Download Angiogenesis PCR Array

Apoptosis and Cell Cycle PCR Array
细胞凋亡与细胞周期基因芯片
凋亡 PCR 芯片
细胞凋亡 PCR 芯片 384HT
细胞周期 PCR 芯片
Catalog No. PAHS-012A（人）
Apoptosis PCR Array
凋亡 PCR 芯片
Catalog No. PAMM-012A（小鼠）
Catalog No. PARN-012A（大鼠）
The Apoptosis RT² Profiler™ PCR Array profiles the expression of 84 key genes involved in apoptosis, or programmed cell death. The array includes the TNF ligands
and their receptors; members of the bcl-2, caspase, IAP, TRAF, CARD, death domain, death effector domain, and CIDE families; as well as genes involved in the p53
and ATM pathways. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to apoptosis with this array.
细胞凋亡 RT² Profiler™ PCR Array 可以同时测定 84 个与凋亡即细胞程序性死亡有关的关键基因。其中包括 TNF 配基及其受体，Bcl-2 家族成员、
caspase、IAP、TRAF、CARD、死亡结构域、死亡效应结构域和 CIDE 家族，同时还包括 p53 和 ATM 信号通路相关的基因。利用实时定量 PCR，
你可以方便并且可信地对与凋亡相关的基因进行同时检测。
TNF Ligand Family: CD40LG (TNFSF5), FASLG (TNFSF6), LTA, TNF, TNFSF10, TNFSF7, TNFSF8.
TNF Receptor Family: CD40 (TNFRSF5), FAS (TNFRSF6), LTBR, TNFRSF10A, TNFRSF10B, TNFRSF11B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25,
TNFRSF7, TNFRSF9.
Bcl-2 Family: BAD, BAG1, BAG3, BAG4, BAK1, BAX, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L11, BCL2L2, BCLAF1, BID, BIK, BNIP1, BNIP2, BNIP3, BNIP3L,
HRK, MCL1.
Caspase Family: CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9.
IAP Family: BIRC1, BIRC2, BIRC3, BIRC4, BIRC6, BIRC8.
TRAF Family: TRAF2, TRAF3, TRAF4.
CARD Family: APAF1, BCL10, BIRC2, BIRC3, CARD4, CARD6, CARD8, CASP1, CASP2, CASP4, CASP5, CASP9, CRADD, NOL3, PYCARD, RIPK2.
Death Domain Family: CRADD, DAPK1, FADD, FAS (TNFRSF6), TNFRSF10A, TNFRSF10B, TNFRSF11B, TNFRSF1A, TNFRSF21, TNFRSF25, TRADD.
Death Effector Domain Family: CASP8, CASP10, CFLAR, FADD.
CIDE Domain Family: CIDEA, CIDEB, DFFA.
p53 and DNA Damage Response: ABL1, AKT1, APAF1, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, GADD45A, TP53, TP53BP2, TP73.
Anti-apoptosis: AKT1, BAG1, BAG3, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L2, BFAR, BIRC1, BIRC2, BIRC3, BIRC4, BIRC6, BIRC8, BNIP1, BNIP2, BNIP3,
BRAF, CASP2, CFLAR, FAS (TNFRSF6), IGF1R, MCL1, TNF, TNFRSF7.
TNF 配基家族;TNF 受体家族；Bcl-2 家族；Caspase 家族；IAP 家族；TRAF 家族；CARD 家族；死亡结构域家族；死亡效应结构域家族；CIDE 结构域；P53 和 DNA
损伤反应有关基因；抗凋亡基因
Apoptosis PCR Array 384HT
细胞凋亡 PCR 芯片 384HT
Catalog No. PAHS-3012A（人）
The Human Apoptosis RT² Profiler PCR Array 384HT profiles the expression of 370 key genes involved in apoptosis, or programmed cell death. The array includes the
TNF ligands and their receptors; members of the bcl-2 family, BIRC (baculoviral IAP repeat) domain proteins, CARD domain (caspase recruitment domain) proteins,
death domain proteins, TRAF (TNF receptor-associated factor) domain proteins and caspases. These 370 genes are also grouped by their functional contribution to
apoptosis, either anti-apoptotic regulation or the induction of apoptosis by death domain receptors, DNA damage, oxidative stress, or extracellular and intracellular
signals. Using real-time PCR, you can easily and reliably analyze the expression of a focused panel of genes related to apoptosis with this array.
细胞凋亡 RT² Profiler™ PCR Array384HT 可以同时测定 370 个与细胞凋亡、程序性死亡相关的关键基因的表达谱。其中包括 TNF 配体及其受体、
bcl-2 家族成员、BIRC（baculoviral）结构域蛋白、CARD（caspase recruitment domain）结构域蛋白、
死亡结构域蛋白、TRAF（TNF receptor-associated
facor）结构域蛋白和 caspases。这 370 个基因涉及以下几种功能：凋亡、通过死亡结构域受体诱导凋亡或抗凋亡、DNA 损伤、氧化应激以及细胞
内和细胞外信号转导。利用实时定量 PCR，你可以方便并且可信地对与凋亡相关的基因进行同时检测。
TNF Domain Proteins: EDA, FASLG, LTA, LTB, TNF, TNFSF10, TNFSF14, TNFSF15, TNFSF8.
TNFR Domain Proteins: CD27, CD40, FAS, LTBR, NGFR, TNFRSF10A, TNFRSF10B, TNFRSF10D, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21,
TNFRSF25, TNFRSF6B, TNFRSF8, TNFRSF9.
BCL2 and BAG Domain Proteins: BAG1, BAG3, BAG4, BAX, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L13, BCL2L2, MCL1.
BIR Domain Proteins: BIRC2, BIRC3, BIRC4, BIRC5, BIRC6, BIRC7, BIRC8, NAIP (BIRC1).
CARD Domain Proteins: APAF1, BCL10, BIRC2, BIRC3, CARD10, CARD11, CARD14, CARD6, CARD8, CARD9, CASP1, CASP2, CASP4, CASP5, CASP9,
CRADD, ICEBERG, INCA, NLRP1 (NALP1), NOD1, NOD2, NOL3, PYCARD, RFWD2 (COP1), RIPK2.
DEATH Domain Proteins: CRADD, DAPK1, EDAR, FADD, LRDD, MALT1, NFKB1, NFKB2, NGFR, RIPK1, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF21,
TNFRSF25, TRADD.
TRAF Domain Proteins: TRAF2, TRAF3, TRAF5, TRAF7.
Caspases and Regulators:
Caspases: CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9, CFLAR, CRADD, ICEBERG, INCA, MALT1,
PYCARD, RFWD2 (COP1).
Caspase activators: AIFM3, APAF1, BAX, BBC3, BCL2L10, BCL2L13, CARD8, CASP1, CASP8AP2, CASP9, COL4A3, CYCS, DIABLO, EIF2AK3, F2, F2R,
FOXL2, HIP1, HSPE1, IFNB1, IFT57, LCK, MAP3K5, MOAP1, MTCH1, MYC, NLRC4, NLRP1, NLRP12, NLRP2, NLRP3, NOD1, PMAIP1, PYCARD, STAT1,
TNFRSF10A, TNFRSF10B, TNFSF15, TP53, TPD52L1, VCP.
Caspase inhibitors: BIRC4, BIRC5, CD27, DHCR24, HBXIP, IFI6, SFN, TNFAIP8, TNFSF14, TRIAP1.
Anti-Apoptosis Genes:
Positive regulation of anti-apoptosis: BCL2L1, BRE, CD28, ERC1, MAPK8IP2, OPA1, PRKAA1, RASA1.
Negative regulation of anti-apoptosis: PIK3R2, RTN4, TNFAIP8.
Other genes involved in anti-apoptosis: AATF, AKT1, ALOX12, ANXA1, ANXA4, API5, ATF5, AVEN, AZU1, BAG1, BAG3, BAG4, BCL2, BCL2A1, BCL2L1,
BCL2L10, BCL2L2, BDNF, BECN1, BFAR, BIRC2, BIRC3, BIRC4, BIRC5, BIRC6, BIRC7, BIRC8, BNIP1, BNIP2, BNIP3, BRAF, CASP2, CBX4, CCL2, CD27,
CD40LG, CEBPB, CFDP1, CFL1, CFLAR, CRYAA, CRYAB, DAD1, DDAH2, DHCR24, EEF1A2, FAIM, FAIM2, FAS, FOXO1, GDNF, GFRAL, GLO1, GSTP1,
HBXIP, HD, HDAC1, HDAC3, HIPK3, HMGB1, HSP90B1, HSPA1B, HSPA9, HSPB1, HTATIP2, IER3, IFI6, IGF1R, IL10, IL1A, IL2, IL31RA, MALT1, MCL1, MKL1,
MPO, MTL5, MYBL2, MYO18A, NAIP, NFKB1, NME5, NOL3, NOTCH2, NPM1, NRG2, NTF3, PAK7, PAX7, PEA15, PIK3CA, PIM2, POGK, POLB, PRDX2,
PRKCZ, PRLR, PROK2, PSEN1, RELA, RNF7, SEMA4D, SERPINB2, SERPINB9, SFRP1, SH3GLB1, SNCA, SOCS2, SOCS3, SON, SPHK1, SPP1, STAMBP,
TAX1BP1, TBX3, TGFB1, TIAF1, TNF, TNFAIP3, TNFAIP8, TNFRSF10D, TNFRSF18, TNFRSF6B, TNFSF18, TPT1, TRIAP1, TSC22D3, TXNDC1, VHL,
YWHAZ, ZC3HC1.
Induction of Apoptosis:
Induction of apoptosis via death domain receptors: BID, CRADD, DAXX, DEDD2, FADD, IL18, TNF, TNFRSF10B.
induction of apoptosis by DNA damage: ABL1, AIFM1, BCL3, BRCA1, CHEK2, CIDEA, CIDEB, DYRK2, IFI16, MBD4, MSH6, PCBP4, PML, SFN, TP53, TP73.
Induction of apoptosis by oxidative stress: GPX1, PRODH, RNF7, TP53I3
Induction of apoptosis by extracellular signals: ADORA1, BTK, CASP8AP2, CD28, CD38, CD5, CFLAR, DAP, DAP3, DAPK1, DPF2, FASTK, MAP3K5, NDUFA13,
PDCD6, PRKCA, RIPK3, SPN, TIMP3, TNFRSF25.
Induction of apoptosis by intracellular signals: CDKN1A, CUL1, CUL2, CUL3, CUL4A, CUL5, HIPK2, MYC, SART1.
Other genes involved in induction of apoptosis: ACVR1B, AIFM2, AIFM3, ALOX15B, APOE, BAD, BAK1, BAX, BBC3, BCL10, BCL2L11, BCL2L13, BCLAF1, BIK,
BNIP1, BNIP3, BNIP3L, BOK, CASP10, CASP3, CASP4, CASP6, CD2, CD27, CD70, CEBPB, CIDEC, COL4A3, DAPK2, DAPK3, DCC, DDX20, DEDD, DIABLO,
EI24, ERCC2, ERCC3, ERN1, ERN2, FAS, FASLG, FEM1B, FOXL2, FOXO3, HD, HRK, HTATIP2, IFNA2, IFNB1, IKBKG, IKIP, IL19, INHA, INHBA, JMY, LALBA,
LCK, LTA, MAL, MAP3K10, MAPK1, MX1, NDUFS3, NGFR, NLRP1, NLRP3, NME3, NOTCH2, NOX5, NUDT2, NUPR1, PDCD5, PLAGL1, PLAGL2, PLEKHF1,
PLG, PMAIP1, PPP1R13B, PPP2CA, PPP2R1A, PPP2R1B, PRKCE, PRKRA, PRUNE2, PTEN, PTH, PYCARD, RPS3A, RUNX3, S100B, SAP30BP, SERINC3,
SIPA1, SIVA1, SMNDC1, SST, SSTR3, STK17A, STK17B, TBX5, TIA1, TIAL1, TLR2, TNFRSF10A, TNFRSF19, TNFRSF9, TNFSF10, TNFSF14, TNFSF8,
TP53BP2, TP73L, TPD52L1, TRADD, TRAF3, TRAIP, UNC13B, UTP11L, ZNF443.
Other Regulators of Apoptosis: BAPX1, BCL6, CEBPG, DBP, DDIT3, GRM4, LGALS1, MADD, MAPK8, POU4F1, PROP1, RARG, STAT5A, STAT5B, TBK1,
TDGF1, TRAF6, ZAK.
TNF 结构域家族;TNF 受体家族；Bcl-2 和 BAG 结构域家族；BIR 结构域家族；CARD 家族；死亡结构域家族；Caspase 家族；抗凋亡基因；促凋亡基因
Cell Cycle PCR Array
Catalog No. PAHS-020A（人）
细胞周期 PCR 芯片
Catalog No. PAMM-020A（小鼠）
Catalog No. PARN-020A（大鼠）
The Cell Cycle RT²Profiler™ PCR Array profiles the expression of 84 genes key to cell cycle regulation. This array contains genes that both positively and negatively
regulate the cell cycle, the transitions between the each of the phases, DNA replication, checkpoints and arrest. Using real-time PCR, you can easily and reliably analyze
expression of a focused panel of genes related to the cell cycle with this array.
细胞周期 RT² Profiler™ PCR Array 可以同时测定 84 个与细胞周期调节有关的关键基因。这些基因包括细胞周期的正调控、负调控等调控因子、各
细胞周期转换控制因子、DNA 复制相关基因、检验点和细胞周期阻滞相关基因。利用实时定量 PCR，你可以方便并且可信地对与细胞周期相关的基
因进行同时检测。
G1 phase and G1/S transition: ANAPC2, CCND1, CCNE1, CDC34, CDK4, CDK6, CDKN1B, CDKN3, CUL1, CUL2, CUL3, SKP2.
S phase and DNA replication: ABL1, MCM2, MCM3, MCM4, MCM5, PCNA, RPA3, SUMO1, UBE1.
G2 phase and G2/M transition: ANAPC2, ANAPC4, ARHI, BCCIP, BIRC5, CCNB1, CCNG1, CCNH, CCNT1, CCNT2, CDK5R1, CDK5RAP1,
CDK7, CDKN3, CKS1B, CKS2, DDX11, DNM2, GTF2H1, GTSE1, HERC5, KPNA2, MNAT1, SERTAD1.
M phase: CCNB2, CCNF, CDC2, CDC16, CDC20, MRE11A, RAD51.
Cell cycle checkpoint and cell cycle arrest: ATM, ATR, BRCA1, BRCA2, CCNG2, CDC2, CDC34, CDK2, CDKN1A, CDKN1B, CDKN2A,
CDKN2B, CDKN3, CHEK1, CHEK2, CUL1, CUL2, CUL3, GADD45A, HUS1, KNTC1, MAD2L1, MAD2L2, NBS1, RAD1, RAD17, RAD9A, RB1,
RBBP8, TP53.
Regulation of cell cycle: ABL1, ANAPC2, ANAPC4, ARHI, ATM, ATR, BCCIP, BCL2, BRCA2, CCNB1, CCNB2, CCNC, CCND1, CCND2,
CCNE1, CCNF, CCNH, CCNT1, CCNT2, CDC16, CDC2, CDC20, CDK2, CDK4, CDK5R1, CDK6, CDK7, CDK8, CDKN1A, CDKN1B, CKS1B,
DDX11, E2F4, GADD45A, KNTC1, MKI67, PCNA, RAD9A, RB1, SKP2, TFDP1, TFDP2.
Negative regulation of cell cycle: ATM, BAX, BRCA1, CDKN2B, RBL1, RBL2, TP53.
G1 期和 G1/S 期转换有关基因；S 期和 DNA 复制有关基因；G2 期和 G2/M 期转换有关基因；M 期有关基因；细胞周期检验点和细胞周期阻滞基因；细胞周期调节因子；
细胞周期副调控因子
Cancer PCR Array
肿瘤 PCR 芯片
肿瘤转移 PCR 芯片
血管生成 PCR 芯片
肿瘤转移 PCR 芯片
血管生长因子与血管生成抑制因子 PCR 芯片
Catalog No. PAHS-024A（人）
Angiogenesis PCR Array
血管生成 PCR 芯片
Catalog No. PAMM-024A（小鼠）
Catalog No. PARN-024A（大鼠）
The Angiogenesis RT² Profiler™ PCR Array profiles the expression of 84 key genes involved in modulating the biological processes of angiogenesis. The array includes
growth factors and their receptors, chemokines and cytokines, matrix and adhesion molecules, proteases and their inhibitors, as well as transcription factors, all involved
in the development of new blood vessels. Angiogenesis is a hallmark in the pathology of many diseases, including cancer, ischemia, atherosclerosis, and inflammatory
diseases. Angiogenesis plays additional roles in normal development and physiological processes in adults, including wound healing and tissue regeneration. Using
real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to angiogenesis with this array.
血管生成 RT² Profiler™ PCR Array 可以同时测定调节 84 个与血管生成相关的关键基因表达谱。其中包括与新的血管发育有关的生长因子、生长因
子受体、趋化因子、细胞因子、细胞外基质、黏附分子、蛋白酶及其抑制剂、转录因子等。血管生成是多种疾病的一个标志性事件，如肿瘤、局部
缺血、动脉粥样硬化和炎症疾病。血管生成在正常发育和成人的生理过程中发挥重要功能，如伤口愈合和组织再生。利用实时定量 PCR，你可以方
便并且可信地对与之相关的基因进行同时检测。
Angiogenic factors:
Growth factors and receptors: ANGPT1, ANGPT2, ANPEP, ECGF1, EREG, FGF1, FGF2, FIGF, FLT1, JAG1, KDR, LAMA5, NRP1, NRP2, PGF, PLXDC1, STAB1,
VEGF, VEGFC.
Adhesion molecules: ANGPTL3, BAI1, COL4A3, IL8, LAMA5, NRP1, NRP2, STAB1.
Proteases, inhibitors and other matrix proteins: ANGPTL4, PECAM1, PF4, PROK2, SERPINF1, TNFAIP2.
Transcription factors and others: HAND2, SPHK1.
Other factors involved in angiogenesis:
Cytokines and chemokines: CCL11, CCL2, CXCL1, CXCL10, CXCL3, CXCL5, CXCL6, CXCL9, IFNA1, IFNB1, IFNG, IL1B, IL6, MDK, TNF.
Other growth factors and receptors: EDG1, EFNA1, EFNA3, EFNB2, EGF, EPHB4, FGFR3, HGF, IGF1, ITGB3, PDGFA, TEK, TGFA, TGFB1, TGFB2, TGFBR1.
Adhesion molecules: CCL11, CCL2, CDH5, COL18A1, EDG1, ENG, ITGAV, ITGB3, THBS1, THBS2.
Proteases, inhibitors and other matrix proteins: LECT1, LEP, MMP2, MMP9, PLAU, PLG, TIMP1, TIMP2, TIMP3.
Transcription factors and others: AKT1, HIF1A, HPSE, ID1, ID3, NOTCH4, PTGS1. 、
血管生成因子；血管生成相关的其他因子
Catalog No. PAHS-072A（人）
Angiogenic Growth Factors & Angiogenesis Inhibitors PCR Array
血管生长因子与血管生成抑制因子 PCR 芯片
Catalog No. PAMM-072A（小鼠）
Catalog No. PARN-072A（大鼠）
The Angiogenic Growth Factors & Angiogenesis Inhibitors RT² Profiler™ PCR Array profiles the expression of 84 growth factors and inhibitors related to angiogenesis.
This array contains the growth factors, cytokines, and chemokines that promote the biogenesis of new blood vessels and the genes that encode inhibitors of this process.
Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to the promotion and inhibition of angiogenesis with this array.
血管生成因子与血管生成抑制因子 RT² Profiler™ PCR Array 可以同时测定调节 84 个与血管生成相关的生长因子或抑制基因的表达谱。其中包括与
促进或抑制新的血管生成相关的生长因子、细胞因子、趋化因子等。利用实时定量 PCR，你可以方便并且可信地对与促进或抑制血管生成相关的基
因进行同时检测。
Angiogenic Growth Factors and Related Genes:
Growth Factors: ECGF1, FGF1, FGF13, FGF2, FGFBP1, FIGF, GRN, GRP, HGF, KITLG, LEP, MDK, PDGFB, PDGFD, PGF, PROK1, TGFA, VEGFA.
Cytokines and Chemokines: BMP2, CCL15, CCL2, CSF3, CXCL11, CXCL12, CXCL13, CXCL14, CXCL3, CXCL5, CXCL6, CXCL9, IL10, IL6, IL8, PPBP, PTN, TNF.
Other Positive Regulators of Angiogenesis: AGGF1, AMOT, ANG, ANGPT1, BTG1, EDIL3, EREG, FST, RHOB, RUNX1.
Angiogenesis Inhibitors and Related Genes:
Cytokines, Chemokines and Growth Factors: CXCL10, CXCL2, IFNG, IL12A, IL12B, IL17F, PF4, TGFB1.
Other Negative Regulators of Angiogenesis: ANGPT2, ANGPTL1, BAI1, CD55, CD59, CHGA, COL18A1, COL4A3, FN1, IFNA1, IFNB1, KLK3, MLLT7, NPPB,
NPR1, PLG, PRL, RNH1, SERPINC1, SERPINE1, SERPINF1, SPINK5, STAB1, THBS1, TIE1, TIMP1, TIMP2, TIMP3, TNNI2, TNNI3.
血管生长因子及相关基因、血管生成抑制因子及相关基因
Tumor Metastasis PCR Array
Catalog No. PAHS-028A（人）
肿瘤转移 PCR 芯片
Catalog No. PAMM-028A（小鼠）
The Tumor Metastasis RT² Profiler™ PCR Array is designed to represent 84 genes known to be involved in metastasis. Genes selected for this array encode several
classes of protein factors including cell adhesion, ECM components, cell cycle, cell growth and proliferation, apoptosis, transcription factors and regulators and other
genes related to tumor metastasis. This array can help you investigate the molecular mechanism of metastasis or understand how a particular tumor metastasized.
Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to metastasis.
肿瘤转移 RT² Profiler™ PCR Array 可以同时检测已知的参与肿瘤转移的 84 个基因表达谱。本芯片所选的基因编码以下几类蛋白因子：细胞黏附，
ECM 成分，细胞周期，细胞生长和增殖，凋亡，转录因子和调节子以及其他一些转移相关因子。本芯片能够帮助研究者研究转移的分子机制或者了
解一个特定的肿瘤转移过程。利用实时定量 PCR，你可以方便并且可信地对与肿瘤转移相关的基因进行同时检测。
Cell Adhesion Genes:
Cell to Cell Adhesion: APC, CD44, CDH1 (cadherin-1 / E-cadherin), CDH11, CDH6, FAT, FXYD5, ITGA7, PNN, SYK, VEGF.
Transmembrane Receptors: CD44, ITGA7, ITGB3, LAMR1.
Other Genes Related to Adhesion: CTNNA1, FN1, MCAM, MGAT5 (acetylglucosaminyltransferase V), MTSS1.
Extracellular Matrix Proteins:
Matrix Metalloproteinases: MMP10, MMP11, MMP13, MMP2, MMP3, MMP7, MMP9.
MMP Inhibitors: TIMP2, TIMP3, TIMP4.
Other ECM Proteins: COL4A2 (collagen a2(IV)), HPSE (heparanase).
Cell Cycle Genes:
Regulation of the Cell Cycle: HRAS, IL1B, KRAS, TGFB1(TGF-β1), VEGF.
Negative Regulation of the Cell Cycle: APC, BRMS1 (BrMS1), CDKN2A, MTSS1, NF2, NME1, NME2, PTEN, RB1, TP53.
Cell Cycle Arrest and Checkpoint: CDKN2A, MYC (c-myc), RB1, TP53.
Cell Growth and Proliferation Genes:
Negative Regulation of Cell Proliferation: CDKN2A, CTBP1, GNRH1, IL1B, MDM2, NF2, NME1, NME2, SSTR2.
Positive Regulation of Cell Proliferation: IGF1, IL18, TSHR, VEGF.
Growth Factors and Hormones: GNRH1, HGF (Scatter Factor), IGF1, TGFB1 (TGF-β1), VEGF.
Cytokines and Chemokines: CCL7, CXCL12, IL18, IL1B, TNFSF10.
Receptors: CXCR4, EPHB2, FGFR4, FLT4, GPR54, IL8RB, MET, NR4A3, PLAUR (uPAR), RORB, SSTR2, TSHR.
Other Genes Related to Growth: DENR, EWSR1, HRAS (c-hRas), MYC (c-myc), SET, SRC (c-src), SYK, TRPM1.
Apoptosis genes:
Induction of Apoptosis: HTATIP2, IL18, TIMP3, TNFSF10, TP53.
Anti-apoptosis: HTATIP2, TGFB1.
Other Genes Related to Apoptosis: CXCR4, IL1B.
Transcription Factors and Regulators:
Transcription Factors: ETV4, HTATIP2, MTA1, MYC (c-myc), MYCL1, NME2, NR4A3, RB1, RORB, SMAD4, TCF20, TP53.
Regulators: CHD4, EWSR1, SMAD2.
Other Genes Related to Metastasis: CST7, CTSK, CTSL (cathepsin L), KAI1, KISS1 (KiSS-1), METAP2, NME4.
细胞黏附有关基因；细胞外基质蛋白分子；细胞周期相关基因；细胞生长和分化有关基因；细胞凋亡相关基因；转录因子及其调节因子；其他与肿瘤转移相关基因
肿瘤发生机理 PCR 芯片
癌通路发现者 PCR 芯片
氧化应激与抗氧化 PCR 芯片
DNA 损伤信号通路 PCR 芯片
应激与毒性通路发现者 PCR 芯片
p53 信号通路 PCR 芯片
细胞损失应激反应 PCR 芯片
Catalog No. PAHS-033A（人）
Cancer PathwayFinder PCR Array
癌通路发现者 PCR 芯片
Catalog No. PAMM-033A（小鼠）
Catalog No. PARN-033A（大鼠）
The Cancer Drug Resistance & Metabolism RT² Profiler™ PCR Array profiles the expression of 84 genes involved in the body's response to chemotherapy. The genes
encoding important enzymes for drug resistance (such as the P-glycoproteins), phase I metabolism (specifically the P450 family), and phase II metabolism (such as
various covalent modification enzymes) are all represented on the array. Cancer-related genes involved in aspects of resistance are also included on the array such as
DNA repair enzymes, cell cycle regulators, growth factor and hormone receptors, and transcription factors. Using real-time PCR, you can easily and reliably analyze
expression of a focused panel of genes related to cancer drug resistance and metabolism with this array.
肿瘤信号通路发现者 RT² Profiler™ PCR Array 可以同时测定 84 个与转化和肿瘤发生密切相关的代表性的六个信号通路有关的关键基因。使用此
Array，你可以首先确定哪个信号通路在你的实验处理中被激活。你可以通过其他的信号通路特异性的 PCR Array 来研究更为细节的基因表达谱。
利用实时定量 PCR，你可以方便并且可信地对与肿瘤发生相关的基因进行同时检测。
Cell Cycle Control & DNA Damage Repair:
ATM, BRCA1, CCNE1 (cyclin E1), CDC25A, CDK2, CDK4, CDKN1A (p21Waf1), CDKN2A (p16Ink4), CHEK2 (chk2 / Rad53), E2F1, MDM2, RB1, S100A4, TP53
(p53).
Apoptosis and Cell Senescence:
APAF1, BAD, BAX, BCL2, BCL2L1 (bcl-X), CASP8, CFLAR (CASPER), GZMA, HTATIP2, TERT (telomerase), TNFRSF1A (TNF-α receptor), TNFRSF10B (DR5),
TNFRSF25 (DR3).
Signal Transduction Molecules and Transcription Factors:
AKT1, ERBB2, ETS2, FOS, JUN, MAP2K1 (MEK), MYC, NFKB1 (NFκB), NFKBIA (IκBα), PIK3R1 (PI3K p85α), RAF1, SNCG.
Adhesion:
ITGA1 (integrin α1), ITGA2 (integrin α2), ITGA3 (integrin α3), ITGA4 (integrin α4), ITGAV (integrin αV), ITGB1 (integrin β1), ITGB3 (integrin β3), ITGB5 (integrin β5),
MCAM, MTSS1, PNN, SYK, UCC1.
Angiogenesis:
ANGPT1 (angiopoietin-1), ANGPT2 (angiopoietin-2), COL18A1 (endostatin), FGFR2, IFNA1 (IFNα), IFNB1 (IFNβ), IGF1, IL8, PDGFA, PDGFB, TEK (tie-2), TGFB1,
TGFBR1 (ALK-5), THBS1 (thrombospondin-1), TNF, VEGF.
Invasion and Metastasis:
MET, MMP1 (collagenase-1), MMP2 (gelatinase A), MMP9 (gelatinase B), MTA1, MTA2, NME1, NME4, PLAU, PLAUR, S100A4, SERPINB5 (maspin), SERPINE1
(PAI1), TIMP1, TIMP3, TWIST1.
细胞周期控制和 DNA 损伤修复相关基因；凋亡和细胞衰老有关基因；信号转导分子和转录因子；黏附分子；血管生成有关基因；侵入和转移有关基因
Catalog No. PAHS-029A（人）
DNA Damage Signaling Pathway PCR Array
DNA 损伤信号通路 PCR 芯片
Catalog No. PAMM-029A（小鼠）
Catalog No. PARN-029A（大鼠）
The DNA Damage Signaling RT² Profiler™ PCR Array profiles the expression of 84 genes involved in DNA damage signaling pathways. The genes featured are those
associated with the ATR/ATM signaling network and transcriptional targets of DNA damage response. DNA damage can result in cell cycle arrest, apoptosis, and the
stabilization and repair of the cellular genome. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to DNA Damage
Signaling with this array.
DNA 损伤信号通路 RT² Profiler™ PCR Array 可以同时测定 84 个与 DNA 损伤信号通路有关的基因。这些基因包括与 ART/ATM 信号通路有关的基
因，还包括 DNA 损伤反应转录靶基因。DNA 损伤可以导致细胞周期阻滞、凋亡、细胞基因组的稳定和修复。利用实时定量 PCR，你可以方便并且
可信地对与 DNA 损伤信号通路相关的基因进行同时检测。
Apoptosis: ABL1, BRCA1, CIDEA, GADD45A, GADD45G, GML, IHPK3, PCBP4, PDCD8, PPP1R15A, RAD21, TP53, TP73.
Cell Cycle:
Cell Cycle Arrest: CHEK1, CHEK2, DDIT3 (CHOP), GADD45A, GML, GTSE1, HUS1, MAP2K6, MAPK12, PCBP4, PPP1R15A, RAD17, RAD9A, SESN1, ZAK.
Cell Cycle Checkpoint: ATR, BRCA1, FANCG, NBS1, RAD1, RBBP8, SMC1L1, TP53.
DNA Repair:
Damaged DNA Binding: ANKRD17, BRCA1, DDB1, DMC1, ERCC1, FANCG, FEN1, MPG, MSH2, MSH3, N4BP2, NBS1, OGG1, PMS2L3 (PMS2L9), PNKP, RAD1,
RAD18, RAD51, RAD51L1, REV1L, SEMA4A, XPA, XPC, XRCC1, XRCC2, XRCC3.
Base-excision Repair: APEX1, MBD4, MPG, MUTYH, NTHL1, OGG1, UNG.
Double-strand Break Repair: CIB1, FEN1, G22P1, KUB3, MRE11A, NBS1, PRKDC, RAD21, RAD50.
Mismatch Repair: ABL1, ANKRD17, EXO1, MLH1, MLH3, MSH2, MSH3, MUTYH, N4BP2, PMS1, PMS2, PMS2L3 (PMS2L9), TP73, TREX1.
Other Genes Related to DNA Repair: APEX2, ATM, ATRX, BTG2, CCNH, CDK7, CRY1, ERCC2 (XPD), GTF2H1, GTF2H2, IGHMBP2, LIG1, MNAT1, PCNA, RPA1,
SUMO1.
凋亡相关基因；细胞周期有关基因；DNA 修复有关基因
Catalog No. PAHS-027A（人）
p53 Signaling Pathway PCR Array
p53 信号通路 PCR 芯片
Catalog No. PAMM-027A（小鼠）
Catalog No. PARN-027A（大鼠）
The p53 Signaling Pathway RT² Profiler™ PCR Array profiles the expression of 84 genes related to p53-mediated signal transduction. The array includes p53-related
genes involved in the processes of apoptosis, the cell cycle, cell growth, proliferation, and differentiation, and DNA repair. Using real-time PCR, you can easily and
reliably analyze expression of a focused panel of genes related to p53 signaling pathway with this array.
p53 信号通路 RT² Profiler™ PCR Array 可以同时测定 84 个与 p53 信号通路相关的基因。这些基因包括与 p53 信号通路相关的基因，这些基因参与
细胞凋亡、细胞周期、细胞生长、增殖和分化以及 DNA 修复等。利用实时定量 PCR，你可以方便并且可信地对与 p53 信号通路相关的基因进行同
时检测。
Apoptosis Genes:
Induction of Apoptosis: BAX, BID, CDKN1A, CRADD, EI24, FADD, FASLG (TNFSF6), FOXO3, PCBP4, PRKCA, TNFRSF10B, TP53, TP73, TP73L.
Anti-Apoptosis: BCL2, BCL2A1, BIRC5, CASP2, HDAC1, IGF1R, MCL1, NFKB1, RELA, TNF, TNFRSF10D.
Other Apoptosis Genes: APAF1, BRCA1, CASP9, E2F1, GADD45A, GML, LRDD, P53AIP1, SIAH1, SIRT1, TP53BP2, TRAF2.
Cell Cycle Genes:
Cell Cycle Arrest: CDKN1A, CDKN2A, CHEK1, CHEK2, GADD45A, GML, MYC, PCAF, PCBP4, RPRM, SESN1, SESN2.
Cell Cycle Checkpoint: ATR, BRCA1, CCNE2, CCNG2, CDKN2A, RB1, TP53.
Negative Regulation of the Cell Cycle: ATM, BAX, BRCA1, CDKN2A, MSH2, NF1, PTEN, RB1, TP53, TP73, TP73L, TSC1, WT1.
Regulation of the Cell Cycle: BRCA2, CDC2, CDC25A, CDK4, E2F1, E2F3, HK2, IGF1R, KRAS, PPM1D, PRKCA, STAT1, TADA3L, TP53BP2.
Other Cell Cycle Genes: BIRC5, CCNH, CCNB2, ESR1, MLH1, PCNA, PRC1.
Cell Growth, Proliferation and Differentiation Genes:
Negative Regulation of Cell Proliferation: BAI1, BCL2, BTG2, CDKN1A, CDKN2A, CHEK1, GML, IFNB1, IL6, MDM2, MDM4, NF1, PCAF, PPM1D, SESN1.
Positive Regulation of Cell Proliferation: IGF1R, IL6.
Cell Proliferation: BRCA1, CDC25A, CDC25C, CDK4, E2F1, MYC, PCNA, PRKCA.
