-Group C-X
Disconnections; Strategy III; Amine Synthesis; Protecting Groups; One Group C-C Disconnections I: Alcohols; General
Strategy A: Choosing Disconnections; Stereoselectivity A; One Group C-C Disconnections II: Carbonyl Compounds;
Regioselectivity; Alkene Synthesis; Strategy VII: Use of Acetylenes; Diels-Alder; Strategy VIII: Carbonyl Condensations; 1,3diCO Compounds; Control in C=O Condensations; 1,5-diCO Compounds; Nitro Groups; 1,2-diCO Compounds; Radicals; 1,4diCO Compounds; Reconnection; 1,6-diCO Compounds; Strategy of C=O Disconnections; Saturated Heterocycles;
Cyclopropanes; Rearrangements; Four-Membered Rings; Ketenes; Five-Membered Rings; Pericyclic Reactions; SixMembered Rings; Strategy of Ring Synthesis; Stereoselectivity B; Aromatic Heterocycles; Advanced Strategy.
LANGUAGE OF INSTRUCTION
 Serbian (complete course)
☐ English (complete course)
☐Serbian with English mentoring
☐Serbian with other mentoring ______________
☐ Other _____________ (complete course)
ASSESSMENT METHODS AND CRITERIA
Pre exam duties
Points
Final exam
points
Activity during lectures
10
Written examination
40
Practical teaching
10
Oral examination
10
Teaching colloquia
30
OVERALL SUM
100
*Final examination mark is formed in accordance with the Institutional documents