Cell Growth and Differentiation: ESR1, MCL1, MYOD1.
Other Genes Related to Cell Growth, Proliferation, and Differentiation: EGR1, FOXO3A, JUN, KRAS, PTTG1.
DNA Repair Genes: ATM, ATR, BRCA1, BTG2, CCNH, DNMT1, GADD45A, MSH2, PCNA, PTTG1, TP53, XRCC5.
细胞凋亡相关基因；细胞周期相关基因；细胞生长、增殖和分化相关基因
Catalog No. PAHS-065A（人）
Oxidative Stress and Antioxidant Defense PCR Array
氧化应激与抗氧化 PCR 芯片
Catalog No. PAMM-065A（小鼠）
Catalog No. PARN-065A（大鼠）
The Oxidative Stress and Antioxidant Defense RT² Profiler™ PCR Array profiles the expression of 84 genes related to oxidative stress. Peroxidases are represented on
this array including glutathione peroxidases (GPx) and peroxiredoxins (TPx). Also included are the genes involved in reactive oxygen species (ROS) metabolism, such
as oxidative stress responsive genes and genes involved in superoxide metabolism such as superoxide dismutases (SOD). Using real-time PCR, you can easily and
reliably analyze expression of a focused panel of genes related to oxidative stress with this array.
氧化应激和抗氧化 RT2 ProfilerTM PCR Array 可以同时检测 84 个与氧化压力有关的基因。过氧化物酶类包括谷胱甘肽过氧化物酶和过氧化物酶。其
他活性氧自由基代谢的酶类，如：氧化应激反应基因、超氧化物代谢相关基因如超氧化物歧化酶 A（SOD）等也包含在内。利用实时定量 PCR，你
可以方便并且可信地对与氧化应激反应相关的基因进行同时检测。
Antioxidants:
Glutathione Peroxidases (GPx): GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSTZ1.
Peroxiredoxins (TPx): PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, PRDX6.
Other Peroxidases: CAT, CSDE1, CYGB, DUOX1, DUOX2, EPX, GPR156, LPO, MGST3, MPO, PIP3-E, PTGS1, PTGS2, PXDN, PXDNL, TPO, TTN.
Other Antioxidants: ALB, APOE, GSR, MT3, SELS, SOD1, SOD3, SRXN1, TXNDC2, TXNRD1, TXNRD2.
Genes Involved in Reactive Oxygen Species (ROS) Metabolism:
Superoxide Dismutases (SOD): SOD1, SOD2, SOD3.
Other Genes Involved in Superoxide Metabolism: ALOX12, CCS, CYBA, DUOX1, DUOX2, GTF2I, MT3, NCF1, NCF2, NOS2A, NOX5, PREX1, PRG3.
Other Genes Involved in ROS Metabolism: AOX1, BNIP3, EPHX2, MPV17, SFTPD.
Oxidative Stress Responsive Genes: ANGPTL7, APOE, ATOX1, CAT, CCL5, CSDE1, CYGB, DGKK, DHCR24, DUOX1, DUOX2, DUSP1, EPX, FOXM1, GLRX2,
GPR156, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSS, KRT1, LPO, MBL2, MPO, MSRA, MTL5, NME5, NUDT1, OXR1, OXSR1, PDLIM1, PIP3-E, PNKP,
PRDX2, PRDX5, PRDX6, PRNP, RNF7, SCARA3, SELS, SEPP1, SGK2, SIRT2, SOD1, SOD2, SRXN1, STK25, TPO, TTN, TXNRD2.
抗氧化相关的基因；活性氧自由基代谢有关的基因
Catalog No. PAHS-003A（人）
Stress & Toxicity PathwayFinder PCR Array
应激与毒性通路发现者 PCR 芯片
Catalog No. PAMM-003A（小鼠）
Catalog No. PARN-003A（大鼠）
The Stress and Toxicity PathwayFinder™ RT²Profiler™ PCR Array profiles the expression of 84 genes whose expression level is indicative of stress and toxicity. The
array includes genes that are directly up-regulated by oxidative or metabolic stress and by heat shock. The array also includes genes representative of pathways
activated by prolonged stress, which range from cell death by apoptosis or necrosis to growth arrest and senescence to proliferation and carcinogenesis. This kit is also
designed to include only those genes that have been reported in the literature to respond to a toxic compound at the transcriptional level. Using real-time PCR, you can
easily and reliably analyze expression of a focused panel of genes related to Stress & Toxicity Pathway with this array.
应激和毒性通路发现者 RT2 ProfilerTM PCR Array 可以同时检测与应激和毒性相关的 84 个基因表达谱。其中包括氧化和代谢应激以及热休克应激直
接上调基因。也包括延缓应激通路活化指示基因，这些延缓应激包括凋亡或坏死等细胞死亡、生长抑制、衰老、增殖和癌症发生。本芯片还包括文
献已经报道的在转录水平响应毒性化合物反应的基因。利用实时定量 PCR，你可以方便并且可信地对与应激和毒性通路相关的基因进行同时检测。
Oxidative or Metabolic Stress: CAT (catalase), CRYAB (a-Crystallin B), CYP1A1, CYP2E1, CYP7A1, EPHX2, FMO1, FMO5, GPX1 (glutathione peroxidase), GSR
(glutathione reductase), GSTM3 (glutathione S-transferase M3), HMOX1, MT2A, POR, PRDX1, PRDX2, PTGS1, SOD1, SOD2.
Heat Shock: DNAJA1, DNAJB4, HSF1 (tcf5), HSPA1A (hsp70 1A), HSPA1L (hsp70 1L), HSPA2 (hsp70 2), HSPA4 (hsp70), HSPA5 (grp78), HSPA6 (hsp70B), HSPA8,
HSPB1 (hsp27), HSPCA (hsp90), HSPCB (hsp90 b), HSPD1 (chaperonin), HSPE1 (chaperonin 10), HSPH1 (hsp105).
Proliferation and Carcinogenesis: CCNC (cyclin C), CCND1 (cyclin D1), CCNG1 (cyclin G), E2F1, EGR1, PCNA.
Growth Arrest and Senescence: CDKN1A (p21Waf1/p21Cip1), DDIT3 (GADD153/CHOP), GADD45A, GDF15 (PLAB), IGFBP6, MDM2, TP53.
Inflammation: CCL3 (MIP-1a), CCL4 (MIP-1b), CCL21 (MIP-2), CXCL10 (IP10), CSF2 (GM-CSF), IL1A, IL1B, IL6, IL18, LTA (TNF b), MIF, NFKB1, NOS2A (iNOS),
SERPINE1 (PAI-1).
Necrosis or Apoptosis:
DNA Damage and Repair: ATM, CHEK2 (RAD53), DDB1, ERCC1, ERCC3, RAD23A, RAD50, UGT1A4, UNG, XRCC1, XRCC2.
Apoptosis Signaling: ANXA5 (annexin v), BAX, BCL2L1 (bcl-x), CASP1 (caspase1/ ICE), CASP8 (FLICE), CASP10 (mch4), FASLG (TNFSF6), NFKBIA (ikBa/mad3),
TNF, TNFRSF1A (TNFR1), TNFSF10 (TRAIL).
氧化、代谢有关的基因；热激蛋白类基因；增殖和肿瘤发生有关的基因；生长阻滞和衰老有关的基因；炎症有关的基因；细胞坏死和凋亡相关基因
Stress Response to Cellular Damage PCR Array
Catalog No. PAMM-019A（小鼠）
细胞损伤应激反应 PCR 芯片
The Mouse Stress Response to Cellular Damage RT² Profiler™ PCR Array profiles the expression of 84 genes involved in cellular stress response. This array includes
genes encoding antioxidant and pro-oxidant enzymes, molecular chaperones and proteins involved in xenobiotic metabolism. Representative heat shock proteins and
cytochrome P450s are included. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to cellular stress response with
this array.
细胞损伤应激反应 RT2 ProfilerTM PCR Array 可以同时检测与细胞应激反应相关的 84 个基因表达谱。本芯片包括编码参与外源物质代谢的抗氧化或
促氧化的酶、分子伴侣和蛋白的基因，最典型的代表是热激蛋白和细胞色素 P450s。利用实时定量 PCR，你可以方便并且可信地对与细胞应激反应
相关的基因进行同时检测。
Antioxidant and Pro-Oxidant Enzymes: Acadsb, Cat, Gpx1, Gpx2, Sod1, Sod2, Sod3, Xdh.
Molecular Chaperones:
Heat Shock Proteins: Cryaa, Cryab, Dnaja1, Dnaja2, Dnaja3, Dnaja4, Dnajb1, Dnajb10, Dnajb11, Dnajb12, Dnajb4, Dnajb5, Dnajb6, Dnajb9, Dnajc1, Dnajc4,
Dnajc5, Dnajc6, Dnajc7, Dnajc8, Dnajc9, Hmox1, Hmox2, Hspa12a, Hspa1a, Hspa1l, Hspa2, Hspa4, Hspa5, Hspa8, Hspa9, Hspb1, Hspb2, Hspb3, Hspd1, Hspe1,
Serpinh1 (HSP47).
Other Molecular Chaperones: Bag1, Calr, Canx, Cct2, Cct3, Cct4, Cct5, Cct7, Cct8, Clu, Hod, Ppid, St13, Tcp1.
Xenobiotic Metabolism:
Cytochrome P450s: Cyp11a1, Cyp11b2, Cyp17a1, Cyp1a1, Cyp1a2, Cyp1b1, Cyp2c29, Cyp2c37, Cyp2c38, Cyp2c40, Cyp2d22, Cyp2e1, Cyp2f2, Cyp4a10,
Cyp4b1, Cyp7a1, Cyp7b1.
Other Genes Related to Xenobiotic Metabolism: Ces1, Ephx2, Fmo1, Fmo4, Fmo5, Gsr, Gsta1, Gstm1
抗氧化和促氧化酶类；分子伴侣；外源物质代谢相关基因
肿瘤药物代谢耐受 PCR 芯片
肿瘤药物耐受与代谢 PCR 芯片
药物代谢：II 相代谢酶类 PCR 芯片
药物代谢：I 相反应酶类 PCR 芯片
Cancer Drug Resistance & Metabolism PCR Array
Catalog No. PAHS-004A（人）
肿瘤药物耐受与代谢 PCR 芯片
Catalog No. PAMM-004A（小鼠）
The Cancer Drug Resistance & Metabolism RT² Profiler™ PCR Array profiles the expression of 84 genes involved in the body's response to chemotherapy. The genes
encoding important enzymes for drug resistance (such as the P-glycoproteins), phase I metabolism (specifically the P450 family), and phase II metabolism (such as
various covalent modification enzymes) are all represented on the array. Cancer-related genes involved in aspects of resistance are also included on the array such as
DNA repair enzymes, cell cycle regulators, growth factor and hormone receptors, and transcription factors. Using real-time PCR, you can easily and reliably analyze
expression of a focused panel of genes related to cancer drug resistance and metabolism with this array.
肿瘤抗药性和药物代谢 RT² Profiler™ PCR Array 可以同时测定 84 个与体内响应化学治疗有关的关键基因。这些基因包括编码重要的药物抗性相关
的以及 I 相、II 相代谢酶类。还包括其他与肿瘤抗药性有关的如 DNA 修复酶类、细胞周期调节因子、生长因子、激素受体、转录因子等基因。 利
用实时定量 PCR，你可以方便并且可信地对与肿瘤抗药性和药物代谢相关的基因进行同时检测。
Drug Resistance: ABCB1 (PGY1, MDR1), ABCC1 (MRP1), ABCC2 (cMOAT, MRP2), ABCC3 (MOAT-D, MRP3), ABCC5 (MRP5), ABCC6 (MRP6, CFTR), ABCG2
(BCRP), BAX, BCL2, BCL2L1 (bcl-x), MVP (LRP), RB1, TOP1, TOP2A, TOP2B, TP53 (p53).
Drug Metabolism: ARNT, BLMH, CRR9 (DKFZP761M2324), CYP1A1, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A5,
DHFR, EPHX1, GSK3A, GSTP1, NAT2, SOD1, SULT1E1 (STE), TPMT.
DNA Repair: APC, ATM, BRCA1, BRCA2, ERCC3, MSH2, XPA, XPC.
Cell Cycle: CCND1 (cyclin D1), CCNE1 (cyclin E1), CDK2, CDK4, CDKN1A (p21Waf1, p21Cip1), CDKN1B (p27Kip1), CDKN2A (p16Ink4), CDKN2D (p19Ink4d).
Growth Factor Receptors: EGFR (ERBB1), ERBB2 (Her-2), ERBB3, ERBB4, FGF2, IGF1R, IGF2R, MET.
Hormone Receptors: AR, ESR1 (ER-alpha), ESR2 (ER-beta-cx), PPARA, PPARD, PPARG, RARA, RARB, RARG, RXRA, RXRB.
Transcription Factors: AHR, AP1S1, ELK1, FOS (c-fos), HIF1A, MYC (c-myc), NFKB1, NFKB2, NFKBIB (TRIP9), NFKBIE, RELB (l-rel), TNFRSF11A (Rank).
抗药性相关基因；药物代谢有关基因；DNA 修复相关基因；细胞周期有关基因；生长因子受体；激素受体；转录因子
Drug Metabolism: Phase I Enzymes PCR Array
药物代谢：I 相反应酶类 PCR 芯片
Catalog No. PAHS-068A（人）
The Human Drug Metabolism: Phase I Enzymes RT² Profiler™ PCR Array contains 84 genes involved in phase I drug metabolism. Phase I drug metabolism enzymes
make compounds more hydrophilic and add functional groups necessary for the completion of Phase II drug metabolism. This array represents genes involved in Phase
I drug metabolism reactions including oxidation, reduction, hydrolysis, cyclization, and decyclization. Members of the Cytochrome P450 enzyme family that play a key
role in mediating phase I drug metabolism reactions are also included on this array. Using real-time PCR, you can easily and reliably analyze expression of a focused
panel of genes related to drug phase I metabolism with this array.
药物代谢：Ⅰ相反应酶类 RT² Profiler™ PCR Array 可以同时测定 84 个与药物Ⅰ相代谢反应相关的基因。Ⅰ相药物代谢酶类可以增强药物的亲水性并
且添加完成药物Ⅱ相代谢反应所需的功能基团。本芯片中的基因参与Ⅰ相药物代谢反应：氧化、还原、水解、环化和去环化作用。芯片中包含的细胞
色素 P450 家族的基因在调节药物Ⅰ相代谢反应过程中起关键作用。利用实时定量 PCR，你可以方便并且可信地对与药物Ⅰ相代谢反应相关的基因进
行同时检测。
Cytochrome P450: CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP21A2, CYP24A1, CYP26A1, CYP26B1, CYP26C1,
CYP27A1, CYP27B1, CYP2A13, CYP2A6, CYP2A7, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2W1, CYP3A4, CYP3A43,
CYP3A5, CYP3A7, CYP4A11, CYP4A22, CYP4B1, CYP4F11, CYP4F12, CYP4F2, CYP4F3, CYP4F8, CYP7A1, CYP7B1, CYP8B1.
Alcohol Dehydrogenase: ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, DHRS2, HSD17B10 (HADH2).
Esterase: AADAC, CEL, ESD, GZMA, GZMB, UCHL1, UCHL3.
Aldehyde Dehydrogenase: ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH4A1, ALDH5A1, ALDH6A1,
ALDH7A1, ALDH8A1, ALDH9A1.
Flavin containing Monooxygenase: FMO1, FMO2, FMO3, FMO4, FMO5.
Monoamine Oxidase: MAOA, MAOB.
Prostaglandin-endoperoxide Synthase: PTGS1, PTGS2.
Xanthine Dehydrogenase: XDH.
Dihydropyrimidine Dehydrogenase: DPYD.
细胞色素 P450s；乙醇脱氢酶；酯酶；乙醛脱氢酶；黄素单氧化酶；单胺氧化酶；前列腺素内过氧化物合酶；黄嘌呤脱氢酶；二氢嘧啶脱氢酶
Drug Metabolism: Phase II Enzymes PCR Array
药物代谢：II 相代谢酶类 PCR 芯片
Catalog No. PAHS-069A（人）
The Human Drug Metabolism Phase II Enzymes RT² Profiler™ PCR Array contains 84 genes involved in the enzymatic processes of drug biotransformation. Phase II
drug metabolism enzymes catalyze the conjugation of lipophilic compounds with hydrophilic functional groups or moieties to form water-soluble conjugates that can be
cleared from cells and from the body. This array represents genes encoding the seven major classes of phase II drug metabolism enzymes catalyzing such reactions as
glutathione conjugation, glucuronidation, sulfation, methylation, amino acid conjugation, epoxidation, and esterification. Using real-time PCR, you can easily and reliably
analyze expression of a focused panel of drug metabolism enzymes with this array.
药物代谢：Ⅱ相反应酶类 RT² Profiler™ PCR Array 可以同时测定 84 个与药物生物转化过程中酶反应相关的基因。Ⅱ相药物代谢酶类催化脂溶性成
分结合亲水功能基团而变可溶性，可溶性的成分便可以从细胞或体内清除出去。本芯片包括 7 大类代谢酶类，这些酶参与以下反应：谷光甘肽结合、
葡醛酸结合、磺化反应、甲基化、氨基酸结合、环氧化和酯化。利用实时定量 PCR，你可以方便并且可信地对与药物Ⅱ相代谢反应相关的基因进行
同时检测。
Amino Acid Transferase: AGXT, BAAT, CCBL1, GLYAT.
Dehydrogenase: NQO1, NQO2, XDH.
Epoxidase: EPHX1, EPHX2.
Esterase: CES1, CES2, CES3, CES7.
Glucuronosyl Transferase: DDOST, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10,
UGT2B17, UGT2B28, UGT2B4, UGT2B7, UGT3A1, UGT8.
Glutathione Transferase: GSTA1, GSTA3, GSTA4, GSTA5, GSTK1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO1, GSTO2, GSTP1, GSTT1, GSTT2, HNMT, INMT,
MGST1, MGST2, MGST3, PETGS.
Methyl Transferase: AS3MT, ASMT, COMT, GAMT, GNMT, NNMT, PNMT, TPMT.
N-Acetyl Transferase: AANAT, ACSL1, ACSL3, ACSL4, ACSM1, ACSM2, ACSM3, NAT1, NAT2, NAT5, SAT1.
Sulfotransferase: SULT1A1, SULT1A2, SULT1A3, SULT1B1, SULT1C1, SULT1C2, SULT1C3, SULT1E1, SULT2A1, SULT2B1, SULT4A1, SULT6B1, TST.
氨基转移酶；脱氢酶；环氧酶；酯酶；葡萄糖醛酸基转移酶；谷光甘肽转移酶；甲基转移酶；N-乙酰转移酶；磺基转移酶
特别肿瘤 PCR 芯片
乳腺癌与雌激素受体信号通路 PCR 芯片
Catalog No. PAHS-005A（人）
Breast Cancer & Estrogen Receptor Signaling PCR Array
Catalog No. PAMM-005A（小鼠）
乳腺癌与雌激素受体信号通路 PCR 芯片
Catalog No. PARN-005A（大鼠）
The Breast Cancer and Estrogen Receptor Signaling RT² Profiler™ PCR Array profiles the expression of 84 genes related to breast cancer regulation and estrogen
receptor-dependent signal transduction. Genes directly associated with breast cancer are included as well as related genes involved in estrogen-dependent signaling.
Genes known to be preferentially expressed in breast cancer cells are represented for use as biomarkers of the disease. Also included are genes associated with cancer
cells' response to chemotherapy. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to breast cancer and estrogen
receptor signaling with this array.
乳腺癌和雌激素受体信号通路 RT² Profiler™ PCR Array 可以同时测定 84 个与乳腺癌和雌激素受体信号传导有关的关键基因。其中包括与乳腺癌直
接相关的基因，和雌激素信号传导相关的基因。其中还包括用作疾病标记物的在乳腺癌中表达的基因。一些与肿瘤化疗相关的基因也包括其中。利
用实时定量 PCR，你可以方便并且可信地对与乳腺癌和雌激素受体信号通路相关的基因进行同时检测。
Genes Directly Associated with Breast Cancer: CDKN1A (p21Wap1/Cip1), CLDN7 (claudin-7), CLU (clusterin), ERBB2 (Her-2), FGF1, FLRT1 (fibronectin), GABRP
(GABAa), GNAS, ID2, ITGA6, ITGB4 ( 4 integrin), KLF5 (GC Box BP), KRT19 (Keratin 19), MT3 (metallothionectin-III), MUC1 (mucin), PTGS2 (COX-2), RAC2
(p21Rac2), SCGB1D2 (lipophilin B), SCGB2A1 (mammaglobin 2), SPRR1B (Spr1), THBS1, THBS2, TNFAIP2 (B94).
Genes Associated with the Estrogen Receptor Signaling Pathway: AR, C3 (Complement component 3), CCND1, CTSD (cathepsin D), ESR1, ESR2, GATA3,
HSPB1 (HSP28), KRT18, KRT19 (Keratin 19), PGR, SERPINA3 (a1-antichmotrypsin), SLC7A5, STC2, TFF1 (pS2).
Genes Associated with Breast Cancer Prognosis: BAD, BAG1, BCL2, CCNA1, CCNA2, CCND1, CCNE1, CDH1 (E-cadherin), CDKN1B (p27Kip1), CDKN2A
(p16INK4a), COL6A1, CTNNB1 (b-catenin), CTSB (cathepsin B), EGFR, ERBB2 (Her-2), ESR1, ESR2, FAS (TNFRSF6), FASLG (TNFSF6), FOSL1 (FRA-1), GATA3,
GSN (Gelsolin), IGFBP2, IL2RA, IL6, IL6R, IL6ST (glycoprotein 130), ITGA6 ( 6 integrin), JUN, KLK5, KRT19, MAP2K7, MKI67 (Ki-67), NGFB (NGF), NGFR, NME1
(NM23A), PGR, PLAU (uPA), PTEN, SERPINB5 (maspin), SERPINE1 (PAI-1), TGFA, THBS1 (thrombospondin-1), TIE1(Tie-1), TOP2A (topoisomerase Iia), TP53,
VEGF.
Genes Associated with the Response to Chemotherapy: BCL2, BCL2L2, CD44, CTSD (cathepsin D), CYP19A1, DLC1, ESR1, ESR2, HMGB1, KIT, NFYB, PAPPA,
PGR, RPL27, VEGF.
与乳腺癌直接相关的基因；与雌激素受体信号通路有关的基因；与乳腺癌预后有关的基因；与化疗反应有关的基因
Toxicology and Pharmacology PCR Array
药物代谢 PCR 芯片
毒理与药理 PCR 芯片
药物转运蛋白 PCR 芯片
Catalog No. PAHS-002A（人）
Drug Metabolism PCR Array
药物代谢 PCR 芯片
Catalog No. PAMM-002A（小鼠）
Catalog No. PARN-002A（大鼠）
The Drug Metabolism RT² Profiler™ PCR Array contains 84 genes critical in the metabolism of drugs, toxic chemicals, hormones and micronutrients important to
pharmacology, endocrinology and food science. Drug metabolism is also often implicated in many disease states including cancer, intoxification, addiction, and
metabolic diseases. The genes encoding enzymes that are important for drug transport (such as metallothioneins and P-glycoproteins), phase I metabolism (specifically
the P450 family), and phase II metabolism (such as transferases and hydrolases) are represented on the array. Using real-time PCR, you can easily and reliably analyze
expression of a focused panel of genes related to drug metabolism with this array.
药物代谢 RT² Profiler™ PCR Array 可以同时测定 84 个药理学内分泌学和食品科学上重要的药物代谢、毒性化学物质代谢、激素、微量元素代谢有
关的关键基因。药物代谢常常与包括癌症、成瘾、代谢疾病等多种疾病状态有关。这些基因编码药物传输有关的酶类和 I 相、II 相代谢酶类。利用实
时定量 PCR，你可以方便并且可信地对与药物代谢相关的基因进行同时检测。
Drug Transporters:
Metallothioneins: MT2A, MT3.
P-Glycoprotein family: ABCB1 (PGY1, mdr-1), ABCC1, GPI.
Phase I Metabolizing Enzymes:
P450 gene family: CYP11B2, CYP17A1, CYP19A1, CYP1A1, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A5.
Phase II Metabolizing Enzymes:
Carboxylesterase: CES2, CES4.
Decarboxylase: GAD1.
Dehydrogenase: ADH1B, ADH1C, ADH4, ADH5, ADH6, ALAD, ALDH1A1, HSD17B1, HSD17B2, HSD17B3.
Glutathione peroxidases: GPX1, GPX2, GPX3, GPX4, GPX5, GSTA3, GSTA4, GSTM2, GSTM3, GSTM5, GSTP1, GSTT1, GSTZ1, LPO, MPO.
Hydrolases: EPHX1, FAAH, FBP1.
Kinases: HK2, PKLR, PKM2.
Lipoxygenase: ALOX12, ALOX15, ALOX5, APOE.
Oxidoreductases: BLVRA, BLVRB, DIA1, GPX1, GPX2, GSR, MTHFR, NOS3, NQO1, SRD5A1, SRD5A2.
Paraoxonase: PON1, PON2, PON3.
Sulfotransferases: CHST1, GSTA3, GSTA4, GSTM2, GSTM3, GSTM5, GSTP1, GSTT1, MGST1, MGST2, MGST3.
Transferases: NAT1, NAT2, COMT, GGT1.
Other Related Genes:
ABP1, AHR, ARNT, ASNA1, GCKR, MARCKS, SMARCAL1, SNN.
药物转运蛋白；I 相代谢酶类；II 相代谢酶类；其他相关基因
Drug transporters PCR Array
药物转运蛋白 PCR 芯片
Catalog No. PAHS-070A（人）
The Human Drug Transporters RT² Profiler™ PCR Array contains 84 transporter genes. Transporters play key roles in pharmacology, affecting entry and extrusion of
drugs into and out of cells. Transporters important to the absorption, distribution, metabolism and excretion of many drugs are included on this array. In addition,
transporters that contribute to sensitivity and resistance of tumor cells to anticancer agents are represented. Using real-time PCR, you can easily and reliably analyze
expression of a focused panel of genes related to drug transporters with this array.
药物转运蛋白 RT² Profiler™ PCR Array 可以同时测定 84 转运蛋白编码基因。转运蛋白在药理过程中起关键作用，这些蛋白影响药物进出细胞。本
芯片包含与药物吸收、分布、代谢和分泌相关的转运蛋白编码基因。另外，还包括与肿瘤细胞的药敏性和耐药性相关的转运蛋白编码基因。利用实
时定量 PCR，你可以方便并且可信地对与药物转运相关的基因进行同时检测。
ABC Transporters Involved in Drug Transport: ABCA1, ABCA2, ABCA3, ABCA4, ABCA9, ABCA12, ABCA13, ABCB1, ABCB4, ABCB5, ABCB6, ABCB11, ABCC1,
ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC10, ABCC11, ABCC12, ABCD1, ABCD3, ABCD4, ABCF1, ABCG2, ABCG8, TAP1 (ABCB2), TAP2 (ABCB3).
SLC Transporters Involved in Drug Transport:
SLC10: SLC10A1, SLC10A2.
SLC15: SLC15A1, SLC15A2.
SLC16: SLC16A1, SLC16A2, SLC16A3.
SLC19: SLC19A1, SLC19A2, SLC19A3.
SLC22: SLC22A1, SLC22A2, SLC22A3, SLC22A6, SLC22A7, SLC22A8, SLC22A9.
SLC25: SLC25A13.
SLC28: SLC28A1, SLC28A2, SLC28A3.
SLC29: SLC29A1, SLC29A2.
SLC2: SLC2A1, SLC2A2, SLC2A3.
SLC3: SLC3A1, SLC3A2.
SLC31: SLC31A1.
SLC38: SLC38A2, SLC38A5.
SLC5: SLC5A1, SLC5A4.
SLC7: SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A9, SLC7A11.
SLCO: SLCO1A2, SLCO1B1, SLCO1B3, SLCO2A1, SLCO2B1, SLCO3A1, SLCO4A1.
Other Transporters Involved in Drug Transport:
Vacuolar H+-ATPase: ATP6V0C.
Copper Pumps: ATP7A, ATP7B.
Aquaporins: AQP1, AQP7, AQP9.
Major Vault Protein: MVP.
Voltage-dependent Anion Channels: VDAC1 , VDAC2.
ABC 转运蛋白；SLC 转运蛋白；药物转运过程中其他转运蛋白
Cell and Developmental Biology PCR Array
细胞与发育生物学研究 PCR 芯片
胚胎干细胞 PCR 芯片
骨再生 PCR 芯片
内皮细胞生物学功能研究 PCR 芯片
干细胞 PCR 芯片（263 个 PCR）
造血干细胞与造血功能 PCR 芯片
Embryonic Stem Cells PCR Array
Catalog No. PAHS-081A（人）
胚胎干细胞 PCR 芯片
Catalog No. PAMM-081A（小鼠）
The Embryonic Stem Cell RT2 Profiler™ PCR Array profiles the expression of 84 key genes involved in the maintenance of pluripotency and the self-renewal status of
embryonic stem cells. Embryonic stem cells (ESC) hold great potential in treating diseases and injuries. However, turning them into a safe therapeutic agent still requires
a deeper understanding how the control mechanisms for cell-lineage commitment and differentiation work. The array includes embryonic stem cell-specific genes that
define the "stemness" of the cells and that maintain their pluripotent and self-renewal characteristics. The array also includes differentiation markers that can be used to
monitor the early events of ESC differentiation. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes involved in embryonic
stem cells maintenance and differentiation with this array.
胚胎干细胞 RT2 ProfilerTM PCR Array 可以同时检测与维持干细胞多能性及自我更新能力相关的 84 个关键基因的表达谱。干细胞对于疾病和损伤的
治疗具有很大的潜能。然而，要将对干细胞的研究转化为安全的治疗药物尚需深入了解细胞分化及定向分化的机制。本芯片中包含胚胎干细胞特异
性基因，这些基因决定细胞“干性”以及保持干细胞的多能性及自我更新的特性。该芯片也包括分化标志基因，这些基因对胚胎干细胞分化早期事
件起监视作用。利用实时定量 PCR，你可以方便并且可信地对与干细胞的维持和分化相关的基因进行同时检测。
Embryonic Stem Cell-Specific Genes:
Transcription Factors Maintaining "Stem-ness": FOXD3, GATA6, GBX2, NANOG, NR5A2, NR6A1, POU5F1, SOX2, TFCP2L1, UTF1, ZFP42.
Signaling Molecules Required for Pluripotency and Self-Renewal: COMMD3, CRABP2, EDNRB, FGF4, FGF5, GABRB3, GAL, GRB7, HCK, IFITM1, IL6ST, KIT,
LEFTY1, LEFTY2, LIFR, NODAL, NOG, NUMB, PTEN, SFRP2, TDGF1.
Cytokines and Growth Factors: FGF4, FGF5, GDF3, LEFTY1, LEFTY2, NODAL, TDGF1.
Other Embryonic Stem Cell-Specific Genes: BXDC2, CD9, DIAPH2, DNMT3B, IFITM2, IGF2BP2, LIN28, PODXL, REST, SEMA3A, TERT.
Selected Embryonic Stem Cell Differentiation / Lineage Markers:
Extra-Embryonic Endoderm Markers: FOXA2, GATA4, PTF1A.
Trophoblast Markers: CDX2, EOMES, GCM1, KRT1.
Viseral Endoderm Markers: AFP, SERPINA1.
Parietal Endoderm Markers: FN1, LAMA1, LAMB1, LAMC1, SOX17.
Mesoderm Markers: T, WT1.
Muscle: DES, MYF5, MYOD1.
Blood: HBB, HBZ.
Bone: COL1A1, RUNX2.
Neural: NES, NEUROD1, PAX6.
Endothelial: CD34, CDH5, FLT1, PECAM1.
Germ Cell: DDX4, SYCP3.
Pancreas: GCG, IAPP, INS, PAX4, PDX1, SST.
Other Embryonic Stem Cell-Differentiation / Lineage Markers: OLIG2, TAT.
胚胎干细胞特异性基因；胚胎干细胞分化/谱系标志基因
Catalog No. PAHS-015A（人）
Endothelial Cell Biology PCR Array
内皮细胞生物学功能研究 PCR 芯片
Catalog No. PAMM-015A（小鼠）
Catalog No. PARN-015A（大鼠）
The Endothelial Cell Biology RT² Profiler™ PCR Array profiles the expression of 84 genes related to endothelial cell biology. Endothelial cells play a critical role in the
progression of disease processes including inflammation, atherosclerosis, and tumor angiogenesis. This array includes genes involved in permissibility and vessel tone,
angiogenesis, endothelial cell activation and endothelial cell injury. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes
related to the atherosclerosis with this array.
内皮细胞生物学 RT² Profiler™ PCR Array 可以同时测定 84 个与内皮细胞生物学密切相关的基因。内皮细胞在炎症、动脉硬化、肿瘤发展等疾病进
程中发挥关键作用。此 array 包括血管通透性、血管生成、内皮细胞激活、内皮细胞损伤相关的基因。利用实时定量 PCR，你可以方便并且可信地
对与动脉硬化相关的基因进行同时检测。
Permissibility and Vessel Tone:
Angiotensin System: AGTR1, BLR1.
NO System: NOS2A, NOS3.
Prostacyclin System: PTGIS.
Endothelin System: EDNRA.
Oxidoreductase Activity: ALOX5, NOS2A, NOS3, PTGIS, SOD1.
Regulation of Blood Pressure: ACE, AGT, EDN1, EDN2, EDNRA, NPPB, NPR1.
Regulation of Vascular Permeability: NPPB, NPR1.
Vasoconstriction: EDN1, EDN2.
Angiogenesis:
Negative Regulation of Angiogenesis: KLK3, NPPB, NPR1, PF4.
Positive Regulation of Angiogenesis: RHOB, SPHK1.
Other Genes Involved in Angiogenesis: ANGPT1, ECGF1, FGF1, FLT1, KDR, PGF, VEGF.
Endothelial Cell Activation:
Adhesion Molecules: CCL2, CCL5, CDH5, COL18A1, CX3CL1, FN1, ICAM1, ITGA5, ITGAV, ITGB1, ITGB3, OCLN, PECAM1, RHOB, SELE, SELL, SELPLG, TEK,
THBS1, TNF, VCAM1, VWF.
Extracellular Matrix (ECM) Molecules: ACE, ADAM17, AGT, CCL2, CCL5, COL18A1, CPB2, CSF2, ECGF1, EDN1, EDN2, FASLG (TNFSF6), FGF1, FLT1, FN1,
IL1B, IL3, IL6, IL7, KLK3, MMP1, MMP2, MMP9, NPPB, PLAT, PLAU, SERPINE1, TFPI, THBS1, TIMP1, VWF.
Cytokine Activity: CCL5, CSF2, CX3CL1, FASLG (TNFSF6), IFNB1, IL11, IL1B, IL3, IL6, IL7, PF4, TNF, TNFSF10.
Thrombin Activity: ANXA5, PLAT, PLAU, PLG, THBD.
Vascular Endothelial Growth Factor (VEGF) Receptor Activity: FLT1, KDR, KIT, PDGFRA, VEGF.
Other Genes Involved in Cell Growth: BAX, BCL2, COL18A1, CSF2, ECGF1, EDN1, EDN2, EDNRA, FGF1, IFNB1, IL11, IL1B, IL3, IL6, IL7, NOS2A, NPPB, PGF,
PLG, RHOB, SPHK1, TIMP1, VWF.
Endothelial Cell Injury:
Response to Stress: ALOX5, BCL2, CCL2, CCL5, CSF2, CX3CL1, FN1, IFNB1, IL1B, IL6, IL7, ITGB1, NOS2A, PF4, PLA2G4C, SELE, SELPLG, SOD1, TNF, VEGF,
VWF.
Anti-Apoptosis: BAX, BCL2, BCL2A1, BCL2L1, CCL2, CFLAR, FAS (TNFRSF6), FASLG (TNFSF6), SPHK1, TNF, TNFAIP3.
Caspase Activation: CASP1, CASP3, CASP6, CFLAR, IFNB1.
Induction of Apoptosis: BAX, CASP3, CASP6, CFLAR, CRADD, FAS (TNFRSF6), FASLG (TNFSF6), TNFSF10.
Other Genes Related to Apoptosis: IL1B, RHOB, RIPK1, TNFRSF10C, VEGF.
血管通透性和血管紧张有关基因；血管生成有关基因；内皮细胞激活有关基因；内皮细胞损伤有关基因
Hematopoietic Stem Cells and Hematopoiesis PCR Array
造血干细胞与造血功能 PCR 芯片
Catalog No. PAHS-054A（人）
The Human Hematopoietic Stem Cells and Hematopoiesis RT² Profiler™ PCR Array profiles the expression of 84 genes related to the development of blood-cell
lineages from HSCs through progenitor stem cells. Blood cell lineage-specific molecular markers are represented on this array. The cytokines, signaling molecules, and
other regulators that are important in stem cell commitment and differentiation are included as well. Using real-time PCR, you can easily and reliably analyze expression
of a focused panel of genes related to hematopoietic stem cells and hematopoiesis with this array.
造血干细胞与造血功能 RT² Profiler™ PCR Array 可以同时测定 84 个与从造血干细胞和祖/干细胞发育分化成血细胞谱系相关的基因。本芯片中包含
血细胞谱系特异性标志基因。还包括在干细胞分化及定向分化过程中起重要作用的细胞因子、信号分子及其他相关调节基因。利用实时定量 PCR，
你可以方便并且可信地对与造血干细胞及造血功能相关的基因进行同时检测。
Cell Surface / Cell Lineage Markers: CCR1, CD164, CD1D, CD2, CD34, CD3D, CD3G, CD4, CD44, CD80, CD86, CD8A, CSF1, DLL1, FLT3LG, FUT10, FZD1,
GALNAC4S-6ST, IL31RA, IL6ST, JAG1, JAG2, KDR, KIT, KITLG, LRMP, MAL, NOTCH2, NOTCH4, PECAM1, PTPRC, SFXN1, STIM2, TEK, TLR3, TLR4, CD27
(TNFRSF7), TNFSF11.
Cytokines and Growth Factors:
Cytokines: CSF1, CSF2, FLT3LG, IL10, IL11, IL12B, IL25 (IL17E), IL1A, IL2, IL20, INHA, INHBA, PF4, SPP1, TNFSF11.
Growth Factors: CSF1, CSF2, IL10, IL11, IL1A, IL2, INHA, INHBA, JAG1, JAG2, KITLG, SPP1, VEGF.
Cell Cycle Regulators:
Cell Cycle Arrest: INHA, INHBA, NOTCH2.
Other Regulators of the Cell Cycle: APC, HDAC4, HDAC5, HDAC7A, HDAC9, IL1A, JAG2, STAT1, VEGF.
Blood Cell Activation:
B-cell Activation: HDAC4, HDAC5, HDAC7A, HDAC9.
T-cell Activation: CD2, CD3D, CD3G, CD80, CD86, CD8A.
Genes Activating Other Blood Cell Types: CD2, IL11, IL12B, IL2, IL31RA, PF4, TLR4.
Cell Differentiation:
B-cell Differentiation: BLNK, GALNAC4S-6ST, HDAC4, HDAC5, HDAC7A, HDAC9, IL10, IL11, INHA, INHBA, TNFRSF7.
T-cell Differentiation: CD2, CD4, CD80, CD86, IL12B, IL2, JAG2, NOS2A, SOCS5, CD27 (TNFRSF7).
Differentiation Regulators for Other Blood Cell Types: ANGPT1, CD3G, CSF1, DLL1, IL11, IL20, IL31RA, INHA, INHBA, JAG1, MAL, MAP4K1, NCOA6, NOTCH1,
NOTCH2, NOTCH4, PAX5, PF4, SPP1, TAL1, TLR3, TLR4, TNFSF11.
Hematopoiesis Regulators: ASH2L, CD164, CSF1, DLL1, FUT10, IL10, IL20, IL31RA, JAG1, LMO2, MMP9, NOTCH2, NOTCH4, STIM2, TRIM10.
Signaling Molecules:
Notch Signaling Pathway: DLL1, JAG1, JAG2, NOTCH2, NOTCH4.
Wnt Receptor Signaling Pathway: APC, FZD1, LEF1, WNT3A.
JAK / STAT Cascade: IL31RA, SOCS5, STAT1, STAT3.
Cell Surface Receptors Linked to Signal Transduction: CCR1, CD14, CD2, CD3D, CD3G, CD4, CSF2, FZD1, IL6ST, INHA, INHBA, PTPRC, TNFRSF7.
Transcription Factors and Regulators: ASH2L, CBFB, CD80, CD86, CEBPE, CEBPG, ETS1, ETV6, GATA1, GATA2, HDAC4, HDAC5, HDAC7A, HDAC9, IL31RA,
LEF1, NCOA6, NOTCH1, NOTCH2, NOTCH4, PAX5, RBPSUH, RUNX1, STAT1, STAT3, TAL1, VAV1.
胚胎干细胞相关基因
Osteogenesis PCR Array
Catalog No. PAHS-026A（人）
骨再生 PCR 芯片
Catalog No. PAMM-026A（小鼠）
The Osteogenesis RT² Profiler™ PCR Array profiles the expression of 84 genes related to osteogenic differentiation. This array contains genes functioning in the
development of the skeletal system as well as bone mineral metabolism. Growth factors and genes mediating osteogenesis and related cell growth, proliferation, and
differentiation processes are included. Also represented are the extracellular matrix molecules and cell adhesion molecules involved in bone development. Using
real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to osteogenic differentiation with this array.
骨发生 RT2 ProfilerTM PCR Array 可以同时检测与骨分化相关的 84 个基因表达谱。其中包括骨骼系统发育和骨矿物质代谢相关的功能基因。也包括
生长因子和介导骨发生的基因以及与细胞生长、增殖和分化相关基因。还包括参与骨发育的细胞外基质分子和细胞黏附分子基因。
利用实时定量 PCR，
你可以方便并且可信地对与骨分化相关的基因进行同时检测。
Skeletal Development:
Bone Mineralization: AHSG, AMBN, AMELY, BGLAP, ENAM, MINPP1, STATH, TUFT1.
Cartilage Condensation: BMP1, COL11A1, SOX9.
Ossification: ALPL, AMBN, AMELY, BGLAP, CALCR, CDH11, DMP1, DSPP, ENAM, MINPP1, PHEX, RUNX2, STATH, TFIP11, TUFT1.
Osteoclast Differentiation: BGLAP.
Other Genes Involved in Skeletal Development: BMP2, BMP3, BMP4, BMP5, BMP6, COL10A1, COL12A1, COL1A1, COL1A2, COL2A1, COMP, FGFR1, GDF10, IGF1,
IGF2, MSX1, TWIST1.
Bone Mineral Metabolism:
Calcium Ion Binding and Homeostasis: ANXA5, BGLAP, BMP1, CALCR, CDH11, COMP, DMP1, EGF, MMP2, MMP8, VDR.
Phosphate Transport: COL10A1, COL11A1, COL12A1, COL14A1, COL15A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A3, COL5A1.
Cell Growth and Differentiation:
Regulation of the Cell Cycle: EGFR, FGF1, FGF2, FGF3, IGF1R, IGF2, PDGFA, TGFB1, TGFB2, TGFB3, VEGF, VEGFB.
Cell Proliferation: COL4A3, CSF3, EGF, EGFR, FGF1, FGF2, FGF3, FLT1, IGF1, IGF1R, IGF2, PDGFA, SMAD3, TGFB1, TGFB2, TGFB3, TGFBR2, VEGF, VEGFB.
Growth Factors and Receptors: BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, CSF2, CSF3, EGF, EGFR, FGF1, FGF2, FGF3, FGFR1, FGFR2, FLT1, GDF10, IGF1,
IGF1R, IGF2, PDGFA, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, VEGF, VEGFB.
Cell Differentiation: TFIP11, TWIST1.
Extracellular Matrix (ECM) Molecules:
Basement Membrane Constituents: COL4A3.
Collagens: COL10A1, COL11A1, COL12A1, COL14A1, COL15A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A3, COL5A1.
ECM Protease Inhibitors: AHSG, COL4A3, SERPINH1.
ECM Proteases: BMP1, CTSK, MMP10, MMP2, MMP8, MMP9, PHEX.
Structural Constituents of Bone: BGLAP, COL1A1, COL1A2.
Structural Constituents of Tooth Enamel: AMBN, AMELY, ENAM, STATH, TUFT1.
Other ECM Molecules: BGN, BMP2, COMP, CSF2, CSF3, DSPP, EGF, FGF1, FGF2, FGF3, FLT1, GDF10, IGF1, IGF2, PDGFA, VEGF, VEGFB.
Cell Adhesion Molecules:
Cell-cell Adhesion: CDH11, COL11A1, COL14A1, ICAM1, ITGB1, VCAM1.
Cell-matrix Adhesion: ITGA1, ITGA2, ITGA3, ITGAM, ITGB1.
Other Cell Adhesion Molecules: BGLAP, CD36, COL12A1, COL15A1, COL4A3, COL5A1, COMP, FN1, SCARB1, TNF.
Transcription Factors and Regulators: MSX1, NFKB1, RUNX2, SMAD1, SMAD2, SMAD3, SMAD4, SOX9, TNF, TWIST1, VDR.
骨骼发育有关基因；骨矿物代谢有关基因；细胞生长和分化调节基因；细胞外基质分子；细胞黏附分子；转录因子及其调节因子
Catalog No. PAHS-405A（人）
Stem Cell PCR Array
干细胞 PCR 芯片（263 个 PCR）
Catalog No. PAMM-405A（小鼠）
Catalog No. PARN-405A（大鼠）
The Stem Cell RT² Profiler™ PCR Array profiles the expression of 84 genes related to the identification, growth and differentiation of stem cells. Stem-cell specific
markers are included as well as stem cell differentiation markers. Genes involved in signaling pathways important for stem cells maintenance are also contained on this
array. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to stem cell biology with this array.
干细胞 RT2 ProfilerTM PCR Array 可以同时检测与干细胞鉴定、生长和分化相关的 84 个基因表达谱。干细胞特异性标记和干细胞分化标记包含其中。
该芯片也包括与干细胞维持相关的重要信号通路中的基因。利用实时定量 PCR，你可以方便并且可信地对与干细胞生物学相关的基因进行同时检测。
Stem Cell Specific Markers:
Cell Cycle Regulators: APC, AXIN1, CCNA2, CCND1, CCND2, CCNE1, CDC2, CDC42, EP300, FGF1, FGF2, FGF3, FGF4, MYC, NOTCH2, PARD6A, RB1.
Chromosome and Chromatin Modulators: GCN5L2, HDAC2, MYST1, MYST2, RB1, TERT.
Genes Regulating Symmetric/Asymmetric Cell Division: DHH, NOTCH1, NOTCH2, NUMB, PARD6A.
Self-Renewal Markers: HSPA9B, MYST1, MYST2, NEUROG2, SOX1, SOX2.
Cytokines and Growth Factors: BMP1, BMP2, BMP3, CXCL12, FGF1, FGF2, FGF3, FGF4, GDF2, GDF3, IGF1, JAG1.
Genes Regulating Cell-Cell Communication: DHH, DLL1, GJA1, GJB1, GJB2, JAG1.
Cell Adhesion Molecules: APC, BGLAP, CD4, CD44, CDH1, CDH2, COL9A1, CTNNA1, CXCL12, NCAM1.
Metabolic Markers: ABCG2, ALDH1A1, ALDH2, FGFR1.
Stem Cell Differentiation Markers:
Embryonic Cell Lineage Markers: ACTC, ASCL2, FOXA2, IPF1, ISL1, KRT15, MSX1, MYOD1, T.
Hematopoietic Cell Lineage Markers: CD3D, CD4, CD8A, CD8B1, MME.
Mesenchymal Cell Lineage Markers: AGC1, ALPI, BGLAP, COL1A1, COL2A1, COL9A1, PPARG.
Neural Cell Lineage Markers: CD44, NCAM1, OPRS1, S100B, TUBB3.
Signaling Pathways Important for Stem Cell Maintenance:
Notch Pathway: DLL1, DLL3, DTX1, DTX2, DVL1, EP300, GCN5L2, HDAC2, JAG1, NOTCH1, NOTCH2, NUMB.
Wnt Pathway: ADAR, APC, AXIN1, BTRC, CCND1, FRAT1, FZD1, MYC, PPARD, WNT1.
干细胞特异的分子标记；干细胞分化的分子标记；干细胞维持有关的信号通路
Common Diseases PCR Array
常见疾病研究 PCR 芯片
阿兹海默症 PCR 芯片
炎症反应与自身免疫 PCR 芯片 384HT
动脉粥样硬化 PCR 芯片
先天免疫与适应性免疫应答 PCR 芯片
糖尿病 PCR 芯片
肥胖 PCR 芯片
HIV 感染与宿主应答基因芯片
T 细胞与 B 细胞活化 PCR 芯片
炎症反应与自身免疫 PCR 芯片
Alzheimer's Disease PCR Array
阿兹海默症 PCR 芯片
Catalog No. PAHS-057A（人）
The Human Alzheimer’s Disease RT² Profiler™ PCR Array profiles the expression of 84 genes important in the onset, development, and progression of Alzheimer’s
disease. The array includes genes that contribute to amyloid beta-peptide (Aß) generation, clearance, and degradation, as well as genes involved in amyloid
beta-peptide (Aß) signal transduction leading to neuronal toxicity and inflammation. Using real-time PCR, you can easily and reliably analyze expression of a focused
panel of genes related to Alzheimer’s Disease with this array.
阿兹海默症 RT2 ProfilerTM PCR Array 可以同时检测在阿兹海默症发生、发展和进展过程中起重要作用的 84 个基因表达谱。该芯片中包含了与β淀粉样蛋白的产生、清除和降解相关的基因，还包括β-淀粉样蛋白信号转导途径中参与神经毒性和炎症反应的基因。利用实时定量 PCR，你可以方
便并且可信地对与阿兹海默症相关的基因进行同时检测。
Beta-amyloid Generation, Oligomerization, Clearance, and Degradation:
Secretases: ADAM9, APH1A, BACE1, BACE2, CTSB, NCSTN, PSEN1, PSEN2.
Other Peptidases Involved in Beta-amyloid Degradation: IDE, PLAT, PLAU, PLG.
Beta-amyloid Clearance Through Endocytosis: APLP1, APP, LRP1, LRP6, LRP8.
Other Genes Involved in Beta-amyloid Metabolism: A2M, ACHE, APBB1, APBB2, APOE, BCHE, UBQLN1.
Microtubule and Cytoskeleton Reorganization: APOE, MAP2, MAPT, PKP4, PRKCI.
Synaptic Formation:
Synaptic Transmission: APBA1, APOE, CHAT.
Other Synaptic Functions: ACHE, APBA1, APBB1, APBB2, APOE, BDNF.
Cholesterol Metabolism: ABCA1, APOA1, APOE, LRP8.
Lipid and Lipoprotein Metabolism: APOA1, APOE, CLU, HADH2, INS, LPL, LRP1, LRP8, SNCB.
Hormone and Hormone Processing: BACE2, INS.
Apoptosis:
Induction of Apoptosis: APOE, CASP3, CASP4, ERN1, PRKCA, PRKCE.
Anti-apoptosis: IL1A, MPO, PRKCZ, PSEN1, SNCA.
Other Genes Involved in Apoptosis and Cell Death: APLP1, APP, APPBP1, CLU, EP300, MAPT, PSEN2.
Cell Cycle Regulators:
Cell Cycle Arrest: APBB1, APBB2, ERN1.
Other Cell Cycle Genes: APBB1, APBB2, APPBP1, CDC2, CDK5, CDKL1, EP300, IL1A, PRKCA.
Protein Kinases: CDC2, CDK5, CDKL1, ERN1, GSK3A, GSK3B, INSR, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCI, PRKCQ, PRKCZ.
Cell Signaling Molecules:
Wnt Receptor Signaling: GSK3B, LRP6.
Notch Signaling: APH1A, NCSTN, PSEN1, PSEN2.
G-protein Coupled Receptor (Protein Signaling: APLP2, GNAO1, GNAZ, GNB1, GNB4, GNB5, GNG10, GNG11, GNG3, GNG4, GNG5, GNG7, GNG8, GNGT1,
GNGT2.
Intracellular Signaling: APBA3, APBB2, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCI, PRKCQ, PRKCZ, PSEN1, PSEN2.
Other Signaling Molecules: APPBP1, GAP43, GNB2, IDE, IL1A, INSR, PLAU.
Transcription regulators: APBB1, APBB2, EP300, ERN1.
Other Genes Involved in Alzheimer's disease:
Oxidoreductases and Oxidative Stress: HADH2, MPO, UQCRC1, UQCRC2.
Proteases: CTSC, CTSD, CTSG, CTSL, UQCRC2.
Protease Inhibitors: APLP2, APP, SERPINA3.
β-淀粉样蛋白产生、寡聚、清除和降解相关的基因、微管和细胞骨架重组相关基因、突触形成相关基因、胆固醇代谢相关基因、脂和脂蛋白代谢相关基因、激素和激素代
谢相关基因、细胞凋亡相关基因、细胞周期调控相关基因、蛋白激酶、细胞信号分子、转录调控因子、其他阿兹海默症相关基因
Atherosclerosis PCR Array
Catalog No. PAHS-038A（人）
动脉粥样硬化 PCR 芯片
Catalog No. PAMM-038A（小鼠）
The Atherosclerosis RT² Profiler™ PCR Array profiles the expression of 84 genes related to atherosclerosis. Genes involved in the processes of blood coagulation and
circulation are included as well as genes involved in cell-adhesion and lipid transport and metabolism. Genes involved in the stress response, cell growth and
proliferation, and apoptosis are represented as well. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to the
atherosclerosis with this array.
动脉粥样硬化 RT² Profiler™ PCR Array 可以同时测定 84 个与动脉粥样硬化有关的关键基因。其中包括与血液循环和血液凝结过程有关的基因，还
有与细胞黏附和脂转运代谢有关的基因。同时还包括了一些与应激反应、细胞生长和增殖、凋亡相关的基因。利用实时定量 PCR，你可以方便并且
可信地对与动脉粥样硬化相关的基因进行同时检测。
Response to Stress:
Inflammatory Response: CCL2, CCL5, CCR1, CCR2, IL1R1, IL1R2, ITGB2, NFKB1, NOS3, SELE, SPP1, TNF.
Response to Oxidative Stress: APOE, CCL5, SOD1.
Response to Pests, Pathogens or Parasites: CCL2, CCR2, CSF2, FN1, IL4, ITGB2, TNF.
Response to Virus: CCL5, IFNAR2, TNF.
Response to Wounding: CCR1, CCR2, CTGF, FN1, PDGFB, TNF, VWF.
Other Genes Related to Stress Response: IFNG, PPARG, VEGF.
Apoptosis:
Anti-apoptosis: BCL2, BCL2A1, BCL2L1, BIRC3, CCL2, CFLAR, FAS (TNFRSF6), IL1A, IL2, NFKB1, SERPINB2, SPP1, TGFB1, TNF, TNFAIP3.
Induction of Apoptosis: APOE, BAX, BID, CFLAR, FAS (TNFRSF6).
Other Genes Related to Apoptosis: IL5, ITGB2.
Blood Coagulation and Circulation:
Blood Coagulation: FGA, ITGA2, LPA, SERPINE1.
Circulation: APOA1, APOB, APOE, COL3A1, ELN, ENG, LPA, LPL, NPY.
Platelet Activation: PDGFA, PDGFB, PDGFRB, VWF.
Regulation of Blood Pressure: ACE, FGA.
Adhesion Molecules:
Cell-cell Adhesion: CD44, CDH5, ICAM1, ITGB2, SELE, SELL, TNF, VCAM1, VEGF.
Cell-matrix Adhesion: CD44, ITGA2, ITGA5, ITGAX, ITGB2, SPP1.
Other Genes Involved in Adhesion: CCL2, CCL5, CCR1, CTGF, ELN, ENG, FN1, LAMA1, SELPLG, THBS4, TNC, VWF.
Extracellular Molecules:
ECM Protease Inhibitors: LPA, SERPINB2, SERPINE1.
ECM Proteases: ACE, MMP1, MMP3.
Extracellular Matrix (ECM) Structural Constituents: COL3A1, ELN, FN1.
Other Extracellular Molecules: ADFP, APOA1, APOB, APOE, CCL2, CCL5, CSF2, CTGF, FGA, FGF2, HBEGF (DTR), IFNAR2, IFNG, IL1A, IL2, IL3, IL4, IL5,
LAMA1, LIF, LPL, NPY, PDGFA, PDGFB, SPP1, THBS4, TNC, VEGF, VWF.
Lipid Transport and Metabolism:
Cholesterol Metabolism: ABCA1, APOA1, APOB, APOE, IL4, LDLR.
Fatty Acid Metabolism: FABP3, LPL, PPARA, PTGS1.
Lipid Transport: ABCA1, APOA1, APOB, APOE, FABP3, LDLR, LPA, LPL, MSR1.
Lipoprotein Metabolism: APOA1, APOE, LDLR, LPL.
Steroid Metabolism: NR1H3, PPARA, PPARD, PPARG, RXRA.
Other Genes Related to Lipid Metabolism: ADFP, APOE, LPA.
Cell Growth and Proliferation:
Growth Factors and Receptors: CSF2, KDR, PDGFRB, SPP1.
Negative Regulation of Cell Proliferation: BCL2, FABP3, IL1A.
Positive Regulation of Cell Proliferation: CSF1, FGA, FGF2, HBEGF (DTR), IL2, IL3, IL5, IL6, IL7, LIF, VEGF.
Regulation of the Cell Cycle: FGF2, IL1A, PDGFA, PDGFB, TGFB1, TGFB2, VEGF.
Other Genes Involved in Cell Growth and Proliferation: CTGF, ELN, IFNG, IL4, NPY.
Transcription Regulators:
Nuclear Receptors: NR1H3, PPARA, PPARD, PPARG, RXRA.
Other Transcription Regulators: EGR1, KLF2, NFKB1, TNF, TNFAIP3.
应激反应有关基因；凋亡相关基因；凝血及血循环相关基因；黏附分子；细胞外分子；脂类转运和代谢分子；细胞生长和增殖相关基因；转录调节因子
Catalog No. PAHS-023A（人）
Diabetes PCR Array
糖尿病 PCR 芯片
Catalog No. PAMM-023A（小鼠）
Catalog No. PARN-023A（大鼠）
The Diabetes RT² Profiler™ PCR Array profiles the expression of 84 genes related to the onset, development, and progression of diabetes. They include genes that
contribute to obesity, insulin resistance, the early onset of diabetes, and complications from diabetes mellitus. These genes are grouped into six functional categories:
receptors, transporters & channels; nuclear receptors; metabolic enzymes; secreted factors; signal transduction proteins; and transcription factors. Many of the genes
included have a tissue-specific or tissue-biased expression pattern which can also be affected by different pathophysiological states. This array can be used to study
models of obesity and diabetes, to screen for therapeutics and their targets, and to profile the effect of various epidemiological and environmental factors on gene
expression in various tissues or cell lines. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to diabetes with this
array.
糖尿病 RT² Profiler™ PCR Array 可以同时测定 84 个与糖尿病发生、发展有关的基因。这些基因包括与肥胖有关的基因，胰岛素耐受，糖尿病早期
发生、糖尿病并发症有关的基因。这些基因按照功能被分为六类：受体、转运蛋白和通道、核受体、代谢酶类、分泌因子、信号传导蛋白和转录因
子。这些基因中的多数的表达具有组织特异性或者组织偏好，并且会受到生理病理状态的影响。此 Array 可以用来研究肥胖和糖尿病模型，来筛选
治疗药物和靶位点，来检测流行病学和环境因子对于某些组织和细胞系的基因表达谱。利用实时定量 PCR，你可以方便并且可信地对与糖尿病相关
的基因表达谱进行分析。
Receptors, Transporters and Channels: ABCC8, ADRB3, AQP2, CD28, CEACAM1, CTLA4, GCGR, GLP1R, ICAM1, IL4R, INSR, NSF, RAB4A, SELL (LECAM-1),
SLC2A4 (GLUT4), SNAP23, SNAP25, STX4A, STXBP1, STXBP2, TNFRSF1A, VAMP3, VAPA.
Nuclear Receptors: PPARA, PPARG.
Metabolic Enzymes: ACE, ACLY, ENPP1, FBP1, G6PC, G6PD, GCK, GPD1, GSK3B, HMOX1, IDE, ME1, NOS3, PARP1 (ADPRT1), PRKAA1, PRKAG2, PRKCB1,
PYGL.
Secreted Factors: AGT, CCL5 (Rantes), CCR2 (MCP-1), GCG, IFNG, IL6, IL10, IL12B, INS, RETN, TGFB1, TNF, VEGF.
Signal Transduction: AKT2, DUSP4, IGFBP5, IKBKB (IKKbeta), INPPL1 (SHIP2), IRS1, IRS2, MAPK8 (JNK1), MAPK14 (p38 MAPK), PIK3C2B, PIK3CD, PIK3R1,
PTPN1 (PTP-1B), TRIB3 (SKIP3).
Transcription Factors: CEBPA, FOXC2, FOXG1B, FOXP3, HNF4A, IPF1 (PDX-1), NEUROD1, NFKB1, NRF1, PPARGC1, PPARGC1B, SREBF1, TCF2 (HNF1b),
TITF1.
受体、转运蛋白和通道蛋白；核受体；代谢酶类；分泌因子；信号转运相关基因；转录因子
HIV Infection and Host Response PCR Array
HIV 感染与宿主应答 PCR 芯片
Catalog No. PAHS-051A（人）
The Human HIV Infection and Host Response RT² Profiler™ PCR Array profiles the expression of 84 genes involved in the host response to HIV Infection. This array
represents the genes involved in innate and adaptive immunity related to HIV infection along with the key cellular cofactors for HIV replication. The host genes involved in
HIV viral processes such as binding, fusion, uncoating, reverse transcription, nuclear import, integration, transcription, RNA export, assembly and budding are included
on this array. The array also represents the host response to HIV infection with key genes involved in HIV innate response and host genes involved in HIV immune
evasion. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to HIV infection and host response with this array.
HIV 感染与宿主应答 RT² Profiler™ PCR Array 可以同时测定 84 个与 HIV 感染的宿主应答有关的基因。本芯片中包括 HIV 感染引起的先天或适应性
免疫相关的基因以及 HIV 复制过程相关的关键性的宿主辅助因子。宿主基因参与 HIV 感染过程，如病毒与宿主细胞结合、融合、病毒脱去蛋白外壳、
逆转录、入核、整合宿主 DNA、RNA 输出、病毒整合和出芽释放等。芯片中还包括宿主 HIV 感染应答基因，包括 HIV 先天免疫相关基因以及 HIV
免疫逃避相关基因。利用实时定量 PCR，你可以方便并且可信地对与 HIV 感染及宿主应答相关的基因表达谱进行分析。
HIV Receptors and Natural Ligands: CCL2, CCL4, CCL5, CCR5, CD4, CXCL12, CXCR4.
Cellular Cofactors Involved in HIV Infection:
Chemokine Receptors: CCR2, CCR3, CCR4.
G-protein Coupled Receptors: CCR2, CCR3, CCR4.
Protein Kinases: CDK7, CDK9, HCK, PTK2B.
Transcription Factors and Regulators: APEX1, BCL11B, CCNT1, CDK7, CDK9, CREBBP, EP300, HMGA1, HTATSF1, NFATC1, RBL2, SMARCB1, TFCP2,
TSG101, YY1.
Apoptosis Genes: EP300, LTBR, PTK2B.
Cell Cycle Regulators: CCNT1, CDK7, CDK9, EP300, RBL2, SMARCB1.
Genes Regulating Cell Proliferation: CDK7, CDK9, PTK2B.
Inflammatory Response: CCR2, CCR3, CCR4.
Antimicrobial Humoral Response: CCR2, YY1.
Other Immune Response Genes: APOBEC3G, CD209, LTBR.
Genes Involved in Cell Adhesion: CCR3, CD209, PTK2B.
Viral Genome Replication: APOBEC3G, CD209, HTATSF1.
Other Cellular Cofactors: APOBEC3F, BANF1, BTRC, CBX5, CD247 (CD3Z), COPS6, ELA2, PPIA, TRIM5, VPS4A, XPO1.
Genes Involved in Innate Immune Response:
Acute-phase Response: SERPINA1.
Antimicrobial Humoral Response: IL12B, IL1B, KLRD1, XCL1.
Response to Virus: CCL4, CCL5, CCL8, CXCL12, IFNB1, TNF.
Response to Pest, Pathogen or Parasite: CCL2, TNF.
Inflammatory Response: CCL2, CCL4, CCL5, CCL8, CXCL12, IL10, IL1B, IL8, TNF.
Other Genes Involved in the Immune Response: CD74, CR2, CX3CL1, IFNG, IL16, IL2, MBL2.
Natural Killer Cell Activation: IFNB1, IL12B, IL2.
Defense Response Against Pathogens: CD69, CX3CL1, IFNA1, IFNB1, IFNG.
Genes Involved in Cell Adhesion: CCL2, CCL4, CCL5, CD44, CX3CL1, CXCL12, IL8, SELL, TNF.
Other Genes Involved in the Innate Response: PRDX1, SERPINC1, SLPI, TGFB1, TNFRSF1B.
Immune Evasion: CD4, FCAR, MAP3K5.
Cellular Proteins Induced or Activated by HIV Infection:
Apoptosis: BAD, BAX, BCL2, CASP3, CASP8, CDKN1A, GADD45A, NFKBIA, STAT1, TNFSF10.
Cell Cycle Regulators: BAX, BCL2, CDK9, CDKN1A, GADD45A, IRF1, STAT1.
Regulators of Cell Proliferation: BCL2, CDK9, CDKN1A, IRF2.
Transcription Factors and Regulators: CDK9, CEBPB, FOS, IRF1, IRF2, NFATC1, NFKBIA, STAT1, STAT3.
HIV 受体和天然配体、HIV 感染的细胞辅助因子、先天免疫应答相关基因、免疫逃避相关基因、HIV 感染诱导或激活的细胞内蛋白
Inflammatory Response and Autoimmunity PCR Array
炎症反应与自身免疫 PCR 芯片
Catalog No. PAHS-077A（人）
The Human Inflammatory Response and Autoimmunity RT² Profiler™ PCR Array profiles the expression of 84 key genes involved in autoimmune and inflammatory
immune responses. It represents the expression of inflammatory cytokines and chemokines as well as their receptors. It also contains genes related to the metabolism of
cytokines and involved in cytokine-cytokine receptor interactions. Thoroughly researched panels of genes involved in the acute-phase response, inflammatory response,
and humoral immune responses are represented as well. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to
inflammatory and autoimmune responses with this array.
炎症反应与自身免疫 RT² Profiler™ PCR Array 可以同时测定 84 个与炎症反应与自身免疫相关的基因。本芯片可以分析炎症细胞因子和趋化因子以
及它们的受体基因的表达谱。芯片中也包含了与细胞因子代谢和细胞因子及其受体相互作用相关的基因。另外，还包括了急性期反应、炎症反应和
体液免疫应答等相关的基因。利用实时定量 PCR，你可以方便并且可信地对与炎症反应与自身免疫相关的基因表达谱进行分析。
Cytokines:
Chemokines: CCL11, CCL13, CCL16, CCL17, CCL19, CCL2, CCL21, CCL22, CCL23, CCL24, CCL3, CCL4, CCL5, CCL7, CCL8, CXCL1, CXCL10, CXCL2,
CXCL3, CXCL5, CXCL6, CXCL9, IL8.
Other Cytokines: CD40LG, CSF1, FASLG, FLT3LG, IFNG, IL10, IL18, IL1A, IL1B, IL1F10, IL1RN, IL22, IL23A, IL6, LTA, LTB, TNF, TNFSF14.
Cytokine Receptors:
Cytokine Receptors: IL10RB, IL1R1, IL1RAP, IL22RA2, IL6R, IL8RA, IL8RB.
Chemokine Receptors: CCL13, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CXCR4, IL8RA, IL8RB.
Cytokine Metabolism: IL10, IL18, TLR1, TLR3, TLR4, TLR6.
Other Genes involved in Cytokine-Cytokine Receptor Interaction: CCR1, CD40, IL18RAP, IL23R.
Acute-Phase Response: CEBPB, CRP, IL22, IL6.
Inflammatory Response: BCL6, C3, C3AR1, C4A, CCL11, CCL13, CCL16, CCL17, CCL19, CCL2, CCL21, CCL22, CCL23, CCL24, CCL3, CCL4, CCL5, CCL7, CCL8,
CCR1, CCR2, CCR3, CCR4, CCR7, CD40, CD40LG, CEBPB, CRP, CXCL1, CXCL10, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, FOS, HDAC4, IL10, IL10RB,
IL18RAP, IL1A, IL1B, IL1F10, IL1R1, IL1RAP, IL1RN, IL22, IL8, IL8RA, IL8RB, IL9, ITGB2, KNG1, LY96, MYD88, NFATC3, NFKB1, NOS2A, NR3C1, RIPK2, TIRAP,
TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TNF, TOLLIP.
Humoral Immune Response: C3, C4A, CCL16, CCL2, CCL22, CCL3, CCL7, CCR2, CCR7, CD40, IL10, IL18, IL1B, IL6, ITGB2, LY96, NFKB1.
细胞因子、细胞因子受体、细胞因子代谢相关基因、细胞因子及其受体相互作用相关基因、急性期反应相关基因、炎症反应相关基因、体液免疫反应相关基因
Inflammatory Response and Autoimmunity PCR Array 384HT
Catalog No. PAHS-3803A（人）
炎症反应与自身免疫 PCR 芯片 384HT
Catalog No. PAMM-3803A（小鼠）
The Inflammatory Response and Autoimmunity RT² Profiler PCR Array 384HT profiles the expression of 370 key genes involved in immune response during
autoimmunity and inflammation. It represents the expression of inflammatory cytokines, chemokines, and their receptors. It also contains genes related to the production
and metabolism of cytokines. Genes involved in cytokine-cytokine receptor interactions are as well as thoroughly researched panels of genes involved in the
acute-phase, inflammatory, and humoral immune responses. Using real-time PCR, you can easily and reliably analyze the expression of a focused panel of genes
related to autoimmunity and inflammation with this array.
炎症反应与自身免疫 RT² Profiler™ PCR Array 384HT 可以同时测定 370 个与炎症反应和自身免疫相关的基因。本芯片可以分析炎症细胞因子和趋
化因子以及它们的受体基因的表达谱。芯片中也包含了与细胞因子代谢和细胞因子及其受体相互作用相关的基因。另外，还包括了急性期反应、炎
症反应和体液免疫应答等相关的基因。利用实时定量 PCR，你可以方便并且可信地对与炎症反应与自身免疫相关的基因表达谱进行分析。
Cytokines:
Chemokines: CCL1, CCL11, CCL13, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3,
CCL3L1, CCL4, CCL4L1, CCL5, CCL7, CCL8, CKLF, CX3CL1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9,
CYP26B1, IL13, IL8, PF4V1, PPBP, PXMP2, XCL1.
Other Cytokines: BMP1, BMP2, BMP3, BMP7, CAST, CD40LG, CD70 (TNFSF7), CLC, CMTM1 (CKLFSF1), CMTM2 (CKLFSF2), CSF1, CSF2, CSF3, CTF1,
CXCL16, EBI3, ECGF1, EDA, EPO, ERBB2, ERBB2IP, FASLG, FGF10, FGF12, FIGF, FLT3LG, GDF2, GDF3, GDF5, GDF6, GDF8, GDF9, GLMN, GPI, GREM1,
GREM2, GRN, IFNA1, IFNA14, IFNA2, IFNA4, IFNA8, IFNB1, IFNE1, IFNG, IFNK, IFNW1, IFNWP2, IK, IL10, IL11, IL12A, IL12B, IL15, IL16, IL17A, IL17B, IL17C,
IL17D, IL17F, IL18, IL19, IL1A, IL1B, IL1F10, IL1F5, IL1F6, IL1F7, IL1F8, IL1F9, IL1RN, IL2, IL20, IL21, IL22, IL23A, IL24, IL25 (IL17E), IL26, IL27, IL29, IL3, IL32,
IL4, IL5, IL6, IL7, IL9, INHA, INHBA, INHBB, KITLG, LASS1, LEFTY1, LEFTY2, LIF, LTA, LTB, MDK, MIF, MUC4, NODAL, OSM, PBEF1, PDGFA, PDGFB, PRL,
PTN, SCYE1, SDCBP, SECTM1, SIVA1, SLCO1A2, SLURP1, SOCS2, SPP1, SPRED1, SRGAP1, THPO, TNF, TNFRSF11B, TNFSF10, TNFSF11, TNFSF13,
TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TRAP1, VEGFA, VEGFB, YARS.
Cytokine Receptors:
Cytokine Receptors: CNTFR, CSF2RA, CSF2RB, CSF3R, EBI3, EPOR, F3, GFRA1, GFRA2, GHR, IFNAR1, IFNAR2, IFNGR1, IFNGR2, IL10RA, IL10RB, IL11RA,
IL12B, IL12RB1, IL12RB2, IL13RA1, IL13RA2, IL15RA, IL17RA, IL17RB, IL18R1, IL1R1, IL1R2, IL1RAP, IL1RAPL2, IL1RL1, IL1RL2, IL20RA, IL21R, IL22RA1,
IL22RA2, IL28RA, IL2RA, IL2RB, IL2RG, IL31RA, IL3RA, IL4R, IL5RA, IL6R, IL6ST, IL7R, IL8RA, IL8RB, IL9R, LEPR, LIFR, MPL, OSMR, PRLR, TTN.
Chemokine Receptors: BLR1, CCL13, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CX3CR1, CXCR3, CXCR4,
CXCR6, IL8RA, IL8RB, XCR1.
Cytokine Metabolism: APOA2, ASB1, AZU1, B7H3, CD27 (TNFRSF7), CD28, CD4, CD80, CD86, EBI3, GLMN, IL10, IL12B, IL17F, IL18, IL21, IL27, IL4, INHA,
INHBA, INHBB, IRF4, NLRP12 (NALP12), PRG3, S100B, SFTPD, SIGIRR, TLR1, TLR3, TLR4, TLR6, TNFSF15.
Cytokine Production: APOA2, AZU1, CD27 (TNFRSF7), CD28, CD4, CD86, EBI3, GLMN, IL10, IL12B, IL17F, IL18, IL21, IL27, IL4, INHA, INHBA, INHBB, INS, IRF4,
NFAM1, NLRP12 (NALP12), NOX5, PRG3, S100B, SFTPD, SIGIRR, TLR1, TLR3, TLR4, TLR6.
Other Genes Involved in Cytokine-Cytokine Receptor Interaction: CCR1, CD40, CXCR3, IL18RAP, IL23R, XCR1.
Acute-Phase Response: AHSG, APCS, APOL2, CEBPB, CRP, F2, F8, FN1, IL22, IL6, INS, ITIH4, LBP, REG3A (PAP), REG3G, SAA4, SERPINA1, SERPINA3,
SERPINF2, SIGIRR, STAT3.
Inflammatory Response: ADORA1, AHSG, AIF1, APOA2, APOL3, AZU1, BCL6, BLNK, C3, C3AR1, C4A, CCL1, CCL11, CCL13, CCL16, CCL17, CCL18, CCL19,
CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL3, CCL3L1, CCL4, CCL4L1, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR7, CD14,
CD180, CD40, CD40LG, CD74, CD97, CEBPB, CKLF, CRP, CX3CL1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5,
CXCL6, CXCL9, CYBB, DOCK2, EPHX2, F11R, FOS, FPR1, GPR68, HDAC4, HDAC5, HDAC7A, HDAC9, HRH1, ICEBERG, IFNA2, IL10, IL10RB, IL13, IL17A, IL17B,
IL17C, IL17D, IL17F, IL18RAP, IL1A, IL1B, IL1F10, IL1F5, IL1F6, IL1R1, IL1RAP, IL1RN, IL20, IL22, IL25 (IL17E), IL31RA, IL5, IL8, IL8RA, IL8RB, IL9, IRF7, ITGB2,
KNG1, LTB4R, LY75, LY86, LY96, MEFV, MGLL, MIF, MMP25, MYD88, NCR3, NFAM1, NFATC3, NFATC4, NFE2L1, NFKB1, NFRKB, NFX1, NLRP12 (NALP12), NMI,
NOS2A, NR3C1, OLR1, PARP4, PLA2G2D, PLA2G7, PRDX5, PREX1, PRG2, PRG3, PROCR, PROK2, PTAFR, PTGS2, PTPRA, PTX3, REG3A (PAP), REG3G,
RIPK2, S100A12, S100A8, SCUBE1, SCYE1, SELE, SERPINA3, SFTPD, SIGLEC1 (SN), SPACA3, SPP1, STAB1, SYK, TACR1, TIRAP, TLR1, TLR10, TLR2, TLR3,
TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TNFAIP6, TOLLIP, TPST1, VPS45, XCR1.
Humoral Immune Response: BLNK, C3, C4A, CCL16, CCL18, CCL2, CCL20, CCL22, CCL3, CCL7, CCR2, CCR6, CCR7, CCRL2, CD27 (TNFRSF7), CD28, CD40,
CD74, CD86, CLC, CSF2RB, CXCR3, CYBB, EBI3, GPI, IL10, IL12A, IL12B, IL12RB1, IL13, IL18, IL1B, IL2, IL26, IL4, IL6, IL7, IL7R, IRF4, ITGB2, LY86, LY96, NFKB1,
PTAFR, S100B, SFTPD, XCL1, XCR1.
细胞因子、细胞因子受体、细胞因子代谢相关基因、细胞因子及其受体相互作用相关基因、急性期反应相关基因、炎症反应相关基因、体液免疫反应相关基因
Innate & Adaptive Immune Response PCR Array
Catalog No. PAHS-052A（人）
先天免疫与适应性免疫应答 PCR 芯片
Catalog No. PAMM-052A（小鼠）
The Innate and Adaptive Immune Responses RT² Profiler™ PCR Array profiles the expression of 84 genes involved in the host response to bacterial infection and
sepsis. This array includes genes related to the IL-1R and Toll-like Receptor (TLR) Signaling Pathways including IL-1R and TLR genes involved in the detection of
pathogens. Genes related to the host defense to bacteria are represented on this array including genes involved in the detection of bacteria, and genes involved in the
acute-phase response, complement activation, the inflammatory response, and the antibacterial humoral response. Genes involved in the innate immune response and
septic shock are also included on this array. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to the innate and
adaptive immune responses with this array.
先天免疫与适应性免疫 RT² Profiler™ PCR Array 可以同时测定 84 个与细菌感染和坏血症引起的宿主反应相关的基因。
本芯片包含 IL-1R 和 Toll-like
Receptor（TLR）信号通路相关的基因。芯片中也包含了与抗菌宿主防御、急性期反应、补体激活、炎症反应和抗菌体液反应等相关的基因。另外，
还包括了先天免疫应答和感染性休克相关的基因。利用实时定量 PCR，你可以方便并且可信地对与先天免疫和适应性免疫应答相关的基因表达谱进
行分析。
IL-1R / TLR Members and Related Genes:
Detection of Pathogens: TLR1, TLR3, TLR4, TLR6, TLR8.
Interleukin-1 Receptors: IL1R1, IL1R2, IL1RAP, IL1RAPL2, IL1RL2.
Other Genes Involved in the IL-1R Pathway: IKBKB, MAPK14, MAPK8.
Inflammatory Response: IL1A, IL1B, IL1F10, IL1F5, IL1F6, IL1F8, IL1R1, IL1RN, IRAK2, MYD88, NFKB1, TLR1, TLR10, TLR2, TLR3, TLR4, TLR6, TLR8, TLR9,
TNF, TOLLIP.
Apoptosis: IL1A, IL1B, NFKB1, NFKBIA, TGFB1, TNF.
Cytokines: IFNA1, IFNB1, IL1A, IL1B, IL1F10, IL1F5, IL1F6, IL1F7, IL1F8, IL1F9, IL6, TNF.
Genes Involved in NFκB Signaling: CHUK, IRAK2, MYD88, TLR1, TLR3, TLR4, TLR6, TLR8, TRAF6.
Host Defense to Bacteria:
Detection of Bacteria: CD1D, PGLYRP1, PGLYRP2, PGLYRP3, TLR1, TLR3, TLR6.
LSP Receptor: CD14, CXCR4, DAF.
Acute-phase Response: CRP, FN1, LBP.
Complement Activation: C5, C8A, DAF.
Inflammatory Response: C5, CCL2, CD14, CRP, CYBB, LY96, NFKB1, NOS2A, S100A12, TLR1, TLR3, TLR6, TLR9.
Cytokines, Chemokines, and their Receptors: C5, CCL2, CXCR4, IFNGR1, IFNGR2, IL12RB2, PPBP.
Antibacterial Humoral Response: COLEC12, CYBB, LY96, NFKB1.
Defense Response to Bacteria: CAMP, DEFB4, LALBA, LBP, LTF, LYZ, NOS2A, PGLYRP1, PGLYRP2, PGLYRP3, PPBP, S100A12, TLR3, TLR6, TLR9.
Other Genes Involved in the Host Defense Against Bacteria: CARD12, DMBT1, IRF1, NCF4, NFKBIA.
Innate Immune Response:
Innate Immune Response: COLEC12, DMBT1, PGLYRP1, PGLYRP2, PGLYRP3, SFTPD, TLR8
Other Genes Involved in the Innate Immune Response: CD1D, IFNB1, TLR10.
Septic Shock:
Apoptosis: ADORA2A, CASP1, CASP4, IL10, IL1B, NFKB1, PROC, TNF, TNFRSF1A.
Cytokines and Growth Factors: IL10, IL1B, IL6, MIF, TNF.
Inflammatory Response: ADORA2A, CCR3, IL10, IL1B, IL1RN, MIF, NFKB1, PTAFR, TLR2, TLR4, TNF.
Other Genes Involved in Septic Shock: HMOX1, IRAK1, NFKB2, SERPINA1, SERPINE1, TREM1.
IL-1R / TLR 家族及相关基因、抗菌宿主防御相关基因、先天性免疫应当相关基因、感染性休克相关基因
Obesity PCR Array
Catalog No. PAMM-017A（小鼠）
肥胖 PCR 芯片
Catalog No. PARN-017A（大鼠）
The Obesity RT² Profiler™ PCR Array profiles the expression of 84 genes related to Obesity. The control of a relative stable body weight depends on a complex
interaction among the hormone axes in the peripheral nervous system and neurotransmitter signals in the central nervous system that play a crucial role in maintaining a
balanced energy metabolism. This PCR Array includes obesity-related genes that are directly involved in the regulation of energy intake and expenditure. The genes
encode for orexigenic peptides, hormones, and receptors; anorectic peptides, hormones, receptors; and central and peripheral signaling molecules involved in energy
expenditure. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to Obesity with this array.
肥胖 RT² Profiler™ PCR Array 可以同时测定 84 个与肥胖相关的基因。外周激素和中枢神经系统的神经递质信号间复杂的相互作用网络在维持能量
代谢平衡上起重要作用，从而保持相对稳定的体重。本芯片中包含了直接调节能力摄入和消耗过程中与肥胖相关的基因。这些基因编码促进食欲的
神经肽、激素及受体；厌食神经肽、激素及受体；能量消耗相关的中枢和外周信号分子。利用实时定量 PCR，你可以方便并且可信地对与肥胖相关
的基因表达谱进行分析。
Orexigenic Genes:
Neuropeptides and Receptors: Adra2b, Agrp, Cnr1, Gal, Galr1, Mchr1 (Gpr24), Hcrt, Hctr1, Npy, Npy1r, Nr3c1 (Grl1), Oprk1, Oprm1, Oprs1.
Gut Hormone and Receptor: Ghrl (Ghrelin), Ghsr.
Anorectic Genes:
Neuropeptides and Receptors: Atrn (Attractin), Bdnf, Brs3, Calca, Calcr, Cartpt (Cart), Cntfr, Crhr1, Drd1a, Drd2, Gh, Ghr, Nmur1 (Gpr66), Grp, Grpr, Hrh1, Htr2c,
Il1a, Il1b, Il1r1, Il6, Il6ra, Mc3r, Nmb, Nmbr, Nmu, Nmur1 (Gpr66), Ntrk2, Nts, Ntsr1, Plrhr (Gpr10), Pomc1, Sort1, Trh, Ucn, Zfp91 (Cntf).
Gut Hormones and Receptors: Apoa4, Cck, Cckar, Glp1r, Pyy.
Adipocyte-derived Peptides and Receptors: Lep (Leptin), Lepr, Tnf.
Pancrease Derived Peptides and Receptors: Calcr, Clps, Gcg, Gcgr, Glp1r, Iapp, Ins1, Ins2, Insr, Ramp3, Sst, Sstr2.
Genes Related to Energy Expenditure:
Adipocyte-derived Peptides and Receptors: Adipoq (Acrp30), Adipor1, Adipor2, Adrb1, C3, Ppara, Pparg, Ppargc1a, Ptpn1, Ucp1.
CNS-derived Peptides and Receptors: Adcyap1, Adcyap1r1, Cpd, Cpe, Thrb.
促进食欲相关基因、厌食相关基因、能力消耗相关基因
T-cell and B-cell Activation PCR Array
Catalog No. PAHS-053A（人）
T 细胞与 B 细胞活化 PCR 芯片
Catalog No. PAMM-053A（小鼠）
The T-cell and B-cell Activation RT² Profiler™ PCR Array profiles the expression of 84 genes representing T-cell and B-cell activation, a key part of adaptive immunity.
This array includes genes involved B-cell activation as well as genes involved in B-cell proliferation and differentiation. Genes involved in the activation of T-cells and
their proliferation and differentitation are also represented along with genes regulating Th1 and Th2 development and T-cell polarization. Genes involved in the activation
of macrophages, neutrophils, and natural killer cells are also included. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes
related to T-cell and B-cell activation with this array.
T 细胞和 B 细胞活化 RT² Profiler™ PCR Array 可以同时测定 84 个与 T 细胞和 B 细胞活化相关的基因，T 细胞和 B 细胞活化是适应性免疫的一个关
键环节。芯片中包含 B 细胞增殖、分化和活化相关的基因；T 细胞增殖、分化以及 Th1、Th2 的分化、T 细胞极化等相关的基因。芯片中还包含巨
噬细胞、中性粒细胞和自然杀伤细胞激活相关的基因。利用实时定量 PCR，你可以方便并且可信地对与 T 细胞和 B 细胞活化相关的基因表达谱进行
分析。
B-cell Activation:
Antigen Dependent B-cell Activation: CD28, CD4, CD80, HLA-DRA, IL10, IL2, IL4, CD40 (TNFRSF5), FAS (TNFRSF6), CD40LG (TNFSF5), FASLG (TNFSF6).
Other Genes involved in B-cell Activation: BLR1, HDAC4, HDAC5, HDAC7A, HDAC9, ICOSL, IGBP1, MS4A1, RGS1.
B-cell Proliferation: CD81, IFNB1, IL10, CD40 (TNFRSF5), CD27 (TNFRSF7).
B-cell Differentiation: AICDA, BLNK, GALNAC4S-6ST, HDAC4, HDAC5, HDAC7A, HDAC9, IL10, IL11, IL4, INHA, INHBA, KLF6, CD27 (TNFRSF7).
T-cell Activation:
Regulators of T-cell Activation: CD2, CD3D, CD3E, CD3G, CD4, CD7, CD80, CD86, CD8A, CD8B1, CLECSF12, ICOSL, IRF4, KIF13B, NCK1, NCK2, PRLR,
TNFSF14.
T-cell Proliferation: CD28, CD3E, ICOSL, IL10, IL12B, IL18, NCK1, NCK2, SFTPD, TNFSF14.
T-cell Differentiation: CD2, CD4, CD80, CD86, IL12B, IL2, IRF4, NOS2A, SOCS5, CD27 (TNFRSF7).
Regulators of Th1 and Th2 Development: CD2, CD5, CD7, CSF2, IFNB1, IFNG, IL10, IL12A, IL13, IL3, IL4, IL5, TLR2, TLR4, TLR9, CD40 (TNFRSF5).
Genes Involved in Th1/Th2 Differentiation: CD28, CD86, HLA-DRA, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R,
PVRL1, CD40 (TNFRSF5), CD40LG (TNFSF5), .
Genes Involved in T-cell Polarization: CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A,
IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, CD40LG (TNFSF5).
Other Genes Related to Immune Cell Activation:
Macrophage Activation: INHA, INHBA, TLR1, TLR4, TLR6.
Neutrophil Activation: APOA2, IL8.
Natural Killer Cell Activation: CD2, IFNB1, IL12B, IL2.
Others: CX3CL1, TOLLIP.
B 细胞激活相关基因、T 细胞激活相关基因、其他与免疫细胞激活相关的基因
Cytokine and Inflammatory Response PCR Array
细胞因子与炎症反应 PCR 芯片
趋化因子及其受体 PCR 芯片
干扰素及其受体 PCR 芯片
细胞因子 PCR 芯片
T 细胞无反应性与免疫耐受 PCR 芯片
树突状呈递细胞与抗原呈递细胞 PCR 芯片
Th1-Th2-Th3 PCR 芯片
生长因子 PCR 芯片
Th17 细胞自身免疫与炎症反应 PCR 芯片
炎症细胞因子及其受体 PCR 芯片
Toll 样蛋白受体信号转导 PCR 芯片
干扰素 α, β 应答 PCR 芯片
Catalog No. PAHS-022A（人）
Chemo kines & Receptors PCR Array
趋化因子及其受体 PCR 芯片
Catalog No. PAMM-022A（小鼠）
Catalog No. PARN-022A（大鼠）
The Chemokines and Receptors RT² Profiler™ PCR Array profiles the expression of 84 genes that encode chemokines and their receptors. The array contains members
of the C-C and C-X-C motif subfamilies of small inducible cytokines and their receptors as well as other related genes. Using real-time PCR, you can easily and reliably
analyze expression of a focused panel of genes related to the immune system with this array.
趋化因子和受体 RT² Profiler™ PCR Array 可以同时测定 84 个编码趋化因子及其受体的关键基因。这些基因包括 C-C 和 C-X-C 基序家族，小的可
诱导细胞因子以及其受体，也包括一些相关基因。利用实时定量 PCR，你可以方便并且可信地对与免疫系统相关的基因表达谱进行检测。
Chemokine (C-C motif) Ligands: CCL1, CCL11, CCL13, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL3, CCL4, CCL5, CCL7, CCL8.
Chemokine (C-X-C motif) Ligands: CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9.
Chemokine (C-C motif) Receptors: CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR10, CCRL1, CCRL2.
Chemokine (C-X-C motif) Receptors: BLR1, CXCR3, CXCR4, CXCR6, CYFIP2.
Other Chemokines and Related Genes: AGTRL1, BDNF, C5, C5R1 (GPR77), CCBP2, CKLF, CKLFSF1, CKLFSF2, CKLFSF3, CKLFSF4, CMKLR1, CSF3, CX3CL1,
CX3CR1, ECGF1, GDF5, GPR31, GPR77, GPR81, HIF1A, IL13, IL16, IL18, IL1A, IL4, IL8, IL8RA, LTB4R, MMP2, MMP7, MYD88, NFKB1, SCYE1, SDF2, SLIT2,
TCP10, TLR2, TLR4, TNF, TNFRSF1A, TNFSF14, TREM1, VHL, XCL1, XCR1.
趋化因子 A（C-C motif）配基；趋化因子 A（C-X-C motif）配基；趋化因子 A（C-C motif）受体；趋化因子 A（C-X-C motif）受体；其他趋化因子及其相关受体。
Catalog No. PAHS-021A（人）
Common Cytokine PCR Array
细胞因子 PCR 芯片
Catalog No. PAMM-021A（小鼠）
Catalog No. PARN-021A（大鼠）
The Common CytokinesRT² Profiler™ PCR Array profiles the expression of 84 important cytokine genes. This array includes interferons and interleukins as well as the
bone morphogenetic proteins (BMP) and members of the TGF-ß family. Also represented are platelet-derived and vascular endothelial growth factors. Tumor necrosis
factors are included as well as other cytokine-related genes. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to
cytokines with this array.
普通细胞因子 RT² Profiler™ PCR Array 可以同时测定 84 个重要的细胞因子基因。这些基因包括干扰素、白介素、骨形成蛋白和 TGF-ß 家族成员。
血小板生成因子和血管内皮生长因子也包括其中。其中还包括了肿瘤坏死因子和其他细胞因子相关的基因。利用实时定量 PCR，你可以方便并且可
信地对与细胞因子相关的基因进行同时检测。
Interferons: IFNA1 (Interferon α1), IFNA2, IFNA4, IFNA5, IFNA8, IFNB1, IFNG (Interferon γ), IFNK.
Interleukins: : IL10 (Interleukin 10), IL11, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL17B, IL17C, IL17E, IL18, IL19, IL1A, IL1B, IL1F10, IL1F5, IL1F6, IL1F7, IL1F8,
IL1F9, IL2 (Interleukin 2), IL20, IL21, IL22, IL24, IL3, IL4, IL5, IL6, IL7, IL8, IL9.
Bone Morphogenic Proteins (BMPs) and TGF-β Family: BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8B, GDF10 (BMP3B), GDF11 (BMP11), GDF2
(BMP9), GDF3, GDF5, GDF8, GDF9, INHA, INHBA, NODAL, TGFA, TGFB1, TGFB2, TGFB3.
PDGF/VEGF Family: FIGF (VEGFD), PDGFA.
TNF Superfamily: FASLG (TNFSF6), LTA, LTB, TNF, TNFRSF11B, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF4, TNFSF7, TNFSF8.
Other Growth Factors/Cytokines: CSF1 (MCSF), CSF2 (GMCSF), FAM3B, LEFTY2 (EBAF).
干扰素；白介素；骨形成蛋白和 TGF-β 家族；PDGF/VEGF 家族；TNF 超家族；其他生长因子和细胞因子
Dendritic & Antigen Presenting Cell PCR Array
树突状呈递细胞与抗原呈递细胞 PCR 芯片
Catalog No. PAHS-406A（人）
The Human Dendritic and Antigen Presenting Cell RT² Profiler™ PCR Array profiles the expression of 84 genes focused on dendritic cell activation and maturation.
Genes important for dendritic cell activation and maturation such as cytokines, chemokines and their receptors are included on this array along with other related cell
surface receptors and signal transduction molecules. Genes involved in antigen uptake, processing, and presentation are also represented on this array. In addition to
being functionally defined, many of these genes on the array are highly expressed in mature dendritic cells or show significant changes in expression during cell
differentiation. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to dendritic and antigen presenting cells with this
array.
树突状呈递细胞与抗原呈递细胞 RT² Profiler™ PCR Array 可以同时测定 84 个与树突状细胞活化和成熟相关的基因。这些基因包括细胞因子、趋化
因子及受体；细胞表面受体和信号转导分子。抗原摄取、处理和呈递相关的基因也包含在其中。这些基因在成熟的树突状细胞中高表达，或者在分
化过程中表达水平发生明显变化。利用实时定量 PCR，你可以方便并且可信地对与树突状细胞和抗原呈递细胞相关的基因进行同时检测。
Cytokines, Chemokines and Their Receptors: CCL11, CCL13, CCL16, CCL19, CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR5,
CXCL1, CXCL10, CXCL12, CXCL2, CXCR4, ERBB2, IFNG, IFNGR1, IL12A, IL12B, IL16, IL2, IL8, IL8RA, INHBA, LYN, MDK, MIF, TNF, TNFSF11, TRAP1.
Antigen Uptake: CD44, CDC42, ICAM1, ICAM2, RAC1, STK4, TAP2.
Antigen Presentation: B2M, CD1A, CD1B, CD1C, CD1D, CD209, CD28, CD4, CD40, CD40LG, CD74, CD80, CD86, CD8A, HLA-A, HLA-DMA, HLA-DOA, HLA-DPA1,
HLA-DQA1, HLA-DQB1, TAPBP.
Cell Surface Receptors: CD2, CD40, FCER1A, FCER2, FCGR1A, LRP1, TLR1, TLR2.
Signal Transduction: CDKN1A, CEBPA, CSF1R, FAS, FCAR, IFIT3, ITGAM, ITGB2, NFKB1, NFKB2, PDIA3, RELA, RELB, VCL.
细胞因子、趋化因子及受体；抗原摄取相关基因；细胞表面受体相关基因；细胞转导相关基因
Growth Factor PCR Array
Catalog No. PAHS-041A（人）
生长因子 PCR 芯片
Catalog No. PAMM-041A（小鼠）
The Growth Factors RT² Profiler™ PCR Array profiles the expression of 84 genes related to growth factors. Growth factors play a vital role in various normal biological
processes such as embryogenesis, wound healing and inflammation. This array contains angiogenic growth factors and regulators of apoptosis. Genes involved in cell
differentiation are included as well. Also represented are genes related to embryonic development as well as genes involved in tissue-specific development. Using
real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to the growth factors with this array.
生长因子 RT² Profiler™ PCR Array 可以同时测定 84 个与生长因子 有关的基因。生长因子在如胚胎发育、伤口愈合、炎症多种正常生理过程发挥
重要作用。此 array 包括血管生成因子、凋亡调节因子。调节细胞分化的基因也包括在内。此外还包括胚胎发育和特定组织发育有关基因。利用实
时定量 PCR，你可以方便并且可信地对与生长因子相关的基因进行同时检测。
Angiogenic Growth Factors: ARTS-1, ECGF1, EREG, FGF1, FGF2, FGF6, FIGF, IL18, JAG1, PGF, TNNT1, VEGF, VEGFC.
Apoptosis Regulators: CLC, GDNF, IL10, IL1A, IL1B, IL2, NRG2, NTF3, SPP1, TDGF1, TGFB1, VEGF.
Cell Differentiation: ARTS-1, BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8B, CSF1, CSPG5, ECGF1, EREG, FGF1, FGF2, FGF22, FGF23, FGF6, FGF9,
FIGF, IL10, IL11, IL12B, IL2, IL4, INHA, INHBA, INHBB, JAG1, JAG2, LTBP4, MDK, NRG1, OKL38, PGF, SLCO1A2, SPP1, TDGF1, TNNT1, VEGFC.
Development Controllers:
Embryonic Development: BMP10, NRG1, NRG2, NRG3, TDGF1.
Nervous System Development: BDNF, CSPG5, CXCL1, FGF11, FGF13, FGF14, FGF17, FGF19, FGF2, FGF5, GDF11, GDNF, GPI, IL3, INHA, INHBA, JAG1, MDK,
NDP, NRG1, NRTN, NTF3, PTN, VEGF.
Central Nervous System Development: PDGFC, PSPN,
Muscle Development: FGF2, GDF8, HBEGF, IGF1, TNNT1.
Skeletal Development: GDF10, GDF11, IGF1, IGF2, INHA, INHBA.
Cartilage Development: BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8B.
Ovarian Follicle Development: INHA, INHBA, INHBB
Others: AMH, CECR1, CSF2, CSF3, DKK1, FGF7, LEFTY1, LEFTY2, LIF, LTBP4, NGFB, NODAL, TGFB1, THPO.
血管生成因子；凋亡调节基因；调节细胞分化的基因；发育控制有关的基因
Catalog No. PAHS-011A（人）
Inflammatory Cytokines & Receptors PCR Array
炎症细胞因子及其受体 PCR 芯片
Catalog No. PAMM-011A（小鼠）
Catalog No. PARN-011A（大鼠）
The Inflammatory Cytokines & Receptors RT² Profiler™ PCR Array profiles the expression of 84 key genes involved in the inflammatory response. This array contains
genes involved in mediating immune cascade reactions during inflammation. The chemokines, cytokines, and interleukins involved in the inflammatory response are
represented as well as their receptors. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to inflammation with this
array.
炎症细胞因子和受体 RT² Profiler™ PCR Array 可以同时测定 84 个与炎症反应有关的关键基因。这些基因包括介导免疫级联反应途径炎症因子。与
炎症反应有关的趋化因子、细胞因子、白介素和它们相关的受体也包含在内。利用实时定量 PCR，你可以方便并且可信地对与炎症反应相关的基因
表达谱进行检测。
Chemokine Genes:
C5, CCL1 (I-309), CCL11 (eotaxin), CCL13 (mcp-4), CCL15 (MIP-1d), CCL16 (HCC-4), CCL17 (TARC), CCL18 (PARC), CCL19, CCL2 (mcp-1), CCL20 (MIP-3a),
CCL21 (MIP-2), CCL23 (MPIF-1), CCL24 (MPIF-2 / eotaxin-2), CCL25 (TECK) , CCL26, CCL3 (MIP-1a), CCL4 (MIP-1b), CCL5 (RANTES), CCL7 (mcp-3), CCL8
(mcp-2), CXCL1, CXCL10 (IP-10), CXCL11 (I-TAC / IP-9), CXCL12 (SDF1), CXCL13, CXCL14, CXCL2, CXCL3, CXCL5 (ENA-78 / LIX), CXCL6 (GCP-2), CXCL9,
IL13, IL8.
Chemokine Receptors:
CCL13 (mcp-4), CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CX3CR1, IL8RA, XCR1 (CCXCR1).
Cytokine Genes:
IFNA2, IL10, IL13, IL17C, IL1A, IL1B, IL1F10, IL1F5, IL1F6, IL1F7, IL1F8, IL1F9, IL22, IL5, IL8, IL9, LTA, LTB, MIF, SCYE1 (endothelial Monocyte-activating
cytokine), SPP1, TNF, TNFSF5.
Cytokine Receptors:
IFNA2, IL10RA, IL10RB, IL13, IL13RA1, IL5RA, IL9, IL9R.
Other Genes Involved in Inflammatory Response:
ABCF1, BCL6, C3, C4A, CEBPB, CRP, ICEBERG, IL1R1, IL1RN, IL8RB, LTB4R, TOLLIP.
趋化因子基因；趋化因子受体；细胞因子基因；细胞因子受体；其他炎症相关基因
Interferon α, β Response PCR Array
干扰素 α, β 应答 PCR 芯片
Catalog No. PAMM-016A（小鼠）
The Mouse Interferon α, β Response RT² Profiler™ PCR Array profiles the expression of genes involved in the interferon-α and interferon-β immune responses. This
array contains the alpha and beta interferons (IFNs) and their receptors. It also includes signaling molecules involved in the interferon α, β response and IFN-responsive
genes. Genes associated with virally induced and intrinsic interferon resistance are included as well. Using real-time PCR, you can easily and reliably analyze expression
of a focused panel of genes related to Interferon α, β Response with this array.
干扰素α,β应答 RT² Profiler™ PCR Array 可以同时测定 84 个与干扰素α,β免疫应当有关的关键基因。芯片中包含干扰素α,β及受体。还包括干
扰素α,β应答相关的信号分子。另外，病毒诱导或内源性干扰素抗性相关的基因也包含其中。利用实时定量 PCR，你可以方便并且可信地对与干扰
素α,β应答相关的基因表达谱进行检测。
Ligands and Receptors: Ifna2, Ifna4, Ifnar1, Ifnar2, Ifnb1.
Signaling Molecules: Irf3, Irf7, Isgf3g (p48), Stat1, Stat2.
Interferon Responsive Genes with IFN-Responsive Elements: Adar, Anxa11, Casp1, Cxcl10 (INP10), Eif2ak2 (Prkr), Gbp1, Gbp2, Ifi204 (Ifi16), Irf1, Isgf3g (p48),
Mx1, Myd88, Nmi, Oas1a, Oas2, Prkra, Psme2, Stat1, Tap1, Tnfsf10, Traf3.
Genes Associated with HCV-Induced Interferon Resistance: Casp1, Gbp1, Gch1, Ifi204 (Ifi16), Ifit1, Isg20, Isgf3g (p48), Itih2, Nrg1 (HGL), Stat1.
Genes Associated with Intrinsic Interferon Resistance:
Signal Transduction: Arl5b (Arl8), Cav1, Mal, Prkcz, Prkra (PKR), Samsn1, Sh2d1a, Shb.
Apoptosis: Bag3, Dad1, Diablo (SMAC), Pml.
Stress Response: Dnajb10, Hspa1l.
Transcription Regulation: Atf5, Cbfb, Irf2, Irf3, Irf5, Pttg1.
Cell Growth: Cd70 (Tnfsf7), Cdkn1b (p27), Hoxb2 (hox2), Ifi204 (Ifi16), Ifitm1 (9-27), Met, Mnt, Rcbtb1 (RCC1), Vegfa.
Others: B2m, Bst2, Cnp1, Col16a1, H2-Bl, H2-D1, H2-K1, H2-M10.1, H2-M10.2, H2-M10.4, H2-M10.6, H2-M3, H2-Q1, H2-Q7, H2-T10, Ifi30, Ifit3, Ifitm2, Isg15
(G1p2), Mx2, Npepps (Psa), Oas1b, Oas2, Shfm1 (Shfdg1), Slc1a2, Traf3.
干扰素配体及受体、信号分子、干扰素反应基因及干扰素反应元件、HCV 诱导的干扰素抗性相关基因、内源性干扰素抗性相关基因
Interferon (IFN) and Receptor PCR Array
Catalog No. PAHS-064A（人）
干扰素及其受体 PCR 芯片
Catalog No. PAMM-064A（小鼠）
The Interferons and Receptors RT²Profiler™ PCR Array profiles the expression of 84 genes whose expression is controlled by or involved in cell signaling mediated by
interferon ligands and receptors. Four major groups of genes are included on this PCR array: interferons (IFN ligands), interferon receptors, interferon regulatory genes
and interferon-inducible genes. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to IFN signaling with this array.
干扰素及其受体 RT² Profiler™ PCR Array 可以同时测定 84 个与由干扰素及其受体有关的信号通路调节的或者是与之相关的基因。此 PCR array 包
括 4 类基因：干扰素、干扰素受体、干扰素调节基因和干扰素诱导的基因。利用实时定量 PCR，你可以方便并且可信地对与干扰素信号有关的基因
进行同时检测。
Interferons:
Ligands for Interferon-alpha and Interferon-beta Receptors: IFNA1, IFNA4, IFNB1, IFNK, IFNW1.
Ligands for Interferon-gamma Receptors: IFNG.
Ligands for Hematopoietin and Interferon-class (D200-domain) Cytokine Receptors: IFNA14, IFNA2, IFNA21, IFNA5, IFNA6, IFNA8, IFNE1, IL15.
Other Genes Related to Interferons: IFRD1, IFRD2, IL28A, IL29, IL6.
Interferon Receptors:
Interferon-alpha and Interferon-beta Receptors: IFNAR1, IFNAR2.
Interferon-gamma Receptors: IFNGR1, IFNGR2.
Other Hematopoietin and Interferon-class (D200-domain) Cytokine Receptors: CNTFR, CRLF2, CSF2RA, CSF3R, EBI3, F3, FNDC6, IL10RA, IL10RB, IL11RA,
IL12B, IL13RA1, IL20RA, IL21R, IL22RA2, IL28RA, IL2RB, IL2RG, IL31RA, IL3RA, IL4R, IL5RA, IL6R, IL7R, IL9R, LEPR, MPL, TTN.
Interferon Regulatory Factors:
Transcriptional Regulators: IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, IRF8.
Other Interferon Regulatory Proteins: IRF2BP1, IRF2BP2.
Interferon-Inducible Proteins:
Genes Involved in the Response to Virus: G1P2, IFI16, IFI35, IFI44, IFIH1, MX1, OAS1.
Transcriptional Regulators: IFI16, SP110.
Other Interferon-Inducible Genes: ADAR, CXCL10, G1P3, IFI27, IFI30, IFI44L, IFIT1, IFIT1L, IFIT2, IFIT3, IFITM1, IFITM2, IRGM, PSME1, PYHIN1.
干扰素基因；干扰素受体；干扰素调节基因；干扰素诱导蛋白
T Cell Anergy & Immune Tolerance PCR Array
T 细胞无反应性与免疫耐受 PCR 芯片
Catalog No. PAMM-074A（小鼠）
The Mouse T-cell Anergy and Immune Tolerance RT² Profiler™ PCR Array profiles the expression of 84 genes involved in T-cell anergy and immune tolerance. T-cells'
functional unresponsiveness, termed anergy, is a cell-intrinsic mechanism that contributes to peripheral self-tolerance. This array contains T-cell and B-cell regulators,
cytokines and receptors, TNF superfamily members and their receptors and transcriptional factors. Using real-time PCR, you can easily and reliably analyze expression
of a focused panel of genes related to T-cell anergy and immune tolerance with this array.
T 细胞无反应性与免疫耐受 RT² Profiler™ PCR Array 可以同时测定 84 个与 T 细胞无反应性及免疫耐受相关的基因。T 细胞功能性的无应答，也称
为无反应性，这是一种细胞内在的自身耐受机制。芯片中包含 T 细胞和 B 细胞调节因子、细胞因子及受体、TNF 超家族成员及受体、转录因子等。
利用实时定量 PCR，你可以方便并且可信地对与 T 细胞无反应性和免疫耐受有关的基因进行同时检测。
T-Cell Regulators: Btla, Cblb, Cd27, Cd28, Fas, Foxp3, Il15, Il2, Il2ra, Il4, Lat, Tgfb1, Tnfrsf14, Tnfsf14.
B-Cell Regulators: Btla, Cd27, Cd40, Cd40lg, Foxp1, Foxp3, Hdac9, Il4.
Cytokines, Receptors and their related Proteins: Ccl3, Ccr4, Cd40lg, Cd70, Csf1, Csf2, Fasl, Ifng, Il10, Il10ra, Il13, Il15, Il17a, Il1a, Il2, Il2ra, Il2rb, Il31, Il4, Il5, Il6, Il7r,
Lep, Lta, Prf1, Ptger2, Ptgs2, Tgfb1, Tnfsf10, Tnfsf14, Tnfsf8.
TNF Superfamily Members and their Receptors: Cd40lg, Cd70, Fas, Fasl, Lta, Tnfrsf10b, Tnfrsf14, Tnfrsf18, Tnfrsf4, Tnfrsf8, Tnfrsf9, Tnfsf10, Tnfsf14, Tnfsf8.
Transcriptional Regulators: Cdk2, Cdk4, Egr2, Egr3, Eomes, Fos, Foxp1, Foxp2, Foxp3, Gata3, Hdac9, Ifng, Ing4, Irf4, Jak3, Jun, Mef2a, Nfatc1, Nfatc2, Nfatc3,
Nfkb1, Nhlh2, Notch1, Stat3, Stat6, Tbx21, Tgfb1.
Other Genes involved in T-cell Anergy: Cma1, Ctla4, Dgka, Dgkz, Gzmb, Icam1, Icos, Itch, Itga1, Jak1, Lgals3, Pdcd1, Prkcc, Rnf128, Sell.
T 细胞调节因子；B 细胞调节因子；细胞因子、受体及相关蛋白；TNF 超家族成员及受体；转录调节因子；其他 T 细胞无反应性相关基因
Catalog No. PAHS-034A（人）
Th1-Th2-Th3 PCR Array
Th1-Th2-Th3 PCR 芯片
Catalog No. PAMM-034A（小鼠）
Catalog No. PARN-034A（大鼠）
The Th1-Th2-Th3 RT² Profiler™ PCR Array profiles the expression of 84 genes related to the three classes of helper T cells (CD4+ T lymphocytes): Th1, Th2, and Th3.
This array includes cytokine genes representative of Th1, Th2 and Th3 cells. The array also contains genes encoding transcriptional factors that regulate the expression
of these cytokines as well as other markers of CD4+ T lymphocytes. Genes involved in immune cell activation, in the Th1 and Th2 type immune responses, and genes
involved in the antimicrobial humoral response are included on this array as well as other immune response-related genes. Using real-time PCR, you can easily and
reliably analyze expression of a focused panel of genes related to helper T cells with this array.
Th1-Th2-Th3 RT² Profiler™ PCR Array 可以同时检测与 3 类辅助 T 细胞 A（CD4+ T 淋巴细胞）——Th1, Th2, Th3 相关的 84 个基因表达谱。其中
包括 Th1, Th2, Th3 细胞因子指标基因。也包括调节这些细胞因子和其他 CD4+ T 淋巴细胞标记表达的基因。还包括免疫细胞活化基因，Th1 和 Th2
细胞免疫应答基因，抗菌体液免疫应答基因和其他免疫应答相关基因。利用实时定量 PCR，你可以方便并且可信地对与辅助 T 细胞相关的基因进行
同时检测。
TH1 Cytokines and Related Genes: CCR5, CD28, CSF2, CXCR3, HAVCR2, IFNG, IGSF6, IL12B, IL12RB2, IL18, IL18R1, IL2, IL2RA, IRF1, SOCS1, SOCS5, STAT1,
STAT4, TBX21, TNF.
TH2 Cytokines and Related Genes: CCL11, CCL5, CCL7, CCR2, CCR3, CCR4, CEBPB, NFATC2IP (FLJ14639), GATA3, GFI1, GPR44, ICOS, IL10, IL13, IL13RA1,
IL1R1, IL1R2, IL4, IL4R, IL5, IL9, IRF4, JAK1, MAF, NFATC1, NFATC2, NFATC2IP (FLJ14639), PCGF2 (RNF110), STAT6, TLR4, TLR6, TMED1.
CD4+T Cell Markers: BCL3, CD4, CD40LG (TNFSF5), CD69, CD80, CD86, CREBBP, CTLA4, FASLG (TNFSF6), IL15, IL6, IL6R, IL7, JAK2, LAG3, LAT, MAP2K7,
MAPK8, PTPRC, TFCP2, TGFB3, TNFRSF7, TNFRSF8, TNFRSF9, TNFSF4, TNFSF6, TYK2, YY1.
Immune Cell Activation:
T-cell Activation: CD28, CD4, CD80, CD86, GLMN, IL10, IL12B, IL18, IL2, IRF4, SFTPD, SOCS5, SPP1, TNFRSF7.
B-cell Activation: CD40LG (TNFSF5), IL10, IL4, INHA, INHBA, TNFRSF7.
T-helper 1 Type Immune Response: CD4, CD80, CD86, GLMN, IL10, IL12B, IL18, INHA, INHBA, IRF4, SFTPD, SPP1, TLR4, TLR6, TNFRSF7.
T-helper 2 Type Immune Response: CD86, IL10, IL18, IL4, IRF4.
Antimicrobial Humoral Response: CCL7, CCR2, CXCR3, IL12B, IL13, SFTPD, YY1.
Other Genes Related to the Immune Response: CSF2, CEBPB, IRF1.
Transcription Factors and Regulators:
Positive Regulation of Transcription: CD80, CD86, IRF4.
RNA Polymerase II Transcription Factor Activity: GFI1, IRF4, MAF.
Transcription Coactivator Activity: CREBBP, YY1.
Transcription Corepressor Activity: YY1.
Transcription Factor Activity: CEBPB, CREBBP, GATA3, IRF1, NFATC1, NFATC2, PCGF2 (RNF110), STAT1, STAT4, STAT6, TBX21, TFCP2, YY1.
Transcription from Pol II Promoter: CEBPB, GATA3, IRF1, MAF, NFATC1, STAT1.
Other Transcription Factors and Regulators: BCL3, SOCS2, TNF.
TH1 细胞因子及其相关基因；TH2 细胞因子及其相关基因；CD4+细胞分子标记；免疫细胞激活有关基因；TH1 类型免疫反应有关基因；TH2 类型免疫反应有关基因；抗
菌体液免疫有关基因；其他免疫反应相关基因；转录因子及其调节因子
Th17 for Autoimmunity & Inflammation PCR Array
Catalog No. PAHS-073A（人）
Th17 细胞自身免疫与炎症反应 PCR 芯片
Catalog No. PAMM-073A（小鼠）
The Human Th17 for Autoimmunity & Inflammation RT² Profiler PCR Array profiles the expression of 84 genes related to the Th17 Regulatory Network. Th17 is a newly
defined subset of CD4(+) T cells that is distinct from the traditional Th1, Th2 and Treg. Th17 is highly proinflammatory and induces severe autoimmunity. This array
contains surface molecules, cytokines and receptors, chemokines, matrix metalloproteinases, cell signaling molecules and transcriptional factors. Using real-time PCR,
you can easily and reliably analyze expression of a focused panel of genes related to the Th17 regulatory network with this array.
Th17 细胞自身免疫与炎症反应 Profiler™ PCR Array 可以同时检测 84 个与 Th17 细胞信号调控网络相关的基因表达谱。Th17 细胞是区别于 Th1、
Th2 和 Treg 细胞的一类 CD4(+) T 细胞。Th17 在促炎症反应和自身免疫病中发挥重要作用。本芯片中包括细胞表面分子、细胞因子及受体、趋化因
子、基质金属蛋白酶、细胞信号分子和转录因子。利用实时定量 PCR，你可以方便并且可信地对与 Th17 细胞信号调控网络相关的基因进行同时检
测。
Surface Molecules: CD28, CD34, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, ICAM1, ICOS, ISG20.
Chemokines: CCL1, CCL2, CCL20, CCL22, CCL7, CD247, CX3CL1, CXCL1, CXCL12, CXCL2, CXCL5, CXCL6, IL8, MMP13, MMP3, MMP9.
Cytokines: CSF2, CSF3, IFNG, IL10, IL12B, IL13, IL15, IL17A, IL17C, IL17D, IL17F, IL18, IL1B, IL2, IL21, IL22, IL23A, IL25, IL27, IL3, IL4, IL5, IL6, TGFB1, TNF.
Cytokine Receptors: IL12RB1, IL12RB2, IL17RB, IL17RC, IL17RD, IL17RE, IL23R, IL6R, IL7R.
Signaling Pathway Molecules and Transcriptional Factors: CACYBP, CEBPB, CLEC7A, EDG1, FOXP3, GATA3, JAK1, JAK2, NFATC2, NFKB1, RORC, SOCS1,
SOCS3, STAT3, STAT4, STAT5A, STAT6, SYK, TBX21, TIRAP, TLR4, TRAF6, YY1.
细胞表面分子、趋化因子、细胞因子、细胞因子受体、信号分子和转录因子
Catalog No. PAHS-018A（人）
Toll-Like Receptor Signaling Pathway PCR Array
Catalog No. PAMM-018A（小鼠）
Toll 样蛋白受体信号转导 PCR 芯片
Catalog No. PARN-018A（大鼠）
The Toll-Like Receptor (TLR) Signaling pathway RT² Profiler™ PCR Array profiles the expression of 84 genes related to TLR-mediated signal transduction. This array
includes members of the TLR signaling family as well as key mediators of the TLR signaling pathway including adaptors and proteins that interact with toll-like receptors.
Effectors of TLR signaling are represented. Members of the NFKB, JNK/p38, NF/IL6, and IRF signaling pathways downstream of TLR signaling are also included on this
array. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to TLR-mediated signal transduction with this array.
Toll 样受体 A（TLR）信号通路 RT² Profiler™ PCR Array 可以同时检测与 TLR 介导的信号转导相关的 84 个基因表达谱。其中包括 TLR 信号家族成
员基因，TLR 信号通路调控关键元件包括与 Toll 样受体相互作用的接头和蛋白等的基因。也包括 TLR 信号的效应基因。还包括 TLR 信号通路下游
NFKB，JNK/p38，NF/IL6 和 IRF 家族成员基因。利用实时定量 PCR，你可以方便并且可信地对与 TLR 介导的信号转导相关的基因进行同时检测。
Toll-Like Receptors: LY64, SIGIRR, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10.
Adaptors & TLR Interacting Proteins: BTK, CD14, HMGB1, HRAS, HSPA1A, HSPD1, LY86 (MD-1), LY96 (MD-2), MAPK8IP3, MYD88, PELI1, RIPK2, SARM1,
TICAM2, TIRAP, TOLLIP, TRIF.
Effectors: CASP8, EIF2AK2, FADD, IRAK1, IRAK2, MAP3K7 (TAK1), MAP3K7IP1 (TAB1), NR2C2, PPARA, PRKRA, SITPEC, TRAF6, UBE2N, UBE2V1.
Downstream Pathways and Target Genes:
NFκB Pathway: CCL2, CHUK, CSF2 (GMCSF), CSF3 (GCSF), IFNA1, IFNB1, IFNG, IKBKB, IL1A, IL1B, IL2, IL6, IL8, IL10, IL12A, LTA, MAP3K1, MAP4K4, NFKB1,
NFKB2, NFKBIA, NFKBIL1, NFRKB, REL, RELA, TNF, TNFRSF1A.
JNK/p38 Pathway: ELK1, FOS (c-Fos), JUN, MAP2K3, MAP2K4 (JNKK1), MAP3K1 (MEKK), MAPK8 (JNK1).
NF/IL6 Pathway: CLECSF9, PTGS2.
IRF Pathway: CXCL10, IFNA1, IFNB1, IFNG, IRF1, IRF3, TBK1.
Regulation of Adaptive Immunity: CD80, CD86, RIPK2, TRAF6.
Toll 样受体；衔接蛋白和 TLR 相互作用蛋白；效应分子；下游通路及其靶基因；获得性免疫反应调节因子
Extracellular Matrix and Adhesion Molecules PCR Array
细胞外基质与黏连分子 PCR 芯片
细胞外基质与粘连分子 PCR 芯片
Catalog No. PAHS-013A（人）
Extracellular Matrix and Adhesion Molecules PCR Array
细胞外基质与粘连分子 PCR 芯片
Catalog No. PAMM-013A（小鼠）
Catalog No. PARN-013A（大鼠）
The Extracellular Matrix and Adhesion Molecules RT² Profiler™ PCR Array profiles the expression of 84 genes important for cell-cell and cell-matrix interactions. This
array contains extracellular matrix (ECM) proteins including basement membrane constituents, collagens, and genes playing a role in ECM structure. Proteases involved
in remodeling of the ECM are included as well as their inhibitors. This array also represents molecules important to cell adhesion including molecules involved in cell-cell
and cell-matrix adhesion, transmembrane molecules, and others. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes
related to cell adhesion with this array.
细胞外基质和黏附分子 RT² Profiler™ PCR Array 可以同时测定 84 个参与细胞间相互作用和细胞与细胞外基质相互作用的重要基因。这些基因包括
入基底膜成分，胶原等细胞外蛋白，还包括与细胞外基质结构有关的基因。蛋白酶及其抑制剂对于细胞外基质的重新构建也有重要作用。此 array
还包含了参与细胞与细胞、细胞与基质黏附有关的黏附分子和跨膜蛋白和其他相关基因。利用实时定量 PCR，你可以方便并且可信地对与细胞黏附
相关的基因进行同时检测。
Cell Adhesion Molecules:
Transmembrane Molecules: CD44, CDH1, HAS1, ICAM1, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2,
ITGB3, ITGB4, ITGB5, MMP14, MMP15, MMP16, NCAM1, PECAM1, SELE, SELL, SELP, SGCE, SPG7, VCAM1.
Cell-Cell Adhesion: CD44, CDH1, COL11A1, COL14A1, COL6A2, CTNND1, ICAM1, ITGA8, VCAM1.
Cell-Matrix Adhesion: ADAMTS13, CD44, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB3, ITGB4,
ITGB5, SGCE, SPP1, THBS3.
Other Adhesion Molecules: CNTN1, COL12A1, COL15A1, COL16A1, COL5A1, COL6A1, COL7A1, COL8A1, CSPG2, CTGF, CTNNA1, CTNNB1, CTNND2, FN1,
KAL1, LAMA1, LAMA2, LAMA3, LAMB1, LAMB3, LAMC1, THBS1, THBS2, TNA, TNC, VTN.
Extracellular Matrix Proteins:
Basement Membrane Constituents: COL4A2, COL7A1, LAMA1, LAMA2, LAMA3, LAMB1, LAMB3, LAMC1, SPARC.
Collagens & ECM Structural Constituents: COL11A1, COL12A1, COL14A1, COL15A1, COL16A1, COL1A1, COL4A2, COL5A1, COL6A1, COL6A2, COL7A1,
COL8A1, FN1, KAL1.
ECM Proteases: ADAMTS1, ADAMTS13, ADAMTS8, MMP1, MMP10, MMP11, MMP12, MMP13, MMP14, MMP15, MMP16, MMP2, MMP3, MMP7, MMP8, MMP9,
SPG7, TIMP1.
ECM Protease Inhibitors: COL7A1, KAL1, THBS1, TIMP1, TIMP2, TIMP3.
Other ECM Molecules: CSPG2, CTGF, ECM1, HAS1, SPP1, TGFBI, THBS2, THBS3, TNA, TNC, VTN.
细胞黏附分子；细胞外基质蛋白
Neuroscience PCR Array
神经科学 PCR 芯片
神经形成与神经干细胞 PCR 芯片
神经生物学离子通道与转运蛋白 PCR 芯片
神经营养素及其受体 PCR 芯片
神经递质受体与调控因子 PCR 芯片
Neurogenesis and Neural Stem Cell PCR Array
Catalog No. PAHS-404A（人）
神经形成与神经干细胞 PCR 芯片
Catalog No. PAMM-404A（小鼠）
The Human Neurogenesis and Neural Stem Cell RT² Profiler™ PCR Array profiles the expression of 84 genes related to the processes of neurogenesis and neural stem
cell differentiation. Genes related to the regulation of key neurogenesis processes such as the cell cycle and cell proliferation, differentiation, motility, and migration are
included. This array contains the growth factors and cytokines related to neural stem cells as well as genes involved in synaptic functions, apoptosis, and cell adhesion.
Cell signaling genes involved in neurogenesis are represented as well as genes involved in the regulation of transcription. Using real-time PCR, you can easily and
reliably analyze expression of a focused panel of genes related to neurogenesis and neural stem cells with this array.
神经形成与神经干细胞 RT² Profiler™ PCR Array 可以同时测定 84 个参与神经形成和神经干细胞分化过程相关的重要基因，这些基因调控神经形成
过程：细胞周期、细胞增殖、细胞分化、细胞运动和细胞迁移。芯片中包含与神经干细胞相关的生长因子和细胞因子，还有与突触功能、凋亡和细
胞黏附相关的基因。神经形成相关的细胞信号分子和转录调控分子也包含其中。利用实时定量 PCR，你可以方便并且可信地对与神经形成和神经干
细胞相关的基因进行同时检测。
Cell Proliferation:
Positive Regulation of Cell Proliferation: EGF, FGF2, IL3, NRP1, PTN, VEGFA.
Negative Regulation of Cell Proliferation: ALK, BAI1, CXCL1, NDN, NOTCH2, ODZ1.
Other Regulators of Cell Proliferation: ACHE, CDK5R1, CDK5RAP1, CDK5RAP3, ERBB2, MDK, NDP, S100A6, S100B.
Cell Cycle Genes:
Cell Cycle Arrest: APBB1, INHBA, MLL, NOTCH2.
Negative Regulation of the Cell Cycle: APBB1, INHBA.
Other Regulators of the Cell Cycle: EP300, FGF2, HDAC4, HDAC7A, MDK, NDN, PARD3, PARD6B, PTN, S100A6, VEGFA.
Regulation of Cell Motility and Cell Migration: FLNA, NTN1, PAFAH1B1, SLIT2, STAT3, VEGFA.
Regulation of Cell Differentiation:
Regulation of Neuronal Differentiation: CDK5R1, CDK5RAP1, CDK5RAP2, CDK5RAP3, YWHAH.
Cell Fate Determination: DLL1, NOTCH2, SHH.
Other Regulators of Cell Differentiation: ASCL1, HDAC4, HDAC7A, INHBA, MDK, NCOA6, NEUROD1, NOG, NRCAM, NRG1, PAX5, PAX6.
Growth Factors and Cytokines:
Growth Factors: ARTN, BDNF, BMP15, BMP2, BMP4, BMP8B, CXCL1, EGF, FGF13, FGF2, GDNF, GPI, IL3, INHBA, MDK, NDP, NRG1, PTN, S100A6, VEGFA.
Cytokines: BMP15, BMP2, BMP4, BMP8B, CXCL1, GPI, IL3, INHBA, MDK, PTN.
Genes Involved in Synaptic Functions:
Regulation of Synaptic Plasticity: APOE, GRIN1, S100B, YWHAH.
Synaptic Transmission: APOE, CHRM2, DLG4, DRD1, DRD2, GRIN1, NPTX1.
Synaptogenesis: ACHE, NRCAM, POU4F1.
Apoptosis:
Anti-apoptosis: GDNF, NOTCH2, SEMA4D.
Induction of Apoptosis: ADORA1, APOE, INHBA, NOTCH2, S100B.
Other Genes Related to Apoptosis and Cell Death: ADORA2A, EP300, NTN1, PAX3, RTN4, VEGFA, YWHAH.
Cell Adhesion:
Homophilic Cell Adhesion: ROBO1.
Other Genes Related to Cell Adhesion: ACHE, BAI1, DLL1, EFNB1, FEZ1, NRCAM, NRP1, NRP2, RAC1, SEMA4D, SLIT2, TNR.
Cell Signaling Genes Involved in Neurogenesis:
Notch Signaling Pathway: DLL1, NOTCH2.
WNT Receptor/ Frizzled Signaling Pathway: DVL3.
G-protein Coupled Receptor Protein Signaling Pathway: ADORA1, ADORA2A, BAI1, CHRM2, CXCL1, DRD1, DRD2, GNAO1.
Other Genes Related to Signaling: NCOA6, NOTCH2.
Regulation of Transcription: APBB1, ARNT2, ASCL1, EP300, HDAC4, HDAC7A, HES1, HEY1, HEY2, HEYL, MEF2C, MLL, NCOA6, NDN, NEUROD1, NOTCH2,
PAX3, PAX5, PAX6, POU3F3, POU4F1, SOX3, STAT3.
细胞增殖相关基因、细胞周期相关基因、细胞运动和细胞迁移调控基因、细胞分化调控基因、生长因子和细胞因子、突触功能相关基因、凋亡基因、细胞黏附相关基因、
神经形成相关信号分子、转录调控基因
Catalog No. PAHS-031A（人）
Neurotrophin and Receptors PCR Array
神经营养素及其受体 PCR 芯片
Catalog No. PAMM-031A（小鼠）
Catalog No. PARN-031A（大鼠）
The Neurotrophin and Receptors RT² Profiler™ PCR Array profiles the expression of 84 genes related to neuronal processes. Neurotrophic signaling molecules are
represented on this array including neurotrophins and neuropeptides along with their receptors. Genes involved in the normal functions of the neuronal system including
neuronal cell growth and differentiation and neuronal regeneration and survival are included. The cytokines and receptors involved in neuronal signaling are contained
on this array along with genes involved in the transmission of nerve impulses, genes involved in neuronal apoptosis in response to neurotrophic factors and transcription
factors and regulators indicative of the activation pathways downstream of the neuronal system. Using real-time PCR, you can easily and reliably analyze expression of a
focused panel of genes related to the neuronal system with this array.
神经营养素及其受体 RT² Profiler™ PCR Array 包含与神经活动相关的 84 个基因，主要分为以下几类：神经营养素及其受体，神经肽及其受体，神
经细胞生长、分化、再生和生存等正常神经活动相关的基因，细胞因子及其受体，神经冲动传播相关基因，神经营养因子和转录因子相关的神经细
胞凋亡相关基因，神经系统下游信号通路激活相关调节基因。利用实时定量 PCR，你可以方便并且可信地对与神经系统相关的基因进行同时检测。
Neurotrophins and Receptors: ADCYAP1R1, ARTN, BDNF, CD40 (TNFRSF5), CNTF, CNTFR, CRHBP, CRHR1, CRHR2, FRS2, FRS3, FUS, GDNF, GFRA1,
GFRA2, GFRA3, GMFB, GMFG, MAGED1, MT3, NF1, NGFB, NGFR, NGFRAP1, NR1I2, NRG1, NRG2, NTF3, NTF5, NTRK1, NTRK2, PSPN, PTGER2, TFG, TRO,
VGF.
Neuropeptides and Receptors:
Neuropeptide Hormone: CRH, NPFF, NPY, PNOC, UCN.
Bombesin Receptors: GRPR.
Cholecystokinin Receptors: CCKAR.
Galanin Receptors: GALR1, GALR2.
Neuropeptide Y Receptors: NPY1R, NPY2R, PPYR1.
Neurotensin Receptors: NTSR1.
Tachykinin and Receptors: TACR1.
Other Neuropeptides and Receptors: GPR74, HCRT, MC2R.
Neurogenesis:
Central Nervous System Development: PSPN.
Peripheral Nervous System Development: GFRA3.
Negative Regulation of Neurogenesis: MT3.
Other Neurogenesis Related Genes: ARTN, BDNF, CBLN1, CNTF, CNTFR, FGF2, GDNF, MEF2C, NELL1, NGFR, NRG1, NTF3, NTRK1, NTRK2, STAT3, TFG.
Transmission of Nerve Impulse: CBLN1, CNTF, CRH, GALR1, GALR2, HCRT, NPFF, NPY, NTSR1, PNOC.
Cell Growth and Differentiation:
Growth Factors and Receptors: ARTN, BDNF, CNTF, FGF2, FGF9, FGFR1, FRS2, FRS3, GDNF, GMFB, GMFG, IL10, IL1B, IL6, LIF, NGFB, NRG1, NRG2, NRG4,
NTF3, NTF5, PSPN, TGFA, TGFB1, VGF.
Cell Cycle: BAX, BCL2, FGF2, FGF9, IL1B, MYC, NF1, STAT1, TGFA, TGFB1, TP53.
Cell Proliferation: BCL2, FGF2, FGF9, GRPR, IL10, IL1B, IL6, IL6R, LIF, MT3, MYC, NF1, NPY, TGFA, TGFB1, TP53.
Cell Differentiation: FGF9, IL10, NRG1, TP53.
Cytokines and Receptors: CNTFR, CX3CR1, CXCR4, IL10, IL10RA, IL1B, IL1R1, IL6, IL6R, IL6ST, LIF, LIFR.
Apoptosis:
Anti-Apoptosis: BCL2, FAS (TNFRSF6), GDNF, IL10, NRG2, NTF3, TGFB1.
Caspase Activation: STAT1, TP53.
Induction of Apoptosis: BAX, FAS (TNFRSF6), TP53.
Other Genes Related to Apoptosis: CD40 (TNFRSF5), HSPB1, IL1B, NGFR, NGFRAP1.
Immune Response:
Acute-Phase Response: IL6, STAT3.
Humoral Immune Response: BCL2, CD40 (TNFRSF5), IL10, IL1B, IL6.
Inflammatory Response: CD40 (TNFRSF5), FOS, IL10, IL1B, IL1R1, TACR1.
Other Immune Response Genes: FAS (TNFRSF6), CRH, CRHR1, CX3CR1, IL6R, IL6ST, LIF.
Transcription Factors and Regulators:
RNA Polymerase II Transcription Factors: FOS, MEF2C.
Transcription Coactivators: MEF2C, NR1I2.
Transcription Factors: MEF2C, MYC, NR1I2, STAT1, STAT2, STAT3, STAT4, TP53.
神经营养素和受体基因；神经肽和受体基因；神经发生相关基因；神经冲动传送有关基因；细胞生长和分化相关基因；细胞因子和受体；凋亡有关基因；免疫反应有关基
因；转录因子和转录调节因子
Catalog No. PAHS-036A（人）
Neuroscience Ion Channels & Transporters PCR Array
神经生物学离子通道与转运蛋白 PCR 芯片
Catalog No. PAMM-036A（小鼠）
Catalog No. PARN-036A（大鼠）
The Human Neuroscience Ion Channels and Transporters RT² Profiler™ PCR Array was developed to profile expression of a panel of 84 genes encoding
neuroscience-related ion channels and transporters. The genes represented on the array are listed below, grouped according to their functional and structural features.
Included are calcium channels, potassium channels, sodium channels, chloride channels, and transporters. Using real-time PCR, you can easily and reliably analyze
expression of a focused panel of genes related to the neuronal ion channels and transporters with this array.
神经生物学离子通道与转运蛋白 RT² Profiler™ PCR Array 包含 84 个编码神经生物学离子通道和转运蛋白的基因，根据这些基因的功能和结构特征
主要分为以下几类：钙离子通道、钾离子通道、钠离子通道、氯离子通道和转运蛋白。利用实时定量 PCR，你可以方便并且可信地对与神经生物学
离子通道和转运蛋白相关的基因进行同时检测。
Calcium Channel: CACNA1A, CACNA1B, CACNA1C, CACNA1H, CACNA1S, CACNB1, CACNB2, CACNB3, CACNB4, CACNG2.
Potassium Channel:
Calcium-activated Potassium Channels: KCNMB1, KCNN1, KCNN2, KCNN3, KCNN4.
Delayed Rectifier Potassium Channels: KCNA1, KCNA2, KCNA3, KCNA5, KCNB1, KCNB2, KCNE1, KCNH2, KCNQ1, KCNS1.
Inward rectifier Potassium Channels: KCNJ1, KCNJ11, KCNJ3, KCNJ4, KCNJ5, KCNJ6.
Voltage-gated Potassium Channels: KCNA4, KCNC1, KCNC4, KCND1, KCND2, KCNF1, KCNG1, KCNH1, KCNQ2, KCNQ3, KCNQ4, KCNS2, KCNS3.
Sodium Channel:
Amiloride-sensitive Sodium Channels: ACCN1, ACCN2, ACCN3.
Voltage-gated Sodium Channels: SCN1A, SCN1B, SCN2A, SCN2B, SCN3A, SCN4A, SCN5A, SCN7A, SCN8A, SCN9A.
Chloride Channel: CFTR, CLCA1, CLCN1, CLCN2, CLCN3, CLCN4, CLCN5, CLCN6, CLCN7, CLIC1, CLIC2.
Transporters for Other Molecules:
Amine Transporters: ATP1A1, SLC18A1, SLC18A2, SLC1A1, SLC1A2, SLC1A3, SLC6A11, SLC6A12, SLC6A3, SLC6A4, SLC6A9.
Transporters with ATPase Activity: ATP1A1, ATP1B1, ATP2A1, ATP4A, CFTR.
Carbohydrate Transporters: SLC2A1, SLC2A11.
Hydrogen Ion Transporters: ATP4A.
Neurotransmitter Transporters: SLC6A11, SLC6A12, SLC6A3, SLC6A4, SLC6A9.
Sodium:dicarboxylate Symporter: SLC1A1, SLC1A2, SLC1A3.
Other Transporters: KCNA1, KCNMB1, KCNS1.
钙离子通道相关基因、钾离子通道相关基因、钠离子通道相关基因、氯离子通道相关基因、转运蛋白及其他相关分子
Catalog No. PAHS-060A（人）
Neurotransmitter Receptors and Regulators PCR Array
Catalog No. PAMM-060A（小鼠）
神经递质受体与调控因子 PCR 芯片
Catalog No. PARN-060A（大鼠）
The Human Neurotransmitter Receptors and Regulators RT² Profiler™ PCR Array profiles the expression of 84 genes involved in modulating the biological processes of
neurotransmitter biosynthesis, uptake, transport and signaling through neurotransmitter receptors. This array contains receptors for specific neurotransmitters, such as
acetylcholine, benzodiazepine, dopamine, gamma-aminobutyric acid (GABA), glutamate, serotonin, somatostatin and neuropeptides. Genes involved in the regulation of
neurotransmitter levels are included as well. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to the neuronal
system with this array.
神经递质受体与调控因子 RT² Profiler™ PCR Array 包含 84 个调控神经递质生物合成、摄入、转运及信号传递等生物过程的基因。芯片中包含神经
递质特异性受体，例如：乙酰胆碱、苯二氮、多巴胺、伽马氨基丁酸（GABA）、谷氨酸、五羟色胺、生长抑素和神经肽等。调控神经递质水平的
基因也包含其中。利用实时定量 PCR，你可以方便并且可信地对与神经系统相关的基因进行同时检测。
Neurotransmitter Receptors:
Acetylcholine Receptors: ANXA9, CHRNA1, CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNB1, CHRNB2, CHRNB4, CHRND, CHRNE,
CHRNG.
Muscarinic Acetylcholine Receptors: CHRM1, CHRM2, CHRM3, CHRNG.
Benzodiazepine Receptors: TSPO (BZRP), GABRA2, GABRA3, GABRG2.
Bombesin Receptors: BRS3, GRPR, NMBR.
Cholecystokinin Receptors: CCKAR, CCKBR.
Dopamine Receptors: DRD1, DRD2, DRD3.
GABA-A Receptors: GABRA1, GABRA2, GABRB1, GABRB2, GABRD, GABRE, GABRG1, GABRG2, GABRP, GABRQ, GABRR1, GABRR2.
Galanin Receptors: GALR1, GALR2, GALR3.
Glycine Receptors: GLRA1, GLRA2, GLRA3.
Glutamate Receptors: GRIA1, GRIN1
Neuromedin U Receptors: NMUR1, NMUR2.
Neuropeptide Receptors: NPFFR1 (GPR147), MCHR1 (GPR24), NPFFR2 (GPR74), HCRTR2, PRLHR (GPR10), SORCS1, SORCS2.
Neuropeptide Y Receptors: GPR103, PROKR1 (GPR73), PROKR2 (GPR73L1), GPR83, NPY1R, NPY2R, PPYR1, PRLHR (GPR10).
Serotonin Receptors: HTR1B, HTR2A, HTR3A, HTR3B.
Somatostatin Receptors: SSTR1, SSTR2, SSTR3, SSTR4.
Tachykinin Receptors: TACR1, TACR2.
Regulation of Neurotransmitter Levels:
Neurotransmitter Biosynthesis: CHAT, GAD1, SLC5A7, TPH1.
Neurotransmitter Catabolism: ABAT, ACHE, COMT, MAOA.
Neurotransmitter Metabolism: GCH1, GCHFR, PHOX2A.
神经递质受体、调控神经递质水平的基因
Signal Transduction PCR Array
信号转导 PCR 芯片
cAMP / Ca2+信号通路 PCR 芯片
MAPK 信号转导通路 PCR 芯片
EGF/PDGF 信号通路 PCR 芯片
NF-κB 信号通路 PCR 芯片
GPCR 信号通路发现者 PCR 芯片
一氧化氮 PCR 芯片
低氧信号通路 PCR 芯片
Notch 信号通路 PCR 芯片
热激蛋白 PCR 芯片
PI3K-AKT 信号通路 PCR 芯片
Hedgehog 信号通路 PCR 芯片
信号转导通路发现者 PCR 芯片
胰岛素信号通路 PCR 芯片
TGFß / BMP 信号通路 PCR 芯片
JAK / STAT 信号通路 PCR 芯片
TNF 配体及其受体 PCR 芯片
泛素（泛素化）信号通路 PCR 芯片
Wnt 信号通路 PCR 芯片
脂蛋白信号通路与胆固醇代谢 PCR 芯片
cAMP / Ca2+ Signaling PathwayFinder PCR Array
Catalog No. PAHS-066A（人）
cAMP / Ca 信号通路 PCR 芯片
Catalog No. PAMM-066A（小鼠）
2+
The Human cAMP/Ca2+ PathwayFinder RT² Profiler™ PCR Array contains 84 target genes that are responsive to cAMP or calcium ion (Ca 2+). This array contains genes
whose promoters contain SRE or SRE-like enhancer sequences, the CRE enhancer sequence, and other Ca2+ responsive elements. Using real-time PCR, you can
easily and reliably analyze expression of a focused panel of genes involved in cAMP/Ca2+ signaling with this array.
＋
cAMP/Ca2 信号通路 RT² Profiler™ PCR Array 包含 84 个 cAMP 或钙离子通道效应基因，这些基因的启动子区域含有 SRE 或类似 SRE 的增强子序
＋
＋
列、CRE 增强子序列和 Ca2 效应元件。利用实时定量 PCR，你可以方便并且可信地对与 cAMP/Ca2 信号相关的一组基因进行同时检测。
Genes whose promoters contain SRE or SRE-like enhancer sequences: CNN1 (calponin), CYR61, EGR1, EGR2, FOS, FOSB, HSPA4 (hsp70), JUNB, NR4A2
(Nur77), S100A6 (Calcyclin), SCG2 (secretogranin II), SRF, THBS1 (TSP-1), VCL.
Genes whose promoters contain the CRE enhancer sequence:
Neuropeptides / Neurotransmitters: ADRB1 (b1 adrenergic receptor), CGA (Chorionic gonadotropin A), CHGA (Chromogranin), GCG (Glucagon), GIPR, INHBA
(Inhibin A), KCNA5 (KV1.5), NOS2A (Inducible nitric oxide synthase), PENK (Enkephalin), PRL, S100A12 (CGRP), S100G, SCG2, SLC18A1 (Vesicular monoamine
transporter), SST (Somatostatin), SSTR2 (Somatostatin receptor 2), TACR1 (Substance P receptor), TH(Tyrosine hydroxylase), VIP.
Cell Cycle / Cell Survival / DNA Repair: BCL2, BRCA1, CCNA1 (CyclinA), CCND1 (CyclinD1), CDK5, CDKN2B (p15IND4b), GEM, NF1, PCNA, PMAIP1 (NoxA),
PPP1R15A (GADD34), RB1.
Growth Factor: AREG (Amphiregulin), BDNF, CTF1 (Cardiotrophin), FGF6, TGFB3, TNF.
Signaling: DUSP1 (Ptpn16), HSPA5 (Grp78), PLN (Phospholamban), PPP2CA (Protein phosphatase 2A alpha), PRKAR1A (Proteinkinase A regulatory subunit),
SGK.
Transcription: ATF3, CREB1, CREM, EGR1, EGR2, FOS, JUND, MAF, NR4A2 (Nur77), PER1, POU1F1 (Pit-1), POU2AF1 (OCA-B), STAT3.
Metabolism: AHR, AMD1, ENO2, HK2, LDHA, PCK2, SOD2.
Immune Regulation: IL2, IL6, MIF, PTGS2 (Cox-2).
Genes whose promoters contain other Ca2+ responsive elements: ACTB (b-actin), CALB1 (calbindin 1), CALB2 (calbindin 2), CALM1 (Calmodulin 1), CALR
(Calreticulin), DDIT3 (GADD153), NCAM1, NPY, PLAT (tPA).
＋
启动子区域含有 SRE 或类似 SRE 增强子序列的基因、启动子区域含有 CRE 增强子序列的基因、启动子区域含有 Ca2 效应元件的基因
EGF / PDGF Signaling Pathway PCR Array
EGF/PDGF 信号通路 PCR 芯片
Catalog No. PAHS-040A（人）
The Human EGF / PDGF Signaling RT² Profiler™ PCR Array profiles the expression of 84 genes related to EGF / PDGF-mediated signal transduction. This array
includes genes that encode members of the Epidermal Growth Factor (EGF) and Platelet-Derived Growth Factor (PDGF) Signaling Pathways. The array represents
growth factors and their receptors, proteins involved in signaling downstream of the growth factors, and the genes targeted by growth factor-mediated stimulation.
Members of the MAP Kinase pathway, the AKT / PI3K pathway, and other downstream signaling cascades are included as well. Using real-time PCR, you can easily and
reliably analyze expression of a focused panel of genes related to EGF / PDGF signaling with this array.
EGF/PDGF 信号通路 RT² Profiler™ PCR Array 包含 84 个与 EGF/PDGF 调控的信号转导相关的基因，这些基因编码表皮生长因子（EGF）和血小
板源生长因子（PDGF）信号通路中的蛋白成员。芯片中包含生长因子及受体、生长因子下游信号通路中的蛋白、生长因子调控的靶基因、MAP Kinase
信号通路成员、AKT/PI3K 信号通路成员和各信号通路下游一系列信号级联反应相关的基因。利用实时定量 PCR，你可以方便并且可信地对与
EGF/PDGF 信号通路相关的一组基因进行同时检测。
Epidermal Growth Factor Receptor Signaling Pathway: BCAR1, CBL, EGF, EGFR, EPS8, GAB1, GRB2, HBEGF, NCK2, NUP62, RPS6KA5, SHC1.
Platelet-Derived Growth Factor Receptor Signaling Pathway: BCAR1, PDGFA, PDGFB, PDGFRA, PLAT.
Intracellular Signaling Molecules:
AKT Signaling Pathway: AKT1, AKT2, AKT3, BAD, CASP9, CHUK, FASLG, FOXO3A, NFKB1, PTEN.
Erk1 / Erk2 MAPK Signaling Pathway: EGFR, ELK1, GRB2, MAP2K1, MAPK1, MAPK3, MKNK1, PDGFRA, RAF1, RPS6KA5, SHC1, SRC, STAT3.
IκB Kinase / NFκB Cascade: CHUK, FASLG, GSK3A, GSK3B, NUP62, RHOA, STAT1.
JAK / STAT Cascade: EPS8, GAB1, GRB2, JAK1, NUP62, PPP2CA, SRC, STAT1, STAT3, STAT5A.
JNK Cascade: MAP2K4, MAP3K2, MAPK10, MAPK8, MAPK9.
MAPKKK Cascade: DUSP1, DUSP6, EGF, EGFR, MAP2K1, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, PPP2CA, PRKCA, SHC1.
PI3K / Phosphoinositide 3-kinase Cascade: PIK3CA, PIK3R1, PIK3R2, PTEN.
Small GTPase Mediated Signal Transduction: GRB2, HRAS, NRAS, NUP62, RAP1A, RASA1, RHOA.
Other Intracellular Signaling Molecules: ARAF, BRAF, CBL, CSNK2A1, CSNK2B, IKBKB, NCK2, PDPK1, PLCG1, RPS6KB1, SFN.
Cell Survival and Growth:
Apoptosis: AKT1, BAD, BCAR1, BCL2, BRAF, CASP3, CASP9, FASLG, FOXO3A, IL2, LTA, MAPK1, NFKB1, NUP62, PIK3R2, PPP2CA, PRKCA, PTEN, RAF1,
RASA1, STAT1, TP53.
Cell Cycle: BCL2, CCND1, DUSP1, DUSP6, EGFR, HRAS, KRAS, MAPK1, MAPK3, NRAS, PDGFA, PDGFB, PPP2CA, PRKCA, PTEN, RAP1A, SHC1, STAT1,
TP53.
Cell Differentiation: FOXO3A, IL2, PPP2CA, TP53.
Cell Growth: BCAR1, CCND1, EGF, HBEGF, IL2, PDGFA, PDGFB, PDGFRA, PPP2CA, RASA1, SHC1, TP53.
Cell Motility: ACTR2, BCAR1, EGFR, FN1, HBEGF, MAP2K1, MAPK8, PTEN, STAT3.
Cell Proliferation: BCAR1, BCL2, EGF, EGFR, EPS8, GAB1, HBEGF, IL2, NCK2, NUP62, PDGFA, PDGFB, PDGFRA, PTEN, RAF1, SHC1, TP53.
Metabolism
DNA Metabolism: ATF1, ATF2, CREB1, EGF, EGFR, FOS, NUP62, PPP2CA, TP53.
Lipid Metabolism: ARAF, BRAF, PIK3R1, PLCG1, PPP2CA, PRKCA, PTEN, RAF1, SHC1.
Protein Metabolism: ACTR2, AKT1, AKT2, AKT3, ARAF, ATF1, ATF2, BRAF, CBL, CHUK, CREB1, CSNK2A1, DUSP1, DUSP6, EGFR, FOS, GSK3A, GSK3B,
IKBKB, JAK1, MAP2K1, MAP2K4, MAP2K7, MAP3K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, PDGFRA, PDPK1, PPP2CA, PRKCA, PTEN, RAF1,
RPS6KA5, RPS6KB1, SRC.
Other Genes Related to Metabolism: COL1A1, EIF4E, FN1, MMP7, RASA1.
Development: BRAF, COL1A1, HBEGF, PTEN, RASA1, STAT3.
Response to Stimulus:
Response to Wounding: BCAR1, BCL2, FN1, HBEGF, IL2, NCK2, NFKB1, PDGFB, STAT3.
Response to Other Stimuli: AKT1, CHUK, COL1A1, DUSP1, EGFR, FASLG, FOS, KRAS, LTA, MAP2K1, MAP2K7, MAPK1, MAPK8, MAPK9, NFATC3, PPP2CA,
RPS6KA5, STAT1, STAT5A, TP53.
Transcription Factors and Regulators: AKT1, ATF1, ATF2, CBL, CREB1, EGR1, EIF4E, ELK1, FOS, FOXO3A, IKBKB, JUN, MKNK1, NFATC3, NFKB1, NUP62,
PPP2CA, RPS6KA5, STAT1, STAT3, STAT5A, TP53.
Actin and Calcium Ion Homeostasis: ACTR2, BCAR1, CBL, EGF, EGFR, MMP7, NCK2, PDPK1, PLCG1, PRKCA, RASA1, RHOA, STAT1, STAT3, STAT5A.
EGF 信号通路相关基因、PDGF 信号通路相关基因、细胞内信号分子、细胞存活和生长相关基因、代谢相关基因、发育相关基因、刺激应答相关基因、转录因子及转录调
控基因、肌动蛋白与钙离子动态平衡相关基因
GPCR Signaling PathwayFinder PCR Array
GPCR 信号通路发现者 PCR 芯片
Catalog No. PAHS-071A（人）
The Human G-Protein-Coupled Receptor Signaling PathwayFinder™ RT² Profiler™ PCR Array profiles the expression of 84 genes representative of and involved in
GPCR-mediated signal transduction pathways. G-protein Coupled Receptors (GPCRs) that are represented on this array include bioactive lipid receptors, metabotropic
glutamate receptors (mGluRs), GABA-B-like receptors, rhodopsin-like receptors, and secretin-like receptors. Members of the intricate network of intracellular signaling
pathways involved in GPCR-mediated signal transduction are also represented on this array including the cAMP / PKA Pathway, Calcium / PKC Pathway, Calcium /
NFAT Pathway, PLC Pathway, Protein Tyrosine Kinase Pathway, PKC / MEK Pathway, p43 / p44MAP Pathway, p38 MAP Pathway, PI-3 Kinase Pathway, NO-cGMP
Pathway, Rho Pathway, NFκB Pathway and Jak / Stat Pathway. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related
to GPCR-mediated signaling with this array.
GPCR 信号通路发现者 RT² Profiler™ PCR Array 包含 84 个与 GPCR 调控的信号转导相关的基因。芯片中包括生物活性的脂受体、代谢型谷氨酸
受体、伽马氨基丁酸 B 型受体、视紫红质样受体和分泌素样受体。GPCR 介导的细胞内信号通路有：cAMP/PKA 信号通路、Calcium/PKC 信号通路、
Calcium/NFAT 信号通路、PLC 信号通路、酪氨酸蛋白激酶信号通路、PKC/MEK 信号通路、p43/p44MAP 信号通路、p38MAP 信号通路、PI-3 Kinase
信号通路、NO-cGMP 信号通路、Rho 信号通路、NFkB 信号通路和 Jak/Stat 信号通路，这些信号通路的相关基因也包含在芯片中。利用实时定量
PCR，你可以方便并且可信地对与 GPCR 信号通路相关的一组基因进行同时检测。
G-Protein-Coupled Receptors (GPCRs)
Bioactive Lipid Receptors: EDG1, EDG2, EDG3, EDG4, EDG5.
Metabotropic Glutamate, GABA-B-like Receptors: CASR, GRM1, GRM2, GRM4, GRM5, GRM7.
Rhodopsin-like Receptors: ADORA2A, ADRB1, ADRB2, AGTR1, AGTR2, AGTRAP, DRD1, DRD2, EDG1, EDG2, EDG3, EDG4, EDG5, GALR2, LHCGR, OPRD1,
OPRK1, PTGDR, RHO, TSHR.
Secretin-like Receptors: ADORA2A, BAI1, CALCR, CALCRL, CRHR1, CRHR2, GCGR, PTHR1, SCTR.
Other G-protein Coupled Receptors: EDN1.
Pathways Related to G-Protein-Coupled Receptor Protein Signaling
Dopamine Receptor Pathway: DRD1, DRD2, OPRD1.
G-protein Signaling, Coupled to cAMP Nucleotide Second Messenger (cAMP / PKA): ADCY5, ADORA2A, ADRB1, ADRB2, CALCR, CALCRL, CCL2, COL1A1,
CRHR1, CRHR2, CYP19A1, DRD1, EDG1, EDG3, EDN1, GALR2, GCGR, GNAQ, GNAS, GRM2, GRM4, IL1R1, IL1R2, LHCGR, NOS2A, OPRD1, OPRK1,
PTGS2, PTHR1, RGS2, TSHR, UCP1, VEGFA.
G-protein Signaling, Coupled to IP3 Second Messenger (PLC): AGTR1, CALCR, CASR, EDG2, EDG4, EDN1, GNAQ, GRM5, PIK3CG.
Metabotropic Glutamate Receptor Pathway: GRM1, GRM2, GRM4, GRM5, GRM7.
Neuropeptide Signaling Pathway: BAI1, OPRD1.
Adenosine Receptor Signaling Pathway: ADCY5, ADORA2A.
Calcium Signaing Pathway (PKC, NFAT, etc.): CCL2, CCL4, COL1A1, EGR1, ELK1, ELK4, PTGS2.
PKC Pathway (Ca2+, MEK, etc.): AGTR2, COL1A1, DUSP14, EGR1, FGF2, FOS, IL1R1, IL1R2, JUN, JUNB, MMP9, MYC, NOS2A, PRKCA, PTGS2, RGS2,
SERPINE1, SOCS1.
Protein Tyrosine Kinase Pathway: ADRB2, AKT1, CCL4, CTGF, PDPK1, PRKCA, RGS2, SOCS1, YWHAZ.
Protein Serine / Threonine Kinase Pathway: AKT1, CDKN1B, PDPK1, PTGDR.
MAPKKK Cascade: ADRB2, AGT, EDG5, FGF2, GRM1, GRM4, PRKCA, TNF, UCP1.
PI-3 Kinase Pathway: AKT1, BCL2, BCL2L1, CCND1, CDKN1B, CFLAR, PDPK1, PIK3CG, PTGS2.
NO-cGMP Pathway: AGTR2, NOS2A, PTGS2, TNF.
Rho Pathway: CDKN1B, CTGF, FOS, IL1B, PTGS2, RHO, SERPINE1.
IκB Kinase / NFκB Cascade: AGT, CFLAR, EDG2, ICAM1, IL1B, IL2, MAX, NOS2A, PTGS2, TNF, VCAM1.
JAK-STAT Cascade: CCL2, CDKN1A, SOCS1.
Other Genes Related to G-Protein-Coupled Receptor Protein Signaling: ARRB1, ARRB2, CCNE1, CCNE2.
GPCR 受体基因、GPCR 介导的信号通路相关基因
Hypoxia Signaling Pathway PCR Array
Catalog No. PAHS-032A（人）
低氧信号通路 PCR 芯片
Catalog No. PAMM-032A（小鼠）
The Hypoxia Signaling Pathway RT² Profiler™ PCR Array profiles the expression of 84 genes involved in hypoxia-related signaling. This array includes genes directly
involved in the response to hypoxia and oxidative stress. Genes associated with the hemoglobin complex are represented as well as genes involved in oxidoreductase
activity. Transcription factors and genes involved in regulating transcription are included. Genes involved in the physiological and pathophysiological processes affected
by hypoxia on the array include those involved in apoptosis, signal transduction, and protein metabolism as well as genes involved in cell growth and metabolism,
extracellular matrix and adhesion molecules, and genes involved in cardiac excitation-contraction coupling. Using real-time PCR, you can easily and reliably analyze
expression of a focused panel of genes related to the hypoxia signaling pathway with this array.
缺氧信号通路 RT² Profiler™ PCR Array 可以同时测定 84 个与缺氧信号通路有关的基因。这些基因包括直接与缺氧反应有关的基因、氧化压力。还
包括与血红蛋白有关的基因和氧化还原酶类活性调节的基因。缺氧引起的生理病理过程如凋亡、信号转导、蛋白代谢、细胞生长、代谢、细胞外基
质、黏附分子、心脏兴奋-收缩偶联等有关的基因也包含在内。利用实时定量 PCR，你可以方便并且可信地对与缺氧信号通路相关的基因进行同时检
测。
Response to Stress:
Response to Hypoxia: ANGPTL4, ARNT2, CREBBP, EP300, HIF1A, MT3, PRKAA1.
Response to Oxidative Stress: CAT, CYGB, GPX1, PIP3-E.
Immune Response: GPI, IL1A, IL6, IL6ST, NOS2A, NOTCH1, PTX3, RARA.
Other Genes Related to Stress Response: ADM, EPO, HYOU1, VEGF.
Hemoglobin Complex Associated Genes: CYGB, EPO, HBB, HMOX1, NOS2A, PIP3-E.
Oxidoreductase:
Peroxidase: CAT, CYGB, GPX1, PIP3-E.
Other Oxidoreductase-Related Genes: HIF1AN, HMOX1, MT3, NOS2A, PLOD3, TH.
Transcription Factors and Regulators:
Transcription Cofactors: CREBBP, DR1, ENO1, EP300, EPAS1, HTATIP, RARA.
Transcription Factors: ARNT2, BHLHB2, CREBBP, ENO1, EP300, EPAS1, HIF1A, HIF3A, KHSRP, MYBL2, PPARA, RARA.
Other Transcription Factors and Regulators: HIF1AN, NOTCH1.
Apoptosis:
Anti-apoptosis: BAX, ANGPTL4, BIRC5, IL1A, MYBL2, PEA15, PRKAA1, VEGF.
Caspase Activity: BIRC5, CASP1.
Induction of Apoptosis: BAX, DAPK3, NUDT2.
Other Apoptosis Genes: EP300.
Signal Transduction: ADM, ARNT2, CASP1, CDC42, CREBBP, EP300, EPAS1, EPO, GNA11, HIF1A, HIF3A, HMOX1, IGFBP1, IL1A, IL6, IL6ST, IQGAP1, KIT, LEP,
PLAU, RARA, VEGF.
Protein Metabolism:
Protein Biosynthesis: EEF1A1, PDIP, PRKAA1, RPL28, RPL32, RPS2, RPS7.
Protein Heterodimerization: ARNT2, HIF1A, RARA, SAE1.
Protein Homodimerization: ARNT2, RARA, VEGF.
Protein Amino Acid Phosphorylation: DAPK3, KIT, PRKAA1.
Protein Binding: CASP1, CREBBP, ENO1, EP300, IQGAP1, NOS2A, PEA15, PPP2CB, RARA.
Other Genes Related to Protein Metabolism: ARD1, CDC42, GNA11, HYOU1, MAN2B1, PLOD3, PSMB3, SUMO2, TUBA1.
Extracellular Matrix (ECM)-Related Molecules:
Protease Inhibitors: BIRC5, CSTB.
Protease Molecules: AGTPBP1, CASP1, ECE1, PLAU, PSMB3.
Other Extracellular Molecules: ADM, ANGPTL4, CHGA, COL1A1, EPO, IGF2, IGFBP1, IL1A, IL6, LEP, NPY, PTX3, VEGF.
Cytoskeleton: DCTN2, SPTBN1.
Cell Growth:
Cell Cycle: BAX, BIRC5, EP300, HK2, IGF2, IL1A, MYBL2, SSSCA1, VEGF.
Cell Proliferation: DCTN2, IGF2, IL1A, IL6, MT3, NPY, RARA, VEGF.
Growth Factors: GPI, IGF2, IGFBP1, IL1A, IL6, KIT, VEGF.
Other Genes Related to Cell Growth: ENO1.
Metabolism:
Carbohydrate Metabolism: GPI, HK2, LCT, MAN2B1, PEA15, PRKAA1, SLC2A1, SLC2A4.
Lipid Metabolism: AGPAT2, ANGPTL4, PPARA, PRKAA1.
One-carbon Compound Metabolism: CA1.
Superoxide Metabolism: MT3, NOS2A.
RNA Metabolism: FNBP3, KHSRP, RARA, RPL28, RPS2, SNRP70.
Other Genes Related to Metabolism: ADM, AGPAT2, MOCS3, NUDT2, TH, TST, UCP2.
Cardiac Excitation-Contraction (E-C) Coupling: ARNT2, CHGA, DAPK3, GNA11, IQGAP1, KIT, NOS2A, NOTCH1, NPY, PRKAA1, SPTBN1.
应激反应有关基因；血红蛋白有关基因；氧化还原酶类；转录因子及其有关基因；凋亡有关基因；信号传导有关基因；蛋白代谢有关基因；细胞外基质相关分子；细胞骨
架；细胞生长有关基因；代谢有关基因；心脏兴奋-收缩偶联有关的基因
Heat Shock Proteins PCR Array
Catalog No. PAHS-076A（人）
热激蛋白 PCR 芯片
Catalog No. PAMM-076A（小鼠）
The Human Heat Shock Proteins RT² Profiler™ PCR Array profiles the expression of 84 Heat Shock Protein genes that regulate protein folding. Heat shock proteins
(HSPs, or molecular chaperones) are important components of cellular networks. HSPs can either aid in the folding and maintenance of newly translated proteins or they
can lead to the degradation of misfolded and destabilized proteins. Included on this PCR Array are HSP90 (81 to 99 kD), HSP70 (65 to 80 kD), HSP60 (55 to 64 kD),
HSP40 (35 to 54 kD), small HSPs (=34 kD) and other chaperone cofactors that are directly involved in the response to unfolded/misfolded proteins or that are involved in
protein folding in general. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of heat shock proteins and chaperones with this array.
热激蛋白 RT² Profiler™ PCR Array 可以同时测定 84 个编码调控蛋白折叠的热激蛋白的基因。热激蛋白（或称 HSPs、分子伴侣）在细胞内网络中
起着重要的作用。一方面，HSPs 能够辅助新翻译的蛋白折叠并维持折叠构型；另一方面，HSPs 则将错误折叠和不稳定的蛋白降解掉。芯片中包含
HSP90（81-99kD）、HSP70（65-80kD）、HSPs60（55－64kD）、HSP40（35-54kD）、小分子量 HSPs（＝34kD）以及其他分子伴侣辅助因
子。利用实时定量 PCR，你可以方便并且可信地对编码热激蛋白及分子伴侣的基因进行同时检测。
HSP90 Family Members: HSP90AA1, HSP90AB1, HSP90B1.
HSP70 Family Members: HSPA14, HSPA1A, HSPA1B, HSPA1L, HSPA2, HSPA4, HSPA4L, HSPA5, HSPA8, HSPA9.
HSP60 Family Members: HSPD1.
HSP40 Family Members: DNAJA1, DNAJA2, DNAJA3, DNAJA4, DNAJA5, DNAJB1, DNAJB11, DNAJB12, DNAJB13, DNAJB14, DNAJB2, DNAJB5, DNAJB6,
DNAJB7, DNAJB8, DNAJB9, DNAJC1, DNAJC10, DNAJC11, DNAJC12, DNAJC13, DNAJC14, DNAJC15, DNAJC16, DNAJC17, DNAJC18, DNAJC19, DNAJC3,
DNAJC4, DNAJC5, DNAJC5B, DNAJC5G, DNAJC6, DNAJC7, DNAJC8, DNAJC9, SERPINH1.
Small HSPs: HSPB1, HSPB2, HSPB3, HSPB6, HSPB7, HSPB8, HSPE1.
Other Regulators of Protein Folding: ATF6, BAG1, BAG2, BAG3, BAG4, BAG5, CABC1, CCS, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT6B, CCT7, CRYAA, CRYAB,
HSF1, HSF2, HSF4, HSPH1, PFDN1, PFDN2, SIL1, TCP1, TOR1A.
HSP90 家族成员、HSP70 家族成员、HSP60 家族成员、HSP40 家族成员、小分子量 HSPs、其他调节蛋白折叠的基因
Hedgehog Signaling Pathway PCR Array
Catalog No. PAHS-078A（人）
Hedgehog 信号通路 PCR 芯片
Catalog No. PAMM-078A（小鼠）
The Human Hedgehog Signaling RT² Profiler™ PCR Array profiles the expression of 84 key genes involved in the hedgehog signaling pathway. The hedgehog family
members, including Sonic hedgehog (Shh), are the most well-known morphogens involved in the developmental pattern formation of various organs, such as the
nervous system, muscle, the heart and the lungs. Hedgehog signaling has also been implicated in the development of several human cancers. The array includes
hedgehog family members, hedgehog receptors, and other associated proteins. The array also includes key genes involved in cell differentiation and multi-cellular
organism development. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to hedgehog signaling with this array.
Hedgehog 信号通路 RT² Profiler™ PCR Array 可以同时测定 84 个与 hedgehog 信号通路相关的基因。包括 Sonic hedgehog
（Shh）
在内的 hedgehog
家族成员都是大家熟知的发育成形素，它们在各种器官发育过程中形态的形成发挥作用，例如神经系统、肌肉、心脏和肺的形成。Hedgehog 信号
通路也有可能在多种人类癌症发生过程中起作用。芯片中包含 hedgehog 家族成、hedgehog 受体和其他相关蛋白。与细胞分化和多细胞生物发育相
关的关键基因也包含其中。利用实时定量 PCR，你可以方便并且可信地对与 hedgehog 信号相关的基因进行同时检测。
Genes Involved in Hedgehog Signaling Pathway:
Hedgehog Family Members and Associated Proteins: DHH, HHAT, HHIP, IHH, SHH, SIAH1.
Hedgehog Receptors: C18orf8, C6orf138, NPC1, NPC1L1, PTCH1, PTCH2, PTCHD1, PTCHD2, PTCHD3.
Sonic Hedgehog (Shh) Pathway: GLI1, GLI2, GLI3, GSK3B, PTCH1, SHH, SMO, SUFU.
Smoothened Signaling Pathway: CDON, CEP76 (C18orf9), FGF9, FKBP8, GLI1, GLI2, GLI3, HHIP, IFT52, OTX2, PTCH1, SHH, SMO.
WNT Receptor Signaling Pathway: BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CTNNB1, FBXW11, GSK3B, PRKACA, PRKACB,
PRKACG, PRKX, PRKY, SFRP1, SIAH1, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6,
WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B.
Other Genes Involved in Hedgehog Signaling Pathway: BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, DHH, GAS1, IHH, LRP2, RAB23, SMO, STK36, ZIC2.
Regulators of Cell Differentiation: BMP2, BMP4, BMP6, BMP7, BMP8A, BMP8B, CTNNB1, FGF9, GLI1, GLI3, IHH, MAPK1, SFRP1, SHH, SIAH1, SMO, WNT1,
WNT3A, WNT7A, ZIC1, ZIC2.
Regulators of Development:
Nervous System Development: BMP4, CRIM1, CTNNB1, GLI2, GLI3, GREM1, LRP2, MTSS1, OTX2, RAB23, SHH, SIAH1, WNT8B, ZIC1, ZIC2.
Camera-Type Eye Development: BMP4, FKBP8, SHH.
Skeletal Development: CTNNB1, FGFR3, GLI2, IHH, SUFU.
Heart Development: BMP4, CTNNB1, GLI2, GLI3, SHH.
Lung Development: BMP4, CTNNB1, GLI1, GLI2, GLI3, HHIP, SHH, WNT5A.
Cartilage Development: BMP2, BMP4, BMP5, BMP6, BMP7.
Other Regulators for Multi-Cellular Organism Development: BMP8A, BMP8B, DHH, ERBB4, FGF9, FOXE1, HHAT, KCTD11, NUMB, PRKACG, SFRP1, SMO,
STK36, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT9A, WNT9B.
Hedgehog 信号通路相关的基因、细胞分化调控基因、发育调控基因
Catalog No. PAHS-030A（人）
Insulin Signaling Pathway PCR Array
胰岛素信号通路 PCR 芯片
Catalog No. PAMM-030A（小鼠）
Catalog No. PARN-030A（大鼠）
The Insulin Signaling Pathway RT² Profiler™ PCR Array profiles the expression of 84 genes related to insulin-responsive genes. This array represents genes associated
with the insulin receptor and target genes for insulin signaling. Genes involved in the metabolism of carbohydrates, lipids, and proteins and other related biological
responses are also included. This array contains members of the PI3K and MAPK Pathways as well. Using real-time PCR, you can easily and reliably analyze
expression of a focused panel of genes related to insulin-responsive with this array.
胰岛素信号通路 RT² Profiler™ PCR Array 可以同时测定 84 个与胰岛素反应有关的关键基因。此 array 包含了与胰岛素受体有关的基因和胰岛素信
号通路的靶基因。糖类、脂类、蛋白代谢有关的基因和相关的生物学反应有关的基因也包括在内。此外，还含有 PI3K 和 MAPK 信号通路的成员。
利用实时定量 PCR，你可以方便并且可信地对与胰岛素反应有关的基因进行同时检测。
Insulin Receptor-Associated Proteins:
Insulin and Receptors: INS, INSL3, IRS1, IRS2, IRS4, SORBS1.
Insulin-like Growth Factors and Receptors: IGF1R, IGF2, IGFBP1.
SH3/SH2 Adaptor Protein: CBL, GAB1, GRB2, IRS4, NCK1.
Other Genes Associated with Insulin Receptor Proteins: CAP1, DOK1, DOK2, DOK3, FRS2, FRS3, INSR, PDPK1, PPP1CA, PTPN1, PTPRF, SHC1.
PI-3 Kinase Pathway:
Components: AKT1, AKT2, AKT3, EIF2B1, EIF4EBP1, FRAP1, GSK3A, GSK3B, PDPK1, PIK3CA, PIK3R1, PIK3R2, PRKCG, PRKCI, PRKCZ.
Target Genes: BCL2L1, DUSP14, G6PC, HK2, IGFBP1, PCK2, SERPINE1, SLC2A4, SREBF1, UCP1, VEGF
MAPK Pathway:
Components: ARAF, BRAF, EIF2B1, GRB2, HRAS, MAP2K1, MAPK1, RAF1, RPS6KA1, RRAS, RRAS2, SHC1, SOS1.
Target genes: ANG, BCL2L1, ERCC1, FOS, LDLR, NOS2A, UCP1.
Primary Target Genes for Insulin Signaling: CEBPA, CEBPB, FOS, JUN, LEP, PRL.
Secondary Effector Target Genes for Insulin Signaling: NPY, PCK2, SLC2A1, SLC2A4, TG.
Target genes for PPARg: ACOX1, ADRB3, AEBP1, CAP1, CEBPA, CEBPB, PCK2, PPARG, RETN.
Target genes for SREBP1: ACACA, FBP1, G6PC, GCK, PCK2, PKM2.
Carbohydrate Metabolism:
Glucose Metabolism: FBP1, G6PC, GCK, HK2, INS, IRS2, PCK2, PKM2, SLC2A1, SLC2A4, SORBS1.
Glycogen Metabolism: G6PC, GSK3B, PPP1CA.
Other Genes Related to Carbohydrate Metabolism: ADRB3, GPD1, INSR.
Lipid Metabolism:
Cholesterol Metabolism: LDLR, SREBF1.
Fatty Acid Metabolism: ACACA, ACOX1, FASN.
Lipid Transport: LDLR, SORBS1.
Other Lipid Metabolism Genes: ARAF, BRAF, INS, LEP, PPARG, PRKCG, PRKCI, PRKCZ, RAF1, SHC1.
Protein Metabolism:
Protein Amino Acid Dephosphorylation: DUSP14, PPP1CA, PTPN1, PTPRF.
Protein Amino Acid Phosphorylation: AKT1, AKT2, AKT3, ARAF, BRAF, GSK3A, GSK3B, IGF1R, INSL3, INSR, MAP2K1, MAPK1, PDPK1, PRKCG, PRKCI, PRKCZ,
RAF1, RPS6KA1.
Protein Biosynthesis: ANG, EIF2B1, EIF4EBP1, LDLR, PPP1CA.
Protein Transport: PRKCI, RRAS2.
Other Protein Metabolism Genes: AEBP1, CBL, DOK1, DOK2, FRS2, GAB1, IRS1, NOS2A, SORBS1, VEGF.
Transcription Factors and Regulators:
DNA-dependent Regulation of Transcription: CEBPA, CEBPB, FOS, JUN, PPARG, SREBF1.
RNA Polymerase II Transcription Factor Activity: CEBPA, FOS, JUN, SREBF1.
Transcription Factors: AEBP1, CBL, CEBPA, CEBPB, JUN, PPARG, SREBF1.
Cell Growth and Differentiation:
Cell Cycle: FRAP1, HK2, HRAS, IGF1R, IGF2, KRAS, MAPK1, VEGF.
Cell Proliferation: GAB1, IGF1R, IGF2, IRS2, NCK1, NPY, PRL, RAF1, SHC1, VEGF.
Growth Factors and Receptors: GAB1, GRB2, IGF1R, IGF2, IGFBP1, INSR, SHC1, VEGF.
Cell differentiation: NOS2A, PPARG.
胰岛素受体有关蛋白；PI-3 激酶途径有关基因；MAPK 途径有关基因；胰岛素信号基本靶基因；胰岛素信号的二级效应靶基因；PPARg 靶基因；SREBP1 靶基因；碳水
化合物代谢有关的基因；脂代谢有关基因；蛋白代谢有关基因；转录因子及其相关基因；细胞生长和分化相关基因
Catalog No. PAHS-039A（人）
JAK / STAT Signaling Pathway PCR Array
JAK / STAT 信号通路 PCR 芯片
Catalog No. PAMM-039A（小鼠）
Catalog No. PARN-039A（大鼠）
The JAK / STAT Signaling Pathway RT² Profiler™ PCR Array profiles the expression of 84 genes related to Jak- and Stat-mediated signaling. The array represents all
known Jak and Stat family members, the receptors that activate them, nuclear co-factors and co-activators associated with the Stat proteins, Stat-inducible genes, and
negative regulators of the pathway. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to the Jak / Stat Signaling
Pathway with this array.
JAK / STAT 信号通路 RT² Profiler™ PCR Array 可以同时测定 84 个 Jak 和 STAT 介导的信号通路相关基因。
此 array 包含了所有已知的 Jak 和 Stat
家族成员，激活它们的受体，核辅助因子，核激活因子，Stat 诱导的基因以及此信号通路的负调控因子。利用实时定量 PCR，你可以方便并且可信
地对与 Jak/Stat 信号通路相关的基因进行同时检测。
JAK and STAT Proteins:
Janus Kinase Activity: JAK1, JAK2, JAK3, TYK2.
STAT Family: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6.
Receptors that Bind and Activate JAK Proteins: CSF1R, CSF2RB, EGFR, EPOR, F2R, GHR, IFNAR1, IFNGR1, IL10RA, IL2RA, IL2RG, IL4R, IL6ST, INSR, MPL,
PDGFRA, SH2B.
SH3/SH2 Adaptor Protein Activity: APS, CRK, SIT, SLA2, SRC, STAM.
STAT Protein Nuclear Translocation: F2, F2R, STAT1.
Tyrosine Phosphorylation of STAT Protein: F2, F2R, IL20, PPP2R1A, PRLR, STAT1.
Transcription Factors or Regulators that Interact with STAT Proteins:
Positive Regulation of Transcription: HMGA1, SMAD3.
Negative Regulation of Transcription: SLA2, SMAD3, SPI1, STAT3.
RNA Polymerase II Transcription Factor Activity: JUNB, SP1, USF1.
Transcription Coactivator Activity: JUNB, YY1.
Transcription Corepressor Activity: JUNB, PIAS1, YY1.
Transcriptional Activator Activity: SMAD1, SMAD5, SP1.
Other Transcription Factors and Regulators: CEBPB, CRK, GATA3, IRF1, ISGF3G, JUN, MYC, NFKB1, NR3C1, PPP2R1A, SMAD2, SMAD4.
Genes Induced by STAT Proteins:
Stat1: CXCL9, IRF1, JUNB, NOS2A.
Stat3: A2M, BCL2L1, CDKN1A, CRP, FAS (TNFRSF6), IRF1, MMP3, MYC, SOCS1.
Stat4: FCGR1A, IFNG, IRF1, MYC.
Stat5: CCND1, CDKN1A, IL2RA, IRF1, OSM.
Stat6: FCER1A, GATA3, IL4, IL4R.
Stat1/Stat1/p48: GBP1.
Stat1/Stat2/p48: G1P2, OAS1.
Negative Regulators of the JAK/ STAT pathway: PIAS1, PIAS2, PTPN1, PTPRC, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5.
Apoptosis: BCL2L1, CDKN1A, F2, F2R, FAS (TNFRSF6), IL2RA, NFKB1, PPP2R1A, PRLR, STAT1.
Cell Differentiation: IL20, IL4, NOS2A, PPP2R1A, SOCS2, SOCS5.
Cell Growth and/or Maintenance:
Cell Cycle: CCND1, CDKN1A, EGFR, F2, F2R, IL2RA, IRF1, JAK2, MYC, PPP2R1A, STAT1.
Cell Growth: A2M, EGFR, GHR, IFNG, IL4, INSR, OSM, PPP2R1A, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5.
Cell Proliferation: CSF1R, IL2RG, IL4, MPL, OSM, PDGFRA, SMAD3.
Immune Response:
Acute-Phase Response: CEBPB, CRP, F2, STAT3.
Antigen Processing: FCER1A, FCGR1A, PPP2R1A.
Humoral Immune Response: APS, CSF1R, CSF2RB, IL4, NFKB1, YY1.
Inflammatory Response: CEBPB, CRP, CXCL9, IL10RB, IL20, NFKB1, NOS2A, NR3C1.
Lymphocyte Activation: IL4, PRLR, SIT, SLA2.
Other Genes Involved in the Immune Response: CXCL9, FAS (TNFRSF6), G1P2, GBP1, IFNG, IL2RA, IL2RG, IL4, IL4R, IL6ST, IRF1, ISGF3G, OAS1, OSM,
STAT5A, STUB1.
JAK 和 STAT 基因；结合激活 JAK 蛋白的受体；SH3/SH2 衔接蛋白；STAT 蛋白核转运有关基因；Jak/STAT 信号通路负调控因子；凋亡有关基因；细胞分化相关基因；
细胞生长维持有关基因；免疫反应有关基因
Ubiquitination (Ubiquitylation) Pathway PCR Array
Catalog No. PAHS-079A（人）
泛素（泛素化）信号通路 PCR 芯片
Catalog No. PAMM-079A（小鼠）
The Human Ubiquitination or Ubiquitylation Pathway RT² Profiler™ PCR Array profiles the expression of 84 key genes involved in the regulated degradation of cellular
proteins by the ubiquitin-proteasome system. Disruption of the proteasomal degradation pathway has been implicated in a wide range of human diseases, such as
cancer, diabetes and cardiovascular and neurodegenerative diseases. The array includes ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and
ubiquitin ligases (E3). These enzymes have also been sub-categorized as regulators of key cellular processes, such as apoptosis, the cell cycle and transcription. Using
real-time PCR, you can easily and reliably analyze expression of a focused panel of genes involved in ubiquitin degradation pathway with this array.
泛素（泛素化）信号通路 RT² Profiler™ PCR Array 可以同时测定 84 个与泛素-蛋白酶体调控的蛋白降解相关的基因。干扰蛋白酶体的降解途径有可
能引起多种人类疾病，例如癌症、糖尿病、心血管疾病和神经退行性疾病。芯片中含有泛素活化酶（E1）、泛素结合酶（E2）和泛素连接酶（E3）。
这三种酶调控一些关键的细胞生物过程，如凋亡、细胞周期和转录。利用实时定量 PCR，你可以方便并且可信地对与泛素降解信号通路相关的基因
进行同时检测。
Ubiquitin-Activating Enzymes (E1):
ATG7, MOCS3, NAE1, NEDD8, SAE1, UBA1, UBA2, UBA3, UBA5, UBA6, UBE2Z.
Ubiquitin-Conjugating Enzymes (E2):
Regulators of Apoptosis: BARD1, BRCA1, TP53, UBE2Z.
Regulators of Cell Cycle: ANAPC2, BARD1, BRCA1, CDC34, TP53, UBE2C, UBE2I.
Regulators of Transcription: BRCA1, TP53, UBE2K, UBE2W.
Other Ubiquitin-Conjugating Enzymes (E2): ARIH1, BTRC, NEDD8, PARK2, STUB1, TMEM189, UBA6, UBE2A, UBE2B, UBE2D1, UBE2D2, UBE2D3, UBE2E1,
UBE2E2, UBE2E3, UBE2G1, UBE2G2, UBE2H, UBE2J1, UBE2J2, UBE2L3, UBE2M, UBE2N, UBE2Q1, UBE2R2, UBE2S, UBE2T, UBR2.
Ubiquitin-Protein Ligases (E3):
Regulators of Apoptosis: BARD1, BRCA1, CUL1, CUL2, CUL3, CUL4A, CUL5, TP53, UBE4B, VHL.
Regulators of Cell Cycle: ANAPC11, ANAPC2, BARD1, BRCA1, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, CUL7, DDB1, MDM2, PARC, SKP1, SKP2, TP53,
VHL.
Regulators of Transcription: BRCA1, CBL, MDM2, SMURF2, TP53, VHL, WWP1.
Other Ubiquitin-Protein Ligases (E3): ARIH1, BRCC3, BTRC, DZIP3, FBXO3, FBXO31, FBXO4, FBXW10, FBXW9, HECW1, HECW2, HERC5, HUWE1, MARCH5,
MIB1, C1orf166 (MUL1), NEDD8, PARK2, RFWD2, RNF123, RNF148, SMURF1, STUB1, SYVN1, UBE2L3, UBE2T, UBR1, UBR2.
泛素活化酶（E1）、泛素结合酶（E2）
、泛素连接酶（E3）
Lipoprotein Signaling & Cholesterol Metabolism PCR Array
Catalog No. PAHS-080A（人）
脂蛋白信号通路与胆固醇代谢 PCR 芯片
Catalog No. PAMM-080A（小鼠）
The Human Lipoprotein Signaling and Cholesterol Metabolism RT² Profiler™ PCR Array profiles the expression of 84 key genes involved in lipoprotein transport and
cholesterol metabolism. Lipoproteins primarily transport structural and nutritional lipids throughout the organism. Two commonly known lipoproteins are the Low Density
Lipoproteins (LDL) and the High Density Lipoproteins (HDL). LDL carries cholesterol from the liver to all other cells of the body. HDL collects cholesterol from the body's
tissues, and brings it back to the liver. Therefore, sometimes LDL is referred to as "bad cholesterol", while HDL is referred to as "good cholesterol". The array includes
LDL and HDL receptors as well as their associated proteins. The array also includes key genes involved in cholesterol metabolism. Using real-time PCR, you can easily
and reliably analyze expression of a focused panel of genes related to lipoprotein signaling and cholesterol metabolism with this array.
脂蛋白信号通路与胆固醇代谢 RT² Profiler™ PCR Array 可以同时测定 84 个与脂蛋白转运和胆固醇代谢相关的基因。脂蛋白将结构性脂肪和营养性
脂肪运输到生物体的各个部位。两种常见的脂蛋白是低密度脂蛋白（LDL）和高密度脂蛋白（HDL）。低密度脂蛋白将胆固醇从肝脏运输到体内其
他细胞中。高密度脂蛋白将身体其他组织中收集胆固醇并运回肝脏。因此，LDL 上的胆固醇是“坏”胆固醇，而 HDL 上的胆固醇是“好”胆固醇。
本芯片中包括 LDL、HDL 受体以及相关蛋白。胆固醇代谢相关的关键基因也包含其中。利用实时定量 PCR，你可以方便并且可信地对与脂蛋白信号
通路及胆固醇代谢相关的基因进行同时检测。
LDL Receptors and Associated Proteins:
LDL Receptors: CXCL16, LDLR, LRP10, LRP12, LRP1B, LRP6, OLR1, STAB1, STAB2, VLDLR, ZMYND15.
LDL Receptor Associated Proteins: LRPAP1, PCSK9, SNX17.
LDL Associated Proteins: ANKRA2, APOA4, CDH13, COLEC12, SCARF1, SORL1.
HDL Associated Proteins: APOA1, APOD, APOF, APOL2, APOL5.
Cholesterol Transport:
Cholesterol Transporters: ABCA1, ABCG1, APOA1, APOE, CETP, STARD3.
Cholesterol Efflux: ABCA1, ABCG1, APOA1, APOA4, APOE.
Reverse Cholesterol Transport: ABCA1, APOA1, APOA2, APOA4, APOE, CETP, LCAT.
Other Genes Involved in Cholesterol Transport: APOB, LDLR, NPC1L1, OSBPL5.
Cholesterol Metabolism:
Cholesterol Absorption: CEL, LDLR, NPC1L1.
Cholesterol Catabolism: AKR1D1, APOE, CEL, CYP39A1, CYP46A1, CYP7A1, SCARF1, SNX17, TRERF1.
Cholesterol Homeostasis: ABCA1, ABCG1, ANGPTL3, APOA1, APOA2, APOA4, APOE, CETP, LCAT, LDLR, LDLRAP1, PCSK9.
Cholesterol Biosynthesis: ACAA2, CNBP, CYB5R3, CYP51A1, DHCR24, DHCR7, FDFT1, FDPS, HMGCR, HMGCS1, HMGCS2, IDI1, IDI2, MVD, MVK, NPC1L1,
NSDHL, PMVK, PRKAA1, PRKAA2, PRKAG2, TM7SF2.
Other Genes Involved in Cholesterol Metabolism: APOB, APOF, APOL1, APOL2, CYP11A1, CYP7B1, ELA3A, ELA3B, HDLBP, IL4, INSIG1, INSIG2, LEP, LIPE,
MBTPS1, NR0B2, NR1H4, OSBPL1A, OSBPL5, PPARD, SCAP, SOAT1, SORL1, SREBF1, SREBF2, STARD3, VLDLR.
LDL 受体及相关蛋白、LDL 相关蛋白、HDL 相关蛋白、胆固醇转运相关基因、胆固醇代谢相关基因。
Catalog No. PAHS-061A（人）
MAP Kinase Signaling Pathway PCR Array
MAPK 信号转导通路 PCR 芯片
Catalog No. PAMM-061A（小鼠）
Catalog No. PARN-061A（大鼠）
The MAP Kinase Signaling Pathway RT2² Profiler™ PCR Array profiles the expression of 84 genes related to the MAP kinase (MAPK) signaling pathway. Members of
the MKKK, MKK, and MAPK families are represented on this array. Transcription factors and genes whose expression is induced by MAP kinase signaling are included
as well. Raf regulating proteins and MEKK1 interacting proteins are found on this array along with cell cycle proteins regulated by the Erk1/2 pathway. Genes related to
scaffolding and anchoring are also included. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to the MAPK
signaling pathway with this array.
MAPK 信号通路 RT² Profiler™ PCR Array 可以同时测定 84 个与 MAPK 信号通路有关的基因。这些基因包括 MKKK、MKK、MAPK 家族成员。MAPK
信号通路的转录因子及其诱导表达的基因也有包括。Raf 调节蛋白、MEKK1 相互作用蛋白和 Erk1/2 调节的细胞周期调节蛋白也包含在内。此外还
含有支架蛋白和锚定蛋白。利用实时定量 PCR，你可以方便并且可信地对与 MAPK 信号通路相关的基因进行同时检测。
MKKK: ARAF, BRAF, DLK1, MAP3K1 (MEKK1), MAP3K2 (MEKK2), MAP3K3 (MEKK3), MAP3K4 (MEKK4), MAP4K1 (HPK1), MOS, MST1, PAK1, RAF1.
MKK: MAP2K1 (MEK1), MAP2K2 (MEK2), MAP2K3 (MEK3), MAP2K4 (Mkk4, JNKK1), MAP2K5 (MEK5), MAP2K6 (MKK6), MAP2K7 (JNKK2).
MAPK: MAPK1 (ERK2, MAPK1), MAPK3 (ERK1), MAPK6 (ERK3), MAPK7 (ERK7), MAPK8 (JNK1), MAPK9 (JNK2), MAPK10 (JNK3), MAPK11 (p38bMAPK),
MAPK12 (p38gMAPK), MAPK13, MAPK14 (p38 MAPK).
Activated Transcription Factors: ATF2 (Creb-2), CREB1, CREBBP (CBP), EGFR, ELK1, ETS1, ETS2, JUN, MAPKAPK2, MAPKAPK3, MAX, MEF2C, MKNK1,
MYC, NFATC4 (NFAT3), PRDX6 (AOP2), SMAD4 (MADH4/DPC4), TP53 (p53).
Genes with Induced Expression: COL1A1 (Collagen I), EGR1, FOS, HSPA5 (Grp78), HSPB1 (Hsp27), JUN, MYC, TP53.
Raf Regulating Proteins: HRAS, KRAS, KSR, MAP2K1, MAP2K2, NRAS.
MEKK1 Interacting Proteins: CDC42, CHUK (IKK-a), GRB2, HRAS, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAP4K1, MST1, NRAS, RAC1, SFN (14-3-3,
Stratifin).
Scaffolding / Anchoring: MAP2K1IP1 (MP1), MAP3K1, MAPK8IP2 (JIP-1).
Cell Cycle Proteins Regulated by Erk1/2 Pathway: CCNA1 (CyclinA1), CCNA2 (CyclinA), CCNB1 (CyclinB1), CCNB2 (CyclinB2), CCND1 (CyclinD1), CCND2
(CyclinD2), CCND3 (CyclinD3), CCNE1 (CyclinE1), CDK2, CDK4, CDK6, CDKN1A (p21CIP1/WAF1), CDKN1B (p27kip1), CDKN1C (p57kip2), CDKN2A (Ind4a,
p16ink4), CDKN2B (Ind4b, p15ink2b), CDKN2C (Ind4c, p18cdk4inhibitor) CDKN2D (Ind4d, p19ink4d), E2F1, RB1.
MKKK 类基因；Mkk 类基因；MAPK 类基因；激活的转录因子；诱导表达的基因；Raf 调节蛋白；MEKK1 相互作用蛋白；脚手架蛋白；Erk1/2 调节的细胞周期蛋白
Catalog No. PAHS-025A（人）
NFkB Signaling Pathway PCR Array
NF-κB 信号通路 PCR 芯片
Catalog No. PAMM-025A（小鼠）
Catalog No. PARN-025A（大鼠）
The NFκB Signaling Pathway RT²Profiler™ PCR Array profiles the expression of 84 key genes related to NFκB-mediated signal transduction. The array includes genes
that encode members of the Rel, NFκB, and IκB families, NFκB-responsive genes, extracellular ligands and receptors that activate the pathway, and kinases and
transcription factors that propagate the signal. NFκB-mediated signal transduction has been implicated in the regulation of viral replication, autoimmune diseases, the
inflammatory response, tumorigenesis and apoptosis. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes involved in the
NFκB signal transduction pathway with this array.
NFκB 信号通路 RT2 ProfilerTM PCR Array 包含了 NFκB 介导的信号转导通路相关的 84 个关键基因。其中的基因主要分为以下几类：Rel, NFκB, 和
IκB 家族成员，NFκB 应答基因，激活此信号通路的细胞外配体及其受体，促进信号传导的激酶和转录因子。NFκB 介导的信号转导通路参与了病毒
复制的调控、自身免疫性疾病、炎症反应、肿瘤发生和凋亡。利用实时定量 PCR，你可以方便并且可信地对与 NFкB 介导的信号转导通路相关的基
因进行同时检测。
Activation of NFκB pathway
Ligands and receptors: IL1B, IL8, MYD88, TLR1, TLR2, TLR3, TLR4, TLR6, TLR8, TNF, TNFRSF10A, TNFRSF10B.
Membrane molecules: IRAK1, IRAK2.
Kinases: CHUK, IKBKB, IKBKG, IRAK1, IRAK2.
I-kappa-B kinase/NF-kappa-B cascade: EDARADD, IKBKG, IRAK2, STAT1, TLR8.
Cytoplasmic sequestering/releasing of NF-kappa-B: BCL3, IL10, NALP12, NFKBIA, TNFRSF7, TNFSF14.
Transcription factors: IKBKB, IKBKG, IRAK1, NFKB1, NFKBIA, RELA, STAT1, TNF.
Inflammatory response: IL1B, IL8, IRAK2, MYD88, NFKB1, TLR1, TLR2, TLR3, TLR4, TLR6, TLR8, TNF.
Positive regulation of I-kappa-B kinase/NF-kappa-B cascade
Ligands and receptors: CD40 (TNFRSF5), F2R, FASLG (TNFSF6), HTR2B, LTBR, SLC20A1, TICAM2, TNFRSF1A, TNFSF10, TRIF.
Membrane molecules: EDG2, GJA1, HMOX1, RHOA.
Kinases: IKBKE, RIPK1, TBK1.
Other: BCL10, BIRC2, CARD4, CASP1, CASP8, CFLAR, CTL2, FADD, MALT1, PPM1A, REL, RFP2, TMED4 (HNLF), TRADD.
NFκB Responsive Genes
Acute phase response proteins: AGT, BF.
Adhesion molecules: ICAM1.
Extracellular molecules: BF, CSF2, CSF3, IFNA1, IFNB1, IFNG, IL6.
Ligands and receptors: AGT, CCL2, ICAM1, LTA.
Cytokines: CCL2, CSF2, CSF3, IFNA1, IFNB1, IFNG, IL6, IL8, LTA, TNF.
Inflammatory response: CCL2.
Other factors involved in NF-kappa-B pathway
Extracellular molecules: IL1A.
Ligands and receptors: IL1R1, RAF1, TLR7, TLR9.
Kinases: AKT1, MAP3K1, RAF1.
Transcription factors: ATF1, EGR1, ELK1, FOS, JUN, NFKB2, RELB, TNFAIP3.
Inflammatory response: FOS, IL1A, IL1R1, TLR7, TLR9
NF-kB 信号通路激活有关基因；正调控 IkB/NF-kB 的基因；NF-kB 反应基因；其他与 NF-kB 信号通路有关的基因
Nitric Oxide Signaling Pathway PCR Array
Catalog No. PAHS-062A（人）
一氧化氮 PCR 芯片
Catalog No. PAMM-062A（小鼠）
The Nitric Oxide Signaling Pathway RT² Profiler™ PCR Array profiles the expression of 84 genes whose expression is controlled by or involved in signaling by the
second messenger nitric oxide (NO). Nitric oxide is a dynamic and bioreactive molecule that can both participate in and inhibit the genesis of disease. Its ability to have
an impact on a wide range of physiological events stems from its capacity to reversibly alter the expression of specific genes and the activities of a wide range of proteins
and signaling pathways. This array contains genes involved in nitric oxide biosynthesis, superoxide metabolism and genes involved in response to oxidative stress. Also
included are genes induced by or repressed by NO, which can be used as indicator for the activation of NO pathway in your cell system. Using real-time PCR, you can
easily and reliably analyze expression of a focused panel of genes related to the Nitric Oxide signaling with this array.
一氧化氮 A（NO）信号通路 RT2 ProfilerTM PCR Array 包含了表达受第二信使 NO 控制及参与 NO 信号通路的 84 个基因。NO 是参与和抑制疾病发
生的动态生物效应分子。NO 分子能够可逆地改变特异基因的表达和许多蛋白的活性以及可逆影响信号通路，从而能够影响许多生理活动。本芯片包
括参与 NO 生物合成、过氧化物代谢的基因和参与氧化应激反应的基因。还包括被 NO 诱导或抑制的基因，这些基因能够作为细胞体系中 NO 信号
通路激活的指标。利用实时定量 PCR，你可以方便并且可信地对与 NO 信号通路相关的基因进行同时检测。
Genes Involved in Nitric Oxide Biosynthesis:
Genes with nitric-oxide synthase activity: NOS1, NOS2A, NOS3.
Genes with oxidoreductase activity: NOS1, NOS2A, NOS3, NQO1.
Positive regulators of nitric oxide biosynthesis: HSPCB, INS.
Negative regulators of nitric oxide biosynthesis: DNCL1, GLA, IL10.
Other genes involved in NO biosynthesis: AKT1, ARG2, DDAH2, DNCL1, EGFR, GCH1, GCHFR.
Genes Induced by NO: CDKN1A, IL8, JUN, VEGF.
Genes Suppressed by NO: CCNA1, MYB, TROAP.
Genes Involved in NO Signaling Pathway: CAMK1, DLG4, GRIN2D, NOS1, PPP3CA, PRKAR1B, PRKCA.
Genes Involved in Superoxide Metabolism:
Genes involved in superoxide release: ALOX12, DUOX1, DUOX2, NOX5, PRG3.
Genes with oxidoreductase activity: ALOX12, CYBA, DUOX1, DUOX2, NOS2A, NOX5, SOD1, SOD2, SOD3.
Genes with peroxidase activity: DUOX1, DUOX2.
Genes with superoxide dismutase activity: SOD2.
Other genes involved in superoxide metabolism: CCS, NCF1, NCF2, PREX1.
Genes Involved in Response to Oxidative Stress:
Anti-apoptosis genes: MPO, MTL5, NME5, PRDX2, RNF7.
Genes with antioxidant activity: APOE, MT3, SELS, SOD1, SOD3, SRXN1 (C20orf139).
Genes with glutathione peroxidase activity: GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, LOC493869.
Genes with oxidoreductase activity: CAT, EPX, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, LPO, MPO, MSRA, PRDX2, PRDX6, SOD1, SOD2, SRXN1 (C20orf139),
TPO, TXNRD2.
Genes with peroxidase activity: CYGB, EPX, GPR156, LPO, MPO, PRDX2, PRDX5, PRDX6, TPO, TTN, UNR.
Transcription regulators: FOXM1, GLRX2, SCRT2, SIRT2, SOD2, UNR.
Other genes involved in oxidative stress: ATOX1, DUSP1, GSS, KRT1, MBL2, NUDT1, OXR1, PNKP, PRNP, SCARA3, SEPP1, SGK2.
NO 生物合成有关的基因；NO 诱导的靶基因；NO 抑制的靶基因；NO 信号通路涉及的基因；过氧化物代谢相关基因；氧化压力反应有关的基因
Notch Signaling Pathway PCR Array
Catalog No. PAHS-059A（人）
Notch 信号通路 PCR 芯片
Catalog No. PAMM-059A（小鼠）
The Notch Signaling Pathway RT² Profiler™ PCR Array profiles the expression of 84 genes involved in Notch signaling. This array contains the Notch pathway’s binding
and receptor processing genes. The putative Notch target genes are also represented. These include genes related to apoptosis, the cell cycle, neurogenesis, and the
regulation of transcription as well as genes involved in cell regulation, proliferation, and differentiation. Genes from other signaling pathways that cross-talk with the
Notch signaling pathway are represented including members of the Sonic Hedgehog and Wnt Receptor Signaling Pathways. Using real-time PCR, you can easily and
reliably analyze expression of a focused panel of genes related to Notch signaling with this array.
Notch 信号通路 RT2 ProfilerTM PCR Array 可以同时检测与 Notch 信号通路相关的 84 个基因表达谱。其中包括 Notch 通路配体、受体及其相关基因，
公认的 Notch 靶基因也包含其中。还包括凋亡、细胞周期、神经发生和转录调控相关基因及参与细胞调控、增殖和分化的基因。该芯片还包括与 Notch
信号通路有交叉的其他信号通路的基因，包括 Sonic Hedgehog 和 Wnt Receptor 信号通路成员基因。利用实时定量 PCR，你可以方便并且可信地
对与 Notch 信号通路相关的基因进行同时检测。
Notch Signaling Pathway:
Notch Binding: DLL1 (DELTA1), DTX1, JAG1, JAG2.
Notch Receptor Processing: ADAM10, PSEN1, PSEN2, PSENEN (PEN2).
Notch Signaling Pathway Target Genes:
Apoptosis Genes: CDKN1A, CFLAR (CASH), IL2RA, NFKB1.
Cell Cycle Regulators: CCND1 (Cyclin D1), CDKN1A (P21), IL2RA.
Cell Proliferation: CDKN1A (P21), ERBB2, FOSL1, IL2RA.
Genes Regulating Cell Differentiation: DTX1, PPARG.
Neurogenesis: HES1, HEY1.
Regulation of Transcription: DTX1, FOS, FOSL1, HES1, HEY1, NFKB1, NFKB2, NR4A2, PPARG, STAT6.
Other Target Genes with Unspecified Functions: CD44, CHUK, IFNG, IL17B, KRT1, LOR, MAP2K7, PDPK1, PTCRA.
Other Genes Involved in the Notch Signaling Pathway:
Apoptosis Genes: AXIN1, EP300, HDAC1, NOTCH2, PSEN1, PSEN2.
Cell Cycle Regulators: AXIN1, CCNE1, CDC16, EP300, FIGF, JAG2, NOTCH2, PCAF.
Cell Proliferation: CDC16, FIGF, FZD3, JAG1, JAG2, LRP5, NOTCH2, PCAF, SIL.
Genes Regulating Cell Differentiation: DLL1, JAG1, JAG2, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PAX5, SHH.
Neurogenesis: DLL1, EP300, HEYL, JAG1, NEURL, NOTCH2, PAX5, RFNG, ZIC2 (HPE5).
Regulation of Transcription: AES, CBL, CTNNB1, EP300, GLI1, HDAC1, HEYL, HOXB4, HR, MYCL1, NCOR2, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PAX5,
PCAF, POFUT1, RUNX1, SKIIP, SUFU, TEAD1, TLE1.
Others Genes with Unspecified Functions: ADAM17, GBP2, LFNG, LMO2, MFNG, MMP7, NOTCH2NL, NUMB, SEL1L, SH2D1A.
Other Signaling Pathways that Crosstalk with the Notch Signaling Pathway:
Sonic Hedgehog (Shh) Pathway: GLI1, GSK3B, SHH, SMO, SUFU.
Wnt Receptor Signaling Pathway: AES, AXIN1, CTNNB1, FZD1, FZD2, FZD3, FZD4, FZD6, FZD7, GSK3B, LRP5, TLE1, WISP1, WNT11.
Other Genes Involved in the Immune Response: CXCL9, FAS (TNFRSF6), G1P2, GBP1, IFNG, IL2RA, IL2RG, IL4, IL4R, IL6ST, IRF1, ISGF3G, OAS1, OSM, STAT5A,
STUB1.
Notch 信号通路基因；Notch 信号通路靶基因；Notch 信号通路相关基因；其他与 Notch 信号通路有关的信号通路的基因
PI3K-AKT Signaling Pathway PCR Array
PI3K-AKT 信号通路 PCR 芯片
Catalog No. PAHS-058A（人）
The Human PI3K-AKT Signaling Pathway RT² Profiler™ PCR Array profiles the expression of 84 genes involved in PI3K-AKT signaling. This array contains members of
the AKT (Protein Kinase B) and PI3K families and their regulators. Genes involved in several biological processes are represented including inactivation of Gsk3 and the
accumulation of b-catenin, regulation of actin organization and cell migration, and BAD phosphorylation. Genes involved in the IGF-1, mTOR, and anti-apoptotic
pathways are also contained in this array. Regulators of eIF4e and p70 S6 kinase activity are included as well. Using real-time PCR, you can easily and reliably analyze
expression of a focused panel of genes related to PI3K-AKT signaling with this array.
PI3K-AKT 信号通路 RT2 ProfilerTM PCR Array 可以同时检测与 PI3K-AKT 信号通路相关的 84 个基因表达谱。芯片中包括 AKT（蛋白激酶 B）和 PI3K
家族成员及他们的调节基因，这些基因参与许多生物学过程：Gsk3 失活、β-catenin 的沉积、肌动蛋白的组装调控及细胞迁移、BAD 磷酸化等。IGF-1、
mTOR 和抗凋亡信号通路相关的基因、调控 elF4e 和 p70 S6 激酶活性的基因也包含其中。利用实时定量 PCR，
你可以方便并且可信地对与 PI3K-AKT
信号通路相关的基因进行同时检测。
AKT and PI3K Family Members and Their Regulators: AKT1, AKT2, AKT3, BTK, GRB10, GRB2, HSPB1, ILK, MTCP1, PDK2, PDPK1, PIK3CA (p110a), PIK3CG,
PIK3R1 (p85a), PIK3R2 (p85b), PIK3R3, PRKCA, PRKCB1, PRKCZ, PTEN, TCL1A.
IGF-1 Signaling Pathway: CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF.
Inactivation of Gsk3 and the Accumulation of β-Catenin: ADAR, AKT1, APC, CCND1, CD14, CTNNB1, EIF2AK2, GJA1, GSK3B, IRAK1, MYD88, NFKB1, PDK1,
TIRAP, TLR4, TOLLIP.
PI3K Subunit p85 Genes and Regulation of Actin Organization and Cell Migration: CDC42, PDGFRA, RAC1, RHOA, WASL.
PTEN Dependent Cell Cycle Arrest and Apoptosis: AKT1, CDKN1B (p27), FASLG, FOXO3, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK1, PDK2, PTEN, PTK2, RBL2,
SHC1, SOS1.
BAD Phosphorylation and Anti-apoptotic Pathways: AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, RAF1, RPS6KA1, SHC1, SOS1, YWHAH.
Genes Involved in the mTOR Signaling Pathway: AKT1, EIF4B, EIF4E, EIF4EBP1, EIF4G1, FKBP1A, FRAP1, PDK1, PDK2, PTEN, RHEB, RPS6KB1, TSC1, TSC2.
Regulation of eIF4e and p70 S6 Kinase: AKT1, CUTL1, EIF4A1, EIF4E, EIF4EBP1 (4E-BP1), EIF4G1, FRAP1(mTOR), IRS1, MAPK1, MAPK14, MAPK3, PABPC1,
PDK1, PDK2, PRKCA, PTEN, RPS6KB1.
Other Genes Involved in the AKT Signaling Pathway: CASP9, CHUK, FOXO1, NFKBIA.
AKT-PI3K 家族成员及其调控基因、IGF-1 信号通路相关基因、Gsk3 失活及β-Catenin 沉积相关基因、PI3K 的亚基 p85 编码基因、调控肌动蛋白组装和细胞迁移的基因、
PTEN 依赖的细胞周期停滞和细胞凋亡相关基因、BAD 磷酸化和抗凋亡信号通路相关基因、mTOR 信号通路相关基因、eIF4e 和 p70 S6 激酶调控相关基因、AKT 信号通
路相关的其他基因
Catalog No. PAHS-014A（人）
Signal Transduction PathwayFinder PCR Array
信号转导通路发现者 PCR 芯片
Catalog No. PAMM-014A（小鼠）
Catalog No. PARN-014A（大鼠）
The Signal Transduction PathwayFinder™ RT²Profiler™ PCR Array profiles the expression of 84 key genes representative of 18 different signal transduction pathways
listed below. Using real-time PCR, you can easily and reliably analyze the expression of a focused panel of genes related to any of the 18 signal transduction pathways
that may be involved in your favorite biological response. Once you have defined the pathways involved, you can perform a comprehensive survey of the genes targeted
by those pathways using our other application-specific PCR Arrays that are designed for each individual pathway.
信号转导通路发现者 RT2 ProfilerTM PCR Array 可以同时检测 18 个不同信号转导通路相关的 84 个关键基因表达谱。利用实时定量 PCR，操作者可
以方便并且可信地分析与 18 个信号通路中任何一个相关的基因的表达情况，这些基因可能参与了你感兴趣的生物学反应。一旦你明确了相关通路，
你就可以利用我们提供的针对单一信号通路的特异性 PCR 芯片对靶向所发现信号通路的基因进行综合检测。
Mitogenic Pathway: EGR1, FOS, JUN.
Wnt Pathway: CCND1, JUN, LEF1, MYC, PPARG, TCF7, VEGF, WISP1.
Hedgehog Pathway: BMP2, BMP4, EN1, FOXA2 (HNF3B), PTCH, WNT1, WNT2.
TGF-β Pathway: CDKN1A, CDKN1B (p27), CDKN2A (p16Ink4), CDKN2B (p15 Ink2b).
Survival Pathway:
PI3 Kinase / AKT Pathway: BCL2, CCND1, FN1, JUN, MMP7 (matrilysin), MYC.
Jak / Src Pathway: BCL2, BCL2L1.
NFκB Pathway: BCL2A1 (Bfl-1/A1), BIRC1 (NAIP), BIRC2 (c-IAP2), BIRC3 (c-IAP1), TERT.
p53 Pathway: BAX, CDKN1A (p21Waf1/p21Cip1), Fas (TNFRSF6), GADD45A, IGFBP3, MDM2, TP53I3 (PIG3).
Stress Pathway: ATF2, FOS, HSF1 (tcf5), HSPB1 (hsp27), HSPCA (hsp90), MYC, TP53.
NFκB Pathway: CCL20, ICAM1, IKBKB, IL1A, IL2, IL8, LTA (TNFβ), NFKB1 (NFκB), NOS2A (iNOS), PECAM1, TANK, TNF, VCAM1.
NFAT Pathway: CD5, FASLG (TNFSF6), IL2.
CREB Pathway: CYP19A1, EGR1, FOS.
Jak-Stat Pathway: CXCL9 (MIG), IL4, IL4R, IRF1, MMP10 (stromelysin-2), NOS2A.
Estrogen Pathway: BCL2, BRCA1, GREB1, NRIP1.
Androgen Pathway: CDK2, CDKN1A (p21Waf1/p21Cip1), KLK2 (hGK2), TMEPAI.
Calcium and Protein Kinase C Pathway: CSF2 (GM-CSF), FOS, IL2, JUN, MYC, ODC1, PRKCA, PRKCE, TFRC.
Phospholipase C Pathway: BCL2, EGR1, FOS, ICAM1, JUN, NOS2A, PTGS2 (COX-2), VCAM1.
Insulin Pathway: CEBPB (C/EBP-beta), FASN, GYS1, HK2, LEP (Ob).
LDL Pathway: CCL2, CSF2 (GM-CSF), SELE, SELPLG (P-selectin), VCAM1.
Retinoic Acid Pathway: EN1, HOXA1, RBP1 (CRBPI).
有丝分裂信号通路相关基因；Wnt 信号通路；Hedgehog 信号通路；TGF-β 信号通路；细胞存活信号通路；P53 信号通路；应激信号通路；NFκB 信号通路；CREB 信号
通路；Jak-Stat 信号通路；雌激素信号通路；雄性激素信号通路；钙与蛋白激酶信号通路；磷酸酶信号通路；胰岛素信号通路；LDL 信号通路；视黄酸信号通路
Catalog No. PAHS-035A（人）
TGFß BMP Signaling Pathway PCR Array
TGFß / BMP 信号通路 PCR 芯片
Catalog No. PAMM-035A（小鼠）
Catalog No. PARN-035A（大鼠）
The TGFβ BMP Signaling Pathway RT² Profiler™ PCR Array profiles the expression of 84 genes related to TGFβ BMP-mediated signal transduction. The array includes
members of the TGFβ superfamily of cytokines and their receptors. SMAD and SMAD target genes are included. Related genes including adhesion and extracellular
molecules and transcription factors are included. Some of the genes involved in downstream cellular and developmental processes are also represented. Using real-time
PCR, you can easily and reliably analyze expression of a focused panel of genes related to TGFβ BMP-mediated signal transduction with this array.
TGFβ BMP 信号通路 RT2 ProfilerTM PCR Array 可以同时检测与 TGFβ BMP 介导的信号转导相关的 84 个基因表达谱。其中包括 TGFβ 细胞因子超
家族及其受体基因，SMAD 和 SMAD 靶基因。也包括细胞黏附、细胞外分子和转录因子相关基因。还包括参与下游细胞信号和发育过程中的一些基
因。利用实时定量 PCR，你可以方便并且可信地对与 TGFβ BMP 介导的信号转导通路相关的基因进行同时检测。
TGF-β Superfamily Cytokines:
TGF-β: TGFB1, TGFB2, TGFB3.
BMP: BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7.
GDF: AMH, GDF2 (BMP9), GDF3 (Vgr-2), GDF5 (CDMP-1), GDF6, GDF7, IGF1, IGFBP3, IL6, INHA (inhibin a), INHBA (inhibin BA), LEFTY1, LTBP1, LTBP2, LTBP4,
NODAL, PDGFB.
Activin: INHA (inhibin a), INHBA (inhibin BA), INHBB (inhibin BB), LEFTY1, NODAL.
Receptors: ACVR1 (ALK2), ACVR2, ACVRL1 (ALK1), AMHR2, BMPR1A (ALK3), BMPR1B (ALK6), BMPR2, ITGB5 (integrin B5), ITGB7 (integrin B7), LTBP1, NR0B1,
STAT1, TGFB1I1, TGFBR1, (ALK5) TGFBR2, TGFBR3, TGFBRAP1.
SMAD: SMAD1 (MADH1), SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SMAD5 (MADH5).
SMAD Target Genes:
TGF-β/ Activin-Responsive: CDC25A, CDKN1A (p21WAF1 / p21CIP1), CDKN2B (p15LNK2B), COL1A1, COL1A2, COL3A1, FOS, GSC (goosecoid), IGF1, IGFBP3,
IL6, ITGB5 (integrin B5), ITGB7 (integrin B7), JUN, JUNB, MYC, PDGFB, SERPINE 1 (PAI-1), TGFB1I1, TGFB1I4, TGFBI, TGIF.
BMP-Responsive: BGLAP (osteocalcin), DLX2, ID1, ID2, JUNB, SOX4, STAT1.
Molecules Regulating Signaling of the TGF-β Superfamily: BAMBI, BMPER, CDKN2B (p15LNK2B), CER1 (cerberus), CHRD (chordin), CST3, ENG (Evi-1), EVI1,
FKBP1B, FST (follistatin), HIPK2, NBL1 (DAN), NOG, PLAU (uPA), RUNX1 (AML1), SMURF1.
Adhesion and Extracellular Molecules:
Adhesion Molecules: BGLAP (osteocalcin), ENG (Evi-1), ITGB5 (integrin B5), ITGB7 (integrin B7), TGFB1I1, TGFBI.
Extracellular Matrix Structural Constituents: BGLAP (osteocalcin), COL1A1, COL1A2, COL3A1, LTBP1, LTBP2, LTBP4, TGFBI.
Other Extracellular Molecules: AMH, BMP1, BMP2, FST (follistatin), GDF2 (BMP9), GDF3 (Vgr-2), IGF1, IGFBP3, IL6, INHA (inhibin a), INHBA (inhibin BA), INHBB
(inhibin BB), PDGFB, PLAU (uPA), SERPINE1.
Transcription Factors and Regulators: DLX2, EVI1, FOS, GSC (goosecoid), HIPK2, ID1, JUN, JUNB, MYC, NR0B1, RUNX1 (AML1), SMAD1 (MADH1), SMAD2
(MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SMAD5 (MADH5), SOX4, STAT1, TGFB1I1, TGFB1I4, TGIF.
Genes Involving in Cellular and Developmental Processes:
Apoptosis: CDKN1A (p21WAF1 / p21CIP1), HIPK2, IGFBP3, INHA (inhibin a), INHBA (inhibin BA), STAT1, TGFB1.
Embryonic Development: BMP4, INHBA (inhibin BA), SMAD3, SMURF1.
Muscle Development: IGF1, SMAD3.
Neurogenesis: DLX2, INHA (inhibin a), INHBA (inhibin BA), NOG.
Reproduction: AMH, AMHR2, FST (follistatin), INHA (inhibin a), INHBA (inhibin BA), INHBB (inhibin BB), NR0B1.
Skeletal Development: BGLAP (osteocalcin), BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMPR2, CHRD (chordin), COL1A1, COL1A2, IGF1, INHA (inhibin a),
INHBA (inhibin BA), NOG.
TGFβ 超家族细胞因子；受体；SMAD 家族；SMAD 靶基因；黏附分子和细胞外基质；转录因子和转录调节因子；发育过程有关的基因
Tumor Necrosis Factor (TNF) Ligand and Receptor PCR Array
Catalog No. PAHS-063A（人）
TNF 配体及其受体 PCR 芯片
Catalog No. PAMM-063A（小鼠）
The Tumor Necrosis Factor (TNF) Ligand and Receptor Signaling Pathways RT² Profiler™ PCR Array profiles the expression of 84 genes whose expression is controlled
by or involved in the TNF ligand and TNF receptor signaling pathways. Members of the TNF Superfamily and TNF Receptor Superfamily are represented on this array.
Genes involved in the TNFR1 and TNFR2 Signaling Pathways are also included. Using real-time PCR, you can easily and reliably analyze expression of a focused panel
of genes related to the TNF signaling with this array.
肿瘤坏死因子 A（TNF）配体和受体信号通路 RT² Profiler™ PCR Array 可以同时检测受 TNF 配体及其受体信号通路调控或参与此信号通路的 84 个
基因表达谱。其中包括 TNF 超家族和 TNF 受体超家族成员基因。也包括 TNFR1 和 TNFR2 信号通路基因。利用实时定量 PCR，你可以方便并且可
信地对与 TNF 信号相关的基因进行同时检测。
TNF Superfamily Members:
Induction of Apoptosis: FASLG, LTA, TNFSF10, TNFSF14, TNFSF8.
Caspase Activation: TNFSF15.
Caspase Inhibition: TNFSF14.
Anti-apoptosis Genes: CD40LG, TNF, TNFSF18.
Other Apoptosis-Related Genes: TNFSF7, TNFSF9.
Inflammatory Response: CD40LG, TNF.
NFκB Signaling Pathway: FASLG, TNF, TNFSF10, TNFSF14, TNFSF15.
Other TNF Superfamily Members: LTB, PGLYRP1, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF4, TNFSF5IP1.
TNF Receptor Superfamily Members:
Induction of apoptosis: FAS, TNFRSF10A, TNFRSF10A, TNFRSF10B, TNFRSF19, TNFRSF25, TNFRSF7, TNFRSF9, TRADD.
Caspase activation: TNFRSF10A, TNFRSF10B.
Caspase inhibition: TNFRSF7.
Anti-apoptosis Genes: FAS, TNFRSF10D, TNFRSF18, TNFRSF6B, TNFRSF7.
Other Apoptosis Genes: CD40, LTBR, NGFR, TNFRSF10C, TNFRSF11B, TNFRSF12A, TNFRSF14, TNFRSF1A, TNFRSF1B, TNFRSF21.
Inflammatory Response: CD40, TNFRSF1A.
NFκB Signaling Pathway:
CD40, EDA2R, LTBR, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF7, TRADD.
JNK Signaling Pathway: EDA2R, TNFRSF19, TNFRSF7.
Other TNF Receptor Superfamily Members: TNFRSF11A, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFRSF19L, TNFRSF4, TNFRSF8.
TNFR1 Signaling Pathway:
Induction of apoptosis: CASP3, CRADD, FADD, TRADD.
Caspases: CASP2, CASP3, CASP8.
Anti-apoptosis Genes: BAG4, CASP2, TNF.
Other Apoptosis Genes: DFFA, PAK1, TNFRSF1A, TRAF2.
Inflammatory Response: TNF, TNFRSF1A.
NFκB Signaling Pathway:
CASP8, FADD, TNF, TNFRSF1A, TRADD.
JNK Signaling Pathway: MAP2K4, MAPK8, PAK1.
Transcription Regulators: JUN, PARP1, RB1, TNF, TNFRSF1A.
TNFR1 Signaling Pathway: ARHGDIB, CAD, HRB, LMNA, LMNB1, LMNB2, MADD, MAP3K1, MAP3K7, PAK2, PRKDC, SPTAN1
TNFR2 Signaling Pathway:
Induction of Apoptosis: IKBKG, LTA, TRAF3.
Anti-apoptosis Genes: NFKB1, TNFAIP3
Other Apoptosis Genes: NFKBIA, TNFRSF1B, TRAF1, TRAF2.
Inflammatory Response: NFKB1.
NFκB Signaling Pathway:
CHUK, IKBKB, IKBKG, NFKBIA, TNFAIP3.
Transcription Regulators: IKBKB, IKBKG, NFKB1, NFKBIA.
TNFR2 Signaling Pathway: DUSP1, HRB, IKBKAP, MAP3K1, MAP3K14, TANK.
TNF 超家族成员；TNF 受体超家族成员；TNFR1 信号通路；TNFR2 号通路
Catalog No. PAHS-043A（人）
Wnt Signaling Pathway PCR Array
Wnt 信号通路 PCR 芯片
Catalog No. PAMM-043A（小鼠）
Catalog No. PARN-043A（大鼠）
The Wnt Signaling Pathway RT² Profiler™ PCR Array profiles the expression of 84 genes related to Wnt-mediated signal transduction. The Wnt family is represented by
19 glycosylated extracellular signaling molecules belonging to the Frizzled-2 signaling pathway on this array. Cell-surface receptors serving as ligands of the Wnt genes
(members of the Frizzled-1 signaling pathway) are also included. Regulators of the Wnt signaling pathway and competitive Wnt binding antagonists are also
represented. Intracellular signaling molecules and target genes involved in growth regulation and proliferation are contained on this array. This array also contains genes
involved in protein modification downstream of Wnt signaling including genes involved in kinase and phosphatase activity and ubiquitination. Using real-time PCR, you
can easily and reliably analyze expression of a focused panel of genes related to Wnt-mediated signal transduction with this array.
Wnt 信号通路 RT² Profiler™ PCR Array 可以同时检测与 Wnt 介导的信号转导相关的 84 个基因表达谱。其中包括属于 Frizzled-2 信号通路的 19 个
糖基化细胞外信号分子。也包括充当 Wnt 基因 A（Frizzled-1 信号通路成员）配体的细胞表面受体。还包括 Wnt 信号通路的调节基因和 Wnt 的竞争
结合基因，细胞内分子基因和参与细胞调控与增殖的靶基因。该芯片还包含参与 Wnt 信号通路下游蛋白修饰的基因，包括激酶、磷酸化酶和参与泛
素化的基因。利用实时定量 PCR，你可以方便并且可信地对与 Wnt 介导的信号转导相关的基因进行同时检测。
Frizzled-1 Signaling Pathway: AXIN1, DIXDC1, DVL1, DVL2, FZD3, FZD4, FZD6, FZD7, FZD8.
Frizzled-2 Signaling Pathway: WNT1, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT9A, WNT10A, WNT11,
WNT16
Regulation of Wnt Receptor Signaling Pathway:
Negative Regulation of Wnt Receptor Signaling Pathway: CXXC4, DKK1, FRZB (FRP-3), FSHB, NLK.
Wnt Binding Antagonists: SFRP1, SFRP4 (FRP-4).
Other Regulators of Wnt Signaling: PPP2CA, PPP2R1A, SENP2, TCF7L1.
Regulation of Growth and Proliferation:
Regulation of Growth: PPP2CA, PPP2R1A, WISP1.
Regulation of Cell Proliferation: CTBP1, CTBP2, LRP5.
Other Genes Related to Growth and Proliferation: FRAT1.
Regulation of the Cell Cycle: APC, CCND1, CCND2, CCND3, FGF4, PPP2CA, PPP2R1A.
Regulation of Transcription:
Transcription Factors: EP300, FOSL1 (Fra-1), FOXN1, JUN, MYC, PITX2, T (Brachyury), TCF7L1.
Other Regulators of Transcription: AES (TLE/ Groucho), CTNNB1 (catenin ß), CTNNBIP1 (ICAT), LEF1, NLK, PPP2CA, PPP2R1A, PYGO1, SOX17, TCF7 (Tcf-1),
TLE1, TLE2, WNT1.
Protein Modification Activities:
Protein Kinase Activity: CSNK1A1, CSNK1D, CSNK1G1, CSNK2A1, CTBP1, GSK3A (GSKalpha), GSK3B (GSKbeta), NLK, WIF1.
Protein Phosphatase Type 2A Complex: PPP2CA, PPP2R1A.
Protein Ubiquitination: BTRC (b-TrCP), FBXW11, FBXW2, SHFM3.
Other Genes Related to Wnt Signaling: BCL9, C2orf31 (FZD5), DAAM1, FZD1, FZD2, KREMEN1, LRP6, NKD1, PORCN, RHOU, SLC9A3R1.
Frizzled-1 信号通路；Frizzled-2 号通路；Wnt 受体信号通路调节因子；生长和增殖的调节因子；细胞周期相关基因；转录调节因子；具有蛋白修饰活性的有关基因；其他
与 Wnt 信号通路有关的基因
Other PCR Array
其他 PCR 芯片
细胞表面标志物 PCR 芯片
转录因子 PCR 芯片
管家基因 PCR 芯片
核受体与辅助调节因子 PCR 芯片
Cell Surface Markers PCR Array
细胞表面标志物 PCR 芯片
Catalog No. PAHS-055A（人）
The Human Cell Surface Markers RT² Profiler™ PCR Array profiles the expression of 84 genes relevant to research at the cell surface marker level. These markers have
been used in studies including: 1) determination of the extent of leukocyte infiltration among cancer tissues; 2) characterization of cell populations isolated from patients
with chronic inflammatory diseases such as atherosclerosis, asthma, inflammatory bowel disease, and arthritis; 3) determination of T- and B-cell lineage and clonality; 4)
characterization of leukocyte populations for use in the prognosis of disease stage and progression; and 5) analysis of the composition of immune infiltrates and their
association with organ rejection. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to cell surface markers with this
array.
细胞表面标记物 RT² Profiler™ PCR Array 可以同时检测 84 个研究中至关重要的细胞表面标志物的表达水平。这些标志物主要用于以下研究：1）
确定肿瘤组织中白细胞浸润的程度；2）对于慢性炎症病人，如动脉粥样硬化、哮喘、炎症性肠病和关节炎等，可通过细胞表面标记物对细胞分型；
3）确定 T 细胞和 B 细胞谱系和克隆系；4）对白细胞进行分型，从而预测疾病的发展阶段及进展；5）分析免疫浸润的原理和与器官排斥反应的关
系。利用实时定量 PCR，你可以方便并且可信地对与 TNF 信号相关的基因进行同时检测。
B-cell Surface Markers:
Activated B-cells: CD28, CD38, CD69, CD80, CD83, CD86, DPP4, FCER2, IL2RA, TNFRSF8, CD70 (TNFSF7).
Mature B-cells: CD19, CD22, CD24, CD37, CD40, CD72, CD74, CD79A, CD79B, CR2, IL1R2, ITGA2, ITGA3, MS4A1, ST6GAL1.
Other B-cell Surface Markers: CD1C, CHST10, HLA-A, HLA-DRA, NT5E.
T-cell surface markers:
Cytotoxic T-cells: CD8A, CD8B1.
Helper T-cells: CD4.
Activated T-cells: ALCAM, CD2, CD38, CD40LG, CD69, CD83, CD96, CTLA4, DPP4, HLA-DRA, IL12RB1, IL2RA, ITGA1, TNFRSF4, TNFRSF8, CD70 (TNFSF7).
Other T-cell Surface Markers: CD160, CD28, CD37, CD3D, CD3G, CD3Z, CD5, CD6, CD7, FAS, KLRB1, KLRD1, NT5E, ST6GAL1.
Natural Killer (NK) Cell Surface Markers: CD2, CD244, CD3Z, CD7, CD96, CHST10, IL12RB1, KLRB1, KLRC1, KLRD1, NCAM1.
Monocyte and Macrophage Cell Surface Markers:
Activated Macrophages: CD69, ENG, FCER2, IL2RA.
Other Monocyte and Macrophage Surface Markers: C5R1, CD163, CD40, CD63, CD74, CD86, CHST10, CSF1R, DPP4, FCGR1A, HLA-DRA, ICAM2, IL1R2,
ITGA1, ITGA2, S100A8, TNFRSF8, CD70 (TNFSF7).
Endothelial Cell Surface Markers: ENG, ICAM2, NOS3, PECAM1, SELP, TEK, VCAM1, VWF.
Smooth Muscle Cell Surface Markers: MYH10, MYH9, MYOCD.
Dendritic Cell Surface Markers: CD1A, CD209, CD40, CD83, CD86, CR2, FCER2.
Mast Cell Surface Markers: C5R1, FCER1A, FCER2, TPSAB1.
Fibroblast (Stromal) Surface Markers: ALCAM, COL1A1, COL1A2.
Epithelial Cell Surface Markers: CD1D, KRT18, KRT5, KRT8, TACSTD1.
Adipocyte Surface Markers: RETN.
B 细胞表面标记物、T 细胞表面标记物、自然杀伤细胞表面标记物、单核细胞和巨噬细胞表面标记物、内皮细胞表面标记物、平滑肌细胞表面标记物、树突状细胞表面标
记物、肥大细胞表面标记物、成纤维细胞（基质细胞）表面标记物、表皮细胞表面标记物、脂肪细胞标记物
Catalog No. PAHS-000A（人）
Housekeeping Genes PCR Array
Catalog No. PAMM-000A（小鼠）
管家基因 PCR 芯片
Catalog No. PARN-000A（大鼠）
The Housekeeping Genes RT² Profiler™ PCR Array profiles the expression of eight (8) identical sets of twelve (12) commonly used housekeeping genes. This array can
be easily used to identify genes with a constant level of expression among your different experimental conditions for use in normalizing your relative gene expression
profiling experiment. Housekeeping genes encode proteins that are usually essential for the maintenance of cellular function. Their expression often, but not always,
remains constant under most experimental conditions. Some of these genes may be regulated under certain circumstances and may vary with cell type. Using real-time
PCR, you can easily and reliably evaluate the expression of these housekeeping genes among your different experiment conditions with this array.
看家基因 RT² Profiler™ PCR Array 可以同时测定 8 套 12 个常用的看家基因。此 array 可以用来检测你不同实验条件下表达水平恒定的看家基因，
以便用来标准化相对基因表达量。看家基因编码维持细胞功能的重要蛋白。它们的表达在大多数不同实验处理中通常稳定，但这不是绝对的。其中
某些基因在特定的环境和特定的细胞系中表达会发生变化。利用实时定量 PCR，你可以方便并且可信地对这些看家基因在不同样品中的表达水平进
行检测。
Column
UniGene
GenBank
Symbol
Description
1
N/A
X03205
18SrRNA
Human 18S ribosomal RNA
2
Hs.520640
NM_001101
ACTB
Actin, beta
3
Hs.534255
NM_004048
B2M
Beta-2-microglobulin
4
Hs.356331
NM_021130
PPIA
Peptidylprolyl isomerase A (cyclophilin A)
5
Hs.544577
NM_002046
GAPDH
Glyceraldehyde-3-phosphate dehydrogenase
6
Hs.255230
NM_000181
GUSB
Glucuronidase, beta
7
Hs.412707
NM_000194
HPRT1
Hypoxanthine phosphoribosyltransferase 1
8
Hs.509736
NM_007355
HSPCB
Heat shock 90kDa protein 1, beta
9
Hs.546356
NM_012423
RPL13A
Ribosomal protein L13a
10
Hs.546285
NM_001002
RPLP0
Ribosomal protein, large, P0
11
Hs.529618
NM_003234
TFRC
Transferrin receptor (p90, CD71)
12
Hs.520348
NM_021009
UBC
Ubiquitin C
Transcription Factors PCR Array
转录因子 PCR 芯片
Catalog No. PAHS-075A（人）
The Human Transcription Factors RT² Profiler™ PCR Array profiles the expression of 84 genes that directly control when, where, and the extent to which genes are
expressed. The array includes transcription factors downstream of signaling from cytokines and chemokines and growth factors like BMP, EGF, EPO, IGF, insulin, PDGF,
TGFß, TPO, and VEGF. Signaling from androgen, B-cell, G-protein coupled, T-cell, and Toll-Like receptors activate transcription factors represented on this array. Target
transcription factors in signal transduction pathways like JAK / STAT, JNK and other MAP Kinases, NFkB, Notch, and WNT are also included in this array. Using real-time
PCR, you can easily and reliably analyze the expression of a focused panel of transcription factors with this array.
转录因子 RT² Profiler™ PCR Array 可以同时测定 84 个直接调控基因何时、何地表达及表达程度的基因。芯片中包含 BMP、EGF、EPO、IGF、insulin、
PDGF、TGFβ、TPO 和 VEGF 等细胞因子、趋化因子和生长因子信号通路激活的转录因子。雄激素受体、B 细胞受体、G 蛋白耦联受体、T 细胞
受体和 Toll-like 受体激活的转录因子也包含其中。另外，芯片中还包含 JAK/STAT、JNK 和 MAP Kinase、NFkB、Notch 和 WNT 信号转导通路激
活的转录因子。利用实时定量 PCR，你可以方便并且可信地对一组转录因子表达水平进行检测。
Androgen Receptor Signaling Pathway: CTNNB1, RB1.
EGF Signaling Pathway: ELK1, FOS, JUN, STAT1, STAT3, STAT5A.
IGF-1 Signaling Pathway: ELK1, FOS, JUN.
Insulin Signaling Pathway: ELK1, FOS, FOXO1, JUN.
PDGF Signaling Pathway: ELK1, FOS, JUN, STAT1, STAT3, STAT5A.
G-Protein-Coupled Receptor Signaling Pathways: CREB1, ELK1, FOS, JUN, NFATC1.
TGFβ / BMP Signaling Pathway: CREBBP, ID1, MYC, SMAD1, SMAD4, SMAD5, SMAD9, SP1.
Toll-like Receptor Signaling Pathway: ELK1, FOS, JUN, NFKB1, PPARA, RELA, STAT1.
VEGF Signaling Pathway: ARNT, HIF1A, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4.
Wnt Signaling Pathway: CREBBP, CTNNB1, HNF4A, JUN, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, SMAD4, TCF7L2, TP53.
Notch Signaling Pathway: CREBBP, HDAC1.
T-Cell Receptor Signaling Pathway: ELK1, FOS, JUN, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1.
B-Cell Receptor Signaling Pathway: ELK1, FOS, JUN, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1.
Cytokine and Chemokine-mediated Signaling Pathways: CEBPA, RELA, STAT3, STAT4, STAT5A, STAT5B.
EPO Signaling Pathway: ELK1, FOS, JUN, STAT5A.
TPO Signaling Pathway: FOS, JUN, STAT1, STAT3, STAT5A.
MAPK Signaling Pathway:
Erk1 / Erk2 Signaling Pathway: ELK1, MYC, STAT3.
p38 Signaling Pathway: ATF2, CREB1, ELK1, MAX, MEF2A, MYC, STAT1.
Other TFs involved in the MAPK Signaling Pathway: ATF4, CEBPA, FOS, JUN, JUND, MEF2C, NFATC2, NFATC4, NFKB1, SP1, STAT1, TP53.
NFκB Signaling Pathway: NFKB1, NR3C1, REL, RELA, STAT1.
JAK / STAT Signaling Pathway: CREBBP, MYC, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6.
JNK Signaling Pathway: ATF2, ELK1, JUN, MEF2A.
Other Transcription Factors: ATF1, ATF3, CEBPB, CEBPG, DR1, E2F1, E2F6, EGR1, ESR1, ETS1, ETS2, FOXA2, GATA1, GATA2, GATA3, GTF2B, GTF2F1,
HAND1, HAND2, HOXA5, HSF1, IRF1, JUNB, MEF2B, MYB, MYF5, MYOD1, NFYB, PAX6, POU2AF1, PPARG, RELB, SP3, TBP, TCF1, TFAP2A, TGIF1, YY1.
雄激素受体信号通路、EGF 信号通路、IGF-1 信号通路、Insulin 信号通路、PDGF 信号通路、G 蛋白耦联受体信号通路、TGFβ/BMP 信号通路、Toll-like 受体信号通路、
VEGF 信号通路、Wnt 信号通路、Notch 信号通路、T 细胞受体信号通路、B 细胞受体信号通路、细胞因子和趋化因子介导的信号通路、EPO 信号通路、TPO 信号通路、
MAPK 信号通路、NFkB 信号通路、JAK/STAT 信号通路、JNK 信号通路、其他转录因子
Nuclear Receptors and Coregulators PCR Array
核受体与辅助调节因子 PCR 芯片
Catalog No. PAHS-056A（人）
The Human Nuclear Receptors and Coregulators RT² Profiler™ PCR Array profiles the expression of 84 genes encoding nuclear receptors and their coregulators. The
array includes receptors for thyroid and steroid hormones, receptors for retinoids and vitamin D, as well as orphan receptors. Coactivators and corepressors of nuclear
receptor activity are also included on this array as well as chromatin modifying enzymes. Using real-time PCR, you can easily and reliably analyze expression of a
focused panel of nuclear receptors and coregulators with this array.
核受体与辅助调节因子 RT² Profiler™ PCR Array 可以同时测定 84 个编码核蛋白受体和辅助调节子的基因。芯片中包括甲状腺和类固醇激素受体、
视黄醇和维他命 D 受体以及孤儿受体。核受体活性的辅助激活因子和辅助抑制因子、染色体修饰酶也包含其中。利用实时定量 PCR，你可以方便并
且可信地对一组核受体和辅助调节因子表达水平进行检测。
Nuclear Receptors:
Androgen Receptors and Related Molecules: AR, CRSP2, CRSP6, MED12, MED4, NR1I3, PPARBP, THRAP1, THRAP4, THRAP5.
Estrogen Receptors and Related Molecules: ESR1, ESR2, NCOA6, PPARGC1B.
Glucocorticoid Receptors and Related Molecules: NCOA6, NR3C1.
Retinoic Acid Receptors and Related Molecules: HMGA1, NCOA6, RARA, RARB, RARG, RXRA, RXRB, RXRG.
Thyroid Hormone Receptors and Related Molecules: BRD8, CRSP2, CRSP6, MED12, MED4, NCOA3, NCOA4, NCOA6, NR1D1, NR1H3, NR1I3, NR2F6, NR4A3,
PPARBP, THRA, THRAP1, THRAP4, THRAP5, THRB.
Vitamin D Receptors and Related Molecules: CRSP2, CRSP6, MED12, MED4, PPARBP, THRAP1, THRAP4, THRAP5, VDR.
Steroid Hormone Receptors: ESRRA, ESRRB, ESRRG, HNF4A, NR0B1, NR0B2, NR1D1, NR1D2, NR1H2, NR1H3, NR1H4, NR1I2, NR2C1, NR2C2, NR2E3,
NR2F1, NR2F2, NR2F6, NR3C2, NR4A1, NR5A1, NR6A1, PPARA, PPARD, PPARG, RARA, RARB, RARG, RORA, RXRA, RXRB, RXRG, THRA, THRB, VDR.
Other Nuclear Receptors: AHR, TRIP4.
Transcription Factors and Regulators:
Ligand-dependent Nuclear Receptor Transcription Coactivators: CRSP2, CRSP6, HMGA1, MED12, MED4, NCOA6, PPARBP, PPARGC1A, PPARGC1B, THRAP1,
THRAP4, THRAP5.
Positive Regulators of Transcription: ARNT, BRD8, CREBBP, ESR2, HTATIP, NCOA1, NCOA2, NCOA3, NCOA4, NFKB2, NR1H3, NR1I2, NR1I3, NR2C2, NR2F1,
NR5A1, NRIP1, PSMC3, RARA, RXRA, RXRB, TRIP4.
Negative Regulators of Transcription: COPS2, HDAC4, HDAC5, HDAC6, HDAC7A, NCOR1, NCOR2, NR0B2, NR1D1, NR2F2, PSMC3, PSMC5, THRA, THRB.
Other Transcription Factors and Regulators: AHR, AR, ESR1, ESRRA, ESRRB, ESRRG, HDAC1, HDAC2, HDAC3, HNF4A, ITGB3BP, MTA1, NOTCH2, NR0B1,
NR1D2, NR1H2, NR1H4, NR2C1, NR2E3, NR2F6, NR3C1, NR3C2, NR4A1, NR6A1, PCAF, PPARA, PPARD, PPARG, RARB, RARG, RBPJ (RBPSUH), RORA,
RXRG, VDR.
Chromatin Modification Molecules:
Histone Acetylation: HTATIP, NCOA1, NCOA3, PCAF.
Histone Deacetylation: HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A.
Other Chromatin Modification Molecules: ESR1, HMGA1, NCOA6, PPARGC1B.
Other Nuclear Receptor Co-regulators: DDX5, NCOA6IP, NONO.
核受体、转录因子和调节子、染色质修饰分